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Fatty acid binding protein 5
E-FABP, FABP5, Fatty acid-binding protein
This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs may play roles in fatty acid uptake, transport, and metabolism. Polymorphisms in this gene are associated with type 2 diabetes. The human genome contains many pseudogenes similar to this locus.[provided by RefSeq, Feb 2011] (from
Thorsby et al., Oslo, Norway. In Diabetes Metab Res Rev, Feb 2016
Moreover, modulations of several proteins implicated in prohormone processing and insulin exocytosis (IGF2, IGFBP7, Scg5, ProSAAS, Fabp5, Ptprn2 and gelsolin) appears to support the hypothesis that 1,25-(OH)2 D3 play positive modulatory role in insulin processing and secretion.
De Leon et al., Loma Linda, United States. In J Neurotrauma, Jan 2016
The objective of the present study was to determine the spatiotemporal expression of the fatty acid binding protein 5 (FABP5) following contusive SCI and to investigate whether this protein plays a role in n-3 PUFAs-mediated functional recovery after SCI.
Balagopal et al., Jacksonville, United States. In J Nutr Sci, 2014
The aim of this post hoc study was to determine the effect of overweight (OW) on FABP4 and FABP5 in boys in relation to indices of adiposity, insulin resistance and inflammation, and to investigate the effects of a 6-month supplementation with an encapsulated fruit and vegetable juice concentrate (FVJC) plus nutritional counselling (NC) on FABP levels.
Plant et al., Guildford, United Kingdom. In Curr Opin Clin Nutr Metab Care, 2014
RECENT FINDINGS: Dysregulated FABPs have been associated with a number of diseases, including obesity and nonalcoholic fatty liver disease (FABP1, FABP2, FABP4), cardiovascular risk (FABP3) and cancer (FABP5, FABP7).
Miura et al., Sapporo, Japan. In Clin Med Insights Cardiol, 2013
Fatty acid-binding protein 4 (FABP4), also known as adipocyte FABP (A-FABP) or aP2, is mainly expressed in adipocytes and macrophages and plays an important role in the development of insulin resistance and atherosclerosis in relation to metaflammation.
Godbout et al., Edmonton, Canada. In Am J Pathol, 2011
The purpose of this study was to investigate the clinicopathological significance of FABP5 in breast cancer and to evaluate FABP5 as a prognostic marker and a possible novel therapeutic target in breast cancer.