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E2F transcription factor 1

E2F1, transcription factor E2F
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, PCNA, p53, V1a, p21
Papers using E2F1 antibodies
Detection of histone H3 phosphorylation in cultured cells and tissue sections by immunostaining
Padmanabhan Jaya et al., In Molecular Neurodegeneration, 2008
... P-APP, MPM-2, and P-cdc2 antibodies were from Cell Signaling, and cyclin D1, cyclin E, and E2F1 antibodies were from Santa Cruz Biotechnology.
Novel ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action.
Wu Gen Sheng, In PLoS ONE, 2008
... Antibodies against human p21 (C-19), p27 (C-19), Cyclin D1 (DCS-6), Cyclin E (HE12), and E2F1 (KH95) were from Santa Cruz Biotechnology, Inc ...
Proteins released from degenerating neurons are surrogate markers for acute brain damage.
Di Giovanni Simone, In PLoS ONE, 2003
... scrambled negative control siRNA duplex (SR30004), constructs expressing 29 mer shRNAs against Rat Cdc2 and E2F1 in pGFP-V-RS vectors were obtained from Origene Technologies Inc ...
Enhanced etoposide sensitivity following adenovirus-mediated human topoisomerase IIalpha gene transfer is independent of topoisomerase IIbeta
Bronner C et al., In British Journal of Cancer, 2000
... The anti-E2F-1 mAb was obtained from BD Biosciences Clontech (Palo Alto, CA, ...
Papers on E2F1
NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.
Machida et al., Los Angeles, United States. In Cell Metab, Feb 2016
Here, we show that NANOG is induced by Toll-like receptor 4 (TLR4) signaling via phosphorylation of E2F1 and that downregulation of Nanog slows down hepatocellular carcinoma (HCC) progression induced by alcohol western diet and hepatitis C virus protein in mice.
E2F1: a promising regulator in ovarian carcinoma.
Wei et al., Hefei, China. In Tumour Biol, Feb 2016
E2F1, the most classic member of the E2F family, exhibits a complex role in tumor development regulation.
Kv10.1 K(+) channel: from physiology to cancer.
Pardo et al., Amiens, France. In Pflugers Arch, Feb 2016
Kv10.1 is in contrast robustly expressed in over 70 % human tumors, where its expression seems to be controlled by key regulators of proliferation and survival such as p53 and E2F1, often altered in cancer.
Oncogene-tumor suppressor gene feedback interactions and their control.
Chan et al., Bethesda, United States. In Math Biosci Eng, Jan 2016
Examples given in this paper are the pairs of MYC and p53, KRAS and INK4A, and E2F1 and miR-17-92.
The CaSm (LSm1) oncogene promotes transformation, chemoresistance and metastasis of pancreatic cancer cells.
Cole et al., Charleston, United States. In Oncogenesis, Dec 2015
CaSm induction decreased gemcitabine-induced cytotoxicity and altered the expression of apoptotic regulation genes, including Bad, E2F1 and Bcl-XL.
Characterization of the promoter region of the bovine long-chain acyl-CoA synthetase 1 gene: Roles of E2F1, Sp1, KLF15, and E2F4.
Zhang et al., China. In Sci Rep, Dec 2015
Mutational analysis and electrophoretic mobility shift assays demonstrated that E2F1, Sp1, KLF15 and E2F4 binding to the promoter region drives ACSL1 transcription.
Fenofibrate unexpectedly induces cardiac hypertrophy in mice lacking MuRF1.
Willis et al., Chapel Hill, United States. In Cardiovasc Pathol, Nov 2015
At both 3 and 8weeks of fenofibrate treatment, the differentially expressed MuRF1-/- genes most commonly had SREBP-1 and E2F1/E2F promoter regions by TRANSFAC analysis (54 and 50 genes, respectively, of the 111 of the genes >4 and <-4 log fold change; P≤.0004).
Transcription factors that interact with p53 and Mdm2.
