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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 25 Jan 2016.

Cadherin 1, type 1, E-cadherin

E-cadherin, CDH1
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: vimentin, CAN, V1a, N-cadherin, SNAIL
Papers using E-cadherin antibodies
Discovery of a novel proteasome inhibitor selective for cancer cells over non-transformed cells
Sebti Saïd M. et al., In Cell death and differentiation, 2008
... following sources: Akt, pAkt(T308), pAkt(S473) and pGSK3-β(S9) (Cell Signaling, Danvers, MA), mTOR (Millipore, Temecula, CA), E-cadherin (BD Biosciences, San José, CA), GAPDH ...
the cytoskeleton, and cancer cell invasion
Olayioye M A et al., In Oncogenesis, 2008
... Antibodies used were: mouse anti-E-cadherin, anti-β-catenin, and anti-p120-catenin (BD, Heidelberg, Germany), rabbit anti-phospho-MLC and anti-E-cadherin pAbs (Cell Signaling, Danvers, MA, USA), rabbit ...
Claudin-1, -2, -3, -4, -5, and -7 in usual interstitial pneumonia and sarcoidosis
Belej Kamil et al., In International Journal of Molecular Sciences, 2008
... The slides were stained with antibodies: Snail-1 (rabbit polyclonal, Ab 85931, 1:150, Abcam), E-cadherin (mouse monoclonal, M3612, 1:50, Dako) and claudin-1 (mouse monoclonal, ...
The epithelial-mesenchymal transition generates cells with properties of stem cells
Orsulic Sandra, In PLoS ONE, 2007
... Anti-E-cadherin mAb was from BD Biosciences (Milan, Italy), anti-Snail, anti-Zeb1, ...
To reg or not to reg: that is the question in COPD.
Idzko Marco, In PLoS ONE, 2007
... mouse anti-human Cytokeratin 18 (Pierce), mouse anti-human E-cadherin (Dako), mouse anti-human Smooth Muscle ...
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Papers on E-cadherin
Abelmoschus esculentus fractions potently inhibited the pathogenic targets associated with diabetic renal epithelial to mesenchymal transition.
Ker et al., Taiwan. In Food Funct, 20 Feb 2016
We used a succession of extractions and obtained the corresponding fractions F1-F5, each with its own individual properties: F1 inhibits high glucose-stimulated vimentin, AT-1, TGF-β1, and DPP-4, and recovers E-cadherin in tubular cells; F2 decreases high glucose-induced vimentin, AT-1 and DPP-4; F3-F5 do not reduce the expression of vimentin.
Cis and Trans Cooperativity of E-Cadherin Mediates Adhesion in Biomimetic Lipid Droplets.
Brujic et al., Paris, France. In Biophys J, 19 Feb 2016
Although the role of active cytoskeleton dynamics in regulating cadherin interactions is crucial in vivo, here we present a biomimetic emulsion system to characterize the passive E-cadherin-mediated adhesion between droplets.
PLC-β2 is modulated by low oxygen availability in breast tumor cells and plays a phenotype dependent role in their hypoxia-related malignant potential.
Bertagnolo et al., Ferrara, Italy. In Mol Carcinog, 19 Feb 2016
Under hypoxia, the down-modulation of PLC-β2 was mainly correlated with the decrease of the EMT marker E-cadherin in the BT-474 cells and with the up-regulation of the stem cell marker CD133 in MCF7 cells.
TUFM downregulation induces epithelial-mesenchymal transition and invasion in lung cancer cells via a mechanism involving AMPK-GSK3β signaling.
Song et al., Shanghai, China. In Cell Mol Life Sci, 18 Feb 2016
TUFM expression level was positively correlated with that of E-cadherin and decreased significantly during the progression of human lung cancer.
Activation of NLRP3 inflammasome enhances the proliferation and migration of A549 lung cancer cells.
Xie et al., Nanjing, China. In Oncol Rep, 18 Feb 2016
Western blot analysis showed that activation of phosphorylation of Akt, ERK1/2, CREB and the expression of Snail increased, while the expression of E-cadherin decreased after the activation of NLRP3 inflammasome.
Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat.
Yang et al., Tangshan, China. In Toxicol Appl Pharmacol, 16 Feb 2016
Western blot analysis was used to examine for changes in the protein levels of E-cadherin (E-cad) and SP-A (epithelial cell markers), vimentin (mesenchymal cell marker), α-SMA (active myofibroblast marker), and collagen I and III in both in vivo and in vitro experiments.
