BDNF - a key transducer of antidepressant effects.
Stockholm, Sweden. In Neuropharmacology, Mar 2016
The antidepressant-like response of ketamine is abolished in BDNF and TrkB conditional knockout mice, eEF2 kinase knockout mice, in mice carrying the BDNF met/met allele, and by intra-cortical infusions of BDNF-neutralizing antibodies.
Stress-mediated translational control in cancer cells.
Vancouver, Canada. In Biochim Biophys Acta, Jul 2015
Here we present the different regulatory signaling pathways which coordinate mRNA translation in the response to different stress forms, including those regulating eIF2α, mTORC1 and eEF2K, and we explain how tumor cells hijack these pathways for survival under stress.
Regulation and roles of elongation factor 2 kinase.
Southampton, United Kingdom. In Biochem Soc Trans, Jun 2015
Eukaryotic elongation factor 2 kinase (eEF2K) belongs to the small family of atypical protein kinases termed α-kinases, and is the only calcium/calmodulin (Ca/CaM)-dependent member of that group.
Adaptation to starvation: translating a matter of life or death.
Boston, United States. In Cancer Cell, 2013
In a recent issue of Cell, Leprivier and colleagues demonstrate that eEF2K, which can inhibit translation elongation acutely during protein synthesis, is a critical switch in the survival versus death fate of starved cancer cells.