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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Epithelial cell transforming sequence 2 oncogene

The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on ECT2
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.
Baum et al., London, United Kingdom. In Dev Cell, 2012
find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the cytoplasm, activating RhoA to induce the formation of a mechanically stiff and rounded metaphase cortex
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
Krause et al., New Haven, United States. In Dev Cell, 2012
It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.
Petronczki et al., London, United Kingdom. In Dev Cell, 2012
targeting of Ect2 to the equatorial membrane represents a key step in the delivery of the cytokinetic signal to the cortex
An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis.
Piekny et al., Montréal, Canada. In Plos One, 2011
Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex.
APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.
Bertoglio et al., Villejuif, France. In Plos One, 2010
identify Ect2 as a cell cycle-regulated protein and suggest that its ubiquitination-dependent degradation may play an important role in RhoA regulation at the time of mitosis.
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