Overexpression of SDF-1 activates the NF-κB pathway to induce epithelial to mesenchymal transition and cancer stem cell-like phenotypes of breast cancer cells.
Li et al., Mudanjiang, China. In Int J Oncol, 15 Feb 2016
Besides, western blot analysis and immunofluorescence assay observed the significant decreased expression of E-cadherin and enhanced expression of slug, fibronectin and vimentin in SDF-1 overexpressed MCF-7 cells in comparison with parental (P<0.01).
miR-200/ZEB axis regulates sensitivity to nintedanib in non-small cell lung cancer cells.
Gemma et al., Tokyo, Japan. In Int J Oncol, 11 Feb 2016
E-cadherin expression was lower, and vimentin and ZEB1 expression were higher in 5 nintedanib-resistant cell lines.
Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.
Wang et al., New York City, United States. In Cancer Cell, 14 Jan 2016
Mist1(+) stem cells serve as a cell-of-origin for intestinal-type cancer with the combination of Kras and Apc mutation and for diffuse-type cancer with the loss of E-cadherin.
ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.
Haura et al., Kitakyūshū, Japan. In Plos One, 31 Dec 2015
Furthermore, numerous ZEB1 responsive genes, such as CDH1 (E-cadherin), ST14, and vimentin, were coordinately regulated along with increased ZEB1 in HCC4006ER cells.
Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
Perou et al., Lausanne, Switzerland. In Cell, Nov 2015
Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTEN, TBX3, and FOXA1 as ILC enriched features.
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions.
Yap et al., Brisbane, Australia. In Nat Cell Biol, Oct 2015
Actomyosin at the epithelial zonula adherens (ZA) generates junctional tension for tissue integrity and morphogenesis.
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Anastasiadis et al., Jacksonville, United States. In Nat Cell Biol, Sep 2015
E-cadherin and p120 catenin (p120) are essential for epithelial homeostasis, but can also exert pro-tumorigenic activities.
Cell adhesion. Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry.
Nelson et al., Stanford, United States. In Science, Jun 2015
Maintenance of quiescence, Yap1 nuclear exclusion, and β-catenin transcriptional responses to mechanical strain required E-cadherin extracellular engagement.
Role of heme oxygenase-1 in demethylating effects on SKM-1 cells induced by decitabine.
Fang et al., Guiyang, China. In Genet Mol Res, 2014
The expressions of p16, p15, TP73, CDH1, ESR1, and PDLIM4 mRNAs were detected by real-time PCR, and those of HO-1, DNMT1, DNMT3A, DNMT3B, HDAC, and p15 proteins were measured by western blot.
The impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity of A431 cancer cells.
Cordes et al., Dresden, Germany. In Radiat Res, 2012
impact of cell-cell contact, E-cadherin and EGF receptor on the cellular radiosensitivity
Regulation of SIRT1 determines initial step of endometrial receptivity by controlling E-cadherin expression.
Taketani et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2012
These findings establish a principal biological function of SIRT1 in the modulation of E-cadherin function.
Impact of E-cadherin expression pattern in melanocytic nevi and cutaneous malignant melanoma.
Bakry et al., Egypt. In Anal Quant Cytopathol Histpathol, 2012
E-cadherin expression in nevi is related to the degree of melanocytic maturation.
Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.
Herrup et al., Xiamen, China. In J Biol Chem, 2012
When a neuronal cell enters S phase, Cdk5 is transported to the cytoplasm where it is ubiquitinated by the E3 ligase APC-Cdh1
Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation.
Ko et al., T'ai-chung-shih, Taiwan. In J Biol Chem, 2012
Specifically, NiCl(2) induces down-regulation of E-cadherin by reactive oxygen species generation and promoter hypermethylation
More papers using E-cadherin antibodies
Beyond tumorigenesis: cancer stem cells in metastasis.
Yang Pan-Chyr, In PLoS ONE, 2006
... Dorothee Herlyn of the Wistar Institute), E-cadherin mAb (Santa Cruz Biotechnology, Santa Cruz, CA), EpCam ...
