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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 31 Oct 2014.

Cadherin 1, type 1, E-cadherin

E-cadherin, CDH1
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vimentin, V1a, CAN, SNAIL, N-cadherin
Papers using E-cadherin antibodies
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
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Sebti Saïd M. et al., In Cell death and differentiation, 2008
... following sources: Akt, pAkt(T308), pAkt(S473) and pGSK3-β(S9) (Cell Signaling, Danvers, MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH ...
the cytoskeleton, and cancer cell invasion
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Olayioye M A et al., In Oncogenesis, 2008
... Antibodies used were: mouse anti-E-cadherin, anti-β-catenin, and anti-p120-catenin (BD, Heidelberg, Germany), rabbit anti-phospho-MLC and anti-E-cadherin pAbs (Cell Signaling, Danvers, MA, USA), rabbit ...
Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis
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Belej Kamil et al., In International Journal of Molecular Sciences, 2008
... The slides were stained with antibodies: Snail-1 (rabbit polyclonal, Ab 85931, 1:150, Abcam), E-cadherin (mouse monoclonal, M3612, 1:50, Dako) and claudin-1 (mouse monoclonal, ...
The epithelial-mesenchymal transition generates cells with properties of stem cells
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Orsulic Sandra, In PLoS ONE, 2007
... Anti-E-cadherin mAb was from BD Biosciences (Milan, Italy), anti-Snail, anti-Zeb1, ...
To reg or not to reg: that is the question in COPD.
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Idzko Marco, In PLoS ONE, 2007
... mouse anti-human Cytokeratin 18 (Pierce), mouse anti-human E-cadherin (Dako), mouse anti-human Smooth Muscle ...
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Papers on E-cadherin
The Wnt Signalling Cascade and the Adherens Junction Complex in Craniopharyngioma Tumorigenesis.
New
Grossman et al., Oxford, United Kingdom. In Endocr Pathol, 30 Nov 2014
We characterised the adherens junction involving α-catenin, β-catenin, γ-catenin, p120 and E-cadherin (cytosolic and membranous components).
Tetraspanin CD63 acts as a pro-metastatic factor via β-catenin stabilization.
New
Krüger et al., München, Germany. In Int J Cancer, 29 Nov 2014
In vitro, knock down of CD63 induced a more epithelial-like phenotype concomitant with increased E-cadherin expression, downregulation of its repressors Slug and Zeb1, and decreased N-cadherin.
Giant cadherins Fat and Dachsous self-bend to organize properly spaced intercellular junctions.
New
Takeichi et al., Kōbe, Japan. In Proc Natl Acad Sci U S A, 29 Nov 2014
When such non-Ca(2+)-binding linkers were substituted for a normal linker in E-cadherin, the mutant E-cadherins deformed more extensively than the wild-type molecule.
ASPP2 controls epithelial plasticity and inhibits metastasis through β-catenin-dependent regulation of ZEB1.
New
Impact
Lu et al., Shanghai, China. In Nat Cell Biol, 26 Nov 2014
ASPP2 prevents β-catenin from transactivating ZEB1, directly by forming an ASPP2-β-catenin-E-cadherin ternary complex and indirectly by inhibiting β-catenin's N-terminal phosphorylation to stabilize the β-catenin-E-cadherin complex.
CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling.
New
Yang et al., Boca Raton, United States. In Oncotarget, 22 Nov 2014
These changes are accompanied by impaired cell-cell contacts and aberrant expression of E-cadherin, Mucin 5AC and fibronectin, largely reminiscent of an epithelial to mesenchymal transition (EMT)-like change.
Bioinformatic Approaches to Augment Study of Epithelial-to-Mesenchymal Transition (EMT) in Lung Cancer.
Review
New
Golemis et al., Temple, United States. In Physiol Genomics, 05 Sep 2014
Besides summarizing recent work in this area, we use four EMT-associated genes, TGF-β (TGFB1), NEDD9/HEF1, β-catenin (CTNNB1) and E-cadherin (CDH1), as exemplars to demonstrate the current capacities and limitations of probing bioinformatic resources to inform hypothesis-driven studies with therapeutic goals.
