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Dual-specificity tyrosine-

DYRK1A, MNB, DYRK, serine/threonine-specific protein kinase
This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, V1a, ACID, PCNA
Papers using DYRK1A antibodies
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.
Supplier
Vosshall Leslie B., In PLoS ONE, 2004
... Mice with heterozygous deletion of Dyrk1a [24] were bred on a Swiss background and transgenic FVB males (YACtg152F7) were ...
Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis
Supplier
Chung Kwang Chul et al., In Experimental Neurobiology, 2004
... Anti-phosphoASK1 (Thr-845), anti-phosphoJNK, and anti-Dyrk1A antibodies were purchased from Cell Signaling Technology (Beverly, MA, USA) ...
Papers on DYRK1A
An ID2-dependent mechanism for VHL inactivation in cancer.
New
Impact
Lasorella et al., New York City, United States. In Nature, Feb 2016
Here we report that DYRK1A and DYRK1B kinases phosphorylate ID2 on threonine 27 (Thr27).
Differential effects of Epigallocatechin-3-gallate containing supplements on correcting skeletal defects in a Down syndrome mouse model.
New
Roper et al., Indianapolis, United States. In Mol Nutr Food Res, Feb 2016
DYRK1A, a kinase encoded on Hsa21, has been linked to deficiencies in bone homeostasis in DS mice and individuals with DS.
DYRK1A-Related Intellectual Disability Syndrome
Review
New
Eichler et al., Seattle, United States. In Unknown Journal, Jan 2016
CLINICAL CHARACTERISTICS: DYRK1A-related intellectual disability syndrome is characterized by intellectual disability including impaired speech development, autism spectrum disorder including anxious and/or stereotypic behavior problems, and microcephaly.
Dyrk1A-ASF-CaMKIIδ Signaling Is Involved in Valsartan Inhibition of Cardiac Hypertrophy in Renovascular Hypertensive Rats.
New
Sheng et al., Nantong, China. In Cardiology, Dec 2015
Recently, we found a further signaling pathway, by which dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) regulates the alternative splicing of CaMKIIδ via the alternative splicing factor (ASF), i.e.
Ruminal degradability and intestinal digestibility of individual amino acids in mixed diets with different crude protein levels measured by the modified in vitro three-step and mobile nylon bag technique.
New
Chen et al., Shihezi, China. In Anim Sci J, Dec 2015
UNASSIGNED: The ruminal degradability and intestinal digestibility of dry matter (DM), crude protein (CP) and amino acids (AA) in three total mixed rations with different CP levels were estimated using the modified in vitro three-step procedure (TSP) and mobile nylon bag (MNB) technique on growing lambs.
Potential Skin Regeneration Activity and Chemical Composition of Absolute from Pueraria thunbergiana Flower.
New
Lee et al., In Nat Prod Commun, Nov 2015
The PTBF absolute, which contained 10 compounds, stimulated migration and proliferation and increased the phosphorylation of serine/threonine-specific protein kinase and extracellular signal-regulated kinasel/2 in HaCats.
Importance of gene dosage in controlling dendritic arbor formation during development.
Review
New
Copf, Irákleion, Greece. In Eur J Neurosci, Sep 2015
One notable disease-related molecule is kinase Dyrk1A, thought to be a causative factor in Down syndrome.
DYRK1A in neurodegeneration and cancer: Molecular basis and clinical implications.
Review
New
Munoz et al., Sydney, Australia. In Pharmacol Ther, Jul 2015
Dual-specificity Tyrosine phosphorylation-Regulated Kinase 1A (DYRK1A) has been much less studied compared to many other kinases.
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
New
Impact
Stewart et al., New York City, United States. In Nat Med, Apr 2015
We also define dual-specificity tyrosine-regulated kinase-1a (DYRK1A) as the likely target of harmine and the nuclear factors of activated T cells (NFAT) family of transcription factors as likely mediators of human beta cell proliferation and differentiation.
DYRK1A Controls HIV-1 Replication at a Transcriptional Level in an NFAT Dependent Manner.
Kootstra et al., Amsterdam, Netherlands. In Plos One, 2014
RESULTS: In our present study we analyzed the effect of host factor dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) on HIV-1 replication.
Prenatal treatment of Down syndrome: a reality?
Review
Delabar et al., Boston, United States. In Curr Opin Obstet Gynecol, 2014
Pharmacological targets include the choline pathway, GABA and NMDA receptors, DYRK1A protein, oxidative stress and pathways involved in development and neurogenesis.
Oxidative stress and Down syndrome. Do antioxidants play a role in therapy?
Review
Ďuračková et al., Bratislava, Slovakia. In Physiol Res, 2013
Potential therapeutic targets on the molecular level (oxidative stress markers, gene for DYRK1A, neutrophic factor BDNF) after intervention of natural polyphenols are also discussed.
Riquiqui and minibrain are regulators of the hippo pathway downstream of Dachsous.
Impact
Harvey et al., Melbourne, Australia. In Nat Cell Biol, 2013
Here we identify two regulators of the Drosophila melanogaster SWH pathway that function downstream of the DsICD: the WD40 repeat protein Riquiqui (Riq) and the DYRK-family kinase Minibrain (Mnb).
Translating dosage compensation to trisomy 21.
Impact
Lawrence et al., Worcester, United States. In Nature, 2013
Using genome editing with zinc finger nucleases, we inserted a large, inducible XIST transgene into the DYRK1A locus on chromosome 21, in Down's syndrome pluripotent stem cells.
Multiplex targeted sequencing identifies recurrently mutated genes in autism spectrum disorders.
Impact
Shendure et al., Seattle, United States. In Science, 2013
We estimate that recurrent disruptive mutations in six genes-CHD8, DYRK1A, GRIN2B, TBR1, PTEN, and TBL1XR1-may contribute to 1% of sporadic ASDs.
Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion.
GeneRIF
Liu et al., Nantong, China. In J Biol Chem, 2012
Phosphorylation of SRp55 by Dyrk1A suppressed its ability to promote Tau exon 10 inclusion.
Phosphorylation of Munc18-1 by Dyrk1A regulates its interaction with Syntaxin 1 and X11α.
GeneRIF
Chung et al., Pusan, South Korea. In J Neurochem, 2012
This study showed Dyrk1A is shown to interact with and phosphorylate Munc18-1 at the Thr479 residue
DYRK1A: a master regulatory protein controlling brain growth.
GeneRIF
Delabar et al., Paris, France. In Neurobiol Dis, 2012
Dyrk1a has two roles in the development process: shaping the brain and controlling the structure of neuronal components.
Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.
GeneRIF
Crispino et al., Chicago, United States. In J Clin Invest, 2012
Dyrk1a has a role in megakaryoblastic leukemia in Down syndrome and the murine model
Down's-syndrome-related kinase Dyrk1A modulates the p120-catenin-Kaiso trajectory of the Wnt signaling pathway.
GeneRIF
McCrea et al., Houston, United States. In J Cell Sci, 2012
Dyrk1A positively and selectively modulates p120-catenin protein levels, thus having an impact on p120-catenin and Kaiso (and canonical Wnt) gene targets such as siamois and wnt11.
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