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Mesoderm induction early response 1 homolog

Early response, ER1
This gene encodes a protein that was first identified in Xenopus laevis by its role in a mesoderm induction early response (MIER). In human, this gene functions as a growth-factor-induced immediate early gene that encodes a transcriptional regulator. Depending on the cellular context, this gene can function as both an activator and repressor of gene transcription. Alternative splicing results in multiple isoforms; some of which contain a nuclear localization signal. [provided by RefSeq, Aug 2011] (from NCBI)
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Top mentioned proteins: HAD, CAN, AGE, iMpact, ACID
Papers on Early response
The predictive value of early response in patients with depressive disorders.
Hiller et al., Mainz, Germany. In Psychother Res, Feb 2016
OBJECTIVE: Several randomized controlled trials have identified early response to psychotherapy as a predictor for later treatment outcome among patients with depressive disorders.
CD68+ cell count, early evaluation with PET and plasma TARC levels predict response in Hodgkin lymphoma.
Hohaus et al., Roma, Italy. In Cancer Med, Feb 2016
UNASSIGNED: Early response evaluation with [(18) F]fluordeoxyglucose (FDG) positron emission tomography after 2 cycles of chemotherapy (interim PET) has been indicated as the strongest predictor for outcome in classical Hodgkin lymphoma (HL).
Liver Malignancies Treated With Intra-Arterial Therapy: Assessment of Early Response as Quantified by Volumetric Enhancement Using Gadoxetate Disodium.
Kamel et al., Baltimore, United States. In J Comput Assist Tomogr, Jan 2016
OBJECTIVE: The aim of the study was to evaluate the value of volumetric contrast-enhanced magnetic resonance imaging (MRI) using gadoxetate disodium in early assessment of treatment response after intra-arterial therapy (IAT).
Early response of the human SOST gene to stimulation by 1α,25-dihydroxyvitamin D3.
Atkins et al., Adelaide, Australia. In J Steroid Biochem Mol Biol, Jan 2016
UNASSIGNED: The osteocyte expressed gene SOST encodes sclerostin, a potent negative regulator of bone formation and inducer of bone resorption.
Hepatic Arterial Infusion Chemotherapy for Advanced Hepatocellular Carcinoma with Portal Vein Thrombosis: Impact of Early Response to 4 Weeks of Treatment.
Lin et al., Taiwan. In Liver Cancer, Dec 2015
AIM: The aim of the study was to investigate the impact of early response (ER) to hepatic arterial infusion chemotherapy (HAIC) on outcomes of patients with advanced hepatocellular carcinoma (HCC) complicated with major portal vein tumor thrombosis (PVTT).
Estrogen receptors in the central nervous system and their implication for dopamine-dependent cognition in females.
Brake et al., Montréal, Canada. In Horm Behav, Aug 2015
However, it is now known that there are at least three estrogen receptors (ERs): ERα, ERβ and G-protein coupled ER1 (GPER1).
Bone marrow minimal residual disease was an early response marker and a consistent independent predictor of survival after anti-GD2 immunotherapy.
Cheung et al., New York City, United States. In J Clin Oncol, Apr 2015
Early response markers of minimal residual disease (MRD) in the BM that are also predictive of survival could help individualize patient therapies.
Aberrant Splicing of Estrogen Receptor, HER2, and CD44 Genes in Breast Cancer.
Fry et al., Winston-Salem, United States. In Genet Epigenet, 2014
ERα36, a splice variant from the ER1 locus, governs nongenomic membrane signaling pathways triggered by estrogen and confers 4-hydroxytamoxifen resistance in BC therapy.
[Non-response to therapy in acute and rehabilitative psychosomatic inpatient care - a systematic review].
Scheidt et al., In Z Psychosom Med Psychother, 2013
Early response to treatment and a dysfunctional therapeutic alliance are possible further predictors, whereas sociodemographic and sociomedical variables are unlikely to have a predictive validity.
Identification and characterization of new mechanisms in vascular oestrogen signalling.
Nilsson et al., Lund, Sweden. In Basic Clin Pharmacol Toxicol, 2013
Although these oestrogen-evoked beneficial effects have been attributed to oestrogen receptor alpha (ERα), also ER beta (ERβ) and the novel ER G protein-coupled receptor 30 (GPR30)/G protein-coupled ER1 probably play significant roles in vascular oestrogen signalling.
Early response to psychological trauma--what GPs can do.
Forbes et al., Melbourne, Australia. In Aust Fam Physician, 2013
OBJECTIVE: This article outlines an evidence-based early response to psychological trauma.
Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells.
Gillespie et al., St. John's, Canada. In Plos One, 2011
Differential splicing alters subcellular localization of the alpha but not beta isoform of the MIER1 transcriptional regulator in breast cancer cells
Phase II genomics study of ixabepilone as neoadjuvant treatment for breast cancer.
Galbraith et al., Barcelona, Spain. In J Clin Oncol, 2009
ER gene expression (ER1) was inversely related to pCR in breast and had a positive predictive value (PPV) of 37% and negative predictive value (NPV) of 92%.
Changes in subcellular localisation of MI-ER1 alpha, a novel oestrogen receptor-alpha interacting protein, is associated with breast cancer progression.
Gillespie et al., St. John's, Canada. In Br J Cancer, 2008
Loss of nuclear MI-ER1 alpha might contribute to the development of invasive breast carcinoma
Early response evaluation in malignant pleural mesothelioma by positron emission tomography with [18F]fluorodeoxyglucose.
Santoro et al., Milano, Italy. In J Clin Oncol, 2006
PURPOSE: Response evaluation with conventional criteria based on computed tomography (CT) is particularly challenging in malignant pleural mesothelioma (MPM) due to its diffuse pattern of growth.
Thiopurine methyltransferase (TPMT) genotype and early treatment response to mercaptopurine in childhood acute lymphoblastic leukemia.
Schwab et al., Hannover, Germany. In Jama, 2005
CONTEXT: Early response to multiagent chemotherapy, including mercaptopurine, as measured by minimal residual disease is an important prognostic factor for children with acute lymphoblastic leukemia (ALL).
Developmentally regulated cytoplasmic retention of the transcription factor XMI-ER1 requires sequence in the acidic activation domain.
Gillespie et al., St. John's, Canada. In Int J Biochem Cell Biol, 2005
XMI-ER1 is retained in the cytoplasm of the early embryo by interaction of the region containing amino acids 144-175 with a cytoplasmic anchor
The SANT domain of human MI-ER1 interacts with Sp1 to interfere with GC box recognition and repress transcription from its own promoter.
Paterno et al., St. John's, Canada. In J Biol Chem, 2004
the association of hMI-ER1 with Sp1 represents a novel mechanism for the negative regulation of Sp1 target promoters
Human MI-ER1 alpha and beta function as transcriptional repressors by recruitment of histone deacetylase 1 to their conserved ELM2 domain.
Paterno et al., St. John's, Canada. In Mol Cell Biol, 2003
we investigated the role of hMI-ER1alpha and hMI-ER1beta in the regulation of transcription.We demonstrate that this repressor activity is due to interaction and recruitment of a trichostatin A-sensitive histone deacetylase 1 (HDAC1).
Early responder myeloma: kinetic studies identify a patient subgroup characterized by very poor prognosis.
Barbui et al., Torino, Italy. In J Clin Oncol, 1989
Early response itself does not correspond to shorter remission duration and shorter survival, but it is a poor prognostic factor if associated with a high plasma cell proliferative activity.
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