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.
New
Impact
Jin et al., Irvine, United States. In Science, Jul 2014
Here, we present the crystal structure of a clostridial hemagglutinin (HA) complex of serotype BoNT/A bound to the cell adhesion protein E-cadherin at 2.4 angstroms.
Actin dynamics modulate mechanosensitive immobilization of E-cadherin at adherens junctions.
New
Impact
Viasnoff et al., Singapore, Singapore. In Nat Cell Biol, Jun 2014
In particular, the interplay between myosin contractility, actin dynamics and E-cadherin recruitment largely remains to be uncovered.
Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer.
New
Impact
Leung et al., San Diego, United States. In Nat Genet, Jun 2014
We identified previously known (TP53, ARID1A and CDH1) and new (MUC6, CTNNA2, GLI3, RNF43 and others) significantly mutated driver genes.
Mechanical feedback through E-cadherin promotes direction sensing during collective cell migration.
New
Impact
Montell et al., Baltimore, United States. In Cell, Jun 2014
E-cadherin is a major homophilic cell-cell adhesion molecule that inhibits motility of individual cells on matrix.
Sonic hedgehog and androgen signaling in tumor and stromal compartments drives epithelial-mesenchymal transition in prostate cancer.
New
Fujisawa et al., Kōbe, Japan. In Scand J Urol, Apr 2014
Real-time reverse transcription-polymerase chain reaction (RT-PCR) was performed to evaluate the expressions of a potential Shh target gene, osteonectin (ON) and EMT-associated markers (E-cadherin, N-cadherin and vimentin).
Regulatory Variants and Disease: The E-Cadherin -160C/A SNP as an Example.
Review
New
Li et al., Guangzhou, China. In Mol Biol Int, Dec 2013
One of such regulatory SNPs (rSNPs) is the E-cadherin (CDH1) promoter -160C/A SNP (rs16260) which is known to affect E-cadherin promoter transcription by displacing transcription factor binding and has been extensively scrutinized for its association with several diseases especially malignancies.
Functional Role of the microRNA-200 Family in Breast Morphogenesis and Neoplasia.
Review
New
Gudjonsson et al., Reykjavík, Iceland. In Genes (basel), Dec 2013
miR-200 inhibits expression of ZEB1/2 mRNA, which in turn can down-regulate the miR-200 family that further results in down-regulation of E-cadherin and induction of a mesenchymal phenotype.
Role of microRNA in epithelial to mesenchymal transition and metastasis and clinical perspectives.
Review
New
Cano et al., Madrid, Spain. In Cancer Manag Res, Dec 2013
The EMT triggering leads to the activation of a core of transcription factors (EMT-TFs) - SNAIL1/SNAIL2, bHLH (E47, E2-2, and TWIST1/TWIST2), and ZEB1/ZEB2 - that act as E-cadherin repressors and, ultimately, coordinate EMT.
Cyclooxygenase-1 and -2: molecular targets for cervical neoplasia.
Review
New
Song et al., Seoul, South Korea. In J Cancer Prev, Jun 2013
Human papillomavirus, a necessary cause of cervical cancer, induces COX-2 expression via E5, E6 and E7 oncoproteins, which leads to prostaglandin E2 increase and the loss of E-cadherin, promotes cell proliferation and production of vascular endothelial growth factor.
The impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity of A431 cancer cells.
GeneRIF
Cordes et al., Dresden, Germany. In Radiat Res, 2012
impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
GeneRIF
Taketani et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
These findings establish a principal biological function of SIRT1 in the modulation of E-cadherin function.
Impact of E-cadherin expression pattern in melanocytic nevi and cutaneous malignant melanoma.
GeneRIF
Bakry et al., Egypt. In Anal Quant Cytol Histol, 2012
E-cadherin expression in nevi is related to the degree of melanocytic maturation.
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.
GeneRIF
Herrup et al., Xiamen, China. In J Biol Chem, 2012
When a neuronal cell enters S phase, Cdk5 is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC-Cdh1
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.
