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Epithelial cell transforming sequence 2 oncogene

The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, CAN, GEF, Actin
Papers on ECT2
Integrated regulatory network involving differently expressed genes and protein-protein interaction on pancreatic cancer.
Ge et al., Shenyang, China. In Eur Rev Med Pharmacol Sci, 31 Jul 2015
The top ten genes with high degrees such as ANLN, PSRC1 and ECT2 were identified in the integrated network, and they were mainly enriched in cell cycle pathway.
Elevated expression of ECT2 predicts unfavorable prognosis in patients with colorectal cancer.
Bian et al., Shanghai, China. In Biomed Pharmacother, 31 Jul 2015
Epithelial cell transforming sequence 2 (ECT2) is a well-studied guanine nucleotide exchange factor for the Rho family GTPase, which has been demonstrated as an oncogene in many types of human cancers.
ECT2 regulates the Rho/ERK signalling axis to promote early recurrence in human hepatocellular carcinoma.
Hui et al., Singapore, Singapore. In J Hepatol, Jun 2015
Epithelial cell transforming sequence 2 (ECT2) has been implicated in human cancers, but its function in HCC is largely unknown.
Small interfering RNA-induced inhibition of epithelial cell transforming sequence 2 suppresses the proliferation, migration and invasion of osteosarcoma cells.
Hu et al., Changsha, China. In Exp Ther Med, May 2015
Epithelial cell transforming sequence 2 (ECT2) has been shown to act as an oncogene in human malignancies.
CSPP-L Associates with the Desmosome of Polarized Epithelial Cells and Is Required for Normal Spheroid Formation.
Patzke et al., Oslo, Norway. In Plos One, Dec 2014
Multi-lumen spheroids of CSPP1 siRNA transfectants showed disrupted apical cell junction localization of the cytoskeleton organizing RhoGEF ECT2.
Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.
Gong et al., Hefei, China. In Febs Lett, Sep 2014
Homo sapiens ECT2 is a cell cycle regulator that plays critical roles in cytokinesis.
Epithelial cell transformation sequence 2 is a potential biomarker of unfavorable survival in human gliomas.
Hueng et al., Taipei, Taiwan. In Neurol India, Jul 2014
Epithelial cell transformation sequence 2 (ECT2) modulates cancer invasion, progression, metastasis and cell cycle regulation.
Up-regulation of ECT2 is associated with poor prognosis in gastric cancer patients.
Xu et al., Hangzhou, China. In Int J Clin Exp Pathol, 2013
OBJECTIVES: The aim of this study was to investigate the expression of ECT2 in gastric cancer and its clinical significance.
Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis.
Yu et al., Ann Arbor, United States. In Cell Cycle, 2013
Here, we show the evidence that PAR is recognized by ECT2, a key guanine nucleotide exchange factor in mitosis.
Copy number gains of FGFR1 and 3q chromosome in squamous cell carcinoma of the lung.
Ramirez et al., Badalona, Spain. In Transl Lung Cancer Res, 2013
Broad 3q chromosome amplification is widely recognized as the most common chromosomal aberration found in SQCCL, where PIK3CA, SOX2, ACK1, PRKCI, TP63, PLD1, ECT2, and others genes are located.
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.
Baum et al., London, United Kingdom. In Dev Cell, 2012
find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the cytoplasm, activating RhoA to induce the formation of a mechanically stiff and rounded metaphase cortex
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.
Yap et al., Brisbane, Australia. In Nat Cell Biol, 2012
Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA.
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
Krause et al., New Haven, United States. In Dev Cell, 2012
It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.
Petronczki et al., London, United Kingdom. In Dev Cell, 2012
targeting of Ect2 to the equatorial membrane represents a key step in the delivery of the cytokinetic signal to the cortex
An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis.
Piekny et al., Montréal, Canada. In Plos One, 2011
Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex.
Ubiquitination in Rho signaling.
Wang et al., Xiamen, China. In Curr Top Med Chem, 2011
Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway.
APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.
Bertoglio et al., Villejuif, France. In Plos One, 2010
identify Ect2 as a cell cycle-regulated protein and suggest that its ubiquitination-dependent degradation may play an important role in RhoA regulation at the time of mitosis.
Signalling through the RhoGEF Pebble in Drosophila.
Saint et al., Adelaide, Australia. In Iubmb Life, 2010
Here we review the role of the Drosophila RhoGEF, Pebble (the Drosophila ortholog of mammalian ECT2).
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Hearing et al., Nagoya, Japan. In J Investig Dermatol Symp Proc, 2009
Furthermore, DKK1 induces the expression of keratin 9 and alpha-Kelch-like ECT2-interacting protein (alphaKLEIP) but downregulates the expression of beta-catenin, glycogen synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2) in keratinocytes.
Oncogene ect2 is related to regulators of small GTP-binding proteins.
Fleming et al., Bethesda, United States. In Nature, 1993
Here we report a second novel transforming gene, ect2.
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