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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 15 Apr 2016.

Early growth response 1

Egr-1, Early Growth Response Protein 1, zif268, NGFI-A
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Fos, V1a, HAD, ERK
Papers using Egr-1 antibodies
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
Santanam Nalini et al., In PPAR Research, 2006
... Rabbit Egr-1 and MCP-1 monoclonal antibody was obtained from Abcam (Cambridge, MA) ...
Structural determinants for transcriptional activation by cAMP-responsive DNA elements
Supplier
Barth Alison L et al., In BMC Neuroscience, 1987
... Mouse genes that had one or more CREB and zif268 binding sites are listed in table format, with the precise nucleotide sequence corresponding to the binding site and the relative position ...
Papers on Egr-1
Neural and neuroendocrine processing of a non-photic cue in an opportunistically-breeding songbird.
New
Bentley et al., Berkeley, United States. In J Exp Biol, Feb 2016
Males receiving a female stimulus showed significantly higher mRNA expression and immunoreactive cell count of the immediate early gene early growth response protein 1 (EGR-1) than isolated males, indicating hypothalamic activation in response to a female.
Tenogenic induction of equine mesenchymal stem cells by means of growth factors and low-level laser technology.
New
Spaas et al., Padova, Italy. In Vet Res Commun, Feb 2016
PB-MSCs were used to study the effects of the addition of some growth factors (GFs) as TGFβ3 (transforming growth factor), EGF2 (Epidermal growth factor), bFGF2 (Fibroblast growth factor) and IGF-1 (insulin-like growth factor) in presence or without Low Level Laser Technology (LLLT) on the mRNA expression levels of genes important in the tenogenic induction as Early Growth Response Protein-1 (EGR1), Tenascin (TNC) and Decorin (DCN).
Suppression of host PTEN gene expression for Leishmania donovani survival in Indian Visceral Leishmaniasis.
New
Sundar et al., Benares, India. In Microbes Infect, Feb 2016
Expression of pten and other genes in vicinity egr1 &4e-bp1 were evaluated in splenic tissue before and after treatment in visceral leishmaniasis patients.
Early Regulation of Profibrotic Genes in Primary Human Cardiac Myocytes by Trypanosoma cruzi.
New
Nde et al., Nashville, United States. In Plos Negl Trop Dis, Jan 2016
Early during infection, T. cruzi significantly upregulated transcription factors including activator protein 1 (AP1) transcription factor network components (including FOSB, FOS and JUNB), early growth response proteins 1 and 3 (EGR1, EGR3), and cytokines/chemokines (IL5, IL6, IL13, CCL11), which have all been implicated in the onset of fibrosis.
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
New
Impact
Morgan et al., Newcastle upon Tyne, United Kingdom. In J Clin Oncol, Dec 2015
RESULTS: We identified 15 significantly mutated genes: IRF4, KRAS, NRAS, MAX, HIST1H1E, RB1, EGR1, TP53, TRAF3, FAM46C, DIS3, BRAF, LTB, CYLD, and FGFR3.
Immunohistochemical detection of STAT6, CD34, CD99 and BCL-2 for diagnosing solitary fibrous tumors/hemangiopericytomas.
Jin et al., Shenyang, China. In Int J Clin Exp Pathol, 2014
Recently, NGFI-A binding protein 2 (NAB2)-signal transducer and the activator of transcription 6 (STAT6) fusion gene were discovered as a hallmark of SFTs/HPCs by using whole-exome, and transcriptome sequencing; consequently, the fusion gene can be rapidly detected by STAT6 immunohistochemistry.
New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc.
Review
Bermudez-Rattoni et al., Mexico. In Neural Plast, 2014
The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein.
Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.
Review
Srivastava et al., In Indian J Biochem Biophys, 2014
An upregulation of early growth response protein 1 (Egr-1), a zinc finger transcription factor has been observed in several models of vascular diseases.
Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging.
Review
Jones et al., Long Beach, United States. In J Gastroenterol Hepatol, 2014
Gastric mucosa of aging rats has increased susceptibility to injury by a variety of damaging agents such as ethanol, aspirin, and other non-steroidal anti-inflammatory drugs because of structural and functional abnormalities including: reduced gastric mucosal blood flow, hypoxia, reduced expression of vascular endothelial growth factor and survivin, and increased expression of early growth response protein 1 (egr-1) and phosphatase and tensin homolog (PTEN).
Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace.
Review
Okuno et al., Kyoto, Japan. In Front Mol Neurosci, 2014
In particular, the expression of immediate-early genes (IEGs) such as egr-1, c-fos, and Arc is rapidly and selectively upregulated in subsets of neurons in specific brain regions associated with learning and memory formation.
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
Impact
West et al., San Francisco, United States. In Nat Biotechnol, 2014
In the developing cortex, we identify diverse cell types, including multiple progenitor and neuronal subtypes, and we identify EGR1 and FOS as previously unreported candidate targets of Notch signaling in human but not mouse radial glia.
The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
Impact
Yamanaka et al., San Francisco, United States. In Cell Stem Cell, 2014
Here we show that the let-7 family of microRNAs acts as an inhibitory influence on the reprogramming process through a regulatory pathway involving prodifferentiation factors, including EGR1.
Early growth response-1 (EGR-1) - a key player in myocardial cell injury.
Review
Vedantham et al., Thanjāvūr, India. In Cardiovasc Hematol Agents Med Chem, 2013
EGR-1, an immediate early gene and a zinc finger transcription factor plays critical role in various cardiovascular patho-biological processes.
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis.
GeneRIF
Malle et al., Graz, Austria. In Biochimie, 2012
a crosslink between Egr-1 and periostin in cancer cells
Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes.
GeneRIF
Moon et al., Yangsan, South Korea. In Biochem Pharmacol, 2012
EGR-1 regulates pro-inflammatory NF-kappaB activation by LPS via PPARgamma although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells.
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.
GeneRIF
Chen et al., Zhengzhou, China. In J Virol, 2012
The present study provides the first evidence that endogenous Egr-1 aggravates herpetic stromal keratitis and that blocking Egr-1 reduces corneal damage in herpes simplex virus 1 infection.
Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
GeneRIF
Thiel et al., Homburg, Germany. In Endocrinology, 2012
Egr proteins play an important role in controlling insulin biosynthesis, glucose homeostasis, and islet size of pancreatic beta-cells in vivo
Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.
GeneRIF
Ehrlich et al., New York City, United States. In J Neurosci, 2012
study is the first to identify a TF, Egr-1, that directly interacts with and regulates Ppp1r1b gene expression in MSNs.
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.
Impact
Wagers et al., Boston, United States. In Cell Stem Cell, 2008
EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues.
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer.
Impact
Haura et al., Tampa, United States. In J Clin Oncol, 2005
PURPOSE: The zinc finger transcription factor early growth response gene 1 (EGR1) is underexpressed in non-small-cell lung cancer (NSCLC) compared with normal lung.
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