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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 11 Nov 2015.

Early growth response 1

Egr-1, Early Growth Response Protein 1, zif268, NGFI-A
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Fos, V1a, HAD, ERK
Papers using Egr-1 antibodies
Lipid peroxidation and redox-sensitive signaling pathways
Santanam Nalini et al., In PPAR Research, 2006
... Rabbit Egr-1 and MCP-1 monoclonal antibody was obtained from Abcam (Cambridge, MA) ...
Structural determinants for transcriptional activation by cAMP-responsive DNA elements
Barth Alison L et al., In BMC Neuroscience, 1987
... Mouse genes that had one or more CREB and zif268 binding sites are listed in table format, with the precise nucleotide sequence corresponding to the binding site and the relative position ...
Papers on Egr-1
Macrophages Are Involved in Gut Bacterial Translocation and Reversed by Lactobacillus in Experimental Uremia.
He et al., Xi'an, China. In Dig Dis Sci, 30 Nov 2015
RT-PCR and Western blot were employed to assess the mRNA and protein expression of early growth response gene 1 (EGR1) and toll-like receptor 4 (TLR4).
Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1.
Kim et al., Seoul, South Korea. In Cancer Lett, 28 Nov 2015
hTERT knockdown showed decreased expression of FAP and early growth response (EGR)-1, one of the transcriptional regulators of FAP in IHOK/hTERT and oral cancer cell line YD10B.
Impairment of PI3K-AKT and WNT-β catenin pathways in bone marrow mesenchymal stem cells isolated from patients with Myelodysplastic Syndromes.
Leone et al., Roma, Italy. In Exp Hematol, 28 Nov 2015
GSK3β impairment translated into decreased β-catenin protein levels and downregulation of several WNT-β-catenin target genes (SOX9, EGR1, WISP1).
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Morgan et al., Newcastle upon Tyne, United Kingdom. In J Clin Oncol, Sep 2015
RESULTS: We identified 15 significantly mutated genes: IRF4, KRAS, NRAS, MAX, HIST1H1E, RB1, EGR1, TP53, TRAF3, FAM46C, DIS3, BRAF, LTB, CYLD, and FGFR3.
Tolstanova et al., In Ukr Biochem J, Jul 2015
Egr-1 and Sp-1 may regulate the transcription of genes that are associated with the pathogenesis of gastric ulcer (growthfactors, cell cycle regulators, etc.).
Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.
Srivastava et al., In Indian J Biochem Biophys, Dec 2014
An upregulation of early growth response protein 1 (Egr-1), a zinc finger transcription factor has been observed in several models of vascular diseases.
Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging.
Jones et al., Long Beach, United States. In J Gastroenterol Hepatol, Dec 2014
Gastric mucosa of aging rats has increased susceptibility to injury by a variety of damaging agents such as ethanol, aspirin, and other non-steroidal anti-inflammatory drugs because of structural and functional abnormalities including: reduced gastric mucosal blood flow, hypoxia, reduced expression of vascular endothelial growth factor and survivin, and increased expression of early growth response protein 1 (egr-1) and phosphatase and tensin homolog (PTEN).
Curcumin and lung cancer--a review.
Sadikot et al., Gainesville, United States. In Target Oncol, Dec 2014
Curcumin can be an effective adjunct in treating solid organ tumors due to its properties of regulating oncogenes like p53, egr-1, c-myc, bcl-XL, etc.; transcription factors like NF-kB, STAT-3, and AP-1; protein kinases like MAPK; and enzymes like COX and LOX.
New Insights on Retrieval-Induced and Ongoing Memory Consolidation: Lessons from Arc.
Bermudez-Rattoni et al., Mexico. In Neural Plast, Dec 2014
The strongest experimental support for the conjunctive trace model comes from the study of immediate early genes such as c-fos, zif268, and activity-regulated cytoskeletal-associated protein.
Downregulation of mPGES-1 Expression via EGR1 Plays an Important Role in Inhibition of Caffeine on PGE2 Synthesis of HBx(+) Hepatocytes.
Tang et al., Fuzhou, China. In Mediators Inflamm, Dec 2014
The PGE2 secretion and the expression of mPGES-1 and EGR1 were downregulated, whereas PPARγ expression was upregulated.
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
West et al., San Francisco, United States. In Nat Biotechnol, Oct 2014
In the developing cortex, we identify diverse cell types, including multiple progenitor and neuronal subtypes, and we identify EGR1 and FOS as previously unreported candidate targets of Notch signaling in human but not mouse radial glia.
The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
Yamanaka et al., San Francisco, United States. In Cell Stem Cell, Feb 2014
Here we show that the let-7 family of microRNAs acts as an inhibitory influence on the reprogramming process through a regulatory pathway involving prodifferentiation factors, including EGR1.
Early growth response-1 (EGR-1) - a key player in myocardial cell injury.
Vedantham et al., Thanjāvūr, India. In Cardiovasc Hematol Agents Med Chem, 2013
EGR-1, an immediate early gene and a zinc finger transcription factor plays critical role in various cardiovascular patho-biological processes.
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis.
Malle et al., Graz, Austria. In Biochimie, 2012
a crosslink between Egr-1 and periostin in cancer cells
Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes.
Moon et al., Yangsan, South Korea. In Biochem Pharmacol, 2012
EGR-1 regulates pro-inflammatory NF-kappaB activation by LPS via PPARgamma although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells.
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.
Chen et al., Zhengzhou, China. In J Virol, 2012
The present study provides the first evidence that endogenous Egr-1 aggravates herpetic stromal keratitis and that blocking Egr-1 reduces corneal damage in herpes simplex virus 1 infection.
Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
Thiel et al., Homburg, Germany. In Endocrinology, 2012
Egr proteins play an important role in controlling insulin biosynthesis, glucose homeostasis, and islet size of pancreatic beta-cells in vivo
Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.
Ehrlich et al., New York City, United States. In J Neurosci, 2012
study is the first to identify a TF, Egr-1, that directly interacts with and regulates Ppp1r1b gene expression in MSNs.
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.
Wagers et al., Boston, United States. In Cell Stem Cell, 2008
EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues.
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer.
Haura et al., Tampa, United States. In J Clin Oncol, 2005
PURPOSE: The zinc finger transcription factor early growth response gene 1 (EGR1) is underexpressed in non-small-cell lung cancer (NSCLC) compared with normal lung.
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