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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Sep 2015.

Early growth response 1

Egr-1, Early Growth Response Protein 1, zif268, NGFI-A
The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppresor gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Fos, V1a, HAD, ERK
Papers using Egr-1 antibodies
Lipid peroxidation and redox-sensitive signaling pathways
Supplier
Santanam Nalini et al., In PPAR Research, 2006
... Rabbit Egr-1 and MCP-1 monoclonal antibody was obtained from Abcam (Cambridge, MA) ...
Structural determinants for transcriptional activation by cAMP-responsive DNA elements
Supplier
Barth Alison L et al., In BMC Neuroscience, 1987
... Mouse genes that had one or more CREB and zif268 binding sites are listed in table format, with the precise nucleotide sequence corresponding to the binding site and the relative position ...
Papers on Egr-1
Regulation of cytochrome P450 2B6 expression by dimethyl sulfoxide and EGR1 in HC-AFW1 hepatocarcinoma cells.
New
Braeuning et al., Reutlingen, Germany. In Drug Metab Dispos, 25 Sep 2015
Interestingly, elevated transcription of CYP2B6 was accompanied by a simultaneous induction of EGR1 (early growth response 1), a transcription factor which is known to influence the expression of CYP2B6.
Gene expression and pathway analysis of human hepatocellular carcinoma cells treated with cadmium.
New
Costa et al., New York City, United States. In Toxicol Appl Pharmacol, 24 Sep 2015
Genes downregulated following chronic exposure included the transcriptional regulator early growth response protein 1. Ingenuity Pathway Analysis revealed that the top networks altered by acute exposure were lipid metabolism, small molecule biosynthesis, cell morphology, organization, and development; while top networks altered by chronic exposure were organ morphology, cell cycle, cell signaling, and renal and urological diseases/cancer.
Detection of Zinc Finger Protein (EGR1) Based on Electrogenerated Chemiluminescence from Singlet Oxygen Produced in a Nanoclay-Supported Porphyrin Environment.
New
Zhang et al., In Anal Chem, 24 Sep 2015
UNASSIGNED: Early growth response protein 1 (EGR1), as a characteristic example of zinc finger proteins, acts as a transcription factor in eukaryotic cells, mediating protein-protein interactions.
Antitumor effects and mechanisms of AZD4547 on FGFR2-deregulated endometrial cancer cells.
New
Sim et al., South Korea. In Mol Cancer Ther, 20 Sep 2015
Unbiased reporter gene assay showed that AZD4547 antagonizes the aFGF-induced activation of several transcription factors including EGR1, ELK-1/SRF, AP-1, and NF-kB.
Amygdaloid zif268 participated in the D-cycloserine facilitation effect on the extinction of conditioned fear.
New
Lu et al., Taipei, Taiwan. In Psychopharmacology (berl), 19 Sep 2015
This study was aimed at elucidating the possible role of zif268 on the D-cycloserine (DCS) facilitation effect on extinction.
Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
New
Impact
Morgan et al., Newcastle upon Tyne, United Kingdom. In J Clin Oncol, 17 Sep 2015
RESULTS: We identified 15 significantly mutated genes: IRF4, KRAS, NRAS, MAX, HIST1H1E, RB1, EGR1, TP53, TRAF3, FAM46C, DIS3, BRAF, LTB, CYLD, and FGFR3.
Angiogenesis in gastric mucosa: an important component of gastric erosion and ulcer healing and its impairment in aging.
Review
New
Jones et al., Long Beach, United States. In J Gastroenterol Hepatol, Dec 2014
Gastric mucosa of aging rats has increased susceptibility to injury by a variety of damaging agents such as ethanol, aspirin, and other non-steroidal anti-inflammatory drugs because of structural and functional abnormalities including: reduced gastric mucosal blood flow, hypoxia, reduced expression of vascular endothelial growth factor and survivin, and increased expression of early growth response protein 1 (egr-1) and phosphatase and tensin homolog (PTEN).
Involvement of the early growth response protein 1 in vascular pathophysiology: an overview.
Review
New
Srivastava et al., In Indian J Biochem Biophys, Dec 2014
An upregulation of early growth response protein 1 (Egr-1), a zinc finger transcription factor has been observed in several models of vascular diseases.
