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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

EGF-like domain 7

EGFL7, VE-statin, vascular endothelial-statin, EGF-like domain 7
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] (from NCBI)
Papers on EGFL7
Gene expression profiling of placentae from women with early- and late-onset pre-eclampsia: down-regulation of the angiogenesis-related genes ACVRL1 and EGFL7 in early-onset disease.
Olovsson et al., Uppsala, Sweden. In Mol Hum Reprod, 2012
Two angiogenesis-associated transcripts (Egfl7 and Acvrl1) showed lower expression in early-onset PE versus late-onset pre-eclampsia and versus gestational age-matched controls.
EGFL7: a unique angiogenic signaling factor in vascular development and disease.
Stuhlmann et al., New York City, United States. In Blood, 2012
Studies indicate that Egfl7 controls blood vessel development by promoting endothelial cell migration and proliferation.
Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation.
Soncin et al., Lille, France. In Cancer Res, 2012
Human breast cancer lesions expressing high levels of Egfl7.
Heterogeneity and degree of TIMP4, GATA4, SOX18, and EGFL7 gene promoter methylation in non-small cell lung cancer and surrounding tissues.
Sverdlov et al., Moscow, Russia. In Cancer Genet, 2011
Heterogeneous methylation in the promoter region of EGFL7 was associated with cancer progression in non-small cell lung cancer.
miR-126 and miR-126*: new players in cancer.
Schmidt et al., Frankfurt am Main, Germany. In Scientificworldjournal, 2009
Studies indicate that two biologically active miRNAs miR-126 and its complement miR-126*, which are encoded by intron 7 of the egfl7 gene, have been described to mediate vascular functions.
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