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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

ECSIT homolog

Ecsit, SITPEC
Top mentioned proteins: TRAF6, TLR4, TGF-beta, Interleukin-6, V1a
Papers on Ecsit
Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death.
New
Laubach et al., Charlottesville, United States. In Transplantation, Dec 2015
Several pathways were uniquely regulated by EVLP + ATL1223 including the downregulation of genes involved in IL-1 signaling, such as ADCY9, ECSIT, IRAK1, MAPK12, and TOLLIP.
Identification and function of an evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) from Crassostrea hongkongensis.
New
Yu et al., Guangzhou, China. In Dev Comp Immunol, Nov 2015
In this study, we identified an ECSIT homolog in the Hong Kong oyster Crassostrea hongkongensis (ChECSIT) and investigated its biological functions.
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity.
New
Impact
Zhou et al., Xiamen, China. In Nat Immunol, Nov 2015
Mst1 and Mst2 activated the GTPase Rac to promote Toll-like receptor (TLR)-triggered assembly of the TRAF6-ECSIT complex that is required for the recruitment of mitochondria to phagosomes.
Hepatitis B virus X protein increases the IL-1β-induced NF-κB activation via interaction with evolutionarily conserved signaling intermediate in Toll pathways (ECSIT).
New
Lin et al., Fuzhou, China. In Virus Res, Feb 2015
This study reports that HBx augments the interleukin-1β (IL-1β)-induced NF-κB activation via interaction with a Toll-like receptor (TLR) adapter protein, ECSIT (evolutionarily conserved signaling intermediate in Toll pathways).
Ubiquitination of ECSIT is crucial for the activation of p65/p50 NF-κBs in Toll-like receptor 4 signaling.
Lee et al., Suwŏn, South Korea. In Mol Biol Cell, 2015
Recent evidence shows that evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) interacts with tumor necrosis factor receptor-associated factor 6 (TRAF6), is ubiquitinated, and contributes to bactericidal activity during Toll-like receptor (TLR) signaling.
TAK1-ECSIT-TRAF6 complex plays a key role in the TLR4 signal to activate NF-κB.
Lee et al., Suwŏn, South Korea. In J Biol Chem, 2015
ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) is known as a multifunctional regulator in different signals, including Toll-like receptors (TLRs), TGF-β, and BMP.
ECSIT bridges RIG-I-like receptors to VISA in signaling events of innate antiviral responses.
Shu et al., Wuhan, China. In J Innate Immun, 2014
In this report, we demonstrate that ECSIT is an essential scaffolding protein that mediates the association of VISA and RIG-I or MDA5.
Role of evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) in the antibacterial immunity of Marsupenaeus japonicus.
Kang et al., Jinan, China. In Dev Comp Immunol, 2014
Evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) is a protein that functions as an adaptor protein for the Toll/TLR and bone morphogenetic protein signaling pathways.
Complexome profiling identifies TMEM126B as a component of the mitochondrial complex I assembly complex.
Impact
Brandt et al., Frankfurt am Main, Germany. In Cell Metab, 2012
TMEM126B was found to comigrate with known assembly factors of mitochondrial complex I, namely CIA30, Ecsit, and Acad9.
Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer's disease pathogenesis.
Aloy et al., Barcelona, Spain. In Bioessays, 2012
Here we postulate that the adapter protein evolutionarily conserved signalling intermediate in Toll pathway (ECSIT) might act as a molecular sensor in the pathogenesis of Alzheimer's disease (AD).
TRIM59 interacts with ECSIT and negatively regulates NF-κB and IRF-3/7-mediated signal pathways.
GeneRIF
Hatakeyama et al., Sapporo, Japan. In Biochem Biophys Res Commun, 2012
TRIM59 interacts with ECSIT as an adaptor protein required for the TLR-mediated transduction pathway.
[Effect of lipopolysaccharide and transforming growth factor-beta 1 on expression and signal pathway of Toll like receptor 4 in dental pulp cells].
Jia et al., Hangzhou, China. In Hua Xi Kou Qiang Yi Xue Za Zhi, 2012
The expressions of signaling molecules evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) and nuclear factor-kappaB (NF-kappaB) were detected by real-time polymerase chain reaction (real-time PCR) and Western blot.
Characterization of the immune defense related tissues, cells, and genes in amphioxus.
Zhang et al., Jinan, China. In Sci China Life Sci, 2011
The expression patterns of TLR1 (toll-like receptor 1), C1Q (complement component 1, q subcomponent), ECSIT (evolutionarily conserved signaling intermediate in Toll pathways), SoxC, DDAHa (Dimethylarginine dimethylaminohydrolase a), and NOS (nitric oxide synthase) show that these genes play key roles in amphioxus immunity.
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
Impact
Ghosh et al., New Haven, United States. In Nature, 2011
This response involves translocation of a TLR signalling adaptor, tumour necrosis factor receptor-associated factor 6 (TRAF6), to mitochondria, where it engages the protein ECSIT (evolutionarily conserved signalling intermediate in Toll pathways), which is implicated in mitochondrial respiratory chain assembly.
Acyl-CoA dehydrogenase 9 is required for the biogenesis of oxidative phosphorylation complex I.
Impact
Vogel et al., Nijmegen, Netherlands. In Cell Metab, 2010
ACAD9 binds complex I assembly factors NDUFAF1 and Ecsit and is specifically required for the assembly of complex I. Furthermore, ACAD9 mutations result in complex I deficiency and not in disturbed long-chain fatty acid oxidation.
Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.
GeneRIF
Nijtmans et al., Nijmegen, Netherlands. In Genes Dev, 2007
Study shows a mitochondrial function for Ecsit in the assembly of mitochondrial complex I, an N-terminal targeting signal directs Ecsit to mitochondria, where it interacts with assembly chaperone NDUFAF1.
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis.
GeneRIF
Ghosh et al., New Haven, United States. In Genes Dev, 2004
functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the bone morphogenetic protein signaling pathway
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