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Epithelial cell transforming sequence 2 oncogene

ECT2
The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Rhodopsin, RhoA, CAN, GEF, Actin
Papers on ECT2
Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4.
New
Gong et al., Hefei, China. In Febs Lett, 25 Sep 2014
Homo sapiens ECT2 is a cell cycle regulator that plays critical roles in cytokinesis.
MgcRacGAP interacts with cingulin and paracingulin to regulate Rac1 activation and development of the tight junction barrier during epithelial junction assembly.
New
Citi et al., Genève, Switzerland. In Mol Biol Cell, Aug 2014
Depletion of either CGN or CGNL1 in epithelial cells results in decreased junctional localization of MgcRacGAP but not of ECT2, a centralspindlin-interacting Rho GEF.
Epithelial cell transformation sequence 2 is a potential biomarker of unfavorable survival in human gliomas.
New
Hueng et al., Taipei, Taiwan. In Neurol India, Jul 2014
Epithelial cell transformation sequence 2 (ECT2) modulates cancer invasion, progression, metastasis and cell cycle regulation.
Prognostic value of microRNA-223/epithelial cell transforming sequence 2 signaling in patients with osteosarcoma.
New
Ji et al., Hefei, China. In Hum Pathol, Jul 2014
MicroRNA-223 (miR-223) has been demonstrated to be implicated in cell proliferation and cell cycle progression of osteosarcoma cell lines by regulating its target gene epithelial cell transforming sequence 2 (ECT2).
Kelch-like ECT2-interacting protein KLEIP regulates late-stage pulmonary maturation via Hif-2α in mice.
New
Kroll et al., Mannheim, Germany. In Dis Model Mech, Jun 2014
Expression of the BTB-and kelch-domain-containing (BTB-kelch) protein KLEIP (Kelch-like ECT2-interacting protein; also named Klhl20) is controlled by two hypoxia response elements, and KLEIP regulates stabilization and transcriptional activation of Hif-2α.
ECT2 amplification and overexpression as a new prognostic biomarker for early-stage lung adenocarcinoma.
New
Noguchi et al., Tsukuba, Japan. In Cancer Sci, Apr 2014
Of the seven genes located in this region, we focused on the epithelial cell transforming sequence 2 (ECT2) oncogene, as ECT2 amplification was detected only in invasive adenocarcinoma, and not in in situ carcinoma.
Pebble/ECT2 RhoGEF negatively regulates the Wingless/Wnt signaling pathway.
New
Bejsovec et al., Durham, United States. In Development, Dec 2013
We have discovered a new mechanism for regulating the Wnt pathway: activity of a Rho guanine nucleotide exchange factor (GEF) encoded by pebble (pbl) in Drosophila and ECT2 in humans.
Differences and similarities in the transcriptional profile of peripheral whole blood in early and late-onset preeclampsia: insights into the molecular basis of the phenotype of preeclampsiaa.
New
Hassan et al., Wayne, United States. In J Perinat Med, Oct 2013
Thirteen genes that encode proteins involved in host defense (DEFA4, BPI, CTSG, LCN2), tight junctions in blood-brain barrier (EMP1) and liver regeneration (ECT2) were differentially expressed in both early- and late-onset PE.
Integrated genomic, transcriptomic, and RNA-interference analysis of genes in somatic copy number gains in pancreatic ductal adenocarcinoma.
New
Moffat et al., Toronto, Canada. In Pancreas, Aug 2013
CONCLUSIONS: Among the candidate genes from the integrative analysis, ECT2 was found to have significantly higher essentiality in specific PDAC cell lines with genomic gains at the 3q26.3
Aurora B but not rho/MLCK signaling is required for localization of diphosphorylated myosin II regulatory light chain to the midzone in cytokinesis.
Hosoya et al., Hiroshima, Japan. In Plos One, 2012
Here, we showed that depletion of the Rho signaling proteins MKLP1, MgcRacGAP, or ECT2 inhibited the localization of 1P-MRLC to the contractile ring but not the localization of 2P-MRLC to the midzone.
Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression.
GeneRIF
Baum et al., London, United Kingdom. In Dev Cell, 2012
find that Ect2 first becomes active in prophase, when it is exported from the nucleus into the cytoplasm, activating RhoA to induce the formation of a mechanically stiff and rounded metaphase cortex
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.
Impact
Yap et al., Brisbane, Australia. In Nat Cell Biol, 2012
Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA.
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
GeneRIF
Krause et al., New Haven, United States. In Dev Cell, 2012
It was shown that the guanine exchange factors GEF-H1 and ECT2 must be downregulated for megakaryote polyploidization. The first (2N-4N) endomitotic cycle requires GEF-H1 downregulation, whereas subsequent cycles (>4N) require ECT2 downregulation.
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.
GeneRIF
Petronczki et al., London, United Kingdom. In Dev Cell, 2012
targeting of Ect2 to the equatorial membrane represents a key step in the delivery of the cytokinetic signal to the cortex
An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis.
GeneRIF
Piekny et al., Montréal, Canada. In Plos One, 2011
Data supports an analogous function for the anillin-Ect2 complex in human cells and one hypothesis is that this complex has functionally replaced the Drosophila anillin-RacGAP50C complex.
Ubiquitination in Rho signaling.
Review
Wang et al., Xiamen, China. In Curr Top Med Chem, 2011
Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway.
APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.
GeneRIF
Bertoglio et al., Villejuif, France. In Plos One, 2010
identify Ect2 as a cell cycle-regulated protein and suggest that its ubiquitination-dependent degradation may play an important role in RhoA regulation at the time of mitosis.
Signalling through the RhoGEF Pebble in Drosophila.
Review
Saint et al., Adelaide, Australia. In Iubmb Life, 2010
Here we review the role of the Drosophila RhoGEF, Pebble (the Drosophila ortholog of mammalian ECT2).
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Review
Hearing et al., Nagoya, Japan. In J Investig Dermatol Symp Proc, 2009
Furthermore, DKK1 induces the expression of keratin 9 and alpha-Kelch-like ECT2-interacting protein (alphaKLEIP) but downregulates the expression of beta-catenin, glycogen synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2) in keratinocytes.
Oncogene ect2 is related to regulators of small GTP-binding proteins.
Impact
Fleming et al., Bethesda, United States. In Nature, 1993
Here we report a second novel transforming gene, ect2.
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