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Dyslexia susceptibility 1 candidate 1

DYX1C1, DYX1, EKN1, dyslexia susceptibility 1 candidate 1
This gene encodes a tetratricopeptide repeat domain-containing protein. The encoded protein interacts with estrogen receptors and the heat shock proteins, Hsp70 and Hsp90. An homologous protein in rat has been shown to function in neuronal migration in the developing neocortex. A chromosomal translocation involving this gene is associated with a susceptibility to developmental dyslexia. Mutations in this gene are associated with deficits in reading and spelling. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream cell cycle progression 1 (CCPG1) gene. [provided by RefSeq, Mar 2011] (from NCBI)
Top mentioned proteins: Ru2, Robo1, OUT, HAD, CAN
Papers on DYX1C1
Mutation in CEP63 co-segregating with developmental dyslexia in a Swedish family.
Matsson et al., Huddinge, Sweden. In Hum Genet, Nov 2015
The brain regions were partly overlapping with the previously reported region influenced by polymorphisms in the dyslexia susceptibility genes DYX1C1 and KIAA0319.
Genetic variant in DIP2A gene is associated with developmental dyslexia in Chinese population.
Song et al., Wuhan, China. In Am J Med Genet B Neuropsychiatr Genet, Nov 2015
Compared with some DD candidate genes that have been extensively studied (e.g., DYX1C1, DCDC2, KIAA0319, and ROBO1), very little is known about the association between candidate gene DIP2A and DD susceptibility.
[Genome-wide association studies on the developmental dyslexia children].
Li et al., In Wei Sheng Yan Jiu, Sep 2015
RESULTS: Genotypes and allele frequencies of rs331142 and rs12495133 from DYX1C1 gene, rs11629841 and rs3743205 from ROBOl gene between cases and control groups were significantly different (P < 0. 05).
Polymorphisms in DCDC2 and S100B associate with developmental dyslexia.
Kere et al., Huddinge, Sweden. In J Hum Genet, Jul 2015
We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B.
An assessment of gene-by-gene interactions as a tool to unfold missing heritability in dyslexia.
Marino et al., Lecco, Italy. In Hum Genet, Jul 2015
We assessed potential G × G interactions among five DD candidate genes, i.e., DYX1C1, DCDC2, KIAA0319, ROBO1, and GRIN2B, upon DD-related neuropsychological phenotypes in 493 nuclear families with DD, by implementing two complementary regression-based approaches: (1) a general linear model equation whereby the trait is predicted by the main effect of the number of rare alleles of the two genes and by the effect of the interaction between them, and (2) a family-based association test to detect G × G interactions between two unlinked markers by splitting up the association effect into a between- and a within-family genetic orthogonal components.
Deficits in learning and memory in mice with a mutation of the candidate dyslexia susceptibility gene Dyx1c1.
Fitch et al., United States. In Brain Lang, Jun 2015
One candidate gene, dyslexia susceptibility 1 candidate 1 (DYX1C1), has been shown to be associated with deficits in short-term memory in dyslexic populations.
A case report of primary ciliary dyskinesia, laterality defects and developmental delay caused by the co-existence of a single gene and chromosome disorder.
Lynch et al., Dublin, Ireland. In Bmc Med Genet, 2014
We recently reported the identification of three disease-causing PCD genes in the Irish Traveller population; RSPH4A, DYX1C1 and CCNO.
DCDC2 polymorphism is associated with left temporoparietal gray and white matter structures during development.
Klingberg et al., Sweden. In J Neurosci, 2014
Three genes, DYX1C1, DCDC2, and KIAA0319, have been previously associated with dyslexia, neuronal migration, and ciliary function.
DYX1C1 is required for axonemal dynein assembly and ciliary motility.
Omran et al., United States. In Nat Genet, 2013
DYX1C1 has been associated with dyslexia and neuronal migration in the developing neocortex.
