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Transcription factor 3

E12, E2A, E47, Transcription Factor-3
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CAN, BCR, HAD, AML1, MLL
Papers using E12 antibodies
Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
Supplier
Sinkovec Jasna et al., In Journal of Biomedicine and Biotechnology, 2009
... E12 (Dako, Glostrup, Denmark) then diluted ...
The influence of chronic inflammation in prostatic carcinogenesis: a 5-year follow-up study
Supplier
Man Yan-Gao et al., In International Journal of Biological Sciences, 2005
... Marque, Foster City, CA) at a 1:50 dilution and cytokeratin (CK) 34βE12 (clone: M0630; Dako, Carpinteria, CA) at a 1:50 ...
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development
Supplier
Beckers Johannes et al., In BMC Developmental Biology, 2001
... Whole mount in situ hybridisations of E12.5 wild-type (wt) and transgenic (tg) mouse embryos ...
Papers on E12
The First Concussion Crisis: Head Injury and Evidence in Early American Football.
New
Harrison, Cambridge, United States. In Am J Public Health, 13 Apr 2014
Published online ahead of print March 13, 2014: e1-e12.
A8.23 E and Id proteins influence invariant Natural Killer T cell sublineage differentiation and proliferation.
New
Goldrath et al., San Diego, United States. In Ann Rheum Dis, 01 Apr 2014
MATERIALS AND METHODS: We generated Vα14-Jα18 transgenic (Vα14tg) mice conditionally deficient for the E proteins Tcf3 (E2A) and Tcf12 (HEB).
Inhibition of histone methyltransferase EZH2 depletes leukemia stem cell of MLL fusion leukemia through up-regulation of p16.
New
Kurokawa et al., Tokyo, Japan. In Cancer Sci, 25 Mar 2014
Chromatin immunoprecipitation assays demonstrated that EZH2 was highly enriched around the transcription-start-site of p16, together with H3K27 methylation marks in MLL/ENL and Hoxa9/Meis1 transduced cells but not in E2A/HLF transduced cells.
Inability of HOXB4 to enhance self-renewal of malignant B cells: favourable profile for the expansion of autologous hematopoietic stem cells.
New
Bijl et al., Montréal, Canada. In Exp Hematol, 03 Mar 2014
A transgenic mouse model for E2A-PBX1 induced pre-B ALL was used in combination with HOXB4 transgenic mice to test oncogenic interactions between HOXB4 and E2A-PBX1.
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.
Review
New
Inman et al., Dundee, United Kingdom. In Cancer Manag Res, Dec 2013
Recurrent mutations in ID3 or TCF3 (E2A) that promote signaling through PI3-kinase have recently been identified in human BL samples, and new therapeutic strategies based on coordinately targeting both the prosurvival factor, B-cell lymphoma-XL, and the PI3-kinase/AKT/mammalian target of rapamycin (mTOR) signaling pathway to synergistically induced BL apoptosis have been proposed.
Direct and indirect targets of the E2A-PBX1 leukemia-specific fusion protein.
New
Wiemels et al., Vienna, Austria. In Plos One, Dec 2013
The E2A-PBX1 chimeric transcription factor contains the N-terminal transactivation domain of E2A (TCF3) fused to the C-terminal DNA-binding homeodomain of PBX1.
The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.
New
Impact
Kanakura et al., Suita, Japan. In Immunity, Jul 2013
Whereas genes that encode Ikaros, E2A, and Notch1 were unaffected, many genes involved in lineage decisions were regulated by Satb1.
B-lineage transcription factors and cooperating gene lesions required for leukemia development.
Review
New
Scheijen et al., Nijmegen, Netherlands. In Leukemia, Mar 2013
Differentiation of hematopoietic stem cells into B lymphocytes requires the concerted action of specific transcription factors, such as RUNX1, IKZF1, E2A, EBF1 and PAX5.
MG132, a proteasome inhibitor, induces apoptosis in tumor cells.
Review
New
Peng et al., Chengdu, China. In Asia Pac J Clin Oncol, Mar 2013
There are many cancer-related molecules in which the protein levels present in cells are regulated by a proteasomal pathway; for example, tumor inhibitors (P53, E2A, c-Myc, c-Jun, c-Fos), transcription factors (transcription factor nuclear factor-kappa B, IκBα, HIFI, YYI, ICER), cell cycle proteins (cyclin A and B, P27, P21, IAP1/3), MG132 induces cell apoptosis through formation of reactive oxygen species or the upregulation and downregulation of these factors, which is ultimately dependent upon the activation of the caspase family of cysteine proteases.
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.
Impact
Murre et al., San Diego, United States. In Nat Immunol, 2012
Structured interaction matrix analysis showed that occupancy by the architectural protein CTCF was associated mainly with intradomain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription factors E2A or PU.1 were associated with intra- and interdomain interactions that are developmentally regulated.
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Impact
Staudt et al., Bethesda, United States. In Nature, 2012
In 70% of sporadic BL cases, mutations affecting the transcription factor TCF3 (E2A) or its negative regulator ID3 fostered TCF3 dependency.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Impact
Look et al., Boston, United States. In Cancer Cell, 2012
Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1.
Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors.
GeneRIF
Gradl et al., Karlsruhe, Germany. In Dev Biol, 2012
Data indicte that Tcf-1 and Lef-1 exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
GeneRIF
Goldrath et al., San Diego, United States. In Eur J Immunol, 2012
Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1.
Impact
Glass et al., Berlin, Germany. In Nat Med, 2012
TRPV1 stimulation triggers tumor cell death through the branch of the endoplasmic reticulum stress pathway that is controlled by activating transcription factor-3 (ATF3).
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A.
GeneRIF
Grundström et al., Umeå, Sweden. In J Immunol, 2012
the feedback inhibition of the BCR signalosome is to a large extent through inhibition of the transcription factor E2A by Ca(2+)/calmodulin
Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.
GeneRIF
Merrill et al., Chicago, United States. In Development, 2012
Wnt/beta-catenin counteracts Tcf3 repression of Lef1, which subsequently activates target gene expression via Lef1-beta-catenin complexes.
The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation.
Review
Paige et al., Toronto, Canada. In Semin Immunol, 2012
IL-7 works together with E2A, EBF, Pax-5 and other transcription factors to regulate B cell commitment, while also functions to regulate Ig rearrangement by modulating FoxO protein activation and Rag enhancer activity.
Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.
GeneRIF
Chaudhary et al., Atlanta, United States. In Biochem Biophys Res Commun, 2012
These results for the first time demonstrate that E2A could in fact acts as a tumor promoter at least in prostate cancer.
HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.
Review
Anderson et al., Toronto, Canada. In Clin Dev Immunol, 2011
These processes require Notch signaling and the activity of GATA3, TCF1, Bcl11b, and the E-proteins HEB and E2A.
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