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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 13 Nov 2015.

Cadherin 1, type 1, E-cadherin

E-cadherin, CDH1
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vimentin, CAN, N-cadherin, SNAIL, V1a
Papers using E-cadherin antibodies
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
Sebti Saïd M. et al., In Cell death and differentiation, 2008
... following sources: Akt, pAkt(T308), pAkt(S473) and pGSK3-β(S9) (Cell Signaling, Danvers, MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH ...
the cytoskeleton, and cancer cell invasion
Olayioye M A et al., In Oncogenesis, 2008
... Antibodies used were: mouse anti-E-cadherin, anti-β-catenin, and anti-p120-catenin (BD, Heidelberg, Germany), rabbit anti-phospho-MLC and anti-E-cadherin pAbs (Cell Signaling, Danvers, MA, USA), rabbit ...
Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis
Belej Kamil et al., In International Journal of Molecular Sciences, 2008
... The slides were stained with antibodies: Snail-1 (rabbit polyclonal, Ab 85931, 1:150, Abcam), E-cadherin (mouse monoclonal, M3612, 1:50, Dako) and claudin-1 (mouse monoclonal, ...
The epithelial-mesenchymal transition generates cells with properties of stem cells
Orsulic Sandra, In PLoS ONE, 2007
... Anti-E-cadherin mAb was from BD Biosciences (Milan, Italy), anti-Snail, anti-Zeb1, ...
To reg or not to reg: that is the question in COPD.
Idzko Marco, In PLoS ONE, 2007
... mouse anti-human Cytokeratin 18 (Pierce), mouse anti-human E-cadherin (Dako), mouse anti-human Smooth Muscle ...
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Papers on E-cadherin
Regulation of Epithelial-Mesenchymal Transition by E3 Ubiquitin Ligases and Deubiquitinase in Cancer.
Hayashi et al., Nagoya, Japan. In Curr Cancer Drug Targets, 12 Dec 2015
One of the hallmarks of EMT is the diminished expression of E-cadherin and gain of mesenchymal traits, which are regulated by core EMT-inducing transcriptional factors (EMT-TFs), such as Snail/Slug, ZEB1/ZEB2, and Twist1.
Inhibition of cyclin D1 enhances sensitivity to radiotherapy and reverses epithelial to mesenchymal transition for esophageal cancer cells.
Chen et al., Wenzhou, China. In Tumour Biol, 11 Dec 2015
Cyclin D1 also reversed EMT phenotypes with significantly increased expression of E-cadherin in KYSE-150R cells.
Expression of calcium sensing receptor and E-cadherin correlated with survival of lung adenocarcinoma.
Cai et al., Harbin, China. In Thorac Cancer, 30 Nov 2015
Recent studies have indicated that the CaSR could promote the expression of E-cadherin, which was considered a tumor suppressor.
The Role of EpCAM in physiology and pathology of the epithelium.
Untergasser et al., Stockholm, Sweden. In Histol Histopathol, 23 Nov 2015
Recent research pointed to a close interaction of EpCAM with other cell-cell contact molecules like E-cadherin and claudins and an intimate crosstalk with Wnt and TGF-beta signaling in the regulation of cell growth.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Perou et al., Lausanne, Switzerland. In Cell, 08 Nov 2015
Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features.
Zebrafish Epiboly: Spreading thin over the yolk.
Bruce, Toronto, Canada. In Dev Dyn, 05 Nov 2015
Here, recent work is reviewed with a focus on findings that advance our understanding of (1) the role of actomyosin motors in the yolk cell to drive epiboly, (2) the mechanisms that underlie the spreading of the epithelial enveloping layer, and (3) the regulation of deep cell movements by E-cadherin based adhesion.
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Yap et al., Brisbane, Australia. In Nat Cell Biol, 31 Oct 2015
Actomyosin at the epithelial zonula adherens (ZA) generates junctional tension for tissue integrity and morphogenesis.
Hereditary diffuse gastric cancer: What the clinician should know.
Ngeow et al., Singapore, Singapore. In World J Gastrointest Oncol, 15 Oct 2015
While it has been shown to be caused mainly by germline alterations in the E-cadherin gene (CDH1), problematically, the genetic diagnosis remains unknown in up to 60% of patients.
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Anastasiadis et al., Jacksonville, United States. In Nat Cell Biol, Sep 2015
E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities.
Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk.
Patrignani et al., Chieti, Italy. In Biochem Soc Trans, Sep 2015
A central event involves an aberrant expression of COX-2 which influences cell-cycle progression and contribute to the acquisition of a cell migratory phenotype through the induction of epithelial mesenchymal transition genes and down-regulation of E-cadherin expression.
Mechanical induction of the tumorigenic β-catenin pathway by tumour growth pressure.
Farge et al., Paris, France. In Nature, Aug 2015
The exertion of pressure mimicking that of tumour growth led to rapid Ret activation and downstream phosphorylation of β-catenin on Tyr654, imparing its interaction with the E-cadherin in adherens junctions, and which was followed by β-catenin nuclear translocation after 15 days.
Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry.
