Kv10.1 K(+) channel: from physiology to cancer.
Amiens, France. In Pflugers Arch, Feb 2016
Kv10.1 is in contrast robustly expressed in over 70 % human tumors, where its expression seems to be controlled by key regulators of proliferation and survival such as p53 and E2F1, often altered in cancer.
Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.
Chapel Hill, United States. In Cardiovasc Pathol, Nov 2015
At both 3 and 8weeks of fenofibrate treatment, the differentially expressed MuRF1-/- genes most commonly had SREBP-1 and E2F1/E2F promoter regions by TRANSFAC analysis (54 and 50 genes, respectively, of the 111 of the genes >4 and <-4 log fold change; P≤.0004).
Roseoloviruses manipulate host cell cycle.
Tel Aviv-Yafo, Israel. In Curr Opin Virol, 2014
During lytic infections HHV-6A and HHV-6B disrupt E2F1-Rb complexes by Rb degradation, releasing E2F1 and driving the infected cells toward the S-phase.
Canonical and atypical E2Fs regulate the mammalian endocycle.
Columbus, United States. In Nat Cell Biol, 2012
Using lineage-specific cre mice we identified two opposing arms of the E2F program, one driven by canonical transcription activation (E2F1, E2F2 and E2F3) and the other by atypical repression (E2F7 and E2F8), that converge on the regulation of endocycles in vivo.