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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Nuclear factor, interleukin 3 regulated

E4BP4, NFIL3
Expression of interleukin-3 (IL3; MIM 147740) is restricted to activated T cells, natural killer (NK) cells, and mast cell lines. Transcription initiation depends on the activating capacity of specific protein factors, such as NFIL3, that bind to regulatory regions of the gene, usually upstream of the transcription start site (Zhang et al., 1995 [PubMed 7565758]).[supplied by OMIM, Feb 2009] (from NCBI)
Papers on E4BP4
PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4.
GeneRIF
Moreau et al., Montréal, Canada. In J Cell Physiol, 2012
PTHrP(1-34)-mediated repression of the PHEX gene in osteoblastic cells involves the transcriptional repressor E4BP4.
Cellular DBP and E4BP4 proteins are critical for determining the period length of the circadian oscillator.
GeneRIF
Hashimoto et al., Tsukuba, Japan. In Febs Lett, 2011
Data show that knockdown of DBP, D-box positive regulator, led to a short-period phenotype, and overexpression of DBP produced a long-period rhythm, while knockdown and overexpression of E4BP4, D-box negative regulator, had the opposite effect of DBP.
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
GeneRIF
Murray et al., Memphis, United States. In J Biol Chem, 2011
A distal enhancer in Il12b is the target of transcriptional repression by the STAT3 pathway and requires the basic leucine zipper (B-ZIP) protein NFIL3.
NFIL3/E4BP4 is a key transcription factor for CD8α⁺ dendritic cell development.
GeneRIF
Rothman et al., Iowa City, United States. In Blood, 2011
NFIL3 plays an essential role in the development of CD8alpha(+) cDCs.
NFIL3/E4BP4 controls type 2 T helper cell cytokine expression.
GeneRIF
Rothman et al., Iowa City, United States. In Embo J, 2011
Taken together, these data indicate that NFIL3 is a key regulator of T(H)2 cytokine expression.
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