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Heterogeneous nuclear ribonucleoprotein U-like 1

E1B-AP5, HNRPUL1, heterogeneous nuclear ribonucleoprotein U-like 1, Adenovirus early region 1B-associated protein 5
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on E1B-AP5
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
GeneRIF
Jackson et al., Cambridge, United Kingdom. In Mol Cell, 2012
hnRNPUL1 and -2 function downstream of MRN and CtBP-interacting protein (CtIP) to promote recruitment of the BLM helicase to DNA breaks.
Identification and characterization of adenovirus early region 1B-associated protein 5 as a surface marker on undifferentiated human embryonic stem cells.
GeneRIF
Ryu et al., Seoul, South Korea. In Stem Cells Dev, 2011
E1B-AP5 is a novel surface molecule that is involved in the undifferentiated state of human embryonic stem cells
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.
GeneRIF
Turnell et al., Birmingham, United Kingdom. In J Virol, 2008
Taken together, these results define a role for E1B-AP5 in ATR signaling pathways activated during adenovirus infection.
Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.
GeneRIF
Devlin et al., Alameda, United States. In Arterioscler Thromb Vasc Biol, 2006
Variants in 2 genes were associated with early-onset myocardial infarct: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein.
Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7.
GeneRIF
Dobner et al., Mannheim, Germany. In Biochem J, 2003
Regulation of transcripton by this protein is mediated by complex formation with BRD7
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