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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Intestinal cell

Eco, MALT1, MRK, RYK
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, BCL10, cIAP2, HAD, POLYMERASE
Papers using Eco antibodies
Hallmarks of cancer: the next generation
Supplier
Fei Peiwen, In PLoS ONE, 2010
... EcoRI and XhoI restriction enzymes (New England BioLabs, Ipswich, MA) ...
Defects in amphiphysin 2 (BIN1) and triads in several forms of centronuclear myopathies.
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Rota Marcello, In PLoS ONE, 2009
... EcoRI restriction sites of the pSIREN-DNR plasmid (Clontech, Palo Alto, CA) to ...
Comparison of antimicrobial resistance patterns between clinical and sewage isolates in a regional hospital in Taiwan
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Harnisz Monika et al., In Water, Air, and Soil Pollution, 2008
... Eco (Merck) using parallel two Petri ...
Direct inhibition of the NOTCH transcription factor complex
Supplier
Osipo Clodia et al., In Breast Cancer Research : BCR, 2008
... MRK-003 GSI was kindly provided by Merck Oncology International, Inc ...
Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4.
Supplier
Masucci Maria G., In PLoS ONE, 2008
... EcoRI and ClaI sites of pSP73 (Promega Corporation).
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Papers on Eco
The paracaspase MALT1: biological function and potential for therapeutic inhibition.
Review
New
Thome et al., Lausanne, Switzerland. In Cell Mol Life Sci, Feb 2016
The paracaspase MALT1 has a central role in the activation of lymphocytes and other immune cells including myeloid cells, mast cells and NK cells.
Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.
New
Krappmann et al., München, Germany. In Oncogene, Feb 2016
Recruitment of the β-catenin destruction complex was independent of CARMA1-BCL10-MALT1 complex formation or constitutive NF-κB activation and promoted the stabilization of β-catenin.
Targeting MALT1 Proteolytic Activity in Immunity, Inflammation and Disease: Good or Bad?
Review
New
Beyaert et al., Gent, Belgium. In Trends Mol Med, Feb 2016
UNASSIGNED: MALT1 is a signaling protein that plays a key role in immunity, inflammation, and lymphoid malignancies.
VariOtator, A Software Tool for Variation Annotation with the Variation Ontology.
New
Vihinen et al., Lund, Sweden. In Hum Mutat, Feb 2016
For VariO terms relating to structure and property, one can use attribute terms as modifiers and Evidence Code (ECO) terms for annotating experimental evidence.
MALT1 protease activity controls the expression of inflammatory genes in keratinocytes upon zymosan stimulation.
New
Hailfinger et al., Tübingen, Germany. In J Invest Dermatol, Feb 2016
UNASSIGNED: The protease activity of the paracaspase MALT1 plays an important role in antigen receptor-mediated lymphocyte activation by controlling the activity of the transcription factor NF-κB and is thus essential for the expression of inflammatory target genes.
Preferential Killing of HIV Latently Infected CD4+ T cells by MALT1 Inhibitor.
New
Wang et al., Qiqihar, China. In Aids Res Hum Retroviruses, Feb 2016
UNASSIGNED: We report that the addition of an host paracaspase MALT1 inhibitor, MI-2, to HIV latently infected ACH-2, Jurkat E4, and J-LAT cells accelerated cell death in the presence of cell stimuli or the PKC agonist, bryostatin 1. MI-2-mediated cell death correlated with the induction of the cellular RNase MCPIP1 and requires the presence of viral component(s).
TCR signaling to NF-κB and mTORC1: Expanding roles of the CARMA1 complex.
Review
New
Sun et al., Baoding, China. In Mol Immunol, Dec 2015
A central mediator of the TCR and CD28 signals is the scaffold protein CARMA1, which functions by forming a complex with partner proteins, Bcl10 and MALT1.
Backbone Assignment of the MALT1 Paracaspase by Solution NMR.
