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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 04 Oct 2015.

Early growth response 1

Egr-1, Early Growth Response Protein 1, zif268, NGFI-A
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Fos, V1a, HAD, ERK
Papers using Egr-1 antibodies
Lipid peroxidation and redox-sensitive signaling pathways
Santanam Nalini et al., In PPAR Research, 2006
... Rabbit Egr-1 and MCP-1 monoclonal antibody was obtained from Abcam (Cambridge, MA) ...
Structural determinants for transcriptional activation by cAMP-responsive DNA elements
Barth Alison L et al., In BMC Neuroscience, 1987
... Mouse genes that had one or more CREB and zif268 binding sites are listed in table format, with the precise nucleotide sequence corresponding to the binding site and the relative position ...
Papers on Egr-1
Social interactions elicit rapid shifts in functional connectivity in the social decision-making network of zebrafish.
Oliveira et al., Lisbon, Portugal. In Proc Biol Sci, 07 Nov 2015
For this purpose we used zebrafish to map different social behaviour states into patterns of neuronal activity, as indicated by the expression of the immediate early genes c-fos and egr-1, across the SDM network.
Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells.
Zhang et al., Zhengzhou, China. In Pharm Biol, 01 Nov 2015
RESULTS AND CONCLUSION: DMU-212 was found to regulate a diverse range of genes, including cytokines (IL8, selectin E, MPZL2, EGR1, CCL20, ITGB8, CXCL1, VCAM1, KITLG, and AREG), transport proteins (TRPC4, SLC41A2, SLC17A5, and CREB5), metabolism (CYP1B1, CYP1A1, PDK4, CSNK1G1, MVK, TCEB3C, and CDKN3), enzymes (RAB23, SPHK1, CHSY3, PLAU, PLA2G4C, and MMP10), and genes involved in signal transduction (TMEM217, DUSP8, and SPRY4), chromosome organization (HIST1H2BH and GEM), cell migration and angiogenesis (ERRFI1, HBEGF, and NEDD9), and apoptosis (TNFSF15, TNFRSF9, CD274, BCL2L11, BIRC3, TNFAIP3, and TIFA), as well as other genes with unknown function (PGM5P2, SNORD1142, LOC151760, KRTAP5-2, C1orf110, SNORA14A, MIR31, C2CD4B, SCARNA4, C2orf66, SC4MOL, LOC644714, and LOC283392).
PI-88 inhibits postoperative recurrence of hepatocellular carcinoma via disrupting the surge of heparanase after liver resection.
Zhou et al., Shanghai, China. In Tumour Biol, 28 Oct 2015
In vitro expression of HPSE was up-regulated by overexpression of early growth response 1 (EGR1), which is induced after hepatectomy.
Histamine H1- and H4-receptor signaling cooperatively regulate MAPK activation.
Neumann et al., Hannover, Germany. In Biochem Pharmacol, 15 Oct 2015
Therefore, we co-expressed both receptor subtypes at comparable levels in HEK 293 cells and investigated HA-induced signaling parameters such as the concentrations of intracellular calcium and cAMP, phosphorylation of the MAPKs p38, ERK 1, and ERK 2, and of the transcription factor CREB, and expression of the immediate early gene EGR-1.
miR675 upregulates long noncoding RNA H19 through activating EGR1 in human liver cancer.
Lu et al., Shanghai, China. In Oncotarget, 10 Oct 2015
Mechanistically, miR675 inhibits the heterochromatin1 isoform HP1α expression in human liver cancer cells which causes a dramatically decrease of the total histone H3 lysine 9 trimethylation (H3K9me3) , histone H3 lysine 27 trimethylation (H3K27me3) and a increase of histone H3 lysine 27 acetylation(H3K27Ac).Notably, a significant reduction of the H3K9me3 and H3K27me3 and the increment of H3K27Ac occupancy on the promoter region of EGR1 triggers EGR1 transcription, translation, sumoylation and activation which upregulates lincRNA H19.
