E3 ubiquitin ligase
Targeting Pink1-Parkin-mediated mitophagy for treating liver injury.
Kansas City, United States. In Pharmacol Res, Dec 2015
Parkin is well-known to be required for mitophagy induction in in vitro models, and we previously showed that the Parkin-mediated mitophagy pathway likely plays a protective role against alcohol and acetaminophen-induced liver injuries.
Parkin-dependent mitophagy in the heart.
Saint Louis, United States. In J Mol Cell Cardiol, Dec 2015
Here, the evidence supporting a role for the prototypical mitochondrial quality control pathway, PINK1-Parkin mediated mitophagy, in cardiac homeostasis and heart disease is reviewed.
Mechanism of phospho-ubiquitin-induced PARKIN activation.
Cambridge, United Kingdom. In Nature, Sep 2015
The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal-recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy.
MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology.
Singapore, Singapore. In Cells, 2014
Recent findings have revealed a myriad of molecules that are associated with MIRO, particularly the kinesin adaptor Milton/TRAK, mitofusin, PINK1 and Parkin, as well as the endoplasmic reticulum-mitochondria encounter structure (ERMES) complex.