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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 02 Oct 2014.

Cadherin 1, type 1, E-cadherin

E-cadherin, CDH1
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vimentin, CAN, V1a, SNAIL, N-cadherin
Papers using E-cadherin antibodies
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
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Sebti Saïd M. et al., In Cell death and differentiation, 2008
... following sources: Akt, pAkt(T308), pAkt(S473) and pGSK3-β(S9) (Cell Signaling, Danvers, MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH ...
the cytoskeleton, and cancer cell invasion
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Olayioye M A et al., In Oncogenesis, 2008
... Antibodies used were: mouse anti-E-cadherin, anti-β-catenin, and anti-p120-catenin (BD, Heidelberg, Germany), rabbit anti-phospho-MLC and anti-E-cadherin pAbs (Cell Signaling, Danvers, MA, USA), rabbit ...
Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis
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Belej Kamil et al., In International Journal of Molecular Sciences, 2008
... The slides were stained with antibodies: Snail-1 (rabbit polyclonal, Ab 85931, 1:150, Abcam), E-cadherin (mouse monoclonal, M3612, 1:50, Dako) and claudin-1 (mouse monoclonal, ...
The epithelial-mesenchymal transition generates cells with properties of stem cells
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Orsulic Sandra, In PLoS ONE, 2007
... Anti-E-cadherin mAb was from BD Biosciences (Milan, Italy), anti-Snail, anti-Zeb1, ...
To reg or not to reg: that is the question in COPD.
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Idzko Marco, In PLoS ONE, 2007
... mouse anti-human Cytokeratin 18 (Pierce), mouse anti-human E-cadherin (Dako), mouse anti-human Smooth Muscle ...
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Papers on E-cadherin
Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance.
New
Zhang et al., Lanzhou, China. In Cell Cycle, Jul 2014
Downregulation of AEG-1 also led to reduced expression of mesenchymal marker vimentin and the transcription factor Snail but upregulation of epithelial marker E-cadherin in HeLa cells.
Increased FoxM1 expression is a target for metformin in the suppression of EMT in prostate cancer.
New
Tang et al., Beijing, China. In Int J Mol Med, Jun 2014
We induced EMT in the PCa cells by the addition of transforming growth factor (TGF)-β1 and verified the process by examining EMT-related gene (E-cadherin, vimentin and Slug) expression.
MiR-101 suppresses the epithelial-to-mesenchymal transition by targeting ZEB1 and ZEB2 in ovarian carcinoma.
New
Zhang et al., Houston, United States. In Oncol Rep, May 2014
Using reporter gene assays, we demonstrated that miR-101 suppressed the expression of the E-cadherin repressors ZEB1 and ZEB2 by directly targeting the 3'-untranslated region (3'UTR) of both ZEB1 and ZEB2.
New markers in pelvic inflammatory disease.
Review
New
Wang et al., T'ai-chung-shih, Taiwan. In Clin Chim Acta, May 2014
Therefore, identifying biological factors that are useful for early diagnosis and correlating their expression with the severity of PID could provide significant benefits to women suffering from PID. Pentraxin 3 (PTX3), E-cadherin, myeloperoxidase, stromal cell-derived factor 1 (SDF-1) and the matrix metalloproteinase-9 (MMP-9)/MMP-2 ratio are potential candidates for detecting PID reliably.
Colorectal cancer progression: lessons from Drosophila?
Review
New
Thompson et al., London, United Kingdom. In Semin Cell Dev Biol, Apr 2014
Carcinomas often exhibit transcriptional downregulation of E-cadherin and other epithelial genes in an epithelial-to-mesenchymal transition (EMT), a mechanism first discovered in Drosophila to be mediated by the transcription factors Twist and Snail.
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
New
Impact
Ma et al., Houston, United States. In Nat Cell Biol, Mar 2014
Aberrant activation of NF-κB signalling is frequently found in triple-negative basal-like breast cancer cells, but the cause of this activation has remained elusive.Here we report that α-catenin functions as a tumour suppressor in E-cadherin-negative basal-like breast cancer cells by inhibiting NF-κB signalling.
