The role of ANGPTL3 in controlling lipoprotein metabolism.
Helsinki, Finland. In Endocrine, Feb 2016
UNASSIGNED: Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids.
HDL biogenesis, remodeling, and catabolism.
Boston, United States. In Handb Exp Pharmacol, 2014
Remodeling and catabolism of HDL is the result of interactions of HDL with cell receptors and other membrane and plasma proteins including hepatic lipase (HL), endothelial lipase (EL), phospholipid transfer protein (PLTP), cholesteryl ester transfer protein (CETP), apolipoprotein M (apoM), scavenger receptor class B type I (SR-BI), ATP-binding cassette transporter G1 (ABCG1), the F1 subunit of ATPase (Ecto F1-ATPase), and the cubulin/megalin receptor.
Cholesterol: the good, the bad, and the ugly - therapeutic targets for the treatment of dyslipidemia.
United States. In Med Princ Pract, 2013
In this article we reviewed some of the current therapeutic targets for the treatment of dyslipidemia, with a primary focus on endothelial lipase and lecithin cholesterol acyl transferase for raising HDL-C, and the proprotein convertase subtilisin-like kexin type 9 (PCSK9), microsomal triglyceride transfer protein, and the messenger RNA of apolipoprotein B for lowering LDL-C.
Hepatic proprotein convertases modulate HDL metabolism.
Philadelphia, United States. In Cell Metab, 2007
This metabolic effect of hepatic PCs is critically dependent on expression of endothelial lipase (EL), an enzyme that directly hydrolyzes HDL phospholipids and promotes its catabolism.