New
Agback et al., Huddinge, Sweden. In Plos One, Dec 2015
UNASSIGNED: Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is a unique paracaspase protein whose protease activity mediates oncogenic NF-κB signalling in activated B cell-like diffuse large B cell lymphomas (ABC-DLBCLs).
Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity.
Review
New
Puel et al., Madrid, Spain. In J Allergy Clin Immunol, Nov 2015
Three members of the caspase recruitment domain (CARD) family of adaptors (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (MALT1).
The Paracaspase MALT1.
Review
New
Salvesen et al., Los Angeles, United States. In Biochimie, Oct 2015
UNASSIGNED: The human paracaspase MALT1 is a caspase homolog that plays a central role in NF-κB signaling.
Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote T(H)17 differentiation.
Impact
Heissmeyer et al., München, Germany. In Nat Immunol, 2014
Upon recognition of antigen by the T cell antigen receptor (TCR), roquin and regnase-1 proteins were cleaved by the paracaspase MALT1.
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation.
Impact
Sun et al., Houston, United States. In Immunity, 2014
We have further shown that TCR-stimulated glutamine uptake and mTORC1 activation also required a TCR signaling complex composed of the scaffold protein CARMA1, the adaptor molecule BCL10, and the paracaspase MALT1.
The protease activity of the paracaspase MALT1 is controlled by monoubiquitination.
Impact
Thome et al., Lausanne, Switzerland. In Nat Immunol, 2013
The protease activity of the paracaspase MALT1 is central to lymphocyte activation and lymphomagenesis, but how this activity is controlled remains unknown.
MALT1 small molecule inhibitors specifically suppress ABC-DLBCL in vitro and in vivo.
Impact
Melnick et al., New York City, United States. In Cancer Cell, 2013
MALT1 cleavage activity is linked to the pathogenesis of activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL), a chemoresistant form of DLBCL.
Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL.
Impact
Krappmann et al., München, Germany. In Cancer Cell, 2013
Proteolytic activity of the mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) paracaspase is required for survival of the activated B cell subtype of diffuse large B cell lymphoma (ABC-DLBCL).
The Wnt receptor Ryk plays a role in mammalian planar cell polarity signaling.
GeneRIF
Stacker et al., Melbourne, Australia. In J Biol Chem, 2012
RYK and VANGL2 proteins form a complex, whereas RYK also activated RhoA, a downstream effector of PCP signaling.
Expression of MALT1 oncogene in hematopoietic stem/progenitor cells recapitulates the pathogenesis of human lymphoma in mice.
GeneRIF
Martinez-Climent et al., Salamanca, Spain. In Proc Natl Acad Sci U S A, 2012
work establishes a molecular link between MALT lymphoma and ABC-DLBCL, and provides mouse models to test MALT1 inhibitors. Finally, our results suggest that hematopoietic stem/progenitor cells may be involved in the pathogenesis of human B-cell lymphomas
Protease activity of MALT1: a mystery unravelled.
Review
GeneRIF
Vucic et al., San Francisco, United States. In Biochem J, 2012
The catalytic activity of MALT1 promotes activation of canonical and non-canonical NF-kappaB as well as other signalling pathways.
Structural determinants of MALT1 protease activity.
GeneRIF
Renatus et al., Basel, Switzerland. In J Mol Biol, 2012
Authors provide biochemical and structural evidence that MALT1 activation is dependent on its dimerization and show that mutations at the dimer interface abrogate activity in cells.
Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908.
GeneRIF
Fu et al., Charlottesville, United States. In J Biol Chem, 2012
an important role for ICK in modulating the activity of mTORC1 through phosphorylation of Raptor Thr-908.
More papers using Eco antibodies
Effects of oestrogen on gene expression in epithelium and stroma of normal human breast tissue
Supplier
Rio M C et al., In Oncogene, 2005
... EcoRI-digested pQCXIP vector (Clontech, Saint-quentin, France) (pQCXIP hTFF1); ...
Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase
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Rice David W. et al., In Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2005
... EcoRI and SalI and ligated into the pMALc2x vector (New England Biolabs), which produces a fusion protein ...
