Archaeal proteasomes and sampylation.
Gainesville, United States. In Subcell Biochem, 2012
Unlike eukaryotes, sampylation only requires an E1 enzyme homolog of the E1-E2-E3 ubiquitylation cascade to mediate protein conjugation.
E3 ubiquitin ligase-mediated regulation of bone formation and tumorigenesis.
Paris, France. In Cell Death Dis, 2012
The ubiquitination of proteins occurs through a three-step process involving ubiquitin activation by the E1 enzyme, allowing for the transfer to a ubiquitin-conjugated enzyme E2 and to the targeted protein via ubiquitin-protein ligases (E3), the most abundant group of enzymes involved in ubiquitination.
[Study on natural products for drug development].
Kumamoto, Japan. In Yakugaku Zasshi, 2010
We succeeded in isolating various compounds with three distinct inhibitory activities against an E1 enzyme reaction, Ubc13 (E2)-Uev1A interaction, and p53-HDM2 (E3) interaction as well as the proteasome inhibitors.