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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Nuclear receptor subfamily 2, group F, member 6

EAR-2, NR2F6
expressed in anterior pituitary [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: COUP Transcription Factor I, CAN, ACID, MANF, TCF
Papers on EAR-2
The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.
Baier et al., Innsbruck, Austria. In Cell Rep, Oct 2015
Nuclear receptor subfamily 2, group F, member 6 (NR2F6) is an orphan member of the nuclear receptor superfamily.
Silicon detectors for monitoring neutron beams in n-TOF beamlines.
Finocchiaro et al., Catania, Italy. In Rev Sci Instrum, Jul 2015
During 2014, the second experimental area (EAR2) was completed at the n-TOF neutron beam facility at CERN (n-TOF indicates neutron beam measurements by means of time of flight technique).
A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation.
Casal et al., Madrid, Spain. In Mol Cell Proteomics, Feb 2015
Among other proteins, multiple transcription factors such as Trip4, OsmR, Nr2f6, Cbx6, and Prrx1 were down-regulated.
A Subset of Nuclear Receptors are Uniquely Expressed in Uveal Melanoma Cells.
Martinez et al., Dallas, United States. In Front Endocrinol (lausanne), 2014
Third, we found that RARg, PPARd, EAR2, RXRa, and TRa expressions could subdivide UM from CM.
Nuclear receptor expression in human differentiated thyroid tumors.
Gilfillan et al., Australia. In Thyroid, 2014
In FC, EAR-2 was overexpressed, while PPAR-α and PPAR-δ were underexpressed compared to MNG.
Minireview: role of orphan nuclear receptors in cancer and potential as drug targets.
Lee et al., Houston, United States. In Mol Endocrinol, 2014
The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF).
The orphan nuclear receptor Ear-2 (Nr2f6) is a novel negative regulator of T cell development.
Wells et al., Toronto, Canada. In Exp Hematol, 2014
We describe a novel role for the orphan nuclear receptor Ear-2 in regulating T cell development.
Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions.
Baier et al., Innsbruck, Austria. In Cell Commun Signal, 2013
In particular, a CD4+ T cell intrinsic and non-redundant function of NR2F6 as a potent and selective repressor of the transcription of the pro-inflammatory cytokines interleukin (Il) 2, interferon y (ifng) and consequently of T helper (Th)17 CD4+ T cell-mediated autoimmune disorders has been discovered.
Quantitative variation in maize kernel row number is controlled by the FASCIATED EAR2 locus.
Jackson et al., New York City, United States. In Nat Genet, 2013
We also show that variation in the CLAVATA receptor-like protein FASCIATED EAR2 leads to increased inflorescence meristem size and KRN.
Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6.
Sigmund et al., Iowa City, United States. In Am J Physiol Renal Physiol, 2012
It was concluded that both Nr2f2 and Nr2f6 negatively regulate renin promoter activity, but may do so by divergent mechanisms.
Leucine-Rich Repeat (LRR) Domains Containing Intervening Motifs in Plants.
Miyashita et al., Sapporo, Japan. In Biomolecules, 2011
The LRR@IR proteins are LRR-containing receptor-like kinases (LRR-RLKs), LRR-containing receptor-like proteins (LRR-RLPs), TONSOKU/BRUSHY1, and MJK13.7; the LRR-RLKs are homologs of TMK1/Rhg4, BRI1, PSKR, PSYR1, Arabidopsis At1g74360, and RPK2, while the LRR-RLPs are those of Cf-9/Cf-4, Cf-2/Cf-5, Ve, HcrVf, RPP27, EIX1, clavata 2, fascinated ear2, RLP2, rice Os10g0479700, and putative soybean disease resistance protein.
The orphan nuclear receptor EAR2 is overexpressed in colorectal cancer and it regulates survivability of colon cancer cells.
Fang et al., Shanghai, China. In Cancer Lett, 2011
study demonstrated that expression of EAR2 was elevated in colorectal cancer and knockdown of EAR2 reduced survivability and tumor growth of colon cancer cells
Rasd1 interacts with Ear2 (Nr2f6) to regulate renin transcription.
Chen et al., Singapore, Singapore. In Bmc Mol Biol, 2010
Ear2 ligand binding domain is required for Rasd1 to alleviate Ear2-mediated repression of renin transcription.
How nuclear receptors tell time.
Delaunay et al., Nice, France. In J Appl Physiol, 2009
Other NR family members, including the orphan NR EAR2, peroxisome proliferator activated receptors-alpha/gamma, estrogen receptor-alpha, and retinoic acid receptors, are also linked to the clockwork mechanism.
The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.
Baier et al., Innsbruck, Austria. In Immunity, 2008
Our study establishes NR2F6 as a transcriptional repressor of IL-17 expression in Th17-differentiated CD4(+) T cells in vitro and in vivo.
Orphans against autoimmunity.
Rao et al., Boston, United States. In Immunity, 2008
In this issue of Immunity, Hermann-Kleiter et al. (2008) identify a nuclear orphan receptor, NR2F6, as a negative regulator of the T helper 17 cell subset and report that NR2F6-deficient mice develop late-onset autoimmune disease.
Positive and negative transcriptional regulation of aromatase expression in human breast cancer tissue.
Zhou et al., Duarte, United States. In J Steroid Biochem Mol Biol, 2005
Our results suggest that in normal breast tissue, the function of promoters I.3 and II is suppressed through the binding of EAR-2, COUP-TFI, and RARgamma to S1, and through the binding of Snail/Slug proteins to their binding site that quenches the CREaro activity.
Cloning, expression and regulation of chicken ovalbumin upstream promoter transcription factors (COUP-TFII and EAR-2) in the rat anterior pituitary gland.
Morel et al., Villeurbanne, France. In Neuroendocrinology, 2004
Cloning of rat pituitary COUP-TFII and EAR-2 genes, demonstrated that they are specifically expressed in lactotropes, and strongly suggested that they may play a role in modulating prolactin (PRL) gene expression during pregnancy.
Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes.
Dufau et al., Bethesda, United States. In J Steroid Biochem Mol Biol, 2003
Endogenous orphan receptors, EAR2 and EAR3/COUP-TFI, bind this motif and repress promoter activity by 70%.
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