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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

EGF-like domain 7

EGFL7, VE-statin, vascular endothelial-statin, EGF-like domain 7
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: CAN, miR, vascular endothelial growth factor, Epidermal Growth Factor, V1a
Papers on EGFL7
Methylation-associated Silencing of microRNA-126 and its Host Gene EGFL7 in Malignant Pleural Mesothelioma.
New
Santoni-Rugiu et al., Copenhagen, Denmark. In Anticancer Res, Nov 2015
Herein we analyzed the epigenetic regulation of miR-126 and its host gene EGF-like domain, multiple 7 (EGFL7).
Different expression of VEGF and EGFL7 in human hepatocellular carcinoma.
New
Baiocchi et al., Roma, Italy. In Dig Liver Dis, Nov 2015
Lately, another angiogenic factor, epidermal growth factor-like domain multiple 7 (EGFL7), has attracted interest due to its possible relationship with hepatocellular carcinoma metastasis.
Genetic compensation induced by deleterious mutations but not gene knockdowns.
New
Impact
Stainier et al., Bad Nauheim, Germany. In Nature, Sep 2015
To identify the reasons underlying the phenotypic differences between mutants and knockdowns, we generated mutations in zebrafish egfl7, an endothelial extracellular matrix gene of therapeutic interest, as well as in vegfaa.
Molecular characterization and expression analysis of mouse epidermal growth factor-like domain 8.
New
Yoon et al., Yangsan, South Korea. In Int J Mol Med, Aug 2015
A phylogenetic tree calculated using the neighbor-joining method revealed that EGFL8 and EGFL7 are more closely associated with each other than either is to EGFL3, and they cluster with EGFL6.
Attenuation of EGFL7 inhibits human laryngocarcinoma cells growth and invasion.
Zhu et al., Xi'an, China. In Int J Clin Exp Med, 2014
METHODS: We constructed a lentiviral vector expressing EGFL7 specific shRNA, and introduced it in EGFL7 functions were attenuated by a lentiviral vector harboring shRNA targeting at EGFL7 in laryngeal carcinoma cell line Hep-2.
Suppression of the Epidermal Growth Factor-like Domain 7 and Inhibition of Migration and Epithelial-Mesenchymal Transition in Human Pancreatic Cancer PANC-1 Cells.
Zhou et al., Suzhou, China. In Asian Pac J Cancer Prev, 2014
BACKGROUND: Epidermal growth factor-like domain multiple 7 (EGFL7), a secreted protein specifically expressed by endothelial cells during embryogenesis, recently was identified as a critical gene in tumor metastasis.
Expression of epidermal growth factor-like domain 7 correlates with clinicopathological features of osteosarcoma.
He et al., Changsha, China. In Am J Transl Res, 2014
Epidermal growth factor-like domain 7 gene (EGFL7) encodes an angiogenesis related factor and plays a crucial role in many human cancers.
In-vitro inhibitory effect of EGFL7-RNAi on endothelial angiogenesis in glioma.
Yu et al., Haikou, China. In Int J Clin Exp Pathol, 2014
OBJECTIVE: To investigate the role and mechanism of epidermal growth factor like domain 7 (EGFL7) in glioma angiogenesis by cell co-culture and RNA interference.
miR-126 in human cancers: clinical roles and current perspectives.
Review
Lam et al., Gold Coast, Australia. In Exp Mol Pathol, 2014
In addition, miR-126 can alter a multitude of cellular mechanisms in cancer pathogenesis via suppressing gene translation of numerous validated targets such as PI3K, KRAS, EGFL7, CRK, ADAM9, HOXA9, IRS-1, SOX-2, SLC7A5 and VEGF.
Notching on Cancer's Door: Notch Signaling in Brain Tumors.
Review
Schmidt et al., Mainz, Germany. In Front Oncol, 2013
Further, non-canonical Notch ligands such as epidermal growth factor like protein 7 (EGFL7) have been identified and serve mostly as antagonists of Notch signaling.
Angiogenic factors in bone local environment.
Review
Xu et al., Australia. In Cytokine Growth Factor Rev, 2013
In addition, the expression of EGFL2, EGFL3, EGFL5, EGFL6, EGFL7, EGFL8 and EGFL9 has been recently identified in the bone local environment, giving important clues to their possible roles in angiogenesis.
Gene expression profiling of placentae from women with early- and late-onset pre-eclampsia: down-regulation of the angiogenesis-related genes ACVRL1 and EGFL7 in early-onset disease.
GeneRIF
Olovsson et al., Uppsala, Sweden. In Mol Hum Reprod, 2012
Two angiogenesis-associated transcripts (Egfl7 and Acvrl1) showed lower expression in early-onset PE versus late-onset pre-eclampsia and versus gestational age-matched controls.
EGFL7: a unique angiogenic signaling factor in vascular development and disease.
Review
GeneRIF
Stuhlmann et al., New York City, United States. In Blood, 2012
Studies indicate that Egfl7 controls blood vessel development by promoting endothelial cell migration and proliferation.
Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation.
GeneRIF
Soncin et al., Lille, France. In Cancer Res, 2012
Human breast cancer lesions expressing high levels of Egfl7.
Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non-small cell lung cancer and surrounding tissues.
GeneRIF
Sverdlov et al., Moscow, Russia. In Cancer Genet, 2011
Heterogeneous methylation in the promoter region of EGFL7 was associated with cancer progression in non-small cell lung cancer.
miR-126 and miR-126*: new players in cancer.
Review
GeneRIF
Schmidt et al., Frankfurt am Main, Germany. In Scientificworldjournal, 2009
Studies indicate that two biologically active miRNAs miR-126 and its complement miR-126*, which are encoded by intron 7 of the egfl7 gene, have been described to mediate vascular functions.
Epidermal growth factor-like domain 7 (EGFL7) modulates Notch signalling and affects neural stem cell renewal.
Impact
GeneRIF
Dikic et al., Frankfurt am Main, Germany. In Nat Cell Biol, 2009
Data identified neurons as a source of EGFL7 in the brain, suggesting that brain-derived EGFL7 acts as an endogenous antagonist of Notch signalling that regulates proliferation and differentiation of subventricular zone-derived adult NSCs.
The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation.
Impact
GeneRIF
Ye et al., San Francisco, United States. In Nature, 2004
loss of Egfl7 function in zebrafish embryos specifically blocks vascular tubulogenesis
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