Acquired resistance to EGFR tyrosine kinase inhibitors alters the metabolism of human head and neck squamous carcinoma cells and xenograft tumours.
London, United Kingdom. In Br J Cancer, 05 Apr 2015
UNASSIGNED: Background:Acquired resistance to molecularly targeted therapeutics is a key challenge in personalised cancer medicine, highlighting the need for identifying the underlying mechanisms and early biomarkers of relapse, in order to guide subsequent patient management.Methods:Here we use human head and neck squamous cell carcinoma (HNSCC) models and nuclear magnetic resonance (NMR) spectroscopy to assess the metabolic changes that follow acquired resistance to EGFR tyrosine kinase inhibitors (TKIs), and which could serve as potential metabolic biomarkers of drug resistance.Results:Comparison of NMR metabolite profiles obtained from control (CAL(S)) and EGFR TKI-resistant (CAL(R)) cells grown as 2D monolayers, 3D spheroids or xenograft tumours in athymic mice revealed a number of differences between the sensitive and drug-resistant models.
The Influence of Triclosan on Biomarkers of Cardiovascular Risk in Patients in the Cardiovascular and Periodontal Study (CAPS): a Randomised Controlled Trial.
Brisbane, Australia. In J Periodontol, 05 Apr 2015
Methods: Patients recruited from the Cardiovascular Unit at Prince Charles Hospital, Brisbane, Australia were randomized to triclosan (n=193) or placebo (n=190) and assessed for total cholesterol (TC), high (HDL) and low density (LDL) cholesterol, triglycerides, C-reactive protein, erythrocyte sedimentation rate (ESR), hemoglobin, total white cell count (WCC), eGFR (estimated glomerular filtration rate) and liver function enzymes, annually for 5-years.
Afatinib for the treatment of metastatic non-small cell lung cancer.
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Penn Hills, United States. In Cancer Manag Res, Dec 2014
Targeting the epidermal growth factor receptor (EGFR) in patients with non-small cell lung cancer (NSCLC) harboring sensitizing mutations in the tyrosine kinase (TKI) domain has led to a significant change in the management of this disease.
Treatment of eccrine porocarcinoma with metastasis to the parotid gland using intensity-modulated radiation therapy: a case report
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