Regulation of translation factor EEF1D gene function by alternative splicing.
Kumamoto, Japan. In Int J Mol Sci, 2014
Previously, we discovered a long form of eukaryotic elongation factor 1Bδ (eEF1Bδ; this long-form eEF1Bδ results from alternative splicing of EEF1D transcripts and regulates the cellular stress response by transcriptional activation, not translational enhancement, of heat-shock responsive genes.
Rare variants in LRRK1 and Parkinson's disease.
München, Germany. In Neurogenetics, 2014
Segregation analysis and frequency assessment in 862 PD cases and 1,014 ethnically matched controls highlighted variants in EEF1D and LRRK1 as the best candidates.
Function of human cytomegalovirus UL97 kinase in viral infection and its inhibition by maribavir.
Birmingham, United States. In Rev Med Virol, 2009
The kinase phosphorylates eukaryotic elongation factor 1delta, the carboxyl terminal domain of the large subunit of RNA polymerase II, the retinoblastoma tumour suppressor and lamins A and C. Each of these is also phosphorylated and regulated by cdc2/cyclin-dependent kinase 1, suggesting that the viral kinase may perform a similar function.