gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

EDC3 Edc3p

EDC3, Edc3p, enhancer of decapping 3, hYjeF_N2, hYjeF_N2-15q23
EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Dcp2, Dcp1, caspase-3, CAN, Lsm1
Papers on EDC3
Mutations in DCPS and EDC3 in autosomal recessive intellectual disability indicate a crucial role for mRNA decapping in neurodevelopment.
Jamra et al., Toronto, Canada. In Hum Mol Genet, Jul 2015
In another family, we identified a homozygous mutation (c.161T>C; p.Phe54Ser) in EDC3 in two affected children.
Deletion analysis of LSm, FDF, and YjeF domains of Candida albicans Edc3 in hyphal growth and oxidative-stress response.
Kim et al., Taejŏn, South Korea. In J Microbiol, Feb 2015
Edc3 is known to be an enhancer of the mRNA decapping reactions and a scaffold protein of cytoplasmic processing bodies (P-bodies).
Roles of Edc3 in the oxidative stress response and CaMCA1-encoded metacaspase expression in Candida albicans.
Kim et al., Taejŏn, South Korea. In Febs J, 2014
The Edc3 protein is an enhancer of mRNA decapping, and acts as a scaffold protein for the mRNA granules that are known as processing bodies in yeast.
The role of disordered protein regions in the assembly of decapping complexes and RNP granules.
Izaurralde et al., Tübingen, Germany. In Genes Dev, 2014
These factors include enhancer of decapping 3 (EDC3), EDC4, like Sm14A (LSm14A), Pat, the LSm1-7 complex, and the RNA helicase DDX6.
Exploration of deleterious single nucleotide polymorphisms in the components of human P bodies: an in silico approach.
Suresh et al., Bengaluru, India. In Gene, 2013
Owing to the essential functions of P bodies in mRNA regulation, we explored computationally the functional significance of SNPs in 7 P body components such as XRN1, DCP2, EDC3, CPEB1, GEMIN5, STAU1 and TRIM71.
The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
Sprangers et al., Tübingen, Germany. In Embo J, 2012
Activator proteins, including Edc3 (enhancer of decapping 3), modulate its activity.
Accumulation of P-bodies in Candida albicans under different stress and filamentous growth conditions.
Kim et al., Taejŏn, South Korea. In Fungal Genet Biol, 2011
The core components of P-bodies, including the decapping machinery (Dcp2 and Dhh1), 5'-3' exoribonuclease (Kem1/Xrn1), and the P-body scaffolding protein (Edc3), were identified and their localizations with respect to P-bodies were demonstrated.
Identification and characterization of protein interactions in the mammalian mRNA processing body using a novel two-hybrid assay.
Yang et al., Boston, United States. In Exp Cell Res, 2011
The assay was used to investigate interactions between P-body components Ge-1, DCP2, DCP1, EDC3, RAP55, and RCK.
Sphingolipids mediate formation of mRNA processing bodies during the heat-stress response of Saccharomyces cerevisiae.
Hannun et al., Charleston, United States. In Biochem J, 2010
In the present study, we demonstrate that mild-heat-stress-induced formation of p-bodies, as determined by localization of a GFP (green fluorescent protein)-tagged Dcp2p and RFP (red fluorescent protein)-tagged Edc3p to discrete cytoplasmic foci.
Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3.
James et al., Sydney, Australia. In Mol Cell Proteomics, 2010
EDC3, a component of the mRNA decay and translation repression pathway associated with mRNA processing bodies, was shown to be phosphorylated by AKT downstream of insulin signaling.
Identification and analysis of the interaction between Edc3 and Dcp2 in Saccharomyces cerevisiae.
Parker et al., Tucson, United States. In Mol Cell Biol, 2010
These results raise a model for Dcp2 recruitment to specific mRNAs where regions outside the catalytic core promote the formation of different complexes involved in mRNA decapping.
Degradation of YRA1 Pre-mRNA in the cytoplasm requires translational repression, multiple modular intronic elements, Edc3p, and Mex67p.
He et al., Worcester, United States. In Plos Biol, 2009
Data indicate that Edc3p-mediated YRA1 pre-mRNA decay occurs independently of translation and also requires Mex67p.
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.
Weichenrieder et al., Tübingen, Germany. In Mol Cell, 2009
Structural basis for the mutually exclusive anchoring of P body components EDC3 and Tral to the DEAD box protein DDX6/Me31B.
Similar modes of interaction enable Trailer Hitch and EDC3 to associate with DCP1 and Me31B in distinct protein complexes.
Truffault et al., Tübingen, Germany. In Mol Cell Biol, 2008
Tral and EDC3 specifically interact with the decapping activator DCP1 and the DEAD-box helicase Me31B, in Drosophila cells.
Crystal structure of human Edc3 and its functional implications.
Song et al., Singapore, Singapore. In Mol Cell Biol, 2008
The dimerization interface of Edc3 is highly conserved in eukaryotes despite the overall low sequence homology across species; structure-based site-directed mutagenesis revealed dimerization is required for efficient RNA binding, P-body formation
Regulation of mRNA decay: decapping goes solo.
Jacobson, Worcester, United States. In Mol Cell, 2004
In this issue of Molecular Cell, Badis et al. demonstrate that autoregulated destabilization of the RPS28B mRNA is mediated by Edc3p interaction with an Rps28p/3'UTR mRNP complex.
share on facebooktweetadd +1mail to friends