Nelson et al., Stanford, United States. In Science, Jun 2015
Maintenance of quiescence, Yap1 nuclear exclusion, and β-catenin transcriptional responses to mechanical strain required E-cadherin extracellular engagement.
Antibiotic-Driven Dysbiosis Mediates Intraluminal Agglutination and Alternative Segregation of Enterococcus faecium from the Intestinal Epithelium.
Willems et al., Utrecht, Netherlands. In Mbio, Dec 2014
E. faecium agglutinates intraluminally in an extracellular matrix consisting of secretory IgA (sIgA), polymeric immunoglobulin receptor (pIgR), and epithelial cadherin (E-cadherin) proteins, thereby maintaining spatial segregation of E. faecium from the intestinal wall.
The role of Snail1 transcription factor in colorectal cancer progression and metastasis.
Wojnicz et al., Katowice, Poland. In Contemp Oncol (pozn), Dec 2014
Snail1 is a zinc-finger transcription factor, which plays a role in colorectal cancer development by silencing E-cadherin expression and inducing epithelialmesenchymal transition (EMT).
Expression of transcription factors Slug in the lens epithelial cells undergoing epithelial-mesenchymal transition induced by connective tissue growth factor.
Pei et al., Xi'an, China. In Int J Ophthalmol, Dec 2014
Expressions of Slug, E-cadherin and alpha smooth muscle actin (α-SMA) were further determined by Western blot analysis.
The impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity of A431 cancer cells.
Cordes et al., Dresden, Germany. In Radiat Res, 2012
impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
Taketani et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
These findings establish a principal biological function of SIRT1 in the modulation of E-cadherin function.
Impact of E-cadherin expression pattern in melanocytic nevi and cutaneous malignant melanoma.
Bakry et al., Egypt. In Anal Quant Cytopathol Histpathol, 2012
E-cadherin expression in nevi is related to the degree of melanocytic maturation.
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.
Herrup et al., Xiamen, China. In J Biol Chem, 2012
When a neuronal cell enters S phase, Cdk5 is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC-Cdh1
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.
Ko et al., T'ai-chung-shih, Taiwan. In J Biol Chem, 2012
Specifically, NiCl(2) induces down-regulation of E-cadherin by reactive oxygen species generation and promoter hypermethylation
More papers using E-cadherin antibodies
Beyond tumorigenesis: cancer stem cells in metastasis.
Yang Pan-Chyr, In PLoS ONE, 2006
... Dorothee Herlyn of the Wistar Institute), E-cadherin mAb (Santa Cruz Biotechnology, Santa Cruz, CA), EpCam ...
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo
Griffin J D et al., In British Journal of Cancer, 2006
... E-cadherin antibody was from BD Biosciences (San Jose, CA, USA) ...
Cell polarity in development and cancer.
Thi Thu Nguyen Hang, In PLoS ONE, 2006
... Antibodies raised against E-cadherin and villin were from BD Biosciences (Mississauga, ON, Canada) ...
A novel system for gene silencing using siRNAs in rice leaf and stem-derived protoplasts
Li Jiayang et al., In Nature Communications, 2005
... The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and ...
Deconstructing the cadherin-catenin-actin complex
Nelson W. James et al., In The Journal of Cell Biology, 2004
... (a) GFP in Lyn-GFP was replaced with the cytosolic domain of E-cadherin using KpnI and XbaI sites (New England Biolabs, Inc.) ...
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Wölfl Stefan, In PLoS ONE, 2004
... Mouse monoclonal antibodies were used to detect E-cadherin (BD Transduction Labs., BD Biosciences, San Jose, CA USA, ...
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
Weiss Stephen J. et al., In The Journal of Cell Biology, 2003
... Antibodies directed against the following molecules were obtained commercially: E-cadherin, β-catenin (BD), FSP-1 (Abcam), Akt, Akt phospho-Ser473, ERK, ...
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
Hong Seong-Doo et al., In Journal of Experimental & Clinical Cancer Research : CR, 2003
... ERK (Tyr 204), phosphorylated JNK (Thr183/Tyr185), phosphorylated p65, p50, p38, Snail, SIP-1/ZEB-2, Twist, β-catenin, and E-cadherin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
Oshima Robert G. et al., In Oncogene, 2003
... E-Cadherin, Clone 24E10, (Cell Signaling Technologies) and Alexa 488 ...
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis
Hall Alan et al., In The Journal of Cell Biology, 2002
... 44; BD), β-actin (clone AC-74; Sigma-Aldrich), Flag (clone M2; Sigma-Aldrich), α-tubulin (clone DM1A; Sigma-Aldrich), rat anti–E-cadherin (clone ECCD-2; Invitrogen), rabbit polyclonal PKCζ (C-20; Santa Cruz Biotechnology, Inc.), ZO-1 (Invitrogen), and ...
E-cadherin engagement stimulates proliferation via Rac1
Chen Christopher S. et al., In The Journal of Cell Biology, 2002
... Reagents were obtained as follows: anti–E-cadherin (36 [BD Biosciences]; HECD-1 and SHE78-7 [Zymed Laboratories]; DECMA-1 [Sigma-Aldrich]); anti-p120 (98; BD Biosciences); anti–α-tubulin (Sigma-Aldrich); anti-GAPDH (Ambion); ...
