GEFs on the RhoAd to a colossal nucleus.
Boston, United States. In Dev Cell, Apr 2012
In this issue of Developmental Cell, Gao et al. (2012) trace the basis of endomitosis to sequential downregulation of guanine nucleotide exchange factors GEF-H1 and ECT2.
Ubiquitination in Rho signaling.
Xiamen, China. In Curr Top Med Chem, 2011
Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway.
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Nagoya, Japan. In J Investig Dermatol Symp Proc, 2009
Furthermore, DKK1 induces the expression of keratin 9 and alpha-Kelch-like ECT2-interacting protein (alphaKLEIP) but downregulates the expression of beta-catenin, glycogen synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2) in keratinocytes.