The hypoxia-inducible factor 2alpha N-terminal and C-terminal transactivation domains cooperate to promote renal tumorigenesis in vivo
Griffin J D et al., In British Journal of Cancer, 2006
... E-cadherin antibody was from BD Biosciences (San Jose, CA, USA) ...
Cell polarity in development and cancer.
Thi Thu Nguyen Hang, In PLoS ONE, 2006
... Antibodies raised against E-cadherin and villin were from BD Biosciences (Mississauga, ON, Canada) ...
A novel system for gene silencing using siRNAs in rice leaf and stem-derived protoplasts
Li Jiayang et al., In Nature Communications, 2005
... The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and ...
Deconstructing the cadherin-catenin-actin complex
Nelson W. James et al., In The Journal of Cell Biology, 2004
... (a) GFP in Lyn-GFP was replaced with the cytosolic domain of E-cadherin using KpnI and XbaI sites (New England Biolabs, Inc.) ...
DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells.
Wölfl Stefan, In PLoS ONE, 2004
... Mouse monoclonal antibodies were used to detect E-cadherin (BD Transduction Labs., BD Biosciences, San Jose, CA USA, ...
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
Weiss Stephen J. et al., In The Journal of Cell Biology, 2003
... Antibodies directed against the following molecules were obtained commercially: E-cadherin, β-catenin (BD), FSP-1 (Abcam), Akt, Akt phospho-Ser473, ERK, ...
NF-κB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
Hong Seong-Doo et al., In Journal of Experimental & Clinical Cancer Research : CR, 2003
... ERK (Tyr 204), phosphorylated JNK (Thr183/Tyr185), phosphorylated p65, p50, p38, Snail, SIP-1/ZEB-2, Twist, β-catenin, and E-cadherin were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
Oshima Robert G. et al., In Oncogene, 2003
... E-Cadherin, Clone 24E10, (Cell Signaling Technologies) and Alexa 488 ...
Cdc42 controls spindle orientation to position the apical surface during epithelial morphogenesis
Hall Alan et al., In The Journal of Cell Biology, 2002
... 44; BD), β-actin (clone AC-74; Sigma-Aldrich), Flag (clone M2; Sigma-Aldrich), α-tubulin (clone DM1A; Sigma-Aldrich), rat anti–E-cadherin (clone ECCD-2; Invitrogen), rabbit polyclonal PKCζ (C-20; Santa Cruz Biotechnology, Inc.), ZO-1 (Invitrogen), and ...
E-cadherin engagement stimulates proliferation via Rac1
Chen Christopher S. et al., In The Journal of Cell Biology, 2002
... Reagents were obtained as follows: anti–E-cadherin (36 [BD Biosciences]; HECD-1 and SHE78-7 [Zymed Laboratories]; DECMA-1 [Sigma-Aldrich]); anti-p120 (98; BD Biosciences); anti–α-tubulin (Sigma-Aldrich); anti-GAPDH (Ambion); ...
Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
Mukhopadhyay Asok et al., In The Indian Journal of Medical Research, 2002
... primary antibodies used were anti-megalin (a kind gift of Mr Dan Biemesderfer, Yale University, USA), anti-E-cadherin (Abcam plc., UK), anti-CK-19 (Santa ...
Evidence for the isolation, growth, and characterization of malignant cells in primary cultures of human tumors
Wells Alan et al., In Molecular Cancer, 2002
... 231-shEcad cells were generated using an E-cadherin shRNA plasmid (Santa Cruz Biotechnology) and stable transfectants were ...
Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions.
Katoh Masaru, In PLoS ONE, 2002
... Santa Cruz (Santa Cruz, CA), anti-HA, anti-FLAG (M2), anti-actin, anti-nucleolin from Sigma-Aldrich (St Louis, MO), anti-E-cadherin from BD Biosciences (San Diego, CA), anti-N-cadherin ...
Direct evidence for a role of β-catenin/LEF-1 signaling pathway in induction of EMT
Kim Dong-Gyu et al., In Journal of Korean Medical Science, 2001
... Monoclonal antibodies against E-cadherin (R&D systems, Minneapolis, MN, U.S.A.), pancytokeratin (Sigma Aldrich, Saint Louis, MO, U.S.A.), ...
