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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

SH2 domain containing 1B

EAT-2
By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: SLAM, SAP, CAN, CD55, V1a
Papers on EAT-2
A network pharmacology approach reveals new candidate caloric restriction mimetics in C. elegans.
New
de Magalhães et al., Liverpool, United Kingdom. In Aging Cell, Jan 2016
An increase in lifespan and healthspan was observed for all drugs except geldanamycin when fed to wild-type worms, but no lifespan effects were observed in eat-2 mutant worms, a genetic model of CR, suggesting that life-extending effects may be acting via CR-related mechanisms.
Identification of the SLAM Adapter Molecule EAT-2 as a Lupus-Susceptibility Gene That Acts through Impaired Negative Regulation of Dendritic Cell Signaling.
New
Wither et al., Toronto, Canada. In J Immunol, Dec 2015
In this article, we show that the promoter region of the NZB gene encoding the SLAM signaling pathway adapter molecule EWS-activated transcript 2 (EAT-2) is polymorphic, which results in an ∼70% reduction in EAT-2 in DC.
Update on the Pharmacotherapy of Cerebellar Ataxia and Nystagmus.
New
Strupp et al., München, Germany. In Cerebellum, Nov 2015
There are ongoing randomized placebo-controlled trials on EA2 with 4-AP versus acetazolamide (EAT-2-TREAT), cerebellar gait ataxia with 4-AP (FACEG), and a multinational trial on cerebellar ataxia with acetyl-DL-leucine (ALCAT).
Acacetin 7-O-α-l-rhamnopyranosyl (1-2) β-D-xylopyranoside Elicits Life-span Extension and Stress Resistance in Caenorhabditis elegans.
New
Pandey et al., Lucknow, India. In J Gerontol A Biol Sci Med Sci, Nov 2015
The effect of ARX on worms with mutations (mev-1, eat-2, sir-2.1,
[Pharmacotherapy of Vestibular Disorders, Nystagmus and Cerebellar Disorders].
Review
New
Strupp et al., In Fortschr Neurol Psychiatr, Sep 2015
There are ongoing RCTs on treatment of vestibular paroxysmia with carbamazepine (VESPA), acute unilateral vestibulopathy with betahistine (BETAVEST), vestibular migraine with metoprolol (PROVEMIG), benign paroxysmal positional vertigo with vitamin D (VitD@BPPV), EA2 with 4-aminopyridine versus acetazolamide (EAT-2-TREAT), and cerebellar ataxias with acetyl-DL-leucine (ALCAT).
Pharmacotherapy of vestibular and cerebellar disorders and downbeat nystagmus: translational and back-translational research.
Review
New
Brandt et al., München, Germany. In Ann N Y Acad Sci, Apr 2015
There are ongoing RCTs on vestibular paroxysmia with carbamazepine (VESPA), acute unilateral vestibulopathy with betahistine (BETAVEST), vestibular migraine with metoprolol (PROVEMIG), benign paroxysmal positional vertigo with vitamin D (VitD@BPPV), EA2 with 4-aminopyridine versus acetazolamide (EAT-2-TREAT), and cerebellar ataxias with acetyl-DL-leucine (ALCAT).
Aiweixin, a traditional Uyghur medicinal formula, protects against chromium toxicity in Caenorhabditis elegans.
Abdukerim et al., China. In Bmc Complement Altern Med, 2014
It was added into M9 buffer in a certain volume for the treatment to the wild-type C. elegans and mutational worms, daf-16, glp-1(notch), daf-2, rsks-1 and eat-2.
Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans.
Kaeberlein et al., Seattle, United States. In Front Genet, 2014
Dietary restriction by bacterial deprivation or mutation of eat-2(ad1113) fails to further extend lifespan in the presence of 5% sorbitol.
Targeting HIV-1 innate immune responses therapeutically.
Review
Larsson et al., Linköping, Sweden. In Curr Opin Hiv Aids, 2011
Interestingly, when used as adjuvants, EAT-2 and heat shock protein gp96 reportedly enhance innate immune responses.
Cutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouse.
GeneRIF
Terhorst et al., Boston, United States. In J Immunol, 2010
EAT-2A and EAT-2B act as positive regulators of signaling lymphocyte activation molecule family receptor-specific NK cell functions in C57BL/6 mice.
SLAM family receptors and the SLAM-associated protein (SAP) modulate T cell functions.
Review
Terhorst et al., Boston, United States. In Semin Immunopathol, 2010
Six of the receptors carry one or more copies of a unique intracellular tyrosine-based switch motif, which has high affinity for the single SH2-domain signaling molecules SLAM-associated protein and EAT-2.
Essential function for SAP family adaptors in the surveillance of hematopoietic cells by natural killer cells.
Impact
Veillette et al., Montréal, Canada. In Nat Immunol, 2009
The adaptors SAP, EAT-2 and ERT are specific to cells of the immune system and belong to the SAP family.
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.
Impact
GeneRIF
Veillette et al., Montréal, Canada. In Nat Immunol, 2009
EAT-2 mediates CRACC function. In the absence of EAT-2, CRACC inhibited natural killer cell function.
Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules.
Review
Impact
Tangye et al., Australia. In Annu Rev Immunol, 2006
During the past eight years, it has been established that the SLAM family of cell surface receptors (SLAM, 2B4, NTB-A, Ly9, CD84) and the SAP family of adaptors (SAP, EAT-2, ERT) play critical roles in lymphocyte development, differentiation, and acquisition of effector functions.
Molecular analysis of NTB-A signaling: a role for EAT-2 in NTB-A-mediated activation of human NK cells.
GeneRIF
Watzl et al., Heidelberg, Germany. In J Immunol, 2006
NTB-A-mediated IFN-gamma production was greatly reduced in the absence of SLAM-associated protein (SAP), demonstrating that cytokine production and cytotoxicity are differentially dependent on SAP and possibly EAT-2
Identification and characterization of two related murine genes, Eat2a and Eat2b, encoding single SH2-domain adapters.
GeneRIF
Lanyi et al., Boston, United States. In Immunogenetics, 2006
Taken together, the data suggest that both EAT-2A and EAT-2B are adapters that recruit Src kinases to SLAM family receptors using a mechanism that is distinct from that of SAP.
Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor.
Impact
Veillette et al., Montréal, Canada. In Nat Immunol, 2005
EAT-2 is an adaptor expressed in innate immune cells, including natural killer (NK) cells.
The dual-function CD150 receptor subfamily: the viral attraction.
Review
Impact
Clark et al., Kiev, Ukraine. In Nat Immunol, 2003
The ITSM (immunoreceptor tyrosine-based switch motif) enables these receptors to bind to and be regulated by small SH2 domain adaptor proteins, including SH2D1A (SH2-containing adaptor protein SH2 domain protein 1A) and EAT-2 (EWS-activated transcript 2).
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