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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Selectin E

E-selectin, ELAM-1
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Intercellular Adhesion Molecule-1, Vascular Cell Adhesion Molecule-1, HAD, IL-1beta, CAN
Papers using E-selectin antibodies
Intravascular photoacoustic imaging
Supplier
Kim Kang et al., In Biomedical Optics Express, 2009
... nanorod-conjugated FITC labeled anti-ICAM-1 (ebioscience, San Diego, CA, USA) and gold nanorod-conjugated Phycoerythrin (PE) labeled anti-E-selectin (ebioscience, San Diego, CA, USA) ...
Small dense low-density-lipoproteins and the metabolic syndrome
Supplier
Rość Danuta et al., In International Journal of Endocrinology, 2005
... using reagents from Bender Medsystems (Biomedica, Poland), and soluble E-selectin was determined by testing E-selectin (ELAM-1) antibody using reagent from IBL (Hamburg, Germany).
Neisseria meningitidis infection of human endothelial cells interferes with leukocyte transmigration by preventing the formation of endothelial docking structures
Supplier
Bourdoulous Sandrine et al., In The Journal of Cell Biology, 2004
... were purchased from R&D Systems, mAb to CD44 (J173) was purchased from Immunotech, mAb to E-selectin (555510) was obtained from BD Biosciences, mAb to ICAM-2 (MAB2147) ...
Papers on E-selectin
Inhibition of complement component C5 prevents clotting in an ex vivo model of xenogeneic activation of coagulation.
New
Tiede et al., Hannover, Germany. In Xenotransplantation, Feb 2016
The activation of PAEC (E-Selectin, tissue factor, ICAM-1, ICAM-2, VCAM-1) was studied after incubation with human serum.
Low n-6/n-3 PUFA Ratio Improves Lipid Metabolism, Inflammation, Oxidative Stress and Endothelial Function in Rats Using Plant Oils as n-3 Fatty Acid Source.
New
Sun et al., Nanjing, China. In Lipids, Jan 2016
Additionally, the 20:1 group had significantly increased serum levels of E-Selectin, von Willebrand factor (vWF), and numerous markers of oxidative stress compared with the other groups (p < 0.05).
CD43 Functions as an E-Selectin Ligand for Th17 Cells In Vitro and Is Required for Rolling on the Vascular Endothelium and Th17 Cell Recruitment during Inflammation In Vivo.
New
Alcaide et al., Boston, United States. In J Immunol, Jan 2016
In this study, we characterize the expression and functionality of E-selectin ligands in Th type 17 lymphocytes (Th17 cells) and report that CD43 functions as a Th17 cell E-selectin ligand in vitro that mediates Th17 cell rolling on the vascular endothelium and recruitment in vivo.
GlycA, a novel marker of inflammation, is elevated in systemic lupus erythematosus.
New
Stein et al., Nashville, United States. In Lupus, Jan 2016
In patients with SLE, concentrations of GlycA were significantly associated with sedimentation rate (rho = 0.43), C-reactive protein (rho = 0.59), e-selectin (rho = 0.28), intracellular adhesion molecule-1 (rho = 0.30), triglycerides (rho = 0.45), all p < 0.0023 to account for multiple comparisons, but not with creatinine, SLEDAI, SLICC, or coronary calcium scores.
Comparison of the effects of Crataegus oxyacantha extract, aerobic exercise and their combination on the serum levels of ICAM-1 and E-Selectin in patients with stable angina pectoris.
Moattar et al., Eşfahān, Iran. In Daru, 2014
The aim of this study was comparing the effect of Cratagol herbal tablet, aerobic exercise and their combination on the serum levels of Intercellular adhesion molecule (ICAM)-1 and E-Selectin in patients with stable angina pectoris.
Gene susceptibility in Iranian asthmatic patients: a narrative review.
Review
Arabi et al., Sārī, Iran. In Ann Med Health Sci Res, 2014
Polymorphism in interleukin-13 (IL-13), IL-10, IL-1, IL-2, IL-12, E-Selectin, S128R and Exon 9 Vitamin D Receptor were susceptible for asthma and polymorphism in chemokine receptor 5, transforming growth factor-a (TGF-a), Intron 8 of the Vitamin D Receptor, angiotensin-converting enzyme gene, IL-6 and interferon-c were not susceptible for asthma in Iranian population.
Molecular mechanisms of curcumin action: gene expression.
Review
Shishodia, Houston, United States. In Biofactors, 2013
Curcumin regulates the expression of inflammatory cytokines (e.g., TNF, IL-1), growth factors (e.g., VEGF, EGF, FGF), growth factor receptors (e.g., EGFR, HER-2, AR), enzymes (e.g., COX-2, LOX, MMP9, MAPK, mTOR, Akt), adhesion molecules (e.g., ELAM-1, ICAM-1, VCAM-1), apoptosis related proteins (e.g., Bcl-2, caspases, DR, Fas), and cell cycle proteins (e.g., cyclin D1).