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Morgan et al., Newcastle upon Tyne, United Kingdom. In J Clin Oncol, 17 Sep 2015
RESULTS: We identified 15 significantly mutated genes: IRF4, KRAS, NRAS, MAX, HIST1H1E, RB1, EGR1, TP53, TRAF3, FAM46C, DIS3, BRAF, LTB, CYLD, and FGFR3.
Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.
Srivastava et al., In Indian J Biochem Biophys, Dec 2014
An upregulation of early growth response protein 1 (Egr-1), a zinc finger transcription factor has been observed in several models of vascular diseases.
Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging.
Jones et al., Long Beach, United States. In J Gastroenterol Hepatol, Dec 2014
Gastric mucosa of aging rats has increased susceptibility to injury by a variety of damaging agents such as ethanol, aspirin, and other non-steroidal anti-inflammatory drugs because of structural and functional abnormalities including: reduced gastric mucosal blood flow, hypoxia, reduced expression of vascular endothelial growth factor and survivin, and increased expression of early growth response protein 1 (egr-1) and phosphatase and tensin homolog (PTEN).
Curcumin and lung cancer--a review.
Sadikot et al., Gainesville, United States. In Target Oncol, Dec 2014
Curcumin can be an effective adjunct in treating solid organ tumors due to its properties of regulating oncogenes like p53, egr-1, c-myc, bcl-XL, etc.; transcription factors like NF-kB, STAT-3, and AP-1; protein kinases like MAPK; and enzymes like COX and LOX.
New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc.
Bermudez-Rattoni et al., Mexico. In Neural Plast, Dec 2014
The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein.
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
West et al., San Francisco, United States. In Nat Biotechnol, Oct 2014
In the developing cortex, we identify diverse cell types, including multiple progenitor and neuronal subtypes, and we identify EGR1 and FOS as previously unreported candidate targets of Notch signaling in human but not mouse radial glia.
The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
Yamanaka et al., San Francisco, United States. In Cell Stem Cell, Feb 2014
Here we show that the let-7 family of microRNAs acts as an inhibitory influence on the reprogramming process through a regulatory pathway involving prodifferentiation factors, including EGR1.
Early growth response-1 (EGR-1) - a key player in myocardial cell injury.
Vedantham et al., Thanjāvūr, India. In Cardiovasc Hematol Agents Med Chem, 2013
EGR-1, an immediate early gene and a zinc finger transcription factor plays critical role in various cardiovascular patho-biological processes.
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis.
Malle et al., Graz, Austria. In Biochimie, 2012
a crosslink between Egr-1 and periostin in cancer cells
Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes.
Moon et al., Yangsan, South Korea. In Biochem Pharmacol, 2012
EGR-1 regulates pro-inflammatory NF-kappaB activation by LPS via PPARgamma although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells.
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.
Chen et al., Zhengzhou, China. In J Virol, 2012
The present study provides the first evidence that endogenous Egr-1 aggravates herpetic stromal keratitis and that blocking Egr-1 reduces corneal damage in herpes simplex virus 1 infection.
Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
Thiel et al., Homburg, Germany. In Endocrinology, 2012
Egr proteins play an important role in controlling insulin biosynthesis, glucose homeostasis, and islet size of pancreatic beta-cells in vivo
Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.
Ehrlich et al., New York City, United States. In J Neurosci, 2012
study is the first to identify a TF, Egr-1, that directly interacts with and regulates Ppp1r1b gene expression in MSNs.
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.
Wagers et al., Boston, United States. In Cell Stem Cell, 2008
EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues.
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer.
Haura et al., Tampa, United States. In J Clin Oncol, 2005
PURPOSE: The zinc finger transcription factor early growth response gene 1 (EGR1) is underexpressed in non-small-cell lung cancer (NSCLC) compared with normal lung.
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