Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses.
Buenos Aires, Argentina. In Cell, Oct 2015
Melatonin induces the expression of the repressor transcription factor Nfil3, blocking the differentiation of pathogenic Th17 cells and boosts the generation of protective Tr1 cells via Erk1/2 and the transactivation of the IL-10 promoter by ROR-α.
Terminal differentiation of dendritic cells.
Melbourne, Australia. In Adv Immunol, 2012
Several transcription factors such as Batf3, Nfil3, and Id2 are required for different DC subsets at steady-state and drive segregation into the individual DCs subsets late in development in the CD8 lineage.
E4BP4: an unexpected player in the immune response.
London, United Kingdom. In Trends Immunol, 2012
Until recently, the basic leucine zipper transcription factor E4BP4 (also known as NFIL3) was of little interest to immunologists, being best known for its role in regulating circadian rhythm in chick pineal gland.