The CD16+ (FcγRIII+) Subset of Human Monocytes Preferentially Becomes Migratory Dendritic Cells in a Model Tissue Setting
Schäkel Knut et al., In The Journal of Experimental Medicine, 2001
... purified mAbs to CD3, CD14, CD19, CD36, CD64, CD86, HLA-DR, HLA-DP (all from BD Biosciences), E-cadherin (Santa Cruz Biotechnology, Inc.), and IgM nonbinding ...
Perturbation of the tight junction permeability barrier by occludin loop peptides activates beta-catenin/TCF/LEF-mediated transcription.
Andre Frederic, In PLoS ONE, 2000
... The antibodies against claudin-1 and -4 were from Invitrogen (San Francisco, CA, USA), and E-cadherin was from BD Biosciences (San Jose, CA, USA) ...
An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration.
Ahmad Aamir, In PLoS ONE, 2000
... Antibodies for GEP100 and E-cadherin C36 were from Sigma and BD Biosciences respectively ...
Protein phosphatase 2A associates with and regulates atypical PKC and the epithelial tight junction complex
Sontag Estelle et al., In The Journal of Cell Biology, 2000
... included: anti-HA (Covance); anti-ZO-1 (Chemicon International, Inc.); anti–claudin-1, -occludin, and -phosphoSer (Zymed Laboratories, Inc.); anti-Cα, anti–E-cadherin, and anti-PKCλ (Transduction Laboratories); anti-PKCζ (Alexis Corporation); anti-PKCζ (C-20), anti–p-nPKCζ (Thr410) (Santa Cruz Biotechnology, Inc.); anti-PP1α (Calbiochem); anti-B56γ ...
Endosomes generate localized Rho–ROCK–MLC2–based contractile signals via Endo180 to promote adhesion disassembly
Isacke Clare M. et al., In The Journal of Cell Biology, 2000
... Mouse anti–human E-cadherin (clone HECD-1) was obtained from Abcam; secondary antibodies Alexa Fluor ...
Plakoglobin and β-catenin: protein interactions, regulation and biological roles
Rossini G P et al., In British Journal of Cancer, 1999
... Anti-E-cadherin antibodies were purchased from Santa Cruz Biotechnology (H-108), Transduction Laboratories (C20820) ...
Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development
Miyoshi Jun et al., In Journal of Cell Science, 1998
... from commercial sources: antibodies against afadin and nectin-3 (ABcam), nectin-1 (Santa Cruz Biotechnology), nectin-2 (Hycult), E-cadherin (R&D Systems and BD Biosciences), α-catenin (Sigma-Aldrich), β-catenin (BD ...
A novel mechanism for the regulation of amyloid precursor protein metabolism
Schubert David et al., In The Journal of Cell Biology, 1998
... β-Laminin antibody (sc-6018), N-CAM antibody (sc-1507), N- and E-cadherin antibody from Transduction Laboratories, Notch antibody (sc-6014) were purchased from Santa Cruz Biotechnology, Inc., and APLP was ...
Dual roles of myocardin-related transcription factors in epithelial–mesenchymal transition via slug induction and actin remodeling
Sobue Kenji et al., In The Journal of Cell Biology, 1997
... anti–β-actin (AC-15; Sigma-Aldrich), anti-SRF (G-20; Santa Cruz Biotechnology, Inc.), antivinculin (HVIN-1; Sigma-Aldrich), anti-talin (8d4; Sigma-Aldrich), anti–E-cadherin (BD Biosciences), anti–N-cadherin (BD Biosciences), antivimentin ...
Immuno-localization of the insulin regulatable glucose transporter in brown adipose tissue of the rat.
Arkowitz Robert Alan, In PLoS ONE, 1990
... , mouse anti-E-cadherin (Becton Dickinson Switzerland BD610181), rabbit anti-α-catenin ...
Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
Etienne-Manneville Sandrine et al., In The Journal of Cell Biology, 1990
... reagents: anti–α-tubulin (AbD Serotec); anti-Pan-cadherin CH-19 (Sigma-Aldrich); anti–N-cadherin, anti–β-catenin, anti-GM130, and anti-paxillin (all from BD); anti–E-cadherin (Santa Cruz Biotechnology, Inc.); anti-pericentrin (Covance); anti-microtubule ...
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Linden Rafael, In PLoS ONE, 1984
... Anti E-cadherin monoclonal Ab was from BD Biosciences-Pharmingen (Franklin Lakes, NJ) ...
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