The evolution of the new permeability pathways in Plasmodium falciparum-infected erythrocytes-a kinetic analysis
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Mamoun Choukri, In PLoS Pathogens, 2005
... EcoRI and HindIII prior to insertion in the pMALc2X vector (New England Biolabs).
High resolution colonoscopy in live mice.
Supplier
Minna John, In PLoS ONE, 2005
... EcoR1 and HindIII restriction endonucleases (New England Biolabs).
Dendritic mRNAs encode diversified functionalities in hippocampal pyramidal neurons
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Schratt Gerhard et al., In The EMBO Journal, 2005
... EcoRI–NotI flanked dsRED cassette (Clontech) together with a ...
Identification of PamA as a PII-binding membrane protein important in nitrogen-related and sugar-catabolic gene expression in Synechocystis sp. PCC 6803
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Tabata Satoshi et al., In DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes, 2004
... Eco RI sites of pAS2-1 (Clontech, Mountain View, CA, USA) ...
PKCβ regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1
Supplier
Kurosaki Tomohiro et al., In The Journal of Experimental Medicine, 2004
... Anti-ERK Ab, anti-JNK Ab, anti-TAK1 mAb (C9), anti-Bcl10 mAb (331.3), and anti-MALT1 Ab were purchased from Santa Cruz Biotechnology, Inc ...
Severe acute respiratory syndrome coronavirus nucleocapsid protein expressed by adenovirus vector is phosphorylated and immunogenic in mice
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Zakhartchouk Alexander et al., In Virology Journal, 2004
... EcoR I and Xho I sites of pEGFP-C2 (Clontech, Mountain View, USA) resulting ...
Advanced chemoresistant breast cancer responding to multidisciplinary treatment with hyperthermia, radiotherapy, and intraarterial infusion
Supplier
Osipo C et al., In British Journal of Cancer, 2004
... ; 3 days on, 4 days off) or MRK-003 (kindly provided by Merck & Co., Whitehouse Station, ...
MAE, a dual regulator of the EGFR signaling pathway, is a target of the Ets transcription factors PNT and YAN
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Shilo Ben-Zion et al., In Molecular Systems Biology, 2003
... EcoRI site of pUAST, and transgenic flies were generated ...
Critical roles of TRAIL in hepatic cell death and hepatic inflammation
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Forbes N S et al., In British Journal of Cancer, 2003
... /EcoRI digested fragment from pRSET-B_mCherry into the retroviral vector, pQCXIN (Clontech).
A directed screen for genes involved in Drosophila blood cell activation
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Kimbrell Deborah A. et al., In Biochemical Genetics, 2003
... EcoRI and XbaI sites of the pUAST vector using BamHI/XbaI linkers, and transgenic strains made by Genetic ...
Successful correction of the human beta-thalassemia major phenotype using a lentiviral vector.
Supplier
Thrasher Adrian J. et al., In Blood, 2003
... EcoRI and SalI polylinker sites upstream of the enhanced green fluorescent protein (EGFP) gene in pEGFP-N1 (Clontech Laboratories, Oxford, United Kingdom) ...
Loss of HR6B ubiquitin-conjugating activity results in damaged synaptonemal complex structure and increased crossing-over frequency during the male meiotic prophase.
Supplier
Kirkpatrick David T., In PLoS ONE, 2002
... EcoRI and BamHI and sub-cloned into pEYFP-C1 (Clontech) and mCherry-C1 (Clontech) ...
In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis
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Hallberg Einar et al., In Molecular Neurodegeneration, 2002
... EcoRI of the ECFP-C1 vector (BD Biosciences).
Regulation of ion homeostasis under salt stress
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Bar-Zvi Dudy et al., In Planta, 2002
... EcoRV, PvuII, or StuI and ligated to GenomeWalker™ adapter using the Clontech GenomeWalker™ Universal Kit (Clontech, ...
A new progressive-iterative algorithm for multiple structure alignment
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Craig Alister, In PLoS Pathogens, 2001
... EcoRI and NotI for cloning into the Baculovirus vector, pAcGP67-A (BD Biosciences, ...
