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Transcription factor 3

E12, E2A, E47, Transcription Factor-3
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CAN, BCR, HAD, AML1, MLL
Papers using E12 antibodies
Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
Supplier
Sinkovec Jasna et al., In Journal of Biomedicine and Biotechnology, 2009
... E12 (Dako, Glostrup, Denmark) then diluted ...
The influence of chronic inflammation in prostatic carcinogenesis: a 5-year follow-up study
Supplier
Man Yan-Gao et al., In International Journal of Biological Sciences, 2005
... Marque, Foster City, CA) at a 1:50 dilution and cytokeratin (CK) 34βE12 (clone: M0630; Dako, Carpinteria, CA) at a 1:50 ...
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development
Supplier
Beckers Johannes et al., In BMC Developmental Biology, 2001
... Whole mount in situ hybridisations of E12.5 wild-type (wt) and transgenic (tg) mouse embryos ...
Papers on E12
T-cell receptor α enhancer is inactivated in αβ T lymphocytes.
New
Hernández-Munain et al., Armilla, Spain. In Proc Natl Acad Sci U S A, 07 May 2015
Eα inactivation resulted in the disruption of functional long-range enhancer-promoter interactions and was associated with loss of Eα-dependent histone modifications at promoter and enhancer regions, and reduced expression and recruitment of E2A to the Eα enhanceosome in T cells.
Long Non-Coding RNAs Control Hematopoietic Stem Cell Function.
New
Impact
Goodell et al., Houston, United States. In Cell Stem Cell, 02 May 2015
We mapped the genomic binding sites of one of these candidates and found enrichment for key hematopoietic transcription factor binding sites, especially E2A.
BCL6 Expression Correlates With the t(1;19) Translocation in B-Lymphoblastic Leukemia.
New
Etzell et al., Xonacatlán, Mexico. In Am J Clin Pathol, 30 Apr 2015
Cryptic TCF3(E2A)-PBX1 rearrangements were investigated using interphase fluorescence in situ hybridization.
Analysis of tandem E-box motifs within human Complement receptor 2 (CR2/CD21) promoter reveals cell specific roles for RP58, E2A, USF and localized chromatin accessibility.
New
Ulgiati et al., Australia. In Int J Biochem Cell Biol, 26 Apr 2015
We have identified E2A and USF transcription factors as binding to the distal and proximal E-box sites respectively in CR2-positive B-cells, at a site that is hypersensitive to restriction enzyme digestion compared to non-expressing K562 cells.
Inhibitor of differentiation 4 (ID4): From development to cancer.
Review
New
Chaudhary et al., Atlanta, United States. In Biochim Biophys Acta, Jan 2015
Apart from some degree of functional redundancy such as HLH dependent interactions with bHLH protein E2A, many of the functions of ID4 are distinct from ID1, ID2 and ID3: ID4 proteins a) regulate distinct developmental processes and tissue expression in the adult, b) promote stem cell survival, differentiation and/or timing of differentiation, c) epigenetic inactivation/loss of expression in several advanced stage cancers and d) increased expression in some cancers such as those arising in the breast and ovary.
Nfix expression critically modulates early B lymphopoiesis and myelopoiesis.
New
Keeshan et al., Buffalo, United States. In Plos One, Dec 2014
The lineage choice determined by Nfix correlated with transcriptional changes in a number of genes, such as E2A, C/EBP, and Id genes.
Molecular Cytogenetics in Childhood Acute Lymphoblastic Leukemia: A Hospital-Based Observational Study.
New
Koul et al., Jammu, India. In Clin Med Insights Oncol, Dec 2014
Among the remaining 22 cases, 8 had TEL-AML1 (20%), 6 had BCR-ABL (15%), 4 had MLL-AF4 (10%), 2 had E2A-PBX1 (5%) fusion genes, and 2 had hyperdiploidy.
The establishment of B versus T cell identity.
Review
New
Murre et al., San Diego, United States. In Trends Immunol, May 2014
In B cell progenitors, E-proteins E2A and HEB (HeLa E-box binding protein) are crucial for the induction of a B lineage-specific program of gene expression and for orchestrating the assembly of the immunoglobulin loci.
Transcriptional control of pre-B cell development and leukemia prevention.
Review
Nutt et al., Australia. In Curr Top Microbiol Immunol, 2013
The triad of DNA-binding proteins, E2A, EBF1, and PAX5 is critical for both the early specification and commitment of B cell progenitors, while a larger number of secondary determinants, such as members of the Ikaros, ETS, Runx, and IRF families have more direct roles in promoting stage-specific pre-B gene-expression program.
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.
Review
Inman et al., Dundee, United Kingdom. In Cancer Manag Res, 2013
Recurrent mutations in ID3 or TCF3 (E2A) that promote signaling through PI3-kinase have recently been identified in human BL samples, and new therapeutic strategies based on coordinately targeting both the prosurvival factor, B-cell lymphoma-XL, and the PI3-kinase/AKT/mammalian target of rapamycin (mTOR) signaling pathway to synergistically induced BL apoptosis have been proposed.
The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.
Impact
Kanakura et al., Suita, Japan. In Immunity, 2013
Whereas genes that encode Ikaros, E2A, and Notch1 were unaffected, many genes involved in lineage decisions were regulated by Satb1.
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.
Impact
Murre et al., San Diego, United States. In Nat Immunol, 2012
Structured interaction matrix analysis showed that occupancy by the architectural protein CTCF was associated mainly with intradomain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription factors E2A or PU.1 were associated with intra- and interdomain interactions that are developmentally regulated.
Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics.
Impact
Staudt et al., Bethesda, United States. In Nature, 2012
In 70% of sporadic BL cases, mutations affecting the transcription factor TCF3 (E2A) or its negative regulator ID3 fostered TCF3 dependency.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Impact
Look et al., Boston, United States. In Cancer Cell, 2012
Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1.
Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors.
GeneRIF
Gradl et al., Karlsruhe, Germany. In Dev Biol, 2012
Data indicte that Tcf-1 and Lef-1 exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
GeneRIF
Goldrath et al., San Diego, United States. In Eur J Immunol, 2012
Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A.
GeneRIF
Grundström et al., Umeå, Sweden. In J Immunol, 2012
the feedback inhibition of the BCR signalosome is to a large extent through inhibition of the transcription factor E2A by Ca(2+)/calmodulin
Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.
GeneRIF
Merrill et al., Chicago, United States. In Development, 2012
Wnt/beta-catenin counteracts Tcf3 repression of Lef1, which subsequently activates target gene expression via Lef1-beta-catenin complexes.
Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.
GeneRIF
Chaudhary et al., Atlanta, United States. In Biochem Biophys Res Commun, 2012
These results for the first time demonstrate that E2A could in fact acts as a tumor promoter at least in prostate cancer.
[Development of a novel adenovirus vector exhibiting microRNA-mediated suppression of the leaky expression of adenovirus genes].
Review
Mizuguchi et al., Ōsaka, Japan. In Yakugaku Zasshi, 2011
The results revealed that significant expression was found for E2A, E4, and pIX genes.
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