Sialofucosylated podocalyxin is a functional E- and L-selectin ligand expressed by metastatic pancreatic cancer cells.
GeneRIF
Konstantopoulos et al., Baltimore, United States. In Am J Physiol Cell Physiol, 2012
A correlation exists between sialofucosylated PODXL expression and enhanced binding to selectins by metastatic pancreatic cancer cells.
The role of endothelial cell adhesion molecules P-selectin, E-selectin and intercellular adhesion molecule-1 in leucocyte recruitment induced by exogenous methylglyoxal.
GeneRIF
Liu et al., Saskatoon, Canada. In Immunology, 2012
the up-regulation of P-selectin, E-selectin and intercellular adhesion molecule-1 contributes to the increased leucocyte rolling flux, reduced leucocyte rolling velocity, and increased leucocyte adhesion, respectively.
Differing requirements for CCR4, E-selectin, and α4β1 for the migration of memory CD4 and activated T cells to dermal inflammation.
GeneRIF
Issekutz et al., Halifax, Canada. In J Immunol, 2012
E-selectin blockade similarly inhibits the migration of activated CCR4(negative) and CCR4(positive) CD4 T cells to dermal inflammation.
Genetic variations in E-selectin and ICAM-1: relation to atherosclerosis.
GeneRIF
Abdel Raheem et al., Cairo, Egypt. In Med Sci Monit, 2012
Ser 128Arg of E-selectin and the K469E of ICAM-1 polymorphisms may be involved in predisposition to atherosclerosis.
Endothelial cell markers in patients with pseudoexfoliation syndrome.
GeneRIF
Kaźmierczak et al., Bydgoszcz, Poland. In Scientificworldjournal, 2011
Results indicate that there might be no correlation between pseudoexfoliation syndrome (PEX) and such endothelial cell markers as von Willebrand antigen (vWF Ag), E-selectin, and P-selectin concentrations
Primate models in women's health: inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis).
Review
Register, Winston-Salem, United States. In Am J Primatol, 2009
Circulating and tissue biomarkers with inflammatory and anti-inflammatory characteristics (including adhesion molecules such as e-selectin, VCAM-1, and ICAM-1, chemokines such as MCP-1, cytokines such as interleukins, and acute phase reactants such as CRP, and others) may be useful indicators of disease status.
The effect of angiotensin receptor blockers on C-reactive protein and other circulating inflammatory indices in man.
Review
Pedrinelli et al., Pisa, Italy. In Vasc Health Risk Manag, 2008
That possibility, supported by consistent evidence from in-vitro and animal studies showing pro-inflammatory properties of angiotensin II, has been evaluated clinically by measuring the effect of ARBs on C-reactive protein and other circulating indices of inflammation (e-selectin, adhesion molecules, interleukin-6, tissue necrosis factor-alpha, monocyte chemoattractant protein-1) of potential clinical relevance, a body of evidence that this paper aims to review.
Percutaneous coronary interventions and statins therapy.
Review
Di Sciascio et al., In Ther Adv Cardiovasc Dis, 2008
Statins could also have beneficial effects by reducing expression of adhesion molecules in endothelial cells (ICAM-1 and E-Selectin) as demonstrated in the ARMYDA-CAMS study.
Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype.
Impact
Schuman et al., Boston, United States. In Nat Med, 2001
We found that endothelial leukocyte adhesion molecule-1 (ELAM-1), the earliest marker for the atherosclerotic plaque in the vasculature, was consistently present on trabecular meshwork (TM) cells in the outflow pathways of eyes with glaucomas of diverse etiology.
The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor.
Impact
Vestweber et al., Freiburg, Germany. In Nature, 1995
E-SELECTIN is an inducible cell-adhesion molecule on endothelial cells, which mediates the binding of neutrophils and functions as a Ca(2+)-dependent lectin.
An inducible endothelial cell surface glycoprotein mediates melanoma adhesion.
Impact
Bevilacqua et al., Boston, United States. In Science, 1990
In addition, an inducible endothelial receptor for neutrophils, ELAM-1, supports the adhesion of a human colon carcinoma cell line.
Endothelial cell activation and high interleukin-1 secretion in the pathogenesis of acute Kawasaki disease.
Impact
Pober et al., Boston, United States. In Lancet, 1990
In cell culture, gamma globulin did not inhibit endothelial cell expression of ELAM-1 in response to IL-1 or tumour necrosis factor.
Adhesion molecules controlling lymphocyte migration.
Review
Impact
Stoolman, Ann Arbor, United States. In Cell, 1989
The discovery of a similar structure in ELAM-1 and GMP-140 extends the reach of this family to other leukocyte and platelet interactions with the vessel wall.
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