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex.
New
Impact
West et al., San Francisco, United States. In Nat Biotechnol, Oct 2014
In the developing cortex, we identify diverse cell types, including multiple progenitor and neuronal subtypes, and we identify EGR1 and FOS as previously unreported candidate targets of Notch signaling in human but not mouse radial glia.
Expression, signaling and function of Egr transcription factors in pancreatic β-cells and insulin-responsive tissues.
Review
New
Rössler et al., Homburg, Germany. In Mol Cell Endocrinol, Jun 2014
Egr-1 and the related zinc finger transcription factors Egr-2, Egr-3, and Egr-4 are stimulated by many extracellular signaling molecules and represent a convergence point for intracellular signaling cascades.
Increased susceptibility of aging gastric mucosa to injury: the mechanisms and clinical implications.
Review
New
Jones et al., Long Beach, United States. In World J Gastroenterol, May 2014
Detailed analysis of the above changes indicates that the following events occur in aging gastric mucosa: reduced mucosal blood flow and impaired oxygen delivery cause hypoxia, which leads to activation of the early growth response-1 (egr-1) transcription factor.
Nonsteroidal anti-inflammatory drug activated gene-1 (NAG-1) modulators from natural products as anti-cancer agents.
Review
New
Khan et al., United States. In Life Sci, May 2014
Several transcription factors including EGR-1, p53, ATF-3, Sp1 and PPARγ were involved in natural products-induced NAG-1 transcriptional signaling pathway.
The let-7/LIN-41 pathway regulates reprogramming to human induced pluripotent stem cells by controlling expression of prodifferentiation genes.
New
Impact
Yamanaka et al., San Francisco, United States. In Cell Stem Cell, Feb 2014
Here we show that the let-7 family of microRNAs acts as an inhibitory influence on the reprogramming process through a regulatory pathway involving prodifferentiation factors, including EGR1.
LPA-induced suppression of periostin in human osteosarcoma cells is mediated by the LPA(1)/Egr-1 axis.
GeneRIF
Malle et al., Graz, Austria. In Biochimie, 2012
a crosslink between Egr-1 and periostin in cancer cells
Ambivalent roles of early growth response 1 in inflammatory signaling following ribosomal insult in human enterocytes.
GeneRIF
Moon et al., Yangsan, South Korea. In Biochem Pharmacol, 2012
EGR-1 regulates pro-inflammatory NF-kappaB activation by LPS via PPARgamma although EGR-1 is a positive mediator of chemokine expression following ribosomal insult in intestinal epithelial cells.
Suppression of transcription factor early growth response 1 reduces herpes simplex virus 1-induced corneal disease in mice.
GeneRIF
Chen et al., Zhengzhou, China. In J Virol, 2012
The present study provides the first evidence that endogenous Egr-1 aggravates herpetic stromal keratitis and that blocking Egr-1 reduces corneal damage in herpes simplex virus 1 infection.
Critical role of Egr transcription factors in regulating insulin biosynthesis, blood glucose homeostasis, and islet size.
GeneRIF
Thiel et al., Homburg, Germany. In Endocrinology, 2012
Egr proteins play an important role in controlling insulin biosynthesis, glucose homeostasis, and islet size of pancreatic beta-cells in vivo
Egr-1 induces DARPP-32 expression in striatal medium spiny neurons via a conserved intragenic element.
GeneRIF
Ehrlich et al., New York City, United States. In J Neurosci, 2012
study is the first to identify a TF, Egr-1, that directly interacts with and regulates Ppp1r1b gene expression in MSNs.
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.
Impact
Wagers et al., Boston, United States. In Cell Stem Cell, 2008
EGR1 is a member of the immediate early response transcription factor family and functions in cell growth, development, and stress responses in many tissues.
EGR1 predicts PTEN and survival in patients with non-small-cell lung cancer.
Impact
Haura et al., Tampa, United States. In J Clin Oncol, 2005
PURPOSE: The zinc finger transcription factor early growth response gene 1 (EGR1) is underexpressed in non-small-cell lung cancer (NSCLC) compared with normal lung.
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