Activity, regulation, copy number and function in the glyoxalase system.
Coventry, United Kingdom. In Biochem Soc Trans, 2014
Human GLO1 has MRE (metal-response element), IRE (insulin-response element), E2F4 (early gene 2 factor isoform 4), AP-2α (activating enhancer-binding protein 2α) and ARE (antioxidant response-element) regulatory elements and is a hotspot for copy number variation.
Unraveling the genetics of otitis media: from mouse to human and back again.
Australia. In Mamm Genome, 2011
Single-gene mouse mutants with OM have identified a number of genes, namely, Eya4, Tlr4, p73, MyD88, Fas, E2f4, Plg, Fbxo11, and Evi1, as potential and biologically relevant candidates for human disease.
Tumor suppression by ARF: gatekeeper and caretaker.
Chicago, United States. In Cell Cycle, 2010
While the regulation of the activator E2Fs is related to cell cycle arrest, there is evidence that the regulation of the repressors, E2F4 and E2F5, is significant in maintaining genomic stability.