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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Embryonic ectoderm development

EED, HEED
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on EED
Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis.
GeneRIF
Chae et al., Iksan, South Korea. In Dig Dis Sci, 2012
Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis.
Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
GeneRIF
Armstrong et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
The role of polycomb repressive complex 2 (PRC2) function in leukemia development and progression, is reported.
Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies.
GeneRIF
Jansen et al., In Blood, 2012
Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies.
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.
GeneRIF
Eskeland et al., Edinburgh, United Kingdom. In Plos One, 2011
It was shown that Ring1B interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed, Ring1B and CpG islands in chromatin, H2A.Z still blanketed polycomb target loci in the absence of Suz12, Eed, or Ring1B.
Polycomb repressive complex 2 targets murine cytomegalovirus chromatin for modification and associates with viral replication centers.
GeneRIF
Kulesza et al., Aurora, United States. In Plos One, 2011
Data indicate that binding of EZH2, SUZ12 and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.
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