Frazier et al., Winston-Salem, United States. In Int J Cancer, Aug 2015
In this review, we focus on transcription factors that directly interact with p53/Mdm2 through direct binding including Dmp1, E2F1, YB-1 and YY1.
Resected gastric cancer with D2 dissection: advances in adjuvant chemoradiotherapy and radiotherapy techniques.
Xu et al., Chengdu, China. In Expert Rev Anticancer Ther, Jun 2015
Finally, the status of E2F-1 and HER-2 may be associated with efficacy of radiotherapy based on retrospective studies.
Comprehensive genomic characterization of head and neck squamous cell carcinomas.
Cancer Genome Atlas Network, In Nature, Mar 2015
Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1.
Roseoloviruses manipulate host cell cycle.
Zeigerman et al., Tel Aviv-Yafo, Israel. In Curr Opin Virol, 2014
During lytic infections HHV-6A and HHV-6B disrupt E2F1-Rb complexes by Rb degradation, releasing E2F1 and driving the infected cells toward the S-phase.
Role of E2F-1 and its involving pathway in esophageal squamous cell carcinoma.
Chen et al., Beijing, China. In Thorac Cancer, 2014
Expression of E2F-1 and molecules involved in its targeted pathways, pERK, Bim, pRb, epidermal growth factor receptor, EZH2 and pAKT, was investigated immunohistochemically.
Directed phenotype switching as an effective antimelanoma strategy.
Rodríguez-López et al., Murcia, Spain. In Cancer Cell, 2013
The combination of MTX and TMECG leads to depletion of thymidine pools, double-strand DNA breaks, and highly efficient E2F1-mediated apoptosis in culture and in vivo.
E2F8 is essential for polyploidization in mammalian cells.
de Bruin et al., Utrecht, Netherlands. In Nat Cell Biol, 2012
In contrast, loss of E2f1 enhanced polyploidization and suppressed the polyploidization defect of hepatocytes deficient for atypical E2Fs.
Canonical and atypical E2Fs regulate the mammalian endocycle.
Leone et al., Columbus, United States. In Nat Cell Biol, 2012
Using lineage-specific cre mice we identified two opposing arms of the E2F program, one driven by canonical transcription activation (E2F1, E2F2 and E2F3) and the other by atypical repression (E2F7 and E2F8), that converge on the regulation of endocycles in vivo.
Altered microRNA expression profile in human pituitary GH adenomas: down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1.
Fusco et al., Napoli, Italy. In J Clin Endocrinol Metab, 2012
Down-regulation of miRNA targeting HMGA1, HMGA2, and E2F1 in human pituitary GH adenomas.
The Rb/E2F pathway modulates neurogenesis through direct regulation of the Dlx1/Dlx2 bigene cluster.
Slack et al., Ottawa, Canada. In J Neurosci, 2012
Rb/E2F is required to coordinate the transition between proliferation and differentiation by controlling key aspects of differentiation through regulation of the Dlx1/Dlx2 bigene cluster.
E2F1-dependent methyl cap formation requires RNA pol II phosphorylation.
Cowling et al., Dundee, United Kingdom. In Cell Cycle, 2012
E2F1 increases RNA pol II phosphorylation, which promotes recruitment of the methyl cap synthetic enzymes.
Regulation of E2F1 by APC/C Cdh1 via K11 linkage-specific ubiquitin chain formation.
Lin et al., Houston, United States. In Cell Cycle, 2012
The formation of Ub-K11 chains on E2F1 is increased in the presence of Cdh1 and accumulated in the presence of proteasome inhibitor, suggesting that APC/C (Cdh1) targets E2F1 for degradation by forming Ub-K11 chains.
Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding.
Lopaschuk et al., Edmonton, Canada. In Febs Lett, 2012
Data suggest that nuclear translocation of cardiac E2F1 is enhanced by high-fat diet (HFD) concomitant with induction of pyruvate dehydrogenase kinase 4 (PDK4); HFD may initiate early cardiac metabolic alterations through cyclin D1/E2F1/PDK4 axis.
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