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Transcription factor 3

E12, E2A, E47, Transcription Factor-3
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: CAN, BCR, HAD, AML1, MLL
Papers using E12 antibodies
Embryonic stem cell-like cells established by culture of adult ovarian cells in mice
Sinkovec Jasna et al., In Journal of Biomedicine and Biotechnology, 2009
... E12 (Dako, Glostrup, Denmark) then diluted ...
The influence of chronic inflammation in prostatic carcinogenesis: a 5-year follow-up study
Man Yan-Gao et al., In International Journal of Biological Sciences, 2005
... Marque, Foster City, CA) at a 1:50 dilution and cytokeratin (CK) 34βE12 (clone: M0630; Dako, Carpinteria, CA) at a 1:50 ...
The mineralocorticoid receptor may compensate for the loss of the glucocorticoid receptor at specific stages of mammary gland development
Beckers Johannes et al., In BMC Developmental Biology, 2001
... Whole mount in situ hybridisations of E12.5 wild-type (wt) and transgenic (tg) mouse embryos ...
Papers on E12
Monomethylarsonous acid (MMA+3) Inhibits IL-7 Signaling in Mouse Pre-B Cells.
Burchiel et al., Albuquerque, United States. In Toxicol Sci, 30 Nov 2015
As further evidence for the inhibition of STAT5, we found that the induction of several genes required in B cell development, cyclin D1, E2A, EBF1 and PAX5, were selectively inhibited by MMA(+3).
The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells.
Chen et al., Bethesda, United States. In Nat Immunol, 31 Oct 2015
A reduction in Id3 expression enhanced binding of the transcription factors E2A and GATA-3 to the Il9 promoter region, which promoted Il9 transcription.
Inhibition of testicular embryonal carcinoma cell tumorigenicity by peroxisome proliferator-activated receptor-β/δ- and retinoic acid receptor-dependent mechanisms.
Peters et al., United States. In Oncotarget, 26 Oct 2015
The changes observed in xenografts were associated with decreased PPARβ/δ-dependent expression of proliferating cell nuclear antigen and octamer-binding transcription factor-3/4, suggesting suppressed tumor proliferation and induction of differentiation.
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
Cleary et al., In J Clin Invest, Oct 2015
Here, we engineered mice that conditionally express the E2A-PBX1 fusion oncogene, which results from chromosomal translocation t(1;19) and is present in 5% to 7% of pediatric ALL cases.
The chromatin remodeler Brg1 activates enhancer repertoires to establish B cell identity and modulate cell growth.
Murre et al., San Diego, United States. In Nat Immunol, Jul 2015
Early B cell development is orchestrated by the combined activities of the transcriptional regulators E2A, EBF1, Foxo1 and Ikaros.
Long non-coding RNAs control hematopoietic stem cell function.
Goodell et al., Houston, United States. In Cell Stem Cell, May 2015
We mapped the genomic binding sites of one of these candidates and found enrichment for key hematopoietic transcription factor binding sites, especially E2A.
Inhibitor of differentiation 4 (ID4): From development to cancer.
Chaudhary et al., Atlanta, United States. In Biochim Biophys Acta, Jan 2015
Apart from some degree of functional redundancy such as HLH dependent interactions with bHLH protein E2A, many of the functions of ID4 are distinct from ID1, ID2 and ID3: ID4 proteins a) regulate distinct developmental processes and tissue expression in the adult, b) promote stem cell survival, differentiation and/or timing of differentiation, c) epigenetic inactivation/loss of expression in several advanced stage cancers and d) increased expression in some cancers such as those arising in the breast and ovary.
CDKN2 Gene Deletion as Poor Prognosis Predictor Involved in the Progression of Adult B-Lineage Acute Lymphoblastic Leukemia Patients.