GeneRIF
Ko et al., T'ai-chung-shih, Taiwan. In J Biol Chem, 2012
Specifically, NiCl(2) induces down-regulation of E-cadherin by reactive oxygen species generation and promoter hypermethylation
More papers using E-cadherin antibodies
Beyond tumorigenesis: cancer stem cells in metastasis.
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Yang Pan-Chyr, In PLoS ONE, 2006
... Dorothee Herlyn of the Wistar Institute), E-cadherin mAb (Santa Cruz Biotechnology, Santa Cruz, CA), EpCam ...
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo
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Griffin J D et al., In British Journal of Cancer, 2006
... E-cadherin antibody was from BD Biosciences (San Jose, CA, USA) ...
Cell polarity in development and cancer.
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Thi Thu Nguyen Hang, In PLoS ONE, 2006
... Antibodies raised against E-cadherin and villin were from BD Biosciences (Mississauga, ON, Canada) ...
A novel system for gene silencing using siRNAs in rice leaf and stem-derived protoplasts
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Li Jiayang et al., In Nature Communications, 2005
... The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and ...
Deconstructing the cadherin-catenin-actin complex
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Nelson W. James et al., In The Journal of Cell Biology, 2004
... (a) GFP in Lyn-GFP was replaced with the cytosolic domain of E-cadherin using KpnI and XbaI sites (New England Biolabs, Inc.) ...
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
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Wölfl Stefan, In PLoS ONE, 2004
... Mouse monoclonal antibodies were used to detect E-cadherin (BD Transduction Labs., BD Biosciences, San Jose, CA USA, ...
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
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Weiss Stephen J. et al., In The Journal of Cell Biology, 2003
... Antibodies directed against the following molecules were obtained commercially: E-cadherin, β-catenin (BD), FSP-1 (Abcam), Akt, Akt phospho-Ser473, ERK, ...
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
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Hong Seong-Doo et al., In Journal of Experimental & Clinical Cancer Research : CR, 2003
... ERK (Tyr 204), phosphorylated JNK (Thr183/Tyr185), phosphorylated p65, p50, p38, Snail, SIP-1/ZEB-2, Twist, β-catenin, and E-cadherin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
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Oshima Robert G. et al., In Oncogene, 2003
... E-Cadherin, Clone 24E10, (Cell Signaling Technologies) and Alexa 488 ...
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis
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Hall Alan et al., In The Journal of Cell Biology, 2002
... 44; BD), β-actin (clone AC-74; Sigma-Aldrich), Flag (clone M2; Sigma-Aldrich), α-tubulin (clone DM1A; Sigma-Aldrich), rat anti–E-cadherin (clone ECCD-2; Invitrogen), rabbit polyclonal PKCζ (C-20; Santa Cruz Biotechnology, Inc.), ZO-1 (Invitrogen), and ...
E-cadherin engagement stimulates proliferation via Rac1
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Chen Christopher S. et al., In The Journal of Cell Biology, 2002
... Reagents were obtained as follows: anti–E-cadherin (36 [BD Biosciences]; HECD-1 and SHE78-7 [Zymed Laboratories]; DECMA-1 [Sigma-Aldrich]); anti-p120 (98; BD Biosciences); anti–α-tubulin (Sigma-Aldrich); anti-GAPDH (Ambion); ...
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
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Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... primary antibodies used were anti-megalin (a kind gift of Mr Dan Biemesderfer, Yale University, USA), anti-E-cadherin (Abcam plc., UK), anti-CK-19 (Santa ...
Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors
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Wells Alan et al., In Molecular Cancer, 2002
... 231-shEcad cells were generated using an E-cadherin shRNA plasmid (Santa Cruz Biotechnology) and stable transfectants were ...
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
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Katoh Masaru, In PLoS ONE, 2002
... Santa Cruz (Santa Cruz, CA), anti-HA, anti-FLAG (M2), anti-actin, anti-nucleolin from Sigma-Aldrich (St Louis, MO), anti-E-cadherin from BD Biosciences (San Diego, CA), anti-N-cadherin ...
Direct evidence for a role of β-catenin/LEF-1 signaling pathway in induction of EMT
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Kim Dong-Gyu et al., In Journal of Korean Medical Science, 2001
... Monoclonal antibodies against E-cadherin (R&D systems, Minneapolis, MN, U.S.A.), pancytokeratin (Sigma Aldrich, Saint Louis, MO, U.S.A.), ...
