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Transcription factor 3

E12, E2A, E47, Transcription Factor-3
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CAN, BCR, HAD, AML1, MLL
Papers using E12 antibodies
Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
Sinkovec Jasna et al., In Journal of Biomedicine and Biotechnology, 2009
... E12 (Dako, Glostrup, Denmark) then diluted ...
The influence of chronic inflammation in prostatic carcinogenesis: a 5-year follow-up study
Man Yan-Gao et al., In International Journal of Biological Sciences, 2005
... Marque, Foster City, CA) at a 1:50 dilution and cytokeratin (CK) 34βE12 (clone: M0630; Dako, Carpinteria, CA) at a 1:50 ...
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development
Beckers Johannes et al., In BMC Developmental Biology, 2001
... Whole mount in situ hybridisations of E12.5 wild-type (wt) and transgenic (tg) mouse embryos ...
Papers on E12
Influence of School Architecture and Design on Healthy Eating: A Review of the Evidence.
Huang et al., Charlottesville, United States. In Am J Public Health, 25 Mar 2015
Published online ahead of print February 25, 2015: e1-e12.
Systematic Review of Racial Disparities in Human Papillomavirus-Associated Anal Dysplasia and Anal Cancer Among Men Who Have Sex With Men.
Schneider et al., Chicago, United States. In Am J Public Health, 25 Mar 2015
Published online ahead of print February 25, 2015: e1-e12.
Repression of Ccr9 Transcription in Mouse T Lymphocyte Progenitors by the Notch Signaling Pathway.
Kee et al., Chicago, United States. In J Immunol, 20 Mar 2015
In this article, we show that key regulators of T cell development, Notch1 and the E protein transcription factors E2A and HEB, coordinately control the expression of Ccr9.
ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl dependent signaling axis.
Ravichandran et al., Charlottesville, United States. In Mol Cell Biol, 17 Mar 2015
We found ShcA functions downstream of the pre-TCR and p56(Lck) and show that ShcA is important for ERK-dependent upregulation of transcription factors Egr-1 and -3 in immature thymocytes, and in turn, the expression and function of the Id3 and E2A HLH proteins.
Phenotypic changes in dorsal root ganglion and spinal cord in the collagen antibody-induced arthritis mouse model.
Svensson et al., Stockholm, Sweden. In J Comp Neurol, 01 Mar 2015
On day 15 there was an increase in expression of two factors associated with nerve injury and cell stress, activating transcription factor-3 (ATF3) and growth-associated protein 43 (GAP43) in DRGs, whereby the latter was still dramatically upregulated after 47 days.
Inhibitor of differentiation 4 (ID4): From development to cancer.
Chaudhary et al., Atlanta, United States. In Biochim Biophys Acta, Jan 2015
Apart from some degree of functional redundancy such as HLH dependent interactions with bHLH protein E2A, many of the functions of ID4 are distinct from ID1, ID2 and ID3: ID4 proteins a) regulate distinct developmental processes and tissue expression in the adult, b) promote stem cell survival, differentiation and/or timing of differentiation, c) epigenetic inactivation/loss of expression in several advanced stage cancers and d) increased expression in some cancers such as those arising in the breast and ovary.
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.
Inman et al., Dundee, United Kingdom. In Cancer Manag Res, 2013
Recurrent mutations in ID3 or TCF3 (E2A) that promote signaling through PI3-kinase have recently been identified in human BL samples, and new therapeutic strategies based on coordinately targeting both the prosurvival factor, B-cell lymphoma-XL, and the PI3-kinase/AKT/mammalian target of rapamycin (mTOR) signaling pathway to synergistically induced BL apoptosis have been proposed.
The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.
Kanakura et al., Suita, Japan. In Immunity, 2013
Whereas genes that encode Ikaros, E2A, and Notch1 were unaffected, many genes involved in lineage decisions were regulated by Satb1.
B-lineage transcription factors and cooperating gene lesions required for leukemia development.
Scheijen et al., Nijmegen, Netherlands. In Leukemia, 2013
Differentiation of hematopoietic stem cells into B lymphocytes requires the concerted action of specific transcription factors, such as RUNX1, IKZF1, E2A, EBF1 and PAX5.
MG132, a proteasome inhibitor, induces apoptosis in tumor cells.
Peng et al., Chengdu, China. In Asia Pac J Clin Oncol, 2013
There are many cancer-related molecules in which the protein levels present in cells are regulated by a proteasomal pathway; for example, tumor inhibitors (P53, E2A, c-Myc, c-Jun, c-Fos), transcription factors (transcription factor nuclear factor-kappa B, IκBα, HIFI, YYI, ICER), cell cycle proteins (cyclin A and B, P27, P21, IAP1/3), MG132 induces cell apoptosis through formation of reactive oxygen species or the upregulation and downregulation of these factors, which is ultimately dependent upon the activation of the caspase family of cysteine proteases.
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.
Murre et al., San Diego, United States. In Nat Immunol, 2012
Structured interaction matrix analysis showed that occupancy by the architectural protein CTCF was associated mainly with intradomain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription factors E2A or PU.1 were associated with intra- and interdomain interactions that are developmentally regulated.
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Staudt et al., Bethesda, United States. In Nature, 2012
In 70% of sporadic BL cases, mutations affecting the transcription factor TCF3 (E2A) or its negative regulator ID3 fostered TCF3 dependency.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Look et al., Boston, United States. In Cancer Cell, 2012
Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1.
Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors.
Gradl et al., Karlsruhe, Germany. In Dev Biol, 2012
Data indicte that Tcf-1 and Lef-1 exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
Goldrath et al., San Diego, United States. In Eur J Immunol, 2012
Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Glass et al., Berlin, Germany. In Nat Med, 2012
TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3).
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A.
Grundström et al., Umeå, Sweden. In J Immunol, 2012
the feedback inhibition of the BCR signalosome is to a large extent through inhibition of the transcription factor E2A by Ca(2+)/calmodulin
Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.
Merrill et al., Chicago, United States. In Development, 2012
Wnt/beta-catenin counteracts Tcf3 repression of Lef1, which subsequently activates target gene expression via Lef1-beta-catenin complexes.
Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.
Chaudhary et al., Atlanta, United States. In Biochem Biophys Res Commun, 2012
These results for the first time demonstrate that E2A could in fact acts as a tumor promoter at least in prostate cancer.
[Development of a novel adenovirus vector exhibiting microRNA-mediated suppression of the leaky expression of adenovirus genes].
Mizuguchi et al., Ōsaka, Japan. In Yakugaku Zasshi, 2011
The results revealed that significant expression was found for E2A, E4, and pIX genes.
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