Cortical F-actin stabilization generates apical-lateral patterns of junctional contractility that integrate cells into epithelia.
New
Impact
Yap et al., Brisbane, Australia. In Nat Cell Biol, Feb 2014
E-cadherin cell-cell junctions couple the contractile cortices of epithelial cells together, generating tension within junctions that influences tissue organization.
Lateral junction dynamics lead the way out.
New
Impact
Heisenberg et al., Klosterneuburg, Austria. In Nat Cell Biol, Feb 2014
Cell integration into epithelial sheets is now shown to depend on the N-WASP-regulated stabilization of cortical F-actin, which generates distinct patterns of apical-lateral contractility at E-cadherin-based cell-cell junctions.
Beyond E-cadherin: roles of other cadherin superfamily members in cancer.
Review
New
Impact
van Roy, Gent, Belgium. In Nat Rev Cancer, Feb 2014
Loss of cadherin 1 (CDH1; also known as epithelial cadherin (E-cadherin)) is used for the diagnosis and prognosis of epithelial cancers.
Salt-induced epithelial-to-mesenchymal transition in Dahl salt-sensitive rats is dependent on elevated blood pressure.
New
Yuan et al., Xi'an, China. In Braz J Med Biol Res, Feb 2014
Tubular EMT was evaluated using immunohistochemistry and real-time PCR with E-cadherin and alpha smooth muscle actin (α-SMA).
Diagnostic role of immunohistochemistry in the evaluation of breast pathology specimens.
Review
New
Kandil et al., Worcester, United States. In Arch Pathol Lab Med, Jan 2014
Other markers, such as E-cadherin and those used to differentiate mammary carcinoma from metastatic tumors to the breast, and markers used in the differential diagnosis of Paget disease, are also discussed.
Meloxicam executes its antitumor effects against hepatocellular carcinoma in COX-2- dependent and -independent pathways.
New
Qiao et al., Jinan, China. In Plos One, Dec 2013
METHODS AND FINDINGS: Meloxicam inhibited the ability of human HCC cells expressing higher levels of COX-2 to migrate, invade, adhere and form colonies through upregulating the expression of E-cadherin and downregulating the expression of matrix metalloproteinase (MMP) -2.
Covalent and density-controlled surface immobilization of E-cadherin for adhesion force spectroscopy.
New
Franz et al., Karlsruhe, Germany. In Plos One, Dec 2013
E-cadherin is a key cell-cell adhesion molecule but the impact of receptor density and the precise contribution of individual cadherin ectodomains in promoting cell adhesion are only incompletely understood.
Cadherin-dependent filopodia control preimplantation embryo compaction.
New
Impact
Plachta et al., Australia. In Nat Cell Biol, Dec 2013
Here, using live mouse embryo imaging, we demonstrate that cells extend long E-cadherin-dependent filopodia on to neighbouring cells, which control the cell shape changes necessary for compaction.
DNA methyltransferases and TETs in the regulation of differentiation and invasiveness of extra-villous trophoblasts.
Review
Lobie et al., Auckland, New Zealand. In Front Genet, 2012
There are interesting questions of why trophoblast genomes are globally hypomethylated yet specific genes can be suppressed by hypermethylation (in general, tumor suppressor genes, such as E-cadherin) and how invasive cell-types are liable to have condensed chromatin, as in metastatic cancer cells.
The impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity of A431 cancer cells.
GeneRIF
Cordes et al., Dresden, Germany. In Radiat Res, 2012
impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
GeneRIF
Taketani et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
These findings establish a principal biological function of SIRT1 in the modulation of E-cadherin function.
Impact of E-cadherin expression pattern in melanocytic nevi and cutaneous malignant melanoma.
GeneRIF
Bakry et al., Egypt. In Anal Quant Cytol Histol, 2012
E-cadherin expression in nevi is related to the degree of melanocytic maturation.
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.
GeneRIF
Herrup et al., Xiamen, China. In J Biol Chem, 2012
When a neuronal cell enters S phase, Cdk5 is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC-Cdh1
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.
