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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Jul 2015.

Early growth response 1

Egr-1, Early Growth Response Protein 1, zif268, NGFI-A
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Fos, V1a, HAD, ERK
Papers using Egr-1 antibodies
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
Santanam Nalini et al., In PPAR Research, 2006
... Rabbit Egr-1 and MCP-1 monoclonal antibody was obtained from Abcam (Cambridge, MA) ...
Structural determinants for transcriptional activation by cAMP-responsive DNA elements
Supplier
Barth Alison L et al., In BMC Neuroscience, 1987
... Mouse genes that had one or more CREB and zif268 binding sites are listed in table format, with the precise nucleotide sequence corresponding to the binding site and the relative position ...
Papers on Egr-1
Dyadic social interaction inhibits cocaine-conditioned place preference and the associated activation of the accumbens corridor.
New
Pinheiro et al., Innsbruck, Austria. In Behav Pharmacol, 30 Sep 2015
As the therapeutically most promising finding, only four 15 min episodes of dyadic social interaction were able to inhibit both the subsequent reacquisition/re-expression of preference for cocaine and the neural activation associated with this behavior, that is, an increase in the expression of the immediate early gene Early Growth Response protein 1 (EGR1, Zif268) in the nucleus accumbens, basolateral and central amygdala, and the ventral tegmental area.
Fibroblast growth factor 2 mRNA expression evoked by amitriptyline involves ERK-dependent EGR1 production in rat primary cultured astrocytes.
New
Takebayashi et al., Hiroshima, Japan. In J Neurochem, 16 Aug 2015
Amitriptyline treatment significantly increased early growth response 1 (EGR1), a transcription factor known to regulate FGF2 expression.
Prenatal alcohol exposure alters methyl metabolism and programs serotonin transporter and glucocorticoid receptor expression in brain.
New
Devlin et al., Colombia. In Am J Physiol Regul Integr Comp Physiol, 15 Aug 2015
We found lower Nr3c1 mRNA and lower NGFI-A protein in the hippocampus of E compared to PF females, whereas hippocampal Slc6a4 mRNA was higher in E than C males.
Predicting transcription factors in human alcoholic hepatitis from gene regulatory network.
New
Fallahi et al., Tehrān, Iran. In Eur Rev Med Pharmacol Sci, 30 Jun 2015
These TFs are AR, EGR1, MYC, TCF4, ATF3, JUN, FOXO3, STAT1, HIF1A and EOMES, where ATF3, TCF4 and MYC are the new TFs with a role in AH.
Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.
Review
New
Srivastava et al., In Indian J Biochem Biophys, Dec 2014
An upregulation of early growth response protein 1 (Egr-1), a zinc finger transcription factor has been observed in several models of vascular diseases.
Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.
New
Wang et al., Shanghai, China. In J Transl Med, Dec 2014
Gene expression analysis of hematopoietic primitive cells revealed up-regulated p16, p21, and down-regulated egr1 and fos.
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
New
Impact
West et al., San Francisco, United States. In Nat Biotechnol, Oct 2014
In the developing cortex, we identify diverse cell types, including multiple progenitor and neuronal subtypes, and we identify EGR1 and FOS as previously unreported candidate targets of Notch signaling in human but not mouse radial glia.
Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues.
Review
New
Rössler et al., Homburg, Germany. In Mol Cell Endocrinol, Jun 2014
Egr-1 and the related zinc finger transcription factors Egr-2, Egr-3, and Egr-4 are stimulated by many extracellular signaling molecules and represent a convergence point for intracellular signaling cascades.
Increased susceptibility of aging gastric mucosa to injury: the mechanisms and clinical implications.
Review
New
Jones et al., Long Beach, United States. In World J Gastroenterol, May 2014
Detailed analysis of the above changes indicates that the following events occur in aging gastric mucosa: reduced mucosal blood flow and impaired oxygen delivery cause hypoxia, which leads to activation of the early growth response-1 (egr-1) transcription factor.
Hypoxia and lymphangiogenesis in tumor microenvironment and metastasis.
Review
New
Ji, Ōita, Japan. In Cancer Lett, May 2014
Multiple factors (e.g., ET-1, AP-1, C/EBP-δ, EGR-1, NF-κB, and MIF) are involved in the events of hypoxia-induced lymphangiogenesis.
Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.
Review
New
Khan et al., United States. In Life Sci, May 2014
Several transcription factors including EGR-1, p53, ATF-3, Sp1 and PPARγ were involved in natural products-induced NAG-1 transcriptional signaling pathway.
The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
New
Impact
Yamanaka et al., San Francisco, United States. In Cell Stem Cell, Feb 2014
Here we show that the let-7 family of microRNAs acts as an inhibitory influence on the reprogramming process through a regulatory pathway involving prodifferentiation factors, including EGR1.
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis.
GeneRIF
Malle et al., Graz, Austria. In Biochimie, 2012
a crosslink between Egr-1 and periostin in cancer cells
Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes.
GeneRIF
Moon et al., Yangsan, South Korea. In Biochem Pharmacol, 2012
EGR-1 regulates pro-inflammatory NF-kappaB activation by LPS via PPARgamma although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells.
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.
GeneRIF
Chen et al., Zhengzhou, China. In J Virol, 2012
The present study provides the first evidence that endogenous Egr-1 aggravates herpetic stromal keratitis and that blocking Egr-1 reduces corneal damage in herpes simplex virus 1 infection.
Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
GeneRIF
Thiel et al., Homburg, Germany. In Endocrinology, 2012
Egr proteins play an important role in controlling insulin biosynthesis, glucose homeostasis, and islet size of pancreatic beta-cells in vivo
Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.
GeneRIF
Ehrlich et al., New York City, United States. In J Neurosci, 2012
study is the first to identify a TF, Egr-1, that directly interacts with and regulates Ppp1r1b gene expression in MSNs.
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.
Impact
Wagers et al., Boston, United States. In Cell Stem Cell, 2008
EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues.
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer.
Impact
Haura et al., Tampa, United States. In J Clin Oncol, 2005
PURPOSE: The zinc finger transcription factor early growth response gene 1 (EGR1) is underexpressed in non-small-cell lung cancer (NSCLC) compared with normal lung.
Radiation-induced tumour necrosis factor-alpha expression: clinical application of transcriptional and physical targeting of gene therapy.
Review
Impact
Mauceri et al., Chicago, United States. In Lancet Oncol, 2002
Promising data are emerging on a new anticancer agent, Ad.EGR-TNF, an adenoviral vector, which contains radio-inducible DNA sequences from the early growth response (EGR1) gene promoter and cDNA for the gene encoding human tumour necrosis factor-alpha.
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