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Mesoderm induction early response 1 homolog
Early response, ER1
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). In human, this gene functions as a growth-factor-induced immediate early gene that encodes a transcriptional regulator. Depending on the cellular context, this gene can function as both an activator and repressor of gene transcription. Alternative splicing results in multiple isoforms; some of which contain a nuclear localization signal. [provided by RefSeq, Aug 2011] (from
Hohaus et al., Roma, Italy. In Cancer Med, Feb 2016
UNASSIGNED: Early response evaluation with [(18) F]fluordeoxyglucose (FDG) positron emission tomography after 2 cycles of chemotherapy (interim PET) has been indicated as the strongest predictor for outcome in classical Hodgkin lymphoma (HL).
Kamel et al., Baltimore, United States. In J Comput Assist Tomogr, Jan 2016
OBJECTIVE: The aim of the study was to evaluate the value of volumetric contrast-enhanced magnetic resonance imaging (MRI) using gadoxetate disodium in early assessment of treatment response after intra-arterial therapy (IAT).
AIM: The aim of the study was to investigate the impact of early response (ER) to hepatic arterial infusion chemotherapy (HAIC) on outcomes of patients with advanced hepatocellular carcinoma (HCC) complicated with major portal vein tumor thrombosis (PVTT).
Nilsson et al., Lund, Sweden. In Basic Clin Pharmacol Toxicol, 2013
Although these oestrogen-evoked beneficial effects have been attributed to oestrogen receptor alpha (ERα), also ER beta (ERβ) and the novel ER G protein-coupled receptor 30 (GPR30)/G protein-coupled ER1 probably play significant roles in vascular oestrogen signalling.
CONTEXT: Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an important prognostic factor for children with acute lymphoblastic leukemia (ALL).
Paterno et al., St. John's, Canada. In Mol Cell Biol, 2003
we investigated the role of hMI-ER1alpha and hMI-ER1beta in the regulation of transcription.We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).