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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Embryonic ectoderm development

EED, HEED
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Polycomb, Histone, EZH2, SUZ12, CAN
Papers on EED
PRC2 Epigenetically Silences Th1-Type Chemokines to Suppress Effector T-Cell Trafficking in Colon Cancer.
New
Zou et al., Wuhan, China. In Cancer Res, Feb 2016
Moreover, the expression levels of PRC2 components, including EZH2, SUZ12, and EED, were inversely associated with those of CD4, CD8, and Th1-type chemokines in human colon cancer tissue, and this expression pattern was significantly associated with patient survival.
Inhibition of KDM6 activity during murine ES cell differentiation induces DNA damage.
New
Becker et al., W├╝rzburg, Germany. In J Cell Sci, Feb 2016
Lack of H3K27me3 attenuates the GSK-J4-induced DDR in differentiating Eed KO ES cells.
Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.
New
Impact
van Lohuizen et al., Amsterdam, Netherlands. In Cancer Cell, Feb 2016
Modulation of PRC2 by either Ezh2 overexpression or Eed deletion enhances KRAS-driven adenomagenesis and inflammation, respectively.
Reader interactome of epigenetic histone marks in birds.
New
Butter et al., Mainz, Germany. In Proteomics, Jan 2016
The repressive marks are bound by the HP1 proteins and the EED subunit of the PRC2 complex as well as by WIZ.
miR-101 reverses hypomethylation of the PRDM16 promoter to disrupt mitochondrial function in astrocytoma cells.
New
Wu et al., Changsha, China. In Oncotarget, Jan 2016
In addition, EZH2, EED and DNMT3A were identified as direct targets of miR-101, and miR-101 suppressed PRDM16 expression by targeting DNMT3A which decreases histone H3K27me3 and H3K4me2 at the PRDM16 core promoter.
Loss of H3K27me3 Expression Is a Highly Sensitive Marker for Sporadic and Radiation-induced MPNST.
New
Antonescu et al., Tampa, United States. In Am J Surg Pathol, Jan 2016
UNASSIGNED: Most malignant peripheral nerve sheath tumors (MPNSTs) exhibit combined inactivation of NF1, CDKN2A, and polycomb repressive complex 2 component genes (Embryonic Ectoderm Development [EED] and Suppressor of Zeste 12 [SUZ12]).
Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2.
New
Impact
Liu et al., Dallas, United States. In Science, Nov 2015
Here we report the crystal structures of an active PRC2 complex of 170 kilodaltons from the yeast Chaetomium thermophilum in both basal and stimulated states, which contain Ezh2, Eed, and the VEFS domain of Suz12 and are bound to a cancer-associated inhibiting H3K27M peptide and a S-adenosyl-l-homocysteine cofactor.
Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming.
New
Impact
Meissner et al., Cambridge, United States. In Cell Stem Cell, Nov 2015
Likewise, loss of the PRC2 component EED to prevent H3K27me3 deposition had minimal effect on the transcriptome, implying that it is largely dispensable for continued repression of bivalent genes and de novo silencing in 2i.
Role of PRC2-associated factors in stem cells and disease.
Review
New
Di Croce et al., Barcelona, Spain. In Febs J, May 2015
The core canonical complex PRC2, which contains the EZH1/2, SUZ12 and EED proteins, may be extended and functionally manipulated through interactions with several other proteins.
Product binding enforces the genomic specificity of a yeast polycomb repressive complex.
New
Impact
Madhani et al., San Francisco, United States. In Cell, Feb 2015
Whereas removal of either the EZH or EED ortholog eliminates H3K27me, disruption of mark recognition by Ccc1 causes H3K27me to redistribute.
Systemic antibiotics for treating diabetic foot infections.
Review
Lipsky et al., Barcelona, Spain. In Cochrane Database Syst Rev, 2014
We also searched in the Database of Abstracts of Reviews of Effects (DARE; The Cochrane Library), the Health Technology Assessment database (HTA; The Cochrane Library), the National Health Service Economic Evaluation Database (NHS-EED; The Cochrane Library), unpublished literature in OpenSIGLE and ProQuest Dissertations and on-going trials registers.
PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors.
Impact
Chi et al., New York City, United States. In Nat Genet, 2014
Using comprehensive genomic approaches, we identified loss-of-function somatic alterations of the Polycomb repressive complex 2 (PRC2) components (EED or SUZ12) in 92% of sporadic, 70% of NF1-associated and 90% of radiotherapy-associated MPNSTs.
Childhood malnutrition: toward an understanding of infections, inflammation, and antimicrobials.
Review
Berkley et al., In Food Nutr Bull, 2014
Nutritional status and growth are strongly influenced by environmental enteric dysfunction (EED), which is common among children in developing countries, and by alterations in the gut microbiome.
A systematic review of the quality of economic models comparing thrombosis inhibitors in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
Review
Stollenwerk et al., Hamburg, Germany. In Pharmacoeconomics, 2014
DATA SOURCES: The literature databases MEDLINE, EMBASE, EconLit, National Health Service Economic Evaluation Database (NHS EED), Database of Abstracts of Reviews of Effects (DARE) and Health Technology Assessment (HTA).
Systematic assessment of decision-analytic models for chronic myeloid leukemia.
Review
Siebert et al., Innsbruck, Austria. In Appl Health Econ Health Policy, 2014
DATA SOURCES: We performed a systematic literature search in electronic databases (MEDLINE/PreMEDLINE, EconLit, EMBASE, NHS EED, and Tuft's CEA Registry) to identify published studies evaluating CML treatment strategies using mathematical models.
Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis.
GeneRIF
Chae et al., Iksan, South Korea. In Dig Dis Sci, 2012
Promoter polymorphism of the EED gene is associated with the susceptibility to ulcerative colitis.
Polycomb repressive complex 2 is required for MLL-AF9 leukemia.
GeneRIF
Armstrong et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
The role of polycomb repressive complex 2 (PRC2) function in leukemia development and progression, is reported.
Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies.
GeneRIF
Jansen et al., In Blood, 2012
Genetic defects in PRC2 components other than EZH2 are not common in myeloid malignancies.
Polycomb repressive complex 2 targets murine cytomegalovirus chromatin for modification and associates with viral replication centers.
GeneRIF
Kulesza et al., Aurora, United States. In Plos One, 2011
Data indicate that binding of EZH2, SUZ12 and EED, the 3 subunits of Plybomb repressive complex 2 (PRC2), is required for PRC2 full activity, and late during viral infection, a significant increase in PRC2 protein association with chromatin.
PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.
GeneRIF
Eskeland et al., Edinburgh, United Kingdom. In Plos One, 2011
It was shown that Ring1B interacted with multiple complexes in embryonic stem cells. Although H2A.Z co-localized with Eed, Ring1B and CpG islands in chromatin, H2A.Z still blanketed polycomb target loci in the absence of Suz12, Eed, or Ring1B.
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