E3 ubiquitin ligase
Parkin-dependent mitophagy in the heart.
Saint Louis, United States. In J Mol Cell Cardiol, Dec 2015
Here, the evidence supporting a role for the prototypical mitochondrial quality control pathway, PINK1-Parkin mediated mitophagy, in cardiac homeostasis and heart disease is reviewed.
Mechanism of phospho-ubiquitin-induced PARKIN activation.
Cambridge, United Kingdom. In Nature, Sep 2015
The E3 ubiquitin ligase PARKIN (encoded by PARK2) and the protein kinase PINK1 (encoded by PARK6) are mutated in autosomal-recessive juvenile Parkinsonism (AR-JP) and work together in the disposal of damaged mitochondria by mitophagy.
MIRO GTPases in Mitochondrial Transport, Homeostasis and Pathology.
Singapore, Singapore. In Cells, 2014
Recent findings have revealed a myriad of molecules that are associated with MIRO, particularly the kinesin adaptor Milton/TRAK, mitofusin, PINK1 and Parkin, as well as the endoplasmic reticulum-mitochondria encounter structure (ERMES) complex.
The associations between Parkinson's disease and cancer: the plot thickens.
Boston, United States. In Transl Neurodegener, 2014
This positive association has been supported by several common genetic mutations in SNCA, PARK2, PARK8, ATM, p53, PTEN, and MC1R resulting in cellular changes such as mitochondrial dysfunction, aberrant protein aggregation, and cell cycle dysregulation.