The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting
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Schäkel Knut et al., In The Journal of Experimental Medicine, 2001
... purified mAbs to CD3, CD14, CD19, CD36, CD64, CD86, HLA-DR, HLA-DP (all from BD Biosciences), E-cadherin (Santa Cruz Biotechnology, Inc.), and IgM nonbinding ...
Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription.
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Andre Frederic, In PLoS ONE, 2000
... The antibodies against claudin-1 and -4 were from Invitrogen (San Francisco, CA, USA), and E-cadherin was from BD Biosciences (San Jose, CA, USA) ...
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.
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Ahmad Aamir, In PLoS ONE, 2000
... Antibodies for GEP100 and E-cadherin C36 were from Sigma and BD Biosciences respectively ...
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
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Sontag Estelle et al., In The Journal of Cell Biology, 2000
... included: anti-HA (Covance); anti-ZO-1 (Chemicon International, Inc.); anti–claudin-1, -occludin, and -phosphoSer (Zymed Laboratories, Inc.); anti-Cα, anti–E-cadherin, and anti-PKCλ (Transduction Laboratories); anti-PKCζ (Alexis Corporation); anti-PKCζ (C-20), anti–p-nPKCζ (Thr410) (Santa Cruz Biotechnology, Inc.); anti-PP1α (Calbiochem); anti-B56γ ...
Endosomes generate localized Rho–ROCK–MLC2–based contractile signals via Endo180 to promote adhesion disassembly
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Isacke Clare M. et al., In The Journal of Cell Biology, 2000
... Mouse anti–human E-cadherin (clone HECD-1) was obtained from Abcam; secondary antibodies Alexa Fluor ...
Plakoglobin and β-catenin: protein interactions, regulation and biological roles
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Rossini G P et al., In British Journal of Cancer, 1999
... Anti-E-cadherin antibodies were purchased from Santa Cruz Biotechnology (H-108), Transduction Laboratories (C20820) ...
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
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Miyoshi Jun et al., In Journal of Cell Science, 1998
... from commercial sources: antibodies against afadin and nectin-3 (ABcam), nectin-1 (Santa Cruz Biotechnology), nectin-2 (Hycult), E-cadherin (R&D Systems and BD Biosciences), α-catenin (Sigma-Aldrich), β-catenin (BD ...
A novel mechanism for the regulation of amyloid precursor protein metabolism
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Schubert David et al., In The Journal of Cell Biology, 1998
... β-Laminin antibody (sc-6018), N-CAM antibody (sc-1507), N- and E-cadherin antibody from Transduction Laboratories, Notch antibody (sc-6014) were purchased from Santa Cruz Biotechnology, Inc., and APLP was ...
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
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Sobue Kenji et al., In The Journal of Cell Biology, 1997
... anti–β-actin (AC-15; Sigma-Aldrich), anti-SRF (G-20; Santa Cruz Biotechnology, Inc.), antivinculin (HVIN-1; Sigma-Aldrich), anti-talin (8d4; Sigma-Aldrich), anti–E-cadherin (BD Biosciences), anti–N-cadherin (BD Biosciences), antivimentin ...
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
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Arkowitz Robert Alan, In PLoS ONE, 1990
... , mouse anti-E-cadherin (Becton Dickinson Switzerland BD610181), rabbit anti-α-catenin ...
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
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Etienne-Manneville Sandrine et al., In The Journal of Cell Biology, 1990
... reagents: anti–α-tubulin (AbD Serotec); anti-Pan-cadherin CH-19 (Sigma-Aldrich); anti–N-cadherin, anti–β-catenin, anti-GM130, and anti-paxillin (all from BD); anti–E-cadherin (Santa Cruz Biotechnology, Inc.); anti-pericentrin (Covance); anti-microtubule ...
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
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Linden Rafael, In PLoS ONE, 1984
... Anti E-cadherin monoclonal Ab was from BD Biosciences-Pharmingen (Franklin Lakes, NJ) ...
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