Crystal structure of human Edc3 and its functional implications.
Singapore, Singapore. In Mol Cell Biol, 2008
The dimerization interface of Edc3 is highly conserved in eukaryotes despite the overall low sequence homology across species; structure-based site-directed mutagenesis revealed dimerization is required for efficient RNA binding, P-body formation
Regulation of mRNA decay: decapping goes solo.
Worcester, United States. In Mol Cell, 2004
In this issue of Molecular Cell, Badis et al. demonstrate that autoregulated destabilization of the RPS28B mRNA is mediated by Edc3p interaction with an Rps28p/3'UTR mRNP complex.