GeneRIF
Ko et al., T'ai-chung-shih, Taiwan. In J Biol Chem, 2012
Specifically, NiCl(2) induces down-regulation of E-cadherin by reactive oxygen species generation and promoter hypermethylation
More papers using E-cadherin antibodies
Beyond tumorigenesis: cancer stem cells in metastasis.
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Yang Pan-Chyr, In PLoS ONE, 2006
... Dorothee Herlyn of the Wistar Institute), E-cadherin mAb (Santa Cruz Biotechnology, Santa Cruz, CA), EpCam ...
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo
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Griffin J D et al., In British Journal of Cancer, 2006
... E-cadherin antibody was from BD Biosciences (San Jose, CA, USA) ...
Cell polarity in development and cancer.
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Thi Thu Nguyen Hang, In PLoS ONE, 2006
... Antibodies raised against E-cadherin and villin were from BD Biosciences (Mississauga, ON, Canada) ...
A novel system for gene silencing using siRNAs in rice leaf and stem-derived protoplasts
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Li Jiayang et al., In Nature Communications, 2005
... The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and ...
Deconstructing the cadherin-catenin-actin complex
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Nelson W. James et al., In The Journal of Cell Biology, 2004
... (a) GFP in Lyn-GFP was replaced with the cytosolic domain of E-cadherin using KpnI and XbaI sites (New England Biolabs, Inc.) ...
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
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Wölfl Stefan, In PLoS ONE, 2004
... Mouse monoclonal antibodies were used to detect E-cadherin (BD Transduction Labs., BD Biosciences, San Jose, CA USA, ...
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
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Weiss Stephen J. et al., In The Journal of Cell Biology, 2003
... Antibodies directed against the following molecules were obtained commercially: E-cadherin, β-catenin (BD), FSP-1 (Abcam), Akt, Akt phospho-Ser473, ERK, ...
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
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Hong Seong-Doo et al., In Journal of Experimental & Clinical Cancer Research : CR, 2003
... ERK (Tyr 204), phosphorylated JNK (Thr183/Tyr185), phosphorylated p65, p50, p38, Snail, SIP-1/ZEB-2, Twist, β-catenin, and E-cadherin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
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Oshima Robert G. et al., In Oncogene, 2003
... E-Cadherin, Clone 24E10, (Cell Signaling Technologies) and Alexa 488 ...
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis
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Hall Alan et al., In The Journal of Cell Biology, 2002
... 44; BD), β-actin (clone AC-74; Sigma-Aldrich), Flag (clone M2; Sigma-Aldrich), α-tubulin (clone DM1A; Sigma-Aldrich), rat anti–E-cadherin (clone ECCD-2; Invitrogen), rabbit polyclonal PKCζ (C-20; Santa Cruz Biotechnology, Inc.), ZO-1 (Invitrogen), and ...
E-cadherin engagement stimulates proliferation via Rac1
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Chen Christopher S. et al., In The Journal of Cell Biology, 2002
... Reagents were obtained as follows: anti–E-cadherin (36 [BD Biosciences]; HECD-1 and SHE78-7 [Zymed Laboratories]; DECMA-1 [Sigma-Aldrich]); anti-p120 (98; BD Biosciences); anti–α-tubulin (Sigma-Aldrich); anti-GAPDH (Ambion); ...
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
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Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... primary antibodies used were anti-megalin (a kind gift of Mr Dan Biemesderfer, Yale University, USA), anti-E-cadherin (Abcam plc., UK), anti-CK-19 (Santa ...
Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors
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Wells Alan et al., In Molecular Cancer, 2002
... 231-shEcad cells were generated using an E-cadherin shRNA plasmid (Santa Cruz Biotechnology) and stable transfectants were ...
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
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Katoh Masaru, In PLoS ONE, 2002
... Santa Cruz (Santa Cruz, CA), anti-HA, anti-FLAG (M2), anti-actin, anti-nucleolin from Sigma-Aldrich (St Louis, MO), anti-E-cadherin from BD Biosciences (San Diego, CA), anti-N-cadherin ...
Direct evidence for a role of β-catenin/LEF-1 signaling pathway in induction of EMT
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Kim Dong-Gyu et al., In Journal of Korean Medical Science, 2001
... Monoclonal antibodies against E-cadherin (R&D systems, Minneapolis, MN, U.S.A.), pancytokeratin (Sigma Aldrich, Saint Louis, MO, U.S.A.), ...
