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Kinesin family member 11

Eg5, KIF11
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Hex, Insulysin, HAD, OUT
Papers using Eg5 antibodies
Poleward transport of Eg5 by dynein–dynactin in Xenopus laevis egg extract spindles
Surrey Thomas et al., In The Journal of Cell Biology, 2006
... To generate expression vectors for Eg5 with a C-terminal GFP or paGFP, a PCR-amplified, SalI–XhoI-digested sequence of enhanced GFP (Clontech Laboratories, Inc.) or paGFP ...
Papers on Eg5
Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand.
Wagner et al., München, Germany. In Biomaterials, Jan 2016
The combination of MTX-conjugated polyplexes and eglin 5 (EG5) siRNA provides enhanced antitumoral potency with 50% of recurrence-free survival of KB tumor-bearing mice.
KIF11 mutations are a common cause of autosomal dominant familial exudative vitreoretinopathy.
Zhang et al., Guangzhou, China. In Br J Ophthalmol, Nov 2015
BACKGROUND/AIMS: To identify KIF11 mutations in patients with familial exudative vitreoretinopathy (FEVR) and to describe the associated phenotypes.
Identification of genes associated with osteoarthritis by microarray analysis.
Zhang et al., Shanghai, China. In Mol Med Report, Oct 2015
Functional enrichment analysis of the DEGs demonstrated that FGF19, KIF11 and KIF2C were involved in the response to stress and that ACAN, ADAMTS10 and BGN were associated with proteinaceous ECM.
The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.
Rich et al., Cleveland, United States. In Sci Transl Med, Oct 2015
We identified a molecular target that shuttles between these disparate cellular processes-the molecular motor KIF11.
Characterization of Cep85 - a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction.
Yu et al., Xiamen, China. In J Cell Sci, Oct 2015
Opposite to the effects of Nek2A, overexpression of Cep85 in conjunction with inhibition of the motor protein Eg5 (also known as KIF11) leads to the failure of centrosome disjunction.
Bmk-1 regulates lifespan in Caenorhabditis elegans by activating hsp-16.
Niklason et al., New Haven, United States. In Oncotarget, Sep 2015
Previous reports in C. elegans have shown that the bmk-1 gene has important functions in chromosome segregation, and this has been confirmed with its mammalian homolog, KIF11.
TPX2 regulates neuronal morphology through kinesin-5 interaction.
Baas et al., Tallahassee, United States. In Cytoskeleton (hoboken), Jul 2015
TPX2 (targeting protein for Xklp2) is a multifunctional mitotic spindle assembly factor that in mammalian cells localizes and regulates mitotic motor protein kinesin-5 (also called Eg5 or kif11).
Inhibition of kinesin-5 improves regeneration of injured axons by a novel microtubule-based mechanism.
Matamoros et al., Philadelphia, United States. In Neural Regen Res, Jun 2015
Kinesin-5 (also called kif11 or Eg5), a molecular motor protein best known for its crucial role in mitosis, acts as a brake on microtubule movements by other motor proteins in the axon.
A three-step MTOC fragmentation mechanism facilitates bipolar spindle assembly in mouse oocytes.
Schuh et al., Cambridge, United Kingdom. In Nat Commun, 2014
Third, KIF11 further fragments the MTOCs following nuclear envelope breakdown so that they can be evenly distributed towards the two spindle poles.
Congenital microcephaly and chorioretinopathy due to de novo heterozygous KIF11 mutations: five novel mutations and review of the literature.
Christian et al., Seattle, United States. In Am J Med Genet A, 2014
Recently, heterozygous mutations in KIF11, a gene encoding a critical spindle motor protein of the Kinesin family, have been reported in individuals with MLCRD, and in individuals with CDMMR.
The dynamics of microtubule minus ends in the human mitotic spindle.
Lüders et al., In Nat Cell Biol, 2014
Poleward movement of γTuRC exceeds k-fibre flux, involves the motors dynein, HSET (also known as KIFC1; a kinesin-14 family member) and Eg5 (also known as KIF11; a kinesin-5 family member), and slows down in pole-proximal regions, resulting in the accumulation of minus ends.
Kinesins and cancer.
Kozielski et al., Glasgow, United Kingdom. In Nat Rev Cancer, 2012
Several compounds that inhibit two mitotic kinesins (EG5 (also known as KIF11) and centromere-associated protein E (CENPE)) have entered Phase I and II clinical trials either as monotherapies or in combination with other drugs.
Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2.
Wadsworth et al., Amherst Center, United States. In Mol Biol Cell, 2012
observations explain the poleward accumulation of Eg5 in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 movement on microtubules, whereas depletion of the Eg5-binding protein TPX2 resulted in end-directed Eg5 movement.
Xeroderma pigmentosum group F protein binds to Eg5 and is required for proper mitosis: implications for XP-F and XFE.
Tanaka et al., Suita, Japan. In Genes Cells, 2012
these results suggest that the interaction between XPF and Eg5 plays a role in mitosis and DNA repair and offer new insights into the pathogenesis of XP-F and XFE.
Mutations in KIF11 cause autosomal-dominant microcephaly variably associated with congenital lymphedema and chorioretinopathy.
Jeffery et al., London, United Kingdom. In Am J Hum Genet, 2012
Heterozygous KIF11 mutations in three individuals with a combination of microcephaly and lymphedema from a microcephaly-lymphedema-chorioretinal-dysplasia cohort.
3D-QSAR studies of dihydropyrazole and dihydropyrrole derivatives as inhibitors of human mitotic kinesin Eg5 based on molecular docking.
Lin et al., Chongqing, China. In Molecules, 2011
The CoMFA and CoMSIA models were mapped back to the binding sites of Eg5.
Genetic variants of IDE-KIF11-HHEX at 10q23.33 associated with type 2 diabetes risk: a fine-mapping study in Chinese population.
Shen et al., Nanjing, China. In Plos One, 2011
Genetic variants of the IDE-KIF11-HHEX region at 10q23.33 contribute to type 2 diabetes susceptibility.
Bioconversion of lignocellulosic biomass: biochemical and molecular perspectives.
Singh et al., New Delhi, India. In J Ind Microbiol Biotechnol, 2008
Cellulolytic enzyme systems from the filamentous fungi, especially Trichoderma reesei, contain two exoglucanases or cellobiohydrolases (CBH1 and CBH2), at least four endoglucanases (EG1, EG2, EG3, EG5), and one beta-glucosidase.
A genome-wide association study identifies novel risk loci for type 2 diabetes.
Froguel et al., Montréal, Canada. In Nature, 2007
These loci include a non-synonymous polymorphism in the zinc transporter SLC30A8, which is expressed exclusively in insulin-producing beta-cells, and two linkage disequilibrium blocks that contain genes potentially involved in beta-cell development or function (IDE-KIF11-HHEX and EXT2-ALX4).
Isolation and analysis of microtubule motor proteins.
Saxton, Bloomington, United States. In Methods Cell Biol, 1993
The only work that I am aware of has produced a kinesin-like microtubule motor (D.G.
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