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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Ectodysplasin A

ED1, Tabby
The protein encoded by this gene is a type II membrane protein that can be cleaved by furin to produce a secreted form. The encoded protein, which belongs to the tumor necrosis factor family, acts as a homotrimer and may be involved in cell-cell signaling during the development of ectodermal organs. Defects in this gene are a cause of ectodermal dysplasia, anhidrotic, which is also known as X-linked hypohidrotic ectodermal dysplasia. Several transcript variants encoding many different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, Glial Fibrillary Acidic Protein
Papers using ED1 antibodies
Adiponectin reduces proteinuria in streptozotocin-induced diabetic Wistar rats
Maeda Shiro, In PLoS ONE, 2010
... anti-di-methyl H3 K79 (H3m2K79, abcam), and anti-Dot1l (abcam and Bethyl) antibodies, mouse monoclonal anti-CD63 for ED-1 (abcam), spironolactone (Pharmacia Corp., Zhejiang, ...
Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats.
Combs Colin, In PLoS ONE, 2003
... mouse monoclonal CD11b (OX-42) that recognizes type 3 complement receptors (MCA 275R) and the mouse monoclonal ED-1 raised against rat lysosomal membrane antigen of activated macrophage/microglia were obtained from AbD Serotec (Darmstadt, Germany) ...
Lectin histochemistry of mammalian endothelium.
Cai Huaibin, In PLoS ONE, 1986
... (Iba-1) rabbit anti-Iba-1 polyclonal antibody (1∶500) (Wako Pure Chemical Industries, Osaka, Japan) for microglia, mouse anti-ED1 (Serotec, 1∶500) for macrophages, rat-anti-BrdU (Abcam, 1∶1000) for cell proliferationand ...
Papers on ED1
Retinal and Optic Nerve Damage is Associated with Early Glial Responses in an Experimental Autoimmune Glaucoma Model.
Joachim et al., Bochum, Germany. In J Mol Neurosci, Feb 2016
At 14 and 28 days, immune-histological and Western blot analyses were performed to investigate the optic nerve structure (SMI-32), retinal ganglion cells (Brn-3a), apoptosis (cleaved caspase 3, FasL), and glial profile (Iba1, ED1, GFAP, vimentin).
Meibomian Gland Absence Related Dry Eye in Ectodysplasin A Mutant Mice.
Li et al., Xiamen, China. In Am J Pathol, Jan 2016
To gain insight into this pathophysiology, we characterized the time-dependent tear film and ocular surface changes occurring in X-linked anhidrotic-hypohidrotic ectodermal dysplasia mice (Tabby), which lack the meibomian gland.
The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells From Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis.
Fu et al., Taipei, Taiwan. In Stem Cells Transl Med, Jan 2016
Immunohistochemical analyses indicated neoangiogenesis and significant increase in the numbers of ED-1- and α-smooth muscle actin (α-SMA)-positive cells in the thickened peritoneum in the PD/MGO 3W group, suggesting that PD/MGO induced an inflammatory response.
Distribution and characterization of tumor-associated macrophages/microglia in rat C6 glioma.
Zhang et al., Foshan, China. In Oncol Lett, Oct 2015
Using a rat C6 glioma model, the present study observed a significant heterogeneity of active macrophages and microglia, including cluster of differentiation 8 (CD8)(+), endothelial monocyte-activating polypeptide II (EMAPII)(+) and ED1(+) cells, mostly in the areas of compact tumor growth and inside or around the pannecrosis.
Bone defects and future regenerative nanomedicine approach using stem cells in the mutant Tabby mouse model.
Clauss et al., Strasbourg, France. In Biomed Mater Eng, 2014
Use of osteoblasts or stem cells seeded biomembranes appears as another strategy developed on the Tabby (Ta) model of XLHED.
Cerebral ischemia in the aged. Limited anti-inflammatory efficacy of the indomethacin treatment.