Liu et al., Guangzhou, China. In J Cancer, Dec 2014
This study performed analysis of the CDKN2 deletion in 215 adult B- lineage acute lymphoblastic leukemia (B-ALL) patients, and related cytogenetic prognostic factors (BCR/ABL; E2A/PBXl; TEL/AML1; Mixed Lineage Leukemia (MLL) rearrangement; MYC, Immunoglobulin heavy locus (IGH) translocation).
[Molecular biology and childhood leukemia: E2A-PBX1 and central nervous system relapse].
Mejía-Aranguré et al., Mexico. In Rev Med Inst Mex Seguro Soc, Dec 2014
Abstract available from the publisher.
The regulatory network of B-cell differentiation: a focused view of early B-cell factor 1 function.
Grosschedl et al., Freiburg, Germany. In Immunol Rev, Sep 2014
The process of B lymphopoiesis requires a set of transcription factors, including Ikaros, PU.1, E2A, and FoxO1 to 'prime' cis-regulatory regions for subsequent activation by the B-lineage-specific transcription factors EBF1 and Pax-5.
The establishment of B versus T cell identity.
Murre et al., San Diego, United States. In Trends Immunol, May 2014
In B cell progenitors, E-proteins E2A and HEB (HeLa E-box binding protein) are crucial for the induction of a B lineage-specific program of gene expression and for orchestrating the assembly of the immunoglobulin loci.
Transcriptional control of pre-B cell development and leukemia prevention.
Nutt et al., Australia. In Curr Top Microbiol Immunol, 2013
The triad of DNA-binding proteins, E2A, EBF1, and PAX5 is critical for both the early specification and commitment of B cell progenitors, while a larger number of secondary determinants, such as members of the Ikaros, ETS, Runx, and IRF families have more direct roles in promoting stage-specific pre-B gene-expression program.
Developments in Burkitt's lymphoma: novel cooperations in oncogenic MYC signaling.
Inman et al., Dundee, United Kingdom. In Cancer Manag Res, 2013
Recurrent mutations in ID3 or TCF3 (E2A) that promote signaling through PI3-kinase have recently been identified in human BL samples, and new therapeutic strategies based on coordinately targeting both the prosurvival factor, B-cell lymphoma-XL, and the PI3-kinase/AKT/mammalian target of rapamycin (mTOR) signaling pathway to synergistically induced BL apoptosis have been proposed.
The Satb1 protein directs hematopoietic stem cell differentiation toward lymphoid lineages.
Kanakura et al., Suita, Japan. In Immunity, 2013
Whereas genes that encode Ikaros, E2A, and Notch1 were unaffected, many genes involved in lineage decisions were regulated by Satb1.
Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate.
Murre et al., San Diego, United States. In Nat Immunol, 2012
Structured interaction matrix analysis showed that occupancy by the architectural protein CTCF was associated mainly with intradomain interactions, whereas sites bound by the histone acetyltransferase p300 or the transcription factors E2A or PU.1 were associated with intra- and interdomain interactions that are developmentally regulated.
Subfunctionalization and neofunctionalization of vertebrate Lef/Tcf transcription factors.
Gradl et al., Karlsruhe, Germany. In Dev Biol, 2012
Data indicte that Tcf-1 and Lef-1 exhibit a function in the axis induction assay, which is lacking in Tcf-3 and -4.
Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
Goldrath et al., San Diego, United States. In Eur J Immunol, 2012
Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Negative feedback regulation of antigen receptors through calmodulin inhibition of E2A.
Grundström et al., Umeå, Sweden. In J Immunol, 2012
the feedback inhibition of the BCR signalosome is to a large extent through inhibition of the transcription factor E2A by Ca(2+)/calmodulin
Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction.
Merrill et al., Chicago, United States. In Development, 2012
Wnt/beta-catenin counteracts Tcf3 repression of Lef1, which subsequently activates target gene expression via Lef1-beta-catenin complexes.
Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.
Chaudhary et al., Atlanta, United States. In Biochem Biophys Res Commun, 2012
These results for the first time demonstrate that E2A could in fact acts as a tumor promoter at least in prostate cancer.
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