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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein

Dys, ELP1, IKBKAP, IKAP
The protein encoded by this gene is a scaffold protein and a regulator for 3 different kinases involved in proinflammatory signaling. This encoded protein can bind NF-kappa-B-inducing kinase (NIK) and IKKs through separate domains and assemble them into an active kinase complex. Mutations in this gene have been associated with familial dysautonomia. [provided by RefSeq, Jul 2008] (from NCBI)
Papers using Dys antibodies
Tubulin modifications and their cellular functions.
Supplier
Baccei Mark L., In PLoS ONE, 2007
... siRNA candidates for IKBKAP were identified using the Whitehead Institute for Biomedical Reseach's website ( ...
The synaptic vesicle protein SV2 is complexed with an alpha5-containing laminin on the nerve terminal surface.
Supplier
Andreu Antoni L., In PLoS ONE, 1999
... The Dys-COOH RNAi transgenic flies were described in ...
Papers on Dys
Nutraceutical-mediated restoration of wild-type levels of IKBKAP-encoded IKAP protein in familial dysautonomia-derived cells.
GeneRIF
Rubin et al., United States. In Mol Nutr Food Res, 2012
Combined treatment with epigallocatechin gallate and genistein synergistically upregulates wild-type IKBKAP-encoded RNA and protein levels in familial dysautonomia-derived cells.
IKAP/Elp1 is required in vivo for neurogenesis and neuronal survival, but not for neural crest migration.
GeneRIF
Lefcort et al., Bozeman, United States. In Plos One, 2011
IKAP plays pleiotropic roles in both the peripheral and central nervous systems
Effects of IKAP/hELP1 deficiency on gene expression in differentiating neuroblastoma cells: implications for familial dysautonomia.
GeneRIF
Weil et al., Tel Aviv-Yafo, Israel. In Plos One, 2010
IKAP/hELP1 deficiency has an effect on gene expression in differentiating neuroblastoma cells, and possibly on familial dysautonomia
New dystrophin/dystroglycan interactors control neuron behavior in Drosophila eye.
GeneRIF
Shcherbata et al., Göttingen, Germany. In Bmc Neurosci, 2010
Nrk, mbl, capt and Cam genetically interact with dystrophin and/or dystroglycan in the process of axon path-finding in the eye.
Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality.
GeneRIF
Dragatsis et al., Memphis, United States. In Plos One, 2010
IKAP is essential for expression of specific genes involved in cardiac morphogenesis, and cardiac failure is the likely cause of abnormal vascular development and embryonic lethality; deletion of exon 20 abolishes gene function
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