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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

E2F transcription factor 7

E2F7
E2F transcription factors, such as E2F7, play an essential role in the regulation of cell cycle progression (Di Stefano et al., 2003 [PubMed 14633988]).[supplied by OMIM, May 2008] (from NCBI)
Top mentioned proteins: E2F8, E2F1, CAN, miR, p53
Papers on E2F7
The ovarian DNA damage repair response is induced prior to phosphoramide mustard-induced follicle depletion, and ataxia telangiectasia mutated inhibition prevents PM-induced follicle depletion.
New
Keating et al., Ames, United States. In Toxicol Appl Pharmacol, Jan 2016
ATM, PARP1, E2F7, P73 and CASP3 abundance were increased but RAD51 and BCL2 protein decreased after 96 h of PM exposure.
Genome-wide analysis reveals NRP1 as a direct HIF1α-E2F7 target in the regulation of motorneuron guidance in vivo.
New
Bakker et al., Utrecht, Netherlands. In Nucleic Acids Res, Jan 2016
UNASSIGNED: In this study, we explored the existence of a transcriptional network co-regulated by E2F7 and HIF1α, as we show that expression of E2F7, like HIF1α, is induced in hypoxia, and because of the previously reported ability of E2F7 to interact with HIF1α.
E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter.
New
Liu et al., Guangzhou, China. In Oncotarget, Nov 2015
Further, we identified that a repressive member of E2F family, E2F7, was responsible for the suppression of miR-15a/16 cluster by competing with E2F1 for E2F binding site at the promoter of their host gene DLEU2.
E2F8 as a Novel Therapeutic Target for Lung Cancer.
New
Koo et al., New Haven, United States. In J Natl Cancer Inst, Sep 2015
E2F8 with E2F7 has been known to play an important physiologic role in embryonic development and cell cycle regulation by repressing E2F1.
RacGAP1 Is a Novel Downstream Effector of E2F7-Dependent Resistance to Doxorubicin and Is Prognostic for Overall Survival in Squamous Cell Carcinoma.
New
Saunders et al., Australia. In Mol Cancer Ther, Aug 2015
We have previously shown that E2F7 contributes to drug resistance in head and neck squamous cell carcinoma (HNSCC) cells.
Mature T cell responses are controlled by microRNA-142.
New
Reddy et al., In J Clin Invest, Aug 2015
Moreover, 2 predicted miR-142 target genes, the atypical E2F transcription factors E2f7 and E2f8, were most highly upregulated in miR-142-deficient cells.
MicroRNA-424 may function as a tumor suppressor in endometrial carcinoma cells by targeting E2F7.
New
Xiao et al., Zunyi, China. In Oncol Rep, May 2015
Bioinformatics analysis indicated that E2F7 was a putative target of miR-424.
Unbiased proteomic profiling strategy for discovery of bacterial effector proteins reveals that salmonella protein PheA is a host cell cycle regulator.
New
Lee et al., Seoul, South Korea. In Chem Biol, May 2015
We follow up on the top candidate, chorismate mutase-P/prehenate dehydratase, PheA, and present evidence that PheA is an effector that mimics E2F7 transcription factor of the host cell and promotes G1/S cell cycle arrest.
Downregulation of E2F1 during ER stress is required to induce apoptosis.
New
Corazzari et al., Roma, Italy. In J Cell Sci, Apr 2015
Whereas ATF6 directly interacts with the E2F1 promoter, IRE1 requires the involvement of the known E2F1 modulator E2F7, through the activation of its main target Xbp-1.
Structural insights into the DNA-binding specificity of E2F family transcription factors.
Taipale et al., Stockholm, Sweden. In Nat Commun, 2014
Typical E2Fs bind to DNA as heterodimers with the related dimerization partner (DP) proteins, whereas the atypical E2Fs, E2F7 and E2F8 contain two DNA-binding domains (DBDs) and act as repressors.
Whole-genome cartography of p53 response elements ranked on transactivation potential.
Inga et al., Trento, Italy. In Bmc Genomics, 2014
Based on the mapping of predicted functional REs near TSS, we examined expression changes of thirteen genes as a function of different p53-inducing conditions, providing further evidence for PDE2A, GAS6, E2F7, APOBEC3H, KCTD1, TRIM32, DICER, HRAS, KITLG and TGFA p53-dependent regulation, while MAP2K3, DNAJA1 and potentially YAP1 were identified as new direct p53 target genes.
Identification of Cellular Targets of MicroRNA-181a in HepG2 Cells: A New Approach for Functional Analysis of MicroRNAs.
Chen et al., Singapore, Singapore. In Plos One, 2014
Using bioinformatics analysis, cyclin-dependent kinase inhibitor 1B (CDKN1β) and transcriptional factor E2F7 were identified as potential targets of miR-181a.
Promising roles of mammalian E2Fs in hepatocellular carcinoma.
Review
Li et al., Hefei, China. In Cell Signal, 2014
E2F1 was identified to play overlapping roles in HCC, while E2F2--E2F8 (except E2F6 and E2F7) showed to be tumor-promoter in HCC.
Canonical and atypical E2Fs regulate the mammalian endocycle.
Impact
Leone et al., Columbus, United States. In Nat Cell Biol, 2012
Using lineage-specific cre mice we identified two opposing arms of the E2F program, one driven by canonical transcription activation (E2F1, E2F2 and E2F3) and the other by atypical repression (E2F7 and E2F8), that converge on the regulation of endocycles in vivo.
E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression.
GeneRIF
Manfredi et al., New York City, United States. In Genes Dev, 2012
E2F7-dependent mechanism contributes to p53-dependent cell cycle arrest in response to DNA damage.
The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.
GeneRIF
Lowe et al., New York City, United States. In Genes Dev, 2012
identify a causal role for E2F7 in cellular senescence and uncover a novel link between the RB and p53 pathways.
Loss of E2F7 expression is an early event in squamous differentiation and causes derepression of the key differentiation activator Sp1.
GeneRIF
Saunders et al., Brisbane, Australia. In J Invest Dermatol, 2011
These data indicate that loss of E2F7 during the initiation of differentiation leads to the derepression of Sp1 and subsequent transcription of differentiation-specific genes such as epidermal type I transglutaminase.
The role of the E2F transcription factor family in UV-induced apoptosis.
Review
Saunders et al., Australia. In Int J Mol Sci, 2010
In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death.
E2F7 can regulate proliferation, differentiation, and apoptotic responses in human keratinocytes: implications for cutaneous squamous cell carcinoma formation.
GeneRIF
Saunders et al., Australia. In Cancer Res, 2009
selected disruption of E2F1 and E2F7 in keratinocytes is likely to contribute to cutaneous squamous cell carcinomas (CSCC) formation and may prove to be a viable therapeutic target.
DNA-damage response control of E2F7 and E2F8.
GeneRIF
La Thangue et al., Oxford, United Kingdom. In Embo Rep, 2008
E2F7 and E2F8 act upstream of E2F1, and influence the ability of cells to undergo a DNA-damage response.
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