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Heterogeneous nuclear ribonucleoprotein U-like 1

E1B-AP5, HNRPUL1, heterogeneous nuclear ribonucleoprotein U-like 1, Adenovirus early region 1B-associated protein 5
This gene encodes a nuclear RNA-binding protein of the heterogeneous nuclear ribonucleoprotein (hnRNP) family. This protein binds specifically to adenovirus E1B-55kDa oncoprotein. It may play an important role in nucleocytoplasmic RNA transport, and its function is modulated by E1B-55kDa in adenovirus-infected cells. Two transcript variants encoding different isoforms have been found for this gene. Additional variants have also been found, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, p53, H2A, Nucleoporin, NUP98
Papers on E1B-AP5
Gene polymorphisms associated with susceptibility to coronary artery disease in Han Chinese people.
Zhou et al., Shenzhen, China. In Genet Mol Res, 2013
The HNRPUL1 gene rs11881940T and GATA2 gene rs3803T loci were highly correlated with CAD (P < 0.05).
Heterogeneous nuclear ribonucleoprotein U-like 1 and Poly (ADP-ribose) polymerase 1 are downregulated in renal cell carcinoma and connected with the prognosis.
Zhang et al., Nanjing, China. In Cancer Biomark, 2013
OBJECTIVE: To examine the expression of heterogeneous nuclear ribonucleoprotein U-like 1 (hnRPUL1) and poly (ADP-ribose) polymerase 1 (PARP-1) in renal cell carcinoma (RCC) tissues and the connection between the expressions and prognosis of RCC.
Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA.
Zheng et al., Bethesda, United States. In J Virol, 2013
However, E1B-AP5 (heterogeneous nuclear ribonucleoprotein U-like 1), which interacts with a region outside the 9-nt core to stimulate PAN expression, does not interact or even colocalize with ORF57.
The role of hnRPUL1 involved in DNA damage response is related to PARP1.
Yasui et al., Nanjing, China. In Plos One, 2012
Heterogeneous nuclear ribonucleoprotein U-like 1 (hnRPUL1) -also known as adenovirus early region 1B-associated proteins 5 (E1B-AP5) - plays a role in RNA metabolism.
Regulation of DNA-end resection by hnRNPU-like proteins promotes DNA double-strand break signaling and repair.
GeneRIF
Jackson et al., Cambridge, United Kingdom. In Mol Cell, 2012
hnRNPUL1 and -2 function downstream of MRN and CtBP-interacting protein (CtIP) to promote recruitment of the BLM helicase to DNA breaks.
Identification and characterization of adenovirus early region 1B-associated protein 5 as a surface marker on undifferentiated human embryonic stem cells.
GeneRIF
Ryu et al., Seoul, South Korea. In Stem Cells Dev, 2011
E1B-AP5 is a novel surface molecule that is involved in the undifferentiated state of human embryonic stem cells
Stability of a long noncoding viral RNA depends on a 9-nt core element at the RNA 5' end to interact with viral ORF57 and cellular PABPC1.
Zheng et al., Bethesda, United States. In Int J Biol Sci, 2010
The 9-nt core in the MRE-II also binds cellular PABPC1, but not the E1B-AP5 which binds another region of the MRE-II.
Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
Sijbrands et al., Rotterdam, Netherlands. In Eur Heart J, 2008
P = 0.03), the rs11881940 polymorphism in the heterogeneous nuclear ribonucleoprotein U-like 1 (HNRPUL1) gene (HR 1.27, 95% CI 1.07-1.51,
A role for E1B-AP5 in ATR signaling pathways during adenovirus infection.
GeneRIF
Turnell et al., Birmingham, United Kingdom. In J Virol, 2008
Taken together, these results define a role for E1B-AP5 in ATR signaling pathways activated during adenovirus infection.
Influenza virus targets the mRNA export machinery and the nuclear pore complex.
Fontoura et al., Dallas, United States. In Proc Natl Acad Sci U S A, 2007
We show here that NS1 forms an inhibitory complex with NXF1/TAP, p15/NXT, Rae1/mrnp41, and E1B-AP5, which are key constituents of the mRNA export machinery that interact with both mRNAs and nucleoporins to direct mRNAs through the nuclear pore complex.
Functional analysis of p53 binding under differential stresses.
Giaccia et al., Stanford, United States. In Mol Cell Biol, 2006
Using gene-specific PCR analysis, we have verified an association with CGIs of the highest enrichment (> 2.5-fold) (REV3L, XPMC2H, HNRPUL1, TOR1AIP1, glutathione peroxidase 1, and SCFD2), with CGIs of intermediate enrichment (> 2.2-fold) (COX7A2L, SYVN1, and JAG2), and with CGIs of low enrichment (> 2.0-fold) (MYC and PCNA).
Gene variants of VAMP8 and HNRPUL1 are associated with early-onset myocardial infarction.
GeneRIF
Devlin et al., Alameda, United States. In Arterioscler Thromb Vasc Biol, 2006
Variants in 2 genes were associated with early-onset myocardial infarct: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein.
Gene profiling involved in immature CD4+ T lymphocyte responsible for systemic lupus erythematosus.
Hao et al., Anqing, China. In Mol Immunol, 2006
The genes functions were related to a diverse cellular process including: (1) most of these genes were associated with CD4+ T cells functions, particularly related to cellular developments; (2) Ras pathway genes as RANBP10, GMIP, RASGRP2 and ARL5 might be responsible for the abnormal development of CD4+ T cells of SLE; (3) HIG2, TCF7, KHSRP, WWP1, SMAD3, TLK2, AES, CCNI and PIM2 belong to Wnt/beta-catenin way, they could play roles in modulating proliferation and differentiation of T lymphocytes; (4) uncertain viral infections may initiate autoimmunity because high levels expression genes were detected in T4-1s such as TRIM22, IER2, ABCE1, DUT, G1P2, G1P3, HNRPUL1, EVER2, IFNAR1, TNFSF14, TMP21 and PVRL2; and (5) apoptosis relating genes as EIF3S8, SH3BGRL3, GPX4, TOSO, PFDN5, BIN1, XIAPAF1, TEGT and CUGBP2 may contribute to over uploading of selfantigens in SLE cells.
The interaction of the hnRNP family member E1B-AP5 with p53.
Grand et al., Birmingham, United Kingdom. In Febs Lett, 2005
Adenovirus early region 1B-associated protein 5, E1B-AP5, a member of the heterogeneous nuclear ribonucleoprotein (hnRNP) family, was originally isolated on the basis of its ability to bind to the adenovirus 5 early region1B55K protein.
Protein arginine methylation during lytic adenovirus infection.
Dobner et al., Regensburg, Germany. In Biochem J, 2004
Arginine methylation of Ad (adenovirus) E1B 55-kDa-associated protein E1B-AP5 was recently described by us [Kzhyshkowska, Schutt, Liss, Kremmer, Stauber, Wolf and Dobner (2001) Biochem.
Regulation of transcription by the heterogeneous nuclear ribonucleoprotein E1B-AP5 is mediated by complex formation with the novel bromodomain-containing protein BRD7.
GeneRIF
Dobner et al., Mannheim, Germany. In Biochem J, 2003
Regulation of transcripton by this protein is mediated by complex formation with BRD7
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