Papers on
E3 ubiquitin ligase
Targeting Pink1-Parkin-mediated mitophagy for treating liver injury.Ding et al., Kansas City, United States. In Pharmacol Res, Dec 2015
Parkin is well-known to be required for mitophagy induction in in vitro models, and we previously showed that the Parkin-mediated mitophagy pathway likely plays a protective role against alcohol and acetaminophen-induced liver injuries.
Parkin-dependent mitophagy in the heart.Dorn, Saint Louis, United States. In J Mol Cell Cardiol, Dec 2015
Here, the evidence supporting a role for the prototypical mitochondrial quality control pathway, PINK1-Parkin mediated mitophagy, in cardiac homeostasis and heart disease is reviewed.
Mechanism of phospho-ubiquitin-induced PARKIN activation.Komander et al., Cambridge, United Kingdom. In Nature, Sep 2015
The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal-recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy.
MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology.Tang, Singapore, Singapore. In Cells, 2014
Recent findings have revealed a myriad of molecules that are associated with MIRO, particularly the kinesin adaptor Milton/TRAK, mitofusin, PINK1 and Parkin, as well as the endoplasmic reticulum-mitochondria encounter structure (ERMES) complex.