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Epithelial cell transforming sequence 2 oncogene

The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, CAN, Actin, GEF
Papers on ECT2
ECT2 amplification and overexpression as a new prognostic biomarker for early-stage lung adenocarcinoma.
Noguchi et al., Tsukuba, Japan. In Cancer Sci, Apr 2014
Of the seven genes located in this region, we focused on the epithelial cell transforming sequence 2 (ECT2) oncogene, as ECT2 amplification was detected only in invasive adenocarcinoma, and not in in situ carcinoma.
Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
Bejsovec et al., Durham, United States. In Development, Dec 2013
We have discovered a new mechanism for regulating the Wnt pathway: activity of a Rho guanine nucleotide exchange factor (GEF) encoded by pebble (pbl) in Drosophila and ECT2 in humans.
E-cadherin supports steady-state Rho signaling at the epithelial zonula adherens.
Gomez et al., Brisbane, Australia. In Differentiation, Oct 2013
This impact on Rho signaling was accompanied by reduced junctional localization of the Rho GEF ECT2 and the centralspindlin complex that recruits ECT2.
Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the phenotype of preeclampsiaa.
Hassan et al., Wayne, United States. In J Perinat Med, Oct 2013
Thirteen genes that encode proteins involved in host defense (DEFA4, BPI, CTSG, LCN2), tight junctions in blood-brain barrier (EMP1) and liver regeneration (ECT2) were differentially expressed in both early- and late-onset PE.
Poly(ε-caprolactone)-based copolymers bearing pendant cyclic ketals and reactive acrylates for the fabrication of photocrosslinked elastomers.
Jia et al., Newark, United States. In Acta Biomater, Sep 2013
At an initiator/catalyst molar ratio of 10/1 and a TSU/CL weight ratio of 1/4, a ketal-carrying copolymer (ECT2-CK) with Mn of 52 kDa and a ketal content of 15 mol.% was obtained.
Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma.
Moffat et al., Toronto, Canada. In Pancreas, Aug 2013
CONCLUSIONS: Among the candidate genes from the integrative analysis, ECT2 was found to have significantly higher essentiality in specific PDAC cell lines with genomic gains at the 3q26.3
Dexamethasone-loaded block copolymer nanoparticles induce leukemia cell death and enhance therapeutic efficacy: a novel application in pediatric nanomedicine.
Rajasekaran et al., Newark, United States. In Mol Pharm, Jul 2013
NPs with an average diameter of 110 nm were assembled from an amphiphilic block copolymer of poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) bearing pendant cyclic ketals (ECT2).
Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis.
Hosoya et al., Hiroshima, Japan. In Plos One, 2012
Here, we showed that depletion of the Rho signaling proteins MKLP1, MgcRacGAP, or ECT2 inhibited the localization of 1P-MRLC to the contractile ring but not the localization of 2P-MRLC to the midzone.
Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma.
Teh et al., Grand Rapids, United States. In Cancer Res, 2012
PTTG1-dependent expression of the RhoGEF proto-oncogene ECT2 was observed in a number of ccRCC cell lines.
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.
Baum et al., London, United Kingdom. In Dev Cell, 2012
find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the cytoplasm, activating RhoA to induce the formation of a mechanically stiff and rounded metaphase cortex
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.
Yap et al., Brisbane, Australia. In Nat Cell Biol, 2012
Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA.
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
Krause et al., New Haven, United States. In Dev Cell, 2012
It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.
Petronczki et al., London, United Kingdom. In Dev Cell, 2012
targeting of Ect2 to the equatorial membrane represents a key step in the delivery of the cytokinetic signal to the cortex
An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis.
Piekny et al., Montréal, Canada. In Plos One, 2011
Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex.
Ubiquitination in Rho signaling.
Wang et al., Xiamen, China. In Curr Top Med Chem, 2011
Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway.
The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.
Der et al., Chapel Hill, United States. In Genes Cancer, 2011
Ect2 is a member of the human Dbl family of guanine nucleotide exchange factors (RhoGEFs) that serve as activators of Rho family small GTPases.
APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.
Bertoglio et al., Villejuif, France. In Plos One, 2010
identify Ect2 as a cell cycle-regulated protein and suggest that its ubiquitination-dependent degradation may play an important role in RhoA regulation at the time of mitosis.
Signalling through the RhoGEF Pebble in Drosophila.
Saint et al., Adelaide, Australia. In Iubmb Life, 2010
Here we review the role of the Drosophila RhoGEF, Pebble (the Drosophila ortholog of mammalian ECT2).
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Hearing et al., Nagoya, Japan. In J Investig Dermatol Symp Proc, 2009
Furthermore, DKK1 induces the expression of keratin 9 and alpha-Kelch-like ECT2-interacting protein (alphaKLEIP) but downregulates the expression of beta-catenin, glycogen synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2) in keratinocytes.
Oncogene ect2 is related to regulators of small GTP-binding proteins.
Fleming et al., Bethesda, United States. In Nature, 1993
Here we report a second novel transforming gene, ect2.
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