Carcinogenesis of nasopharyngeal carcinoma: an alternate hypothetical mechanism.
Singapore, Singapore. In Ai Zheng, Dec 2015
This claim is indirectly supported by observations that the East Asian phenotype shares the characteristics of an increased susceptibility to NPC and immature salivary gland morphogenesis, the latter of which is influenced by the association of salivary gland morphogenesis with an evolutionary variant of the human ectodysplasin receptor gene (EDAR), EDARV370A.
Generation of the primary hair follicle pattern.
Manchester, United Kingdom. In Proc Natl Acad Sci U S A, 2006
We find that ectodysplasin receptor (Edar)-bone morphogenetic protein (BMP) signaling and transcriptional interactions are central to generation of the primary hair follicle pattern, with restriction of responsiveness, rather than localization of an inducing ligand, being the key driver in this process.