gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Eukaryotic elongation factor-2 kinase

eEF-2 kinase, Elongation factor-2 kinase, eEF2K, calmodulin-dependent protein kinase III, eukaryotic elongation factor 2 kinase
This gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Elongation Factor 2, CAN, V1a, mTOR, CaM
Papers using eEF-2 kinase antibodies
Papers on eEF-2 kinase
BDNF - a key transducer of antidepressant effects.
Review
New
Monteggia et al., Stockholm, Sweden. In Neuropharmacology, Mar 2016
The antidepressant-like response of ketamine is abolished in BDNF and TrkB conditional knockout mice, eEF2 kinase knockout mice, in mice carrying the BDNF met/met allele, and by intra-cortical infusions of BDNF-neutralizing antibodies.
Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells.
New
Gao et al., Luoyang, China. In Mol Biosyst, Feb 2016
UNASSIGNED: Eukaryotic elongation factor-2 kinase (eEF2K), a unique calcium/calmodulin-dependent protein kinase, is well known to regulate apoptosis, autophagy and ER stress in many types of human cancers.
Expression and localization of calmodulin-related proteins in brain, heart and kidney from spontaneously hypertensive rats.
New
Yamawaki et al., Aomori, Japan. In Biochem Biophys Res Commun, Feb 2016
We have previously demonstrated that expression level of calmodulin-related proteins including eukaryotic elongation factor 2 kinase (eEF2K), death-associated protein kinase (DAPK)3, and histone deacetylase (HDAC)4 was specifically elevated in mesenteric artery from spontaneously hypertensive rats (SHR), which partly contributes to the development of hypertension via vascular inflammation and structural remodeling.
Application of Eukaryotic Elongation Factor-2 Kinase (eEF-2K) for Cancer Therapy: Expression, Purification, and High-Throughput Inhibitor Screening.
New
Cho et al., Austin, United States. In Methods Mol Biol, Dec 2015
Here, we describe the purification of the protein kinase, eEF-2K, and the utilization of three biochemical assays in the course of identifying small molecules that block its enzymatic reaction.
Emodin Inhibits Coxsackievirus B3 Replication via Multiple Signaling Cascades Leading to Suppression of Translation.
New
Yang et al., Vancouver, Canada. In Biochem J, Dec 2015
On the other hand, emodin treatment differentially regulated multiple signal cascades, including Akt-mTORC1-p70S6K, ERK1/2-p90(RSK) and Ca(2+)/calmodulin, leading to activation of eukaryotic translation elongation factor 2 kinase (eEF2K) and subsequent inactivation of eEF2, resulting in inhibition of CVB3 VP1 protein synthesis.
Eukaryotic elongation factor 2 kinase regulates the synthesis of microtubule-related proteins in neurons.
New
Proud et al., Vancouver, Canada. In J Neurochem, Nov 2015
Elongation is primarily regulated via eukaryotic elongation factor 2 kinase (eEF2K).
Stress-mediated translational control in cancer cells.
Review
New
Sorensen et al., Vancouver, Canada. In Biochim Biophys Acta, Jul 2015
Here we present the different regulatory signaling pathways which coordinate mRNA translation in the response to different stress forms, including those regulating eIF2α, mTORC1 and eEF2K, and we explain how tumor cells hijack these pathways for survival under stress.
[Eukaryotic elongation factor 2 kinase and cancer].
New
Li et al., In Yao Xue Xue Bao, Jul 2015
Eukaryotic elongation factor 2 kinase (eEF2K) is well known as a Ca2+/calmodulin (CaM)-dependent kinase.
Regulation and roles of elongation factor 2 kinase.
Review
New
Proud, Southampton, United Kingdom. In Biochem Soc Trans, Jun 2015
Eukaryotic elongation factor 2 kinase (eEF2K) belongs to the small family of atypical protein kinases termed α-kinases, and is the only calcium/calmodulin (Ca/CaM)-dependent member of that group.
Eukaryotic elongation factor 2 kinase confers tolerance to stress conditions in cancer cells.
Review
New
Sun et al., Nanjing, China. In Cell Stress Chaperones, Mar 2015
eEF2 kinase (eEF2K) is a structurally and functionally unique protein kinase in the calmodulin-mediated signaling pathway.
mTORC1-mediated translational elongation limits intestinal tumour initiation and growth.
New
Impact
Sansom et al., Paris, France. In Nature, Feb 2015
Mechanistically, mTORC1-mediated inhibition of eEF2 kinase is required for the proliferation of APC-deficient cells.
Eukaryotic elongation factor 2 kinase, an unusual enzyme with multiple roles.
Review
Proud et al., Southampton, United Kingdom. In Adv Biol Regul, 2014
Eukaryotic elongation factor 2 kinase (eEF2K) is a member of the small group of atypical 'α-kinases'.
Adaptation to starvation: translating a matter of life or death.
Impact
Manning, Boston, United States. In Cancer Cell, 2013
In a recent issue of Cell, Leprivier and colleagues demonstrate that eEF2K, which can inhibit translation elongation acutely during protein synthesis, is a critical switch in the survival versus death fate of starved cancer cells.
The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation.
Impact
Sorensen et al., Vancouver, Canada. In Cell, 2013
We report that eukaryotic elongation factor 2 kinase (eEF2K), which is activated by AMP-kinase (AMPK), confers cell survival under acute nutrient depletion by blocking translation elongation.
Phosphorylation of elongation factor-2 kinase differentially regulates the enzyme's stability under stress conditions.
GeneRIF
Yang et al., Penn Hills, United States. In Biochem Biophys Res Commun, 2012
These data indicate that eEF-2K is regulated at multiple levels with phosphorylation playing a critical role in the enzyme's turnover under stressful conditions.
Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence.
GeneRIF
Dalby et al., Austin, United States. In Biochemistry, 2012
Phosphorylation of Ser-500 lags behind the phosphorylation of Thr-348 and is associated with the Ca(2+)-independent activity of eEF-2K(eEF-2K)
Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase.
GeneRIF
Proud et al., Brussels, Belgium. In Biochem J, 2012
several autophosphorylation sites, including Thr(348), Thr(353), Ser(366) and Ser(445), all of which are highly conserved among vertebrate
Impaired associative taste learning and abnormal brain activation in kinase-defective eEF2K mice.
GeneRIF
Rosenblum et al., Haifa, Israel. In Learn Mem, 2012
Adequate levels of eEF2K phosphorylation are essential for cortical-dependent associative learning; malfunction of memory processing at the systems level can lead to associative memory impairment.
Insights into the regulation of eukaryotic elongation factor 2 kinase and the interplay between its domains.
GeneRIF
Proud et al., Vancouver, Canada. In Biochem J, 2012
highly conserved residues in the C-terminal tip of eEF2K are essential for the phosphorylation of eEF2
NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses.
Impact
Monteggia et al., Dallas, United States. In Nature, 2011
Furthermore, we find that inhibitors of eEF2 kinase induce fast-acting behavioural antidepressant-like effects.
share on facebooktweetadd +1mail to friends