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Endothelin converting enzyme 1

ECE-1, ECE, endothelin-converting enzyme-1
The protein encoded by this gene is involved in proteolytic processing of endothelin precursors to biologically active peptides. Mutations in this gene are associated with Hirschsprung disease, cardiac defects and autonomic dysfunction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: endothelin-1, CAN, ACID, HAD, Angiotensin II
Papers on ECE-1
Inter-relationships among alternative definitions of feed efficiency in grazing lactating dairy cows.
New
Berry et al., Cork, Ireland. In J Dairy Sci, Jan 2016
Additionally, the most efficient 10% of test-day records, as defined by REI, were associated with superior energy conversion efficiency (ECE, i.e., NEL divided by NEI; ECE=0.55)
Induction of endothelium-dependent constriction of mesenteric arteries in endotoxemic hypotensive shock.
New
Lee et al., Taiwan. In Br J Pharmacol, Jan 2016
This vasoconstriction was blocked by endothelin-1 (ET-1)-receptor antagonists, while OroA further enhanced LPS-induced expression of endothelin-converting enzyme (ECE), ET-1 mRNA and proteins, and ET-1 release, suggesting that OroA-induced vasoconstriction was mediated by endothelial ET-1.
Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin-converting enzyme-1c protein stability.
New
Tapia et al., Santiago, Chile. In Oncotarget, Jan 2016
Endothelin-converting enzyme-1c (ECE-1c) is a membrane metalloprotease involved in endothelin-1 synthesis, which has been shown in vitro to have a role in breast, ovary and prostate cancer cell invasion.
Chicken scFvs with an Artificial Cysteine for Site-Directed Conjugation.
New
Chung et al., Seoul, South Korea. In Plos One, Dec 2015
We prepared four charge-variant H13 artificial cysteine mutants (RCK, DCE, ECD and ECE) as scFv-Ckappa fusion proteins and confirmed that the reactivity of the sulfhydryl group on cysteine is active and their binding activity is retained after the conjugation process.
Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system.
New
Bunnett et al., Australia. In Am J Physiol Gastrointest Liver Physiol, Sep 2015
Inhibition of endothelin-converting enzyme-1 (ECE-1), which degrades endosomal SP, prevented recycling.
Archaeal extrachromosomal genetic elements.
Review
New
She et al., Beijing, China. In Microbiol Mol Biol Rev, Mar 2015
In particular, it has been suggested that ECE-host interactions have shaped the coevolution of ECEs and their archaeal hosts.
Effects of Adaptation of Infectious Bronchitis Virus Arkansas Attenuated Vaccine to Embryonic Kidney Cells.
New
Toro et al., In Avian Dis, Mar 2015
The population structure of an embryo-attenuated infectious bronchitis virus (IBV) Arkansas (Ark) Delmarva Poultry Industry (DPI)-derived vaccine was characterized during serial passages in chicken embryo kidney (CEK) cells and after back-passage in embryonated chicken eggs (ECE) and in chickens.
Differential replication properties among H9N2 avian influenza viruses of Eurasian origin.
Vahlenkamp et al., Leipzig, Germany. In Vet Res, 2014
To evaluate the replication properties and compare the different virus quantification methods, four Eurasian H9N2 viruses from different geographical origins were propagated in embryonated chicken egg (ECE) and Madin-Darby canine kidney epithelial cell systems.
The profibrotic role of endothelin-1: is the door still open for the treatment of fibrotic diseases?
Review
González-Santamaría et al., Madrid, Spain. In Life Sci, 2014
The endothelin (ET) system consists of two G-protein-coupled receptors (ETA and ETB), three peptide ligands (ET-1, ET-2 and ET-3), and two activating peptidases (endothelin-converting enzyme-, ECE-1 and ECE-2).
Aβ degradation or cerebral perfusion? Divergent effects of multifunctional enzymes.
Review
Love et al., Bristol, United Kingdom. In Front Aging Neurosci, 2013
Several Aβ-degrading enzymes, including neprilysin (NEP), endothelin-converting enzyme (ECE), and angiotensin-converting enzyme (ACE) reduce Aβ levels and protect against cognitive impairment in mouse models of AD.
Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.
Review
Turner et al., Leeds, United Kingdom. In Front Aging Neurosci, 2013
Intriguingly several of the main amyloid-degrading enzymes (ADEs) are members of the M13 peptidase family (neprilysin (NEP), NEP2 and the endothelin converting enzymes (ECE-1 and -2)).
Role of chymase in preeclampsia.
Review
Alexander et al., Shreveport, United States. In Curr Vasc Pharmacol, 2013
It has been identified as a key angiotensin converting enzyme (ACE)-independent and endothelin converting enzyme (ECE)-independent converting enzyme that generates angiotensin II and endothelin-1 (ET-1).
ECE1 polymorphisms may contribute to the susceptibility of sporadic congenital heart disease in a Chinese population.
GeneRIF
Mo et al., Nanjing, China. In Dna Cell Biol, 2012
results suggest that ECE1 polymorphisms may contribute to the susceptibility of sporadic congenital heart disease in a Chinese population
Endothelin Converting Enzyme-1 phosphorylation and trafficking.
Review
GeneRIF
Smith et al., Australia. In Febs Lett, 2012
review of ECE-1 phosphorylation and other stimuli which act induce trafficking of ECE-1 to the cell surface [review]
Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by β-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1.
GeneRIF
Pothoulakis et al., Los Angeles, United States. In J Biol Chem, 2012
Endothelin-converting enzyme-1 (ECE-1) degrades NT in acidic conditions, and its activity is crucial for NTR1 recycling.
Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations.
GeneRIF
Bhargava et al., San Francisco, United States. In Mol Endocrinol, 2012
Degradation by ECE-1 is a novel mechanism by which CRF(1) receptor is protected from overactivation by physiologically relevant high concentrations of higher affinity ligand to mediate distinct resensitization and downstream signaling.
Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease.
GeneRIF
Hiltunen et al., Kuopio, Finland. In J Alzheimers Dis, 2011
Te results of this study suggested taht genetic variations in MMEL1, ECE1, ECE2, AGER, PLG, PLAT, NR1H3, MMP3, LRP1, TTR, NR1H2, and MMP9 genes do not play major role among the Finnish AD patient cohort.
Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons.
Impact
Yanagisawa et al., Dallas, United States. In Cell, 1995
This mutation prevents the proteolytic activation of big EDN3 by ECE-1.
ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1.
Impact
Yanagisawa et al., Dallas, United States. In Cell, 1994
The protease that catalyzes the conversion, endothelin-converting enzyme (ECE), constitutes a potential regulatory site for the production of the active peptide.
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