Mechanisms of anion conduction by coupled glutamate transporters.
Jülich, Germany. In Cell, Mar 2015
Fluorescence quenching of inserted tryptophan residues indicated the entry of anions into this pathway, and mutations of homologous pore-forming residues had analogous effects on GltPh simulations and EAAT2/EAAT4 measurements of single-channel currents and anion/cation selectivities.
Regulation of cellular transport by klotho protein.
Pristina, Serbia. In Curr Protein Pept Sci, 2013
Klotho regulates diverse calcium and potassium ion channels, as well as several carriers including the Na(+)-coupled excitatory amino acid transporters EAAT3 and EAAT4, the Na(+)-coupled phosphate cotransporters, NaPi-IIa and NaPi-IIb, and a Na(+)/K(+)-ATPase.
The SLC1 high-affinity glutamate and neutral amino acid transporter family.
Suita, Japan. In Mol Aspects Med, 2013
The high-affinity glutamate transporters EAAC1 (SLC1A1), GLT1 (SLC1A2), GLAST (SLC1A3), EAAT4 (SLC1A6), and EAAT5 (SLC1A7) mediate the cellular uptake of glutamate by the co-transport of three sodium ions (Na(+)) and one proton (H(+)), with the counter-transport of one potassium ion (K(+)).
GABA and Glutamate Transporters in Brain.
Oslo, Norway. In Front Endocrinol (lausanne), 2012
The mammalian genome contains four genes encoding GABA transporters (GAT1, slc6a1; GAT2, slc6a13; GAT3, slc6a11; BGT1, slc6a12) and five glutamate transporter genes (EAAT1, slc1a3; EAAT2, slc1a2; EAAT3, slc1a1; EAAT4, slc1a6; EAAT5, slc1a7).
Spinocerebellar ataxia type 5.
Minneapolis, United States. In Handb Clin Neurol, 2011
TIRF microscopy performed on cell lines transiently transfected with mutant or wild-type spectrin shows that mutant β-III spectrin fails to stabilize the glutamate transporter EAAT4 at the plasma membrane.
Hetero-oligomerization of neuronal glutamate transporters.
Hannover, Germany. In J Biol Chem, 2011
EAAT3 and EAAT4, but neither EAAT1 and EAAT2, nor EAAT2 and EAAT3 are capable of co-assembling into heterotrimers. Co-expression of EAAT3 and EAAT4 results in additional appearance of basolateral EAAT3