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E4F transcription factor 1

E4F, p120E4F, E4F1, transcription factor E4F
The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E1A, E4, CAN, p53, PCNA
Papers on E4F
Histone Deacetylase 10 Regulates the Cell Cycle G2/M Phase Transition via a Novel Let-7-HMGA2-Cyclin A2 Pathway.
Seto et al., Tampa, United States. In Mol Cell Biol, Oct 2015
HMGA2 loss resulted in enrichment of the transcriptional repressor E4F at the cyclin A2 promoter.
Description of an optimized ChIP-seq analysis pipeline dedicated to genome wide identification of E4F1 binding sites in primary and transformed MEFs.
Kirsh et al., Montpellier, France. In Genom Data, Sep 2015
This Data in Brief report describes the experimental and bioinformatic procedures that we used to analyze and interpret E4F1 ChIP-seq experiments published in Rodier et al. (2015) [10].
E4F1 is a master regulator of CHK1-mediated functions.
Sauvageau et al., Montréal, Canada. In Cell Rep, May 2015
It has been previously shown that the polycomb protein BMI1 and E4F1 interact physically and genetically in the hematopoietic system.
The transcription factor E4F1 coordinates CHK1-dependent checkpoint and mitochondrial functions.
Sardet et al., Montpellier, France. In Cell Rep, May 2015
Here, we show that another factor, the multifunctional protein E4F1, directly controls genes involved in mitochondria functions and cell-cycle checkpoints, including Chek1, a major component of the DNA damage response.
Global analyses of Chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes.
Wang et al., Shanghai, China. In Biol Direct, 2014
Of them, Mapk14 and Trem2 were up-regulated to indicate the biological function of TCs in immune regulation, and up-regulated MCFD2 and down-regulated E4F1 and PDCD2 had an association with tissue homeostasis for TCs.
Synthetic promoters for CHO cell engineering.
James et al., Sheffield, United Kingdom. In Biotechnol Bioeng, 2014
Comparison of the sequence and relative activity of first generation promoters revealed that individual TFRE blocks were either relatively abundant in active promoters (NFκB, E-box), equally distributed across promoters of varying activity (C/EBPα, GC-box) or relatively abundant in low activity promoters (E4F1, CRE).
Downregulation of transcription factor E4F1 in hepatocarcinoma cells: HBV-dependent effects on autophagy, proliferation and metabolism.
Hainaut et al., Lyon, France. In Carcinogenesis, 2014
The multifunctional E4F1 protein is a cellular target of the E1A adenoviral oncoprotein.
SON connects the splicing-regulatory network with pluripotency in human embryonic stem cells.
Ng et al., Singapore, Singapore. In Nat Cell Biol, 2013
Importantly, we confirmed that SON regulates the proper splicing of transcripts encoding for pluripotency regulators such as OCT4, PRDM14, E4F1 and MED24.
Bilateral radial ulnar synostosis and vertebral anomalies in a child with a de novo 16p13.3 interstitial deletion.
Slavin et al., Honolulu, United States. In Case Rep Genet, 2012
The genes are E4F1, DNASE1L2, ECI1, RNPS1, and ABCA3; miRNAs are MIR3677, MIR940, and MIR4717.
E4F1 dysfunction results in autophagic cell death in myeloid leukemic cells.
Le Cam et al., Montpellier, France. In Autophagy, 2011
The multifunctional E4F1 protein was originally identified as a cellular target of the E1A adenoviral oncoprotein.
E4F1 deficiency results in oxidative stress-mediated cell death of leukemic cells.
Le Cam et al., Montpellier, France. In J Exp Med, 2011
deletion of E4F1 resulted in the death of histiocytic sarcoma cells and tumor regression in vivo and extended the lifespan
Transcription factor E4F1 is essential for epidermal stem cell maintenance and skin homeostasis.
Le Cam et al., Montpellier, France. In Proc Natl Acad Sci U S A, 2011
identify a regulatory axis essential for epidermal stem cell-dependent skin homeostasis implicating E4F1 and the Bmi1-Arf-p53 pathway.
The role of LANP and ataxin 1 in E4F-mediated transcriptional repression.
Opal et al., Chicago, United States. In Embo Rep, 2007
LANP and ATAXN1 interact in E4F-mediated transcriptional repression.
E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.
Sardet et al., Montpellier, France. In Cell, 2006
E4F1 is a key posttranslational regulator of p53, which modulates its effector functions involved in alternative cell fates: growth arrest or apoptosis.
The LIM-only protein FHL2 is a negative regulator of E4F1.
Sardet et al., Montpellier, France. In Oncogene, 2006
findings show that full-length E4F1 protein but not its E1A-activated & truncated form interacts in vitro & in vivo with FHL2; this E4F1-FHL2 association occurs in the nuclear compartment & inhibits the capacity of E4F1 to block cell proliferation
The cell cycle of early mammalian embryos: lessons from genetic mouse models.
Cohen-Tannoudji et al., Paris, France. In Cell Cycle, 2006
Here, we discuss the particularities of the mouse early embryonic cell cycle and review the mutations that result in cell cycle defects during mouse early embryogenesis, including deficiencies for genes of the cyclin family (cyclin A2 and B1), genes involved in cell cycle checkpoints (Mad2, Bub3, Chk1, Atr), genes involved in ubiquitin and ubiquitin-like pathways (Uba3, Ubc9, Cul1, Cul3, Apc2, Apc10, Csn2) as well as genes the function of which had not been previously ascribed to cell cycle regulation (Cdc2P1, E4F and Omcg1).
Adenovirus E1A-dependent trans-activation of transcription.
Nevins, Durham, United States. In Semin Cancer Biol, 1990
At least two factors that appear to be essential for trans-activation, E2F and E4F, are regulated via changes in DNA binding activity, dependent on E1A action.
Transactivation by the adenovirus E1A gene.
Reichel et al., Durham, United States. In Biochem Cell Biol, 1988
This factor, termed E4F, is also increased as a function of the E1A product.
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