The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting
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Schäkel Knut et al., In The Journal of Experimental Medicine, 2001
... purified mAbs to CD3, CD14, CD19, CD36, CD64, CD86, HLA-DR, HLA-DP (all from BD Biosciences), E-cadherin (Santa Cruz Biotechnology, Inc.), and IgM nonbinding ...
Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription.
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Andre Frederic, In PLoS ONE, 2000
... The antibodies against claudin-1 and -4 were from Invitrogen (San Francisco, CA, USA), and E-cadherin was from BD Biosciences (San Jose, CA, USA) ...
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.
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Ahmad Aamir, In PLoS ONE, 2000
... Antibodies for GEP100 and E-cadherin C36 were from Sigma and BD Biosciences respectively ...
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
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Sontag Estelle et al., In The Journal of Cell Biology, 2000
... included: anti-HA (Covance); anti-ZO-1 (Chemicon International, Inc.); anti–claudin-1, -occludin, and -phosphoSer (Zymed Laboratories, Inc.); anti-Cα, anti–E-cadherin, and anti-PKCλ (Transduction Laboratories); anti-PKCζ (Alexis Corporation); anti-PKCζ (C-20), anti–p-nPKCζ (Thr410) (Santa Cruz Biotechnology, Inc.); anti-PP1α (Calbiochem); anti-B56γ ...
Endosomes generate localized Rho–ROCK–MLC2–based contractile signals via Endo180 to promote adhesion disassembly
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Isacke Clare M. et al., In The Journal of Cell Biology, 2000
... Mouse anti–human E-cadherin (clone HECD-1) was obtained from Abcam; secondary antibodies Alexa Fluor ...
Plakoglobin and β-catenin: protein interactions, regulation and biological roles
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Rossini G P et al., In British Journal of Cancer, 1999
... Anti-E-cadherin antibodies were purchased from Santa Cruz Biotechnology (H-108), Transduction Laboratories (C20820) ...
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
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Miyoshi Jun et al., In Journal of Cell Science, 1998
... from commercial sources: antibodies against afadin and nectin-3 (ABcam), nectin-1 (Santa Cruz Biotechnology), nectin-2 (Hycult), E-cadherin (R&D Systems and BD Biosciences), α-catenin (Sigma-Aldrich), β-catenin (BD ...
A novel mechanism for the regulation of amyloid precursor protein metabolism
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Schubert David et al., In The Journal of Cell Biology, 1998
... β-Laminin antibody (sc-6018), N-CAM antibody (sc-1507), N- and E-cadherin antibody from Transduction Laboratories, Notch antibody (sc-6014) were purchased from Santa Cruz Biotechnology, Inc., and APLP was ...
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
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Sobue Kenji et al., In The Journal of Cell Biology, 1997
... anti–β-actin (AC-15; Sigma-Aldrich), anti-SRF (G-20; Santa Cruz Biotechnology, Inc.), antivinculin (HVIN-1; Sigma-Aldrich), anti-talin (8d4; Sigma-Aldrich), anti–E-cadherin (BD Biosciences), anti–N-cadherin (BD Biosciences), antivimentin ...
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
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Arkowitz Robert Alan, In PLoS ONE, 1990
... , mouse anti-E-cadherin (Becton Dickinson Switzerland BD610181), rabbit anti-α-catenin ...
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
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Etienne-Manneville Sandrine et al., In The Journal of Cell Biology, 1990
... reagents: anti–α-tubulin (AbD Serotec); anti-Pan-cadherin CH-19 (Sigma-Aldrich); anti–N-cadherin, anti–β-catenin, anti-GM130, and anti-paxillin (all from BD); anti–E-cadherin (Santa Cruz Biotechnology, Inc.); anti-pericentrin (Covance); anti-microtubule ...
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
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Linden Rafael, In PLoS ONE, 1984
... Anti E-cadherin monoclonal Ab was from BD Biosciences-Pharmingen (Franklin Lakes, NJ) ...
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