The rs3743205 SNP is important for the regulation of the dyslexia candidate gene DYX1C1 by estrogen receptor β and DNA methylation.
Nalvarte et al., Huddinge, Sweden. In Mol Endocrinol, 2012
A single nucleotide polymorphism previously shown to be associated with dyslexia and located in the cis-regulatory region of DYX1C1 may alter the epigenetic and endocrine regulation of this gene.
[Molecular genetics of functional articulation disorder in children].
Ma et al., Shenyang, China. In Zhongguo Dang Dai Er Ke Za Zhi, 2012
ZNF280D gene, TCF12 gene, EKN1 gene in 15q21, and KIAA0319 gene in 6p22 have been candidate genes for the study of functional articulation disorder.
The dyslexia candidate gene DYX1C1 is a potential marker of poor survival in breast cancer.
Kere et al., Huddinge, Sweden. In Bmc Cancer, 2011
the expression of DYX1C1 in breast cancer is associated with several clinicopathological parameters and that loss of DYX1C1 correlates with a more aggressive disease, in turn indicating that DYX1C1 is a potential prognostic biomarker in breast cancer.
Exploring the transcriptome of ciliated cells using in silico dissection of human tissues.
Sergeeva et al., Moscow, Russia. In Plos One, 2011
Mutations in cilia co-expressed DCDC2, DYX1C1 and KIAA0319 genes are associated with a cognitive neurological disorder, dyslexia.
Molecular genetics and molecular biology of dyslexia.
Kere, Stockholm, Sweden. In Wiley Interdiscip Rev Cogn Sci, 2011
More importantly, the first genes, some of them found by the study of rare families, have indicated specific neurodevelopmental processes important for the development of dyslexia, including control of neuronal migration for the DYX1C1, DCDC2, and KIAA0319 genes, and a role of axonal and dendritic guidance suggested by the ROBO1 gene.
A theoretical molecular network for dyslexia: integrating available genetic findings.
Franke et al., Nijmegen, Netherlands. In Mol Psychiatry, 2011
We found that 10 of the 14 dyslexia candidate genes (ROBO1, KIAA0319, KIAA0319L, S100B, DOCK4, FMR1, DIP2A, GTF2I, DYX1C1 and DCDC2) fit into a theoretical molecular network involved in neuronal migration and neurite outgrowth.
An examination of candidate gene SNPs for dyslexia in an Indian sample.
Ramachandra et al., Mysore, India. In Behav Genet, 2011
At this point, there is no statistical evidence of association between the allelic variation in the three candidate genes and DD in our sample.
Association of the rs3743205 variant of DYX1C1 with dyslexia in Chinese children.
Waye et al., Hong Kong, Hong Kong. In Behav Brain Funct, 2010
findings suggest that DYX1C1 is associated with dyslexia in people of Chinese ethnicity.
Progress towards a cellular neurobiology of reading disability.
LoTurco et al., Easton, United States. In Neurobiol Dis, 2010
In this review we discuss recent findings that revealed neuroanatomic anomalies in RD, studies that identified 3 candidate genes (KIAA0319, DYX1C1, and DCDC2), and compelling evidence that potentially link the function of candidate genes to the neuroanatomic anomalies.
The genetics of reading disability.
Pauls et al., Boston, United States. In Curr Psychiatry Rep, 2009
Association studies of positional candidate genes have implicated DCDC2 and KIAA0319 in DYX2, as well as C2ORF3 and MRPL19 (DYX3), whereas DYX1C1/EKN1 (DYX1) and ROBO1 (DYX5) were found to be disrupted by rare translocation breakpoints in reading-disabled individuals.
The human lexinome: genes of language and reading.
Gruen et al., New Haven, United States. In J Commun Disord, 2008
Further genetic studies have identified four dyslexia genes within the DYX loci: DYX1C1 on 15q, KIAA0319 and DCDC2 on 6p22, and ROBO1 on 13q.
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