GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Transcription factor 3
E12, E2A, E47, Transcription Factor-3
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] (from
NCBI)
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Papers using
E12
antibodies
Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
Supplier
In Journal of Biomedicine and Biotechnology, 2009
... E12 (Dako, Glostrup, Denmark) then diluted ...
The influence of chronic inflammation in prostatic
carcinogenesis: a 5-year follow-up study
Supplier
In International Journal of Biological Sciences, 2005
... Marque, Foster City, CA) at a 1:50 dilution and cytokeratin (CK) 34βE12 (clone: M0630; Dako, Carpinteria, CA) at a 1:50 ...
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development
Supplier
In BMC Developmental Biology, 2001
... Whole mount in situ hybridisations of E12.5 wild-type (wt) and transgenic (tg) mouse embryos ...
Papers on
E12
Analysis of safety reporting requirements during medical device clinical trials in Japan.
New
Tokyo, Japan. In J Artif Organs, 15 Mar 2013
First, we compared current reporting requirements for drug and medical devices in Japan with the international guidelines International Conference on Harmonization (ICH)-E2A/E2F and GHTF/SG5/N5.
Safety of daptomycin in patients completing more than 14 days of therapy: results from the Cubicin(®) Outcomes Registry and Experience.
New
Lexington, United States. In Int J Antimicrob Agents, 05 Mar 2013
Investigators assessed adverse events (AEs) using ICH-E2A definitions of seriousness/severity ≤30 days after completing daptomycin.
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.
New
Impact
San Diego, United States. In Nat Immunol, Dec 2012
Structured interaction matrix analysis showed that occupancy by the architectural protein CTCF was associated mainly with intradomain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription factors E2A or PU.1 were associated with intra- and interdomain interactions that are developmentally regulated.
RUNX3 Suppresses Migration, Invasion and Angiogenesis of Human Renal Cell Carcinoma.
New
Xuzhou, China. In Plos One, Dec 2012
RUNX3 (runt-related transcription factor-3) is a known tumor suppressor gene which exhibits potent antitumor activity in several carcinomas.
Comparative analysis of the expression profile of wnk1 and wnk1/hsn2 splice variants in developing and adult mouse tissues.
New
Montréal, Canada. In Plos One, Dec 2012
The hybridization signals in developing mouse tissues, which were prepared at embryonic day e10.5 and e12.5, revealed a homogenous expression profile with both probes.
Analysis of Snail1 function and regulation by Twist1 in palatal fusion.
New
Dallas, United States. In Front Physiol, Dec 2012
Twist1, in collaboration with E2A factors, regulated the expression of Snail1.
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
New
Impact
Bethesda, United States. In Nature, Nov 2012
In 70% of sporadic BL cases, mutations affecting the transcription factor TCF3 (E2A) or its negative regulator ID3 fostered TCF3 dependency.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
New
Impact
Boston, United States. In Cancer Cell, Sep 2012
Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1.
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
New
Impact
Berlin, Germany. In Nat Med, Aug 2012
TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3).
The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation.
Review
New
Toronto, Canada. In Semin Immunol, Jun 2012
IL-7 works together with E2A, EBF, Pax-5 and other transcription factors to regulate B cell commitment, while also functions to regulate Ig rearrangement by modulating FoxO protein activation and Rag enhancer activity.
E protein transcription factors are required for the development of CD4(+) lineage T cells.
New
Impact
Durham, United States. In Immunity, Apr 2012
The double-positive (DP) to single-positive (SP) transition during T cell development is initiated by downregulation of the E protein transcription factors HEB and E2A.
HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.
Review
Toronto, Canada. In Clin Dev Immunol, 2011
These processes require Notch signaling and the activity of GATA3, TCF1, Bcl11b, and the E-proteins HEB and E2A.
HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.
GeneRIF
London, United Kingdom. In Development, 2011
transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt/beta-catenin target activation.
Expression of KIT in the ovary, and the role of somatic precursor cells.
Review
Leipzig, Germany. In Prog Histochem Cytochem, 2011
These cultures demonstrate expression of pluripotency marker genes such as octamer binding transcription factor-3/4 and sex determining region Y-box 2. The KIT/CD14-double-immunopositive cells can be purified and enriched by KIT-immunopositive magnetic cell sorting.
Transcriptional control of T-cell development.
Review
Yokohama, Japan. In Int Immunol, 2011
The transcription factors E2A, GATA-binding protein 3 (Gata3) and RUNT-related transcription factor (Runx) are involved at various stages in the differentiation of double-negative thymocytes and in β-selection, as are transcription factors from the Notch signaling pathway; other transcription factors such as B-cell lymphoma/leukemia 11b (Bcl11b), myeloblastosis viral oncogene homolog (Myb) and inhibitor of DNA binding 3 (Id3) are involved at specific stages.
The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.
GeneRIF
San Diego, United States. In Proc Natl Acad Sci U S A, 2011
E2A binds to enhancer elements across the FOXO1 locus to activate Foxo1 expression, linking E2A and FOXO1 directly in a common pathway.
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.
Impact
GeneRIF
San Diego, United States. In Nat Immunol, 2011
show how E2A promoted T lineage specification and how pre-TCR-mediated signaling affected E2A genome-wide occupancy
Dissecting teleost B cell differentiation using transcription factors.
Review
United States. In Dev Comp Immunol, 2011
This review discusses the structure and function of six transcription factors that play essential roles during teleost B cell development: Ikaros, E2A, EBF, Pax5, Blimp1, and XbpI.
Genomic loss of the putative tumor suppressor gene E2A in human lymphoma.
GeneRIF
Berlin, Germany. In J Exp Med, 2011
E2A exhibits a tumor suppressor function in human lymphoid cells.
HEB and E2A function as SMAD/FOXH1 cofactors.
GeneRIF
Stanford, United States. In Genes Dev, 2011
HEB and E2A-bind the SCA motif at regions overlapping SMAD2/3 and FOXH1
