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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Tripartite motif containing 25

EFP, TRIM25, ZNF147
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, ACID, RIG-I, CAN, VISA
Papers on EFP
Phosphorylation of Influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity.
New
Ludwig et al., Münster, Germany. In Cell Microbiol, Jan 2016
Phosphorylation impairs binding of NS1 to dsRNA and TRIM25 as well as complex formation with RIG-I thereby switching-off its interferon antagonistic activity.
TRIM25 blockade by RNA interference inhibited migration and invasion of gastric cancer cells through TGF-β signaling.
New
Yan et al., Shanghai, China. In Sci Rep, Dec 2015
Tripartite Motif Containing 25 (TRIM25), a member of TRIM proteins, has been found abnormally expressed in cancers of female reproductive system.
Dengue subgenomic RNA binds TRIM25 to inhibit interferon expression for epidemiological fitness.
New
Impact
Ooi et al., Singapore, Singapore. In Science, Nov 2015
PR-2B sfRNA showed sequence-dependent binding to and prevention of tripartite motif 25 (TRIM25) deubiquitylation, which is critical for sustained and amplified retinoic acid-inducible gene 1 (RIG-I)-induced type I interferon expression.
Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384.
New
Zhang et al., Beijing, China. In Immunol Res, Oct 2015
BIK interactive total feedback terms included mitochondrial envelope, endomembrane system, integral to membrane, Golgi apparatus, cytoplasm, nucleus, cytosol, intracellular signaling cascade, mitochondrion, extracellular space, inflammation, immune response, apoptosis, cell differentiation, cell cycle, regulation of cell cycle, cell proliferation, estrogen-responsive protein Efp controls cell cycle and breast tumors growth, induction or regulation of apoptosis based on integrative GO, KEGG, GenMAPP, BioCarta and disease databases in low normal adjacent tissues of lung adenocarcinoma.
Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation.
New
Inn et al., Seoul, South Korea. In Mol Cells, Sep 2015
Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling.
Dengue Non-coding RNA: TRIMmed for Transmission.
New
Pijlman et al., Wageningen, Netherlands. In Cell Host Microbe, Sep 2015
In a recent paper in Science, Manokaran et al. (2015) report that sfRNA binds TRIM25 to evade innate immune sensing of viral RNA by RIG-I.
Structure-function based molecular relationships in Ewing's sarcoma.
Review
Todorova, Sofia, Bulgaria. In Biomed Res Int, 2014
The DNA-binding domain, provided by EFP, is bound to the promoter.
An EEG Finger-Print of fMRI deep regional activation.
Review
Intrator et al., Tel Aviv-Yafo, Israel. In Neuroimage, 2014
This work introduces a general framework for producing an EEG Finger-Print (EFP) which can be used to predict specific brain activity as measured by fMRI at a given deep region.
Methodological approaches for using synchrotron X-ray fluorescence (SXRF) imaging as a tool in ionomics: examples from Arabidopsis thaliana.
Review
Zuber et al., United States. In Metallomics, 2013
These approaches make use of open-access, online databases with which plant molecular genetics researchers working in the model plant Arabidopsis will be familiar, in particular the Ionomics Hub and online transcriptomic databases such as the Arabidopsis eFP browser.
The influenza virus NS1 protein as a therapeutic target.
Review
Engel, Charlottesville, United States. In Antiviral Res, 2013
Binding of NS1 to the E3 ubiquitin ligase TRIM25 prevents activation of RIG-I signaling and subsequent IFN induction.
Design and Implementation of Scientific Software Components to Enable Multiscale Modeling: The Effective Fragment Potential (QM/EFP) Method.
Gordon et al., Ames, United States. In J Chem Theory Comput, 2013
The design and development of scientific software components to provide an interface to the effective fragment potential (EFP) methods are reported.
[Innate immune responses against viral infection and its suppression by viral proteins].
Review
Seya et al., Sapporo, Japan. In Yakugaku Zasshi, 2012
Riplet and TRIM25 ubiquitin ligase deliver Lys63-linked polyubiquitin moiety to RIG-I and result in signal activation.
Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP.
GeneRIF
Dong et al., Atlanta, United States. In Biochem J, 2012
EFP mediates estrogen-induced ATBF1 protein degradation in breast cancer cells.
The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.
GeneRIF
Gale et al., Seattle, United States. In Cell Host Microbe, 2012
14-3-3epsilon is essential for the stable interaction of RIG-I with TRIM25, which facilitates RIG-I ubiquitination and initiation of innate immunity against hepatitis C virus and other pathogenic RNA viruses.
Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I.
Review
GeneRIF
Seya et al., Sapporo, Japan. In J Biochem, 2012
Studies indicate that the splice variant of RIG-I encodes a protein that lacks the first CARD of RIG-I, and the variant RIG-I protein is not ubiquitinated by TRIM25.
MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors.
GeneRIF
Arnoult et al., Villejuif, France. In Bmc Biol, 2011
Study reports that RLR activation triggers MAVS ubiquitination on lysine 7 and 10 by the E3 ubiquitin ligase TRIM25 and marks it for proteasomal degradation concomitantly with downstream signaling.
Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.
GeneRIF
Jung et al., Los Angeles, United States. In Mol Cell, 2011
RING-IBR-RING E3 ligase domains of HOIL-1L and HOIP bind and induce proteasomal degradation of TRIM25, whereas the NZF domain of HOIL-1L competes with TRIM25 for RIG-I binding
Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I.
Impact
Fikrig et al., New Haven, United States. In Nat Immunol, 2010
In vitro studies of primary neurons and mouse embryonic fibroblasts showed that caspase-12 positively modulated the production of type I interferon by regulating E3 ubiquitin ligase TRIM25-mediated ubiquitination of RIG-I, a critical signaling event for the type I interferon response to WNV and other important viral pathogens.
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
Impact
Jung et al., United States. In Nature, 2007
Here we report that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells.
Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
Impact
Inoue et al., Tokyo, Japan. In Nature, 2002
Efp, a target gene product of ER alpha, is a member of the RING-finger B-box coiled-coil (RBCC) motif family.
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