Popa-Wagner et al., Rostock, Germany. In Rom J Morphol Embryol, 2014
At protein level, we observed no change of lysosomal ED1 immunoreactivity under treatment.
Genetics of pigmentation in dogs and cats.
Barsh et al., Stanford, United States. In Annu Rev Anim Biosci, 2013
Exceptions include the K locus in dogs and the Tabby locus in cats, which give rise to alternating stripes or marks of different color, and which illustrate the continued potential of coat color genetics to provide insight into areas that transcend pigment cell biology.
Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.
Thesleff et al., Helsinki, Finland. In Development, 2012
Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling.
[Detection of ED1 gene mutations in six pedigrees with hypohidrotic ectodermal dysplasia].
Kong et al., Zhengzhou, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2012
Various mutations of ED1 gene were detected.
Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB.
Mikkola et al., Helsinki, Finland. In Proc Natl Acad Sci U S A, 2012
NF-kappaB downstream of the TNF-like ligand ectodysplasin (Eda) is identified as a unique regulator of embryonic and prepubertal ductal morphogenesis.
Mutation p.Leu354Pro in EDA causes severe hypohidrotic ectodermal dysplasia in a Chinese family.
Tang et al., Wuhan, China. In Gene, 2012
Direct DNA sequencing of the whole coding region of EDA revealed a novel missense mutation, p.Leu354Pro in a patient affected with XLHED.
Exonization of a LINE1 fragment implicated in X-linked hypohidrotic ectodermal dysplasia in cattle.
Agerholm et al., Frederiksberg, Denmark. In Anim Genet, 2011
The 161-bp-long LINE1-derived-pseudoexon introduces a shift in reading frame and a premature stop codon early in EDA exon 2 and is probably the cause of XHED in this Danish Red Holstein family.
Tri-iodothyronine differentially induces Kupffer cell ED1/ED2 subpopulations.
Videla et al., Brazil. In Mol Aspects Med, 2004
ED1 and ED2 antigens have been particularly useful in the characterization of Kupffer cell subpopulations.
[Cell biology of hyalocytes].
Sakamoto, Kagoshima, Japan. In Nihon Ganka Gakkai Zasshi, 2003
In this study, we investigated various aspects of hyalocytes and, also performed triamcinolone acetonide (TA)-assisted vitrectomy to remove the hyalocytes for diabetic macular edema.
Permanent correction of an inherited ectodermal dysplasia with recombinant EDA.
Schneider et al., Lausanne, Switzerland. In Nat Med, 2003
Mice with the Tabby phenotype share many symptoms with human XLHED patients because both phenotypes are caused by mutations of the syntenic ectodysplasin A gene (Eda) on the X chromosome.
Gene defect in ectodermal dysplasia implicates a death domain adapter in development.
Overbeek et al., Houston, United States. In Nature, 2002
The crinkled mutant has an hypohidrotic ectodermal dysplasia phenotype identical to that of the edar (downless) and eda (Tabby) mutants.
Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia.
Zonana et al., Portland, United States. In Nat Genet, 1999
The gene (ED1) responsible for the disorder has been identified, as well as the analogous X-linked gene (Ta) in the mouse.
[Fibronectin--a multifunctional glycoprotein].
Todorović et al., In Srp Arh Celok Lek, 1995
Cellular fibronectin has ED1 and ED2 components that do no exist in plasma fibronectin.
Induction of sweat glands by epidermal growth factor in murine X-linked anhidrotic ectodermal dysplasia.
Lalonde et al., Guelph, Canada. In Nature, 1990
Tabby (Ta), a murine X-linked mutant gene, produces a syndrome of ectodermal dysplasia including anhidrosis (absence of sweat glands).
Localization of the region homologous to the Duchenne muscular dystrophy locus on the mouse X chromosome.
Avner et al., In Nature, 1987
Both sequences map to the region of 10 centimorgan lying between the Tabby (Ta) and St14-1 (DxPas8) loci, close to the phosphorylase b kinase locus (Phk).
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