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Epithelial cell transforming sequence 2 oncogene
ECT2
The protein encoded by this gene is a transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
ECT2
Nonfunction of the ECT2 gene may cause renal tubulointerstitial injury leading to focal segmental glomerulosclerosis.
New
Sayama, Japan. In Clin Exp Nephrol, Dec 2012
The epithelial cell-transforming sequence 2 gene (ECT2) contributes to tight junction function in epithelial cells.
Dexamethasone-Loaded Block Copolymer Nanoparticles Induce Leukemia Cell Death and Enhance Therapeutic Efficacy: A Novel Application in Pediatric Nanomedicine.
New
Newark, United States. In Mol Pharm, Dec 2012
NPs with an average diameter of 110 nm were assembled from an amphiphilic block copolymer of poly(ethylene glycol) (PEG) and poly(ε-caprolactone) (PCL) bearing pendant cyclic ketals (ECT2).
Expression of the PTTG1 oncogene is associated with aggressive clear cell renal cell carcinoma.
New
Grand Rapids, United States. In Cancer Res, Oct 2012
PTTG1-dependent expression of the RhoGEF proto-oncogene ECT2 was observed in a number of ccRCC cell lines.
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.
New
Impact
Brisbane, Australia. In Nat Cell Biol, Aug 2012
Centralspindlin recruits the RhoGEF, ECT2, to activate Rho and support junctional integrity through myosin IIA.
ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.
New
Toronto, Canada. In Am J Pathol, Aug 2012
The Rho family of cytoskeletal GTPases are key regulators of astrocytoma migration and invasion; expression of the guanine nucleotide exchange factor ECT2 is elevated in primary astrocytomas and predicts both survival and malignancy.
Analysis of differential gene expression in plurihormonal pituitary adenomas using bead-based fiber-optic arrays.
New
Bengbu, China. In J Neurooncol, Jul 2012
Bioinformatic analysis showed that genes HIGD1B, EPS8, ECT2, and BTG2 might play an important role in the tumorigenesis and progression of PHPAs.
Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells.
New
Phoenix, United States. In Mol Cancer Res, Jul 2012
Furthermore, we identified two guanine nucleotide exchange factors (GEF), Ect2 and Trio, involved in TWEAK-induced activation of Cdc42 and Rac1, respectively.
Role of RhoA-specific guanine exchange factors in regulation of endomitosis in megakaryocytes.
New
New Haven, United States. In Dev Cell, Apr 2012
Using primary cells, we demonstrate that the guanine exchange factors GEF-H1 and ECT2, which are often overexpressed in cancer and are essential for RhoA activation during cytokinesis, must be downregulated for Mk polyploidization.
GEFs on the RhoAd to a colossal nucleus.
New
Boston, United States. In Dev Cell, Apr 2012
In this issue of Developmental Cell, Gao et al. (2012) trace the basis of endomitosis to sequential downregulation of guanine nucleotide exchange factors GEF-H1 and ECT2.
Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.
GeneRIF
London, United Kingdom. In Dev Cell, 2012
targeting of Ect2 to the equatorial membrane represents a key step in the delivery of the cytokinetic signal to the cortex
Amplified genes may be overexpressed, unchanged, or downregulated in cervical cancer cell lines.
Mexico City, Mexico. In Plos One, 2011
These include PARP1 in 1q, TNFSF10 and ECT2 in 3q and CLPTM1L, AHRR, PDCD6, and DAP in 5p.
Ubiquitination in Rho signaling.
Review
Xiamen, China. In Curr Top Med Chem, 2011
Importantly, regulators for Rho GTP-GDP cycling such as RhoGDI and Rho-GEF ECT2 were also found to be modulated by the ubiquitin pathway.
The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.
Chapel Hill, United States. In Genes Cancer, 2011
Ect2 is a member of the human Dbl family of guanine nucleotide exchange factors (RhoGEFs) that serve as activators of Rho family small GTPases.
Ect2, an ortholog of Drosophila's pebble, negatively regulates neurite outgrowth in neuroblastoma × glioma hybrid NG108-15 cells.
GeneRIF
Kanazawa, Japan. In Cell Mol Neurobiol, 2011
Ect2 may play a role in neuronal differentiation and brain development in vivo.
Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation.
GeneRIF
Jacksonville, United States. In J Biol Chem, 2011
a model in which PKCiota-mediated phosphorylation regulates Ect2 binding to the oncogenic PKCiota-Par6 complex thereby activating Rac1 activity and driving transformed growth and invasion.
The nuclear guanine nucleotide exchange factors Ect2 and Net1 regulate RhoB-mediated cell death after DNA damage.
GeneRIF
Chapel Hill, United States. In Plos One, 2010
A mechanism involving the nuclear GEFs Ect2 and Net1 for activating RhoB after genotoxic stress, thereby facilitating cell death after treatment with DNA damaging agents.
Localization of the invadopodia-related proteins actinin-1 and cortactin to matrix-contact-side cytoplasm of cancer cells in surgically resected lung adenocarcinomas.
GeneRIF
Tokyo, Japan. In Pathobiology, 2010
Ect2 was a possible regulator of matrix-contact-side localization of invadopodia-related proteins.
Signalling through the RhoGEF Pebble in Drosophila.
Review
Adelaide, Australia. In Iubmb Life, 2010
Here we review the role of the Drosophila RhoGEF, Pebble (the Drosophila ortholog of mammalian ECT2).
Regulation of skin pigmentation and thickness by Dickkopf 1 (DKK1).
Review
Nagoya, Japan. In J Investig Dermatol Symp Proc, 2009
Furthermore, DKK1 induces the expression of keratin 9 and alpha-Kelch-like ECT2-interacting protein (alphaKLEIP) but downregulates the expression of beta-catenin, glycogen synthase kinase 3beta, protein kinase C, and proteinase-activated receptor-2 (PAR-2) in keratinocytes.
Oncogene ect2 is related to regulators of small GTP-binding proteins.
Impact
Bethesda, United States. In Nature, 1993
Here we report a second novel transforming gene, ect2.
