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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Lipase, endothelial

EDL, endothelial lipase
The protein encoded by this gene has substantial phospholipase activity and may be involved in lipoprotein metabolism and vascular biology. This protein is designated a member of the TG lipase family by its sequence and characteristic lid region which provides substrate specificity for enzymes of the TG lipase family. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: FasT, CAN, HAD, ACID, HDL
Papers on EDL
The role of ANGPTL3 in controlling lipoprotein metabolism.
Review
New
Jauhiainen et al., Helsinki, Finland. In Endocrine, Feb 2016
UNASSIGNED: Angiopoietin-like protein 3 (ANGPTL3) is a secretory protein regulating plasma lipid levels via affecting lipoprotein lipase- and endothelial lipase-mediated hydrolysis of triglycerides and phospholipids.
Thyroid hormone reduces inflammatory cytokines improving glycemia control in alloxan-induced diabetic wistar rats.
New
Nunes et al., São Paulo, Brazil. In Acta Physiol (oxf), Feb 2016
Cytokines were measured in serum (MILIplex assay kit) as well as in soleus and EDL skeletal muscles and eWAT by Western blotting.
S1P3 receptor influences key physiological properties of fast-twitch extensor digitorum longus muscle.
New
Danieli-Betto et al., Padova, Italy. In J Appl Physiol, Jan 2016
Morphological analyses of extensor digitorum longus (EDL) muscle did not show evident differences between wild type and S1P3-null mice.
Deletion of Mbtps1 (PCSK8, S1P, SKI-1) in Osteocytes Stimulates Soleus Muscle Regeneration and Increased Size and Contractile Force with Age.
New
Brotto et al., Kansas City, United States. In J Biol Chem, Jan 2016
UNASSIGNED: Conditional deletion of Mbtps1 (cKO) protease in bone osteocytes leads to an age-related increase in mass (12%) and in contractile force (30%) in adult slow twitch soleus muscles (SOL) with no effect on fast twitch extensor digitorum longus muscles (EDL).
Proteome-wide muscle protein fractional synthesis rates predict muscle mass gain in response to a selective androgen receptor modulator in rats.
New
Evans et al., China. In Am J Physiol Endocrinol Metab, Jan 2016
Utilizing Selective Androgen Receptor Modulator (SARM) treatment in the ovariectomized (OVX) rat, we applied an unbiased, dynamic proteomics approach to measure the fractional synthesis rates (FSR) of 167-201 individual skeletal muscle proteins in triceps, EDL and soleus.
Expression of lipases and lipid receptors in sperm storage tubules and possible role of fatty acids in sperm survival in the hen oviduct.
New
Yoshimura et al., Hiroshima, Japan. In Theriogenology, Jan 2016
Expression of genes encoding endothelial lipase (EL), lipase H (LIPH), adipose triglyceride lipase (ATGL), and lipoprotein lipase (LPL) were found in UVJ.
HDL biogenesis, remodeling, and catabolism.
Review
Chroni et al., Boston, United States. In Handb Exp Pharmacol, 2014
Remodeling and catabolism of HDL is the result of interactions of HDL with cell receptors and other membrane and plasma proteins including hepatic lipase (HL), endothelial lipase (EL), phospholipid transfer protein (PLTP), cholesteryl ester transfer protein (CETP), apolipoprotein M (apoM), scavenger receptor class B type I (SR-BI), ATP-binding cassette transporter G1 (ABCG1), the F1 subunit of ATPase (Ecto F1-ATPase), and the cubulin/megalin receptor.
HDL cholesterol: all hope is not lost after the torcetrapib setback--emerging therapeutic strategies on the horizon.
Review
Figueredo et al., In Am J Ther, 2014
ApoA-1-related peptides, peroxisome proliferator-activated receptor agonists, endothelial lipase inhibitors, and liver X receptor agonists are some of the other novel agents currently in various stages of development.
Spherical Oligo-Silicic Acid SOSA Disclosed as Possible Endogenous Digitalis-Like Factor.