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... primary antibodies used were anti-megalin (a kind gift of Mr Dan Biemesderfer, Yale University, USA), anti-E-cadherin (Abcam plc., UK), anti-CK-19 (Santa ...
Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors
Wells Alan et al., In Molecular Cancer, 2002
... 231-shEcad cells were generated using an E-cadherin shRNA plasmid (Santa Cruz Biotechnology) and stable transfectants were ...
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
Katoh Masaru, In PLoS ONE, 2002
... Santa Cruz (Santa Cruz, CA), anti-HA, anti-FLAG (M2), anti-actin, anti-nucleolin from Sigma-Aldrich (St Louis, MO), anti-E-cadherin from BD Biosciences (San Diego, CA), anti-N-cadherin ...
Direct evidence for a role of β-catenin/LEF-1 signaling pathway in induction of EMT
Kim Dong-Gyu et al., In Journal of Korean Medical Science, 2001
... Monoclonal antibodies against E-cadherin (R&D systems, Minneapolis, MN, U.S.A.), pancytokeratin (Sigma Aldrich, Saint Louis, MO, U.S.A.), ...
The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting
Schäkel Knut et al., In The Journal of Experimental Medicine, 2001
... purified mAbs to CD3, CD14, CD19, CD36, CD64, CD86, HLA-DR, HLA-DP (all from BD Biosciences), E-cadherin (Santa Cruz Biotechnology, Inc.), and IgM nonbinding ...
Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription.
Andre Frederic, In PLoS ONE, 2000
... The antibodies against claudin-1 and -4 were from Invitrogen (San Francisco, CA, USA), and E-cadherin was from BD Biosciences (San Jose, CA, USA) ...
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.
Ahmad Aamir, In PLoS ONE, 2000
... Antibodies for GEP100 and E-cadherin C36 were from Sigma and BD Biosciences respectively ...
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
Sontag Estelle et al., In The Journal of Cell Biology, 2000
... included: anti-HA (Covance); anti-ZO-1 (Chemicon International, Inc.); anti–claudin-1, -occludin, and -phosphoSer (Zymed Laboratories, Inc.); anti-Cα, anti–E-cadherin, and anti-PKCλ (Transduction Laboratories); anti-PKCζ (Alexis Corporation); anti-PKCζ (C-20), anti–p-nPKCζ (Thr410) (Santa Cruz Biotechnology, Inc.); anti-PP1α (Calbiochem); anti-B56γ ...
Endosomes generate localized Rho–ROCK–MLC2–based contractile signals via Endo180 to promote adhesion disassembly
Isacke Clare M. et al., In The Journal of Cell Biology, 2000
... Mouse anti–human E-cadherin (clone HECD-1) was obtained from Abcam; secondary antibodies Alexa Fluor ...
Plakoglobin and β-catenin: protein interactions, regulation and biological roles
Rossini G P et al., In British Journal of Cancer, 1999
... Anti-E-cadherin antibodies were purchased from Santa Cruz Biotechnology (H-108), Transduction Laboratories (C20820) ...
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
Miyoshi Jun et al., In Journal of Cell Science, 1998
... from commercial sources: antibodies against afadin and nectin-3 (ABcam), nectin-1 (Santa Cruz Biotechnology), nectin-2 (Hycult), E-cadherin (R&D Systems and BD Biosciences), α-catenin (Sigma-Aldrich), β-catenin (BD ...
A novel mechanism for the regulation of amyloid precursor protein metabolism
Schubert David et al., In The Journal of Cell Biology, 1998
... β-Laminin antibody (sc-6018), N-CAM antibody (sc-1507), N- and E-cadherin antibody from Transduction Laboratories, Notch antibody (sc-6014) were purchased from Santa Cruz Biotechnology, Inc., and APLP was ...
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
Sobue Kenji et al., In The Journal of Cell Biology, 1997
... anti–β-actin (AC-15; Sigma-Aldrich), anti-SRF (G-20; Santa Cruz Biotechnology, Inc.), antivinculin (HVIN-1; Sigma-Aldrich), anti-talin (8d4; Sigma-Aldrich), anti–E-cadherin (BD Biosciences), anti–N-cadherin (BD Biosciences), antivimentin ...
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
Arkowitz Robert Alan, In PLoS ONE, 1990
... , mouse anti-E-cadherin (Becton Dickinson Switzerland BD610181), rabbit anti-α-catenin ...
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
Etienne-Manneville Sandrine et al., In The Journal of Cell Biology, 1990
... reagents: anti–α-tubulin (AbD Serotec); anti-Pan-cadherin CH-19 (Sigma-Aldrich); anti–N-cadherin, anti–β-catenin, anti-GM130, and anti-paxillin (all from BD); anti–E-cadherin (Santa Cruz Biotechnology, Inc.); anti-pericentrin (Covance); anti-microtubule ...
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Linden Rafael, In PLoS ONE, 1984
... Anti E-cadherin monoclonal Ab was from BD Biosciences-Pharmingen (Franklin Lakes, NJ) ...
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