Preferential Killing of HIV Latently Infected CD4+ T cells by MALT1 Inhibitor.
Qiqihar, China. In Aids Res Hum Retroviruses, Feb 2016
UNASSIGNED: We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the PKC agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s).
Backbone Assignment of the MALT1 Paracaspase by Solution NMR.
Huddinge, Sweden. In Plos One, Dec 2015
UNASSIGNED: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a unique paracaspase protein whose protease activity mediates oncogenic NF-κB signalling in activated B cell-like diffuse large B cell lymphomas (ABC-DLBCLs).
The Paracaspase MALT1.
Los Angeles, United States. In Biochimie, Oct 2015
UNASSIGNED: The human paracaspase MALT1 is a caspase homolog that plays a central role in NF-κB signaling.
Structural determinants of MALT1 protease activity.
More papers using
Basel, Switzerland. In J Mol Biol, 2012
Authors provide biochemical and structural evidence that MALT1 activation is dependent on its dimerization and show that mutations at the dimer interface abrogate activity in cells.
In PLoS ONE, 1983
... EcoRV, StuI or PvuII and ligated to adaptors according to the GenomeWalker protocol (Clontech, Mountain View, CA, USA) ...