Review
Voicu et al., Martinsried, Germany. In Front Endocrinol (lausanne), 2013
Our recently disclosed spherical oligo-silicic acids (SOSA) fulfill the main criteria to be identified with the presumed EDL factors.
Cholesterol: the good, the bad, and the ugly - therapeutic targets for the treatment of dyslipidemia.
Review
Abdel-Meguid et al., United States. In Med Princ Pract, 2013
In this article we reviewed some of the current therapeutic targets for the treatment of dyslipidemia, with a primary focus on endothelial lipase and lecithin cholesterol acyl transferase for raising HDL-C, and the proprotein convertase subtilisin-like kexin type 9 (PCSK9), microsomal triglyceride transfer protein, and the messenger RNA of apolipoprotein B for lowering LDL-C.
Endothelial lipase is localized to follicular epithelial cells in the thyroid gland and is moderately expressed in adipocytes.
GeneRIF
Damiano et al., United States. In J Histochem Cytochem, 2012
Endothelial lipase plays a role in thyroid and adipocyte biology in addition to its well-known role in endothelial function and HDL metabolism.
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study.
Impact
Kathiresan et al., Philadelphia, United States. In Lancet, 2012
First, we used as an instrument a single nucleotide polymorphism (SNP) in the endothelial lipase gene (LIPG Asn396Ser) and tested this SNP in 20 studies (20,913 myocardial infarction cases, 95,407 controls).
Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia.
GeneRIF
Plengpanich et al., Bangkok, Thailand. In Am J Cardiol, 2012
Common and rare genetic variants in CETP and LIPC, but not LIPG, were more commonly found in the Thai HALP group, which could potentially contribute to high high-density lipoprotein cholesterol phenotypes in this population.
Differences in metabolite burden of di(2-ethylhexyl)phthalate in pregnant and postpartum dams and their offspring in relation to drug-metabolizing enzymes in mice.
GeneRIF
Nakajima et al., Nagoya, Japan. In Arch Toxicol, 2012
DEHP exposure did not influence lipase activity, whereas it slightly enhanced UGT activity and exclusively increased CYP4A14 levels in pregnant and/or postpartum dams.
Nascent HDL formation by hepatocytes is reduced by the concerted action of serum amyloid A and endothelial lipase.
GeneRIF
Webb et al., Lexington, United States. In J Lipid Res, 2011
a reduction in nascent HDL formation may be partly responsible for reduced HDL-C during inflammation when both EL and SAA are known to be upregulated
Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol.
GeneRIF
Rader et al., Philadelphia, United States. In Plos Genet, 2011
we found that a common nonfunctional coding variant associated with HDL-C (rs2000813) is in linkage disequilibrium with a 5' UTR variant (rs34474737) that decreases LIPG promoter activity
Exome sequencing, ANGPTL3 mutations, and familial combined hypolipidemia.
Impact
Kathiresan et al., Boston, United States. In N Engl J Med, 2011
ANGPTL3 has been reported to inhibit lipoprotein lipase and endothelial lipase, thereby increasing plasma triglyceride and HDL cholesterol levels in rodents.
Hepatic proprotein convertases modulate HDL metabolism.
Impact
Rader et al., Philadelphia, United States. In Cell Metab, 2007
This metabolic effect of hepatic PCs is critically dependent on expression of endothelial lipase (EL), an enzyme that directly hydrolyzes HDL phospholipids and promotes its catabolism.
A novel endothelial-derived lipase that modulates HDL metabolism.
Impact
Rader et al., United States. In Nat Genet, 1999
In contrast to other family members, this new lipase is synthesized by endothelial cells in vitro and thus has been termed endothelial lipase (encoded by the LIPG gene).
Imidazole inhibits a temperature-dependent component of mammalial skeletal muscle action potential.
Impact
Daniel et al., In Nature, 1980
We report here an abrupt change in the maximal rate of rise of the action potentials of the rat extensor digitorum longus (EDL) at 32 degrees C, indicating alteration in the functional characteristics of the sodium channels.
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