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GA binding protein transcription factor, beta subunit 1

E4TF1, GABP beta, E4TF1-53
This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: SP1, ERG3, ACID, GDNF, CAN
Papers on E4TF1
The unliganded glucocorticoid receptor positively regulates the tumor suppressor gene BRCA1 through GABP beta.
Mueller et al., Kingston, Canada. In Mol Cancer Res, 2012
Loss of BRCA1 tumor suppressor function is a critical event in breast tumorigenesis.
Naïve CD4+ T cells of Peyer's patches produce more IL-6 than those of spleen in response to antigenic stimulation.
GeneRIF
Kaminogawa et al., Tokyo, Japan. In Immunol Lett, 2012
After antigenic stimulation CD4+/CD62Lhigh cells from Peyer's patches express a greater amount of transcripts of GA-binding protein beta subunit 1 than those from the spleen.
Decreased expression of BRCA1 in SK-BR-3 cells is the result of aberrant activation of the GABP Beta promoter by an NRF-1-containing complex.
GeneRIF
Mueller et al., Kingston, Canada. In Mol Cancer, 2010
NRF-1 and GABP expression is coordinated by NRF-1's activation of the GABPbeta promoter
Induction of heparanase-1 expression by mutant B-Raf kinase: role of GA binding protein in heparanase-1 promoter activation.
GeneRIF
Xu et al., Chicago, United States. In Neoplasia, 2010
Data show that BRAF knockdown led to suppression of the expression of the GABPbeta, which involved in regulating HPR1 promoter activity.
Targeting the GA binding protein beta1L isoform does not perturb lymphocyte development and function.
GeneRIF
Leonard et al., Iowa City, United States. In Mol Cell Biol, 2008
GABPbeta1S has a critical role in maintaining the transcriptional activity of the GABPalpha/beta complex.
PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression.
GeneRIF
Scarpulla et al., Chicago, United States. In J Biol Chem, 2008
The results are consistent with a pathway whereby PRC regulates NRF-2-dependent genes through a multiprotein complex involving HCF-1.[NRF-2beta]
Identification of functional elements in the murine Gabp alpha/ATP synthase coupling factor 6 bi-directional promoter.
Martin et al., Columbia, United States. In Gene, 2006
GABP is composed of two subunits; the GABP alpha subunit is a member of the Ets-family of transcription factors, and the unrelated ankyrin repeat containing GABP beta subunit.
Differential response at the hGABP/E4TF1 site of retinoblastoma gene promoter in human testicular seminoma cells.
Sakai et al., Kyoto, Japan. In Oncol Rep, 2005
Promoter activity from a construct without a hGABP/E4TF1-binding site was markedly reduced in A549 human lung adenocarcinoma cells, but not in JKT-1.
Genomic structure of the human UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase gene.
Filocamo et al., Genova, Italy. In Dna Seq, 2002
Several potential transcription regulatory motifs, such as Sp-1, E4TF1 and ATF binding sites, were identified in the 5'-flanking region.
YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors.
Handa et al., Yokohama, Japan. In J Biol Chem, 2002
The transcription factor hGABP/E4TF1 is a heterotetrameric complex composed of two DNA-binding subunits (hGABP alpha/E4TF1-60) and two transactivating subunits (hGABP beta/E4TF1-53).
Cell-cycle-dependent regulation of human aurora A transcription is mediated by periodic repression of E4TF1.
Ishigatsubo et al., Yokohama, Japan. In J Biol Chem, 2002
Furthermore, coexpression of E4TF1-60 and E4TF1-53 markedly increased aurora A promoter activity.
Regulation of the Hsp90-binding immunophilin, cyclophilin 40, is mediated by multiple sites for GA-binding protein (GABP).
Ratajczak et al., Australia. In Cell Stress Chaperones, 2001
Furthermore, overexpression of both GABP alpha and GABP beta subunits in Cos1 cells resulted in increased endogenous CyP40 mRNA levels.
Structures, sequence characteristics, and synteny relationships of the transcription factor E4TF1, the splicing factor U2AF35 and the cystathionine beta synthetase genes from Fugu rubripes.
Gardiner et al., Denver, United States. In Gene, 1999
In addition to APP, the cosmid contains the E4TF1-60 transcription factor, the U2AF35 pre-mRNA splicing factor, and the cystathionine beta synthetase (CBS) gene.
Regulation of human B19 parvovirus promoter expression by hGABP (E4TF1) transcription factor.
Morinet et al., Paris, France. In J Biol Chem, 1998
By supershift analysis, we demonstrated the binding of the hGABP (also named E4TF1) protein to the Ets binding site and the fixation of Sp1 and YY1 proteins on their respective motifs.
Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1.
Sakai et al., Kyoto, Japan. In Cancer Res, 1997
However, Sp1 protein was shown not to bind to the Sp1 site; this indicated that the Sp1 consensus site mutation was blocking the action of an alternative transcription factor, which we called RBF-1 (retinoblastoma binding factor 1). Subsequent purification of RBF-1 revealed it to be hGABP/E4TF1, a transactivator from the adenovirus early-region 4 promoter.
GABP cooperates with c-Myb and C/EBP to activate the neutrophil elastase promoter.
Rosmarin et al., Baltimore, United States. In Blood, 1997
GABP is a heteromeric transcription factor complex that consists of GABP alpha, an ets factor, and GABP beta, a Notch-related protein.
Characterization of the human thrombopoietin gene promoter. A possible role of an Ets transcription factor, E4TF1/GABP.
Kitajima et al., Fukuoka, Japan. In J Biol Chem, 1997
Anti-E4TF1-60(GABPalpha) or anti-E4TF1-53/47(GABPbeta) antibodies supershifted the complex in gel shift assay.
[Molecular cancer epidemiology--the present status and future possibilities].
Review
Sakai, Kyoto, Japan. In Nihon Eiseigaku Zasshi, 1996
In summary we found that RBF-1 and ATF sites are the core promoter regions, that the neighboring E2F site is a silencer site, and that E4TF1 preferentially binds to the RBF-1 site.
Identification of Ets- and notch-related subunits in GA binding protein.
Impact
McKnight et al., Baltimore, United States. In Science, 1991
The sequence of the second subunit, GABP beta, contains four 33-amino acid repeats located close to the NH2-terminus of the subunit.
Convergence of Ets- and notch-related structural motifs in a heteromeric DNA binding complex.
Impact
McKnight et al., Baltimore, United States. In Science, 1991
The ETS domain of GABP alpha facilitates weak binding to DNA and, together with an adjacent segment of 37 amino acids, mediates stable interaction with GABP beta.
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