Chemical-regulated, site-specific DNA excision in transgenic plants
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Tabei Yutaka et al., In Plant Cell Reports, 2000
... EcoRI site of pZH2B to yield p35S:GFP.Fig.
The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment.
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van Veen Hendrik W., In PLoS ONE, 1998
... EcoRI and ApaI) (Clontech), to give the plasmids ...
Identification of a pathogenicity island required for Salmonella enteropathogenicity
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Pasmans Frank et al., In Veterinary Research, 1997
... EcoRI and BglII restriction enzymes (New England Biolabs, Ipswich, Massachusetts, USA), ligated ...
The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools.
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Mossman Karen L., In PLoS ONE, 1996
... EcoRI sites of the pQCXIN vector (BD Biosciences Clontech, San Jose, CA) ...
AFLP: a new technique for DNA fingerprinting.
Supplier
Foster John E. et al., In Journal of Insect Science, 1996
... EcoRI adapted ends and MseI ends (Life technologies, ...
Characterization of synthetic human granulocyte chemotactic protein 2: usage of chemokine receptors CXCR1 and CXCR2 and in vivo inflammatory properties
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Rooijakkers Suzan H M et al., In The EMBO Journal, 1996
... EcoRI and PstI enzymes, and cloned into plasmid pMAL-c2X (New England Biolabs) cut with the same ...
Growth and ultrastructure of Arabidopsis root hairs: the rhd3 mutation alters vacuole enlargement and tip growth
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Mercado-Blanco Jesús et al., In Microbial Ecology, 1996
... EcoRI (New England Biolabs) restriction analysis.
Biodegradability of ‘Minipellet’ a new drug formulation using atelocollagen as a drug carrier material, in the rhesus monkey
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Kasugai Shohei et al., In Journal of Tissue Engineering, 1996
... EcoRI, after which the isolated insertion was subcloned in pEGFP-N1 plasmids (Clontech Laboratories Inc., USA) ...
Multiple interactions control the intracellular localization of the herpes simplex virus type 1 capsid proteins
Supplier
Geraghty Robert J., In PLoS ONE, 1995
... EcoRI/BamHI-digested pEYFP-N1 (Clontech, CA, USA) to yield ...
Integrated DNA Technologies OligoAnalyzer
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Davis Thomas M et al., In BMC Research Notes, 1994
... EcoRI, BamHI, or HindIII (New England Biolabs, Ipswich, Massachusetts) in a 40 ...
Two new easy to use vectors for transformations.
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Silar Philippe et al., In BMC Genetics, 1994
... EcoRI and BamHI and cloned into pEGFP-1 (Clontech) at the corresponding sites ...
Combinatorial generation of variable fusion proteins in the Ewing family of tumours
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Kim J et al., In British Journal of Cancer, 1992
... EcoRI and BamHI, and cloned into the corresponding sites of the pM vector (Clontech Laboratories, Mountain View, CA, ...
Somatic Hypermutation Is Limited by CRM1-dependent Nuclear Export of Activation-induced Deaminase
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Nussenzweig Michel C. et al., In The Journal of Experimental Medicine, 1991
... ) were produced using pQCXIP and pCL-ECO plasmids (CLONTECH Laboratories, Inc.) ...
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.
Supplier
Ko Ben C. B., In PLoS ONE, 1991
... EcoRI/SalI fragments of URH49 into the pGAD424 vector (Clontech).
Evolutionary conservation of a microbody targeting signal that targets proteins to peroxisomes, glyoxysomes, and glycosomes.
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Brocard Cecile et al., In Genome Biology, 1990
... EcoRI/BamHI and ligated into pEGFP-C1 (Clontech).
Genomic sequencing.
Supplier
Batzer Mark A., In PLoS ONE, 1983
... EcoRV, StuI or PvuII and ligated to adaptors according to the GenomeWalker protocol (Clontech, Mountain View, CA, USA) ...
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