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G protein-coupled receptor 183

EBI2, GPR183
This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Barr, CAN, GPCR, V1a, CD4
Papers on EBI2
Integrated molecular analysis of adult T cell leukemia/lymphoma.
New
Impact
Ogawa et al., Kyoto, Japan. In Nat Genet, Nov 2015
We also discovered frequent intragenic deletions involving IKZF2, CARD11 and TP73 and mutations in GATA3, HNRNPA2B1, GPR183, CSNK2A1, CSNK2B and CSNK1A1.
Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review.
New
Pereira et al., New Haven, United States. In Clin Rev Allergy Immunol, Nov 2015
Recently, the GPCR EBI2 and its oxysterol ligand 7a, 25 dihydroxycholesterol, were identified as important regulators of osteoclast precursor positioning in proximity to bone surfaces and of osteoclast differentiation under homeostasis.
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis.
New
Pereira et al., Suita, Japan. In J Exp Med, Nov 2015
Here, we show that the Gαi protein-coupled receptor (GPCR) EBI2 is expressed in mouse monocyte/OC precursors (OCPs) and its oxysterol ligand 7α,25-dihydroxycholesterol (7α,25-OHC) is secreted abundantly by OBs.
Dendritic cell SIRPα regulates homeostasis of dendritic cells in lymphoid organs.
New
Matozaki et al., Kōbe, Japan. In Genes Cells, Jun 2015
Expression of SIRPα in DCs was well correlated with that of either endothelial cell-selective adhesion molecule (ESAM) or Epstein-Barr virus-induced molecule 2 (EBI2), both of which were also implicated in the regulation of DC homeostasis.
T follicular helper cells have distinct modes of migration and molecular signatures in naive and memory immune responses.
New
Impact
Phan et al., Australia. In Immunity, May 2015
Restriction of the primary Tfh cell subpopulation in the GC was mediated by downregulation of chemotactic receptor EBI2.
EBI2 regulates intracellular signaling and migration in human astrocyte.
New
Dev et al., Dublin, Ireland. In Glia, Feb 2015
The G protein-coupled receptor EBI2 (Epstein-Barr virus-induced gene 2) is activated by 7α, 25-dihydroxycholesterol (7α25HC) and plays a role in T cell-dependant antibody response and B cell migration.
Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.
Pot et al., Genève, Switzerland. In J Autoimmun, 2015
Mechanistically, we show a critical involvement for oxysterols in recruiting leukocytes into inflamed tissues and propose that 7α,25-OHC preferentially promotes the migration of activated CD44(+)CD4(+) T cells by binding the G protein-coupled receptor called Epstein-Barr virus induced gene 2 (EBI2).
Oxysterols act as promiscuous ligands of class-A GPCRs: in silico molecular modeling and in vitro validation.
Eberini et al., Milano, Italy. In Cell Signal, 2014
Oxysterols are produced at inflammatory sites and can surprisingly potently activate the Epstein Barr virus induced gene receptor-2 (EBI2), a GPCR involved in adaptive immune responses.
EBV, the human host, and the 7TM receptors: defense or offense?
Review
Rosenkilde et al., Copenhagen, Denmark. In Prog Mol Biol Transl Sci, 2014
This is for instance the case for the most upregulated 7TM receptor EBI2 (EBV-induced gene 2 or GPR183).
7α, 25-dihydroxycholesterol-mediated activation of EBI2 in immune regulation and diseases.
Review
Liu et al., San Diego, United States. In Front Pharmacol, 2014
EBI2, aka GPR183, is a G-couple receptor originally identified in 1993 as one of main genes induced in Burkitt's lymphoma cell line BL41 by Epstein-Barr virus (EBV) infection.
25-Hydroxycholesterols in innate and adaptive immunity.
Review
Impact
Yi et al., San Francisco, United States. In Nat Rev Immunol, 2014
In addition, a dihydroxylated form of cholesterol functions as an immune cell guidance cue by engaging the G protein-coupled receptor EBI2, and it is required for mounting adaptive immune responses.
Oxysterol-EBI2 signaling in immune regulation and viral infection.
Review
Rosenkilde et al., Copenhagen, Denmark. In Eur J Immunol, 2014
The seven transmembrane G protein-coupled receptor Epstein-Barr virus (EBV) induced gene 2 (EBI2; also known as GPR183) was identified in 1993 on the basis of its substantial upregulation in EBV-infected cells.
Functional Antagonists of EBI-2
Review
Rickert et al., Bethesda, United States. In Unknown Journal, 2014
An exciting new development in the field is the revelation of a novel chemotactic axis involving the recognition of oxysterol compounds by the orphan G-protein-coupled receptor (GPCR), Epstein-Barr virus-induced gene 2 (EBI2).
Sterols and oxysterols in immune cell function.
Review
Impact
Glass et al., San Diego, United States. In Nat Immunol, 2013
Here we review recent literature reporting on the biological functions of sterol intermediates and oxysterols, acting through transcription factors such as the liver X receptors (LXRs), sterol regulatory element-binding proteins (SREBPs) and the G protein-coupled receptor EBI2, in regulating the differentiation and population expansion of cells of the innate and adaptive immune systems, their responses to inflammatory mediators, their effects on the phagocytic functions of macrophages and their effects on antiviral activities and the migration of immune cells.
The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells.
Impact
Brink et al., Australia. In Nat Immunol, 2013
Here we found a difference in expression of the chemotactic receptor EBI2 (GPR183) on splenic DC subsets and that EBI2 regulated the positioning and homeostasis of DCs in the spleen.
EBI2 operates independently of but in cooperation with CXCR5 and CCR7 to direct B cell migration and organization in follicles and the germinal center.
GeneRIF
Brink et al., Australia. In J Immunol, 2011
Regulation of B cell migration by EBI2 has an important role in controlling the positioning of activated B cells within lymphoid follicles in the early phases of B cell responses during cell differentiation and affinity maturation.
EBI2 guides serial movements of activated B cells and ligand activity is detectable in lymphoid and nonlymphoid tissues.
GeneRIF
Cyster et al., San Francisco, United States. In J Immunol, 2011
These findings establish a role for EBI2 in helping control B cell position at multiple stages during the Ab response
Ligand modulation of the Epstein-Barr virus-induced seven-transmembrane receptor EBI2: identification of a potent and efficacious inverse agonist.
GeneRIF
Rosenkilde et al., Copenhagen, Denmark. In J Biol Chem, 2011
ligand targeting EBI2. In turn, this molecule provides a useful tool for further characterization of EBI2 as well as serving as a potent lead compound.
EBI2, GPR18 and GPR17--three structurally related, but biologically distinct 7TM receptors.
Review
GeneRIF
Rosenkilde et al., Copenhagen, Denmark. In Curr Top Med Chem, 2010
REVIEW: functional properties and in vivo biology
Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses.
Impact
GeneRIF
Brink et al., Australia. In Immunity, 2009
EBI2 provides a previously uncharacterized dimension to B cell migration that is crucial for coordinating rapid versus long-term antibody responses.
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