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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dynamin 3

Dynamin III, dynamin 3, DNM3, testicular dynamin III, KIAA0820
Members of the dynamin family, such as DNM3, possess mechanochemical properties involved in actin-membrane processes, predominantly in membrane budding (Orth and McNiven, 2003 [PubMed 12517701]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Dynamin I, HAD, miR, Actin, AGE
Papers on Dynamin III
DNM3 Attenuates Hepatocellular Carcinoma Growth by Activating P53.
Geng et al., Tongling, China. In Med Sci Monit, Dec 2015
In our previous study, we found that the mRNA level of Dynamin3 (DNM3), a member of the Dynamin family, is significantly lower in hepatocellular carcinoma tissues than in non-tumor tissues.
Two further patients with the 1q24 deletion syndrome expand the phenotype: A possible role for the miR199-214 cluster in the skeletal features of the condition.
Foulds et al., London, United Kingdom. In Am J Med Genet A, Dec 2015
The deletion in the first patient is very small and further narrows the critical interval for the striking skeletal aspects of this condition to a region containing only Dynamin 3 (DNM3) and two microRNAs that are harbored within intron 14 of this gene: miR199 and miR214.
Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1.
Brigstock et al., Columbus, United States. In Am J Physiol Gastrointest Liver Physiol, Oct 2015
CCN2 is increasingly expressed during HSC activation because of diminished expression of microRNA-214 (miR-214), a product of dynamin 3 opposite strand (DNM3os) that directly suppresses CCN2 mRNA.
Differential targeting of dynamin-1 and dynamin-3 to nerve terminals during chronic suppression of neuronal activity.
Halpain et al., San Diego, United States. In Mol Cell Neurosci, Sep 2015
Specifically, when neural activity was chronically silenced for 1-2weeks by tetrodotoxin (TTX), the clustering of dynamin 1 at nerve terminals was reduced, while the clustering of dynamin 3 significantly increased.
Erythropoietin-mediated expression of placenta growth factor is regulated via activation of hypoxia-inducible factor-1α and post-transcriptionally by miR-214 in sickle cell disease.
Kalra et al., Los Angeles, United States. In Biochem J, Jul 2015
Furthermore, synthesis of miR-214, located in an intron of DNM3 (dynamin 3), was transcriptionally regulated by transcription factors, peroxisome proliferator-activated receptor-α (PPARα) and hypoxia-inducible factor-1α (HIF-1α).
Neural activity selects myosin IIB and VI with a specific time window in distinct dynamin isoform-mediated synaptic vesicle reuse pathways.
Mochida et al., Tokyo, Japan. In J Neurosci, Jul 2015
Knockdown of both myosin and dynamin isoforms by mixed siRNA microinjection revealed that myosin IIB-mediated SV resupply follows amphiphysin/dynamin-1-mediated endocytosis, while myosin VI-mediated SV resupply follows dynamin-3-mediated endocytosis.
Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1.
Albanesi et al., Dallas, United States. In Biochim Biophys Acta, Jun 2015
At lower ionic strength Arc also stabilizes pre-formed dynamin 2 polymers against GTP-dependent disassembly, thereby prolonging assembly-dependent GTP hydrolysis catalyzed by dynamin 2. Arc also increases the GTPase activity of dynamin 3, an isoform of implicated in dendrite remodeling, but does not affect the activity of dynamin 1, a neuron-specific isoform involved in synaptic vesicle recycling.
Refinement of genotype-phenotype correlation in 18 patients carrying a 1q24q25 deletion.
Schluth-Bolard et al., Bron, France. In Am J Med Genet A, May 2015
We delineated three regions that may contribute to the phenotype: a proximal one (chr1:164,501,003-167,022,133), associated with cardiac and renal anomalies, a distal one (chr1:178,514,910-181,269,712) and an intermediate 490 kb region (chr1:171970575-172460683, hg19), deleted in the most of the patients, and containing DNM3, MIR3120 and MIR214 that may play an important role in the phenotype.
Assessment of copy number variations in the brain genome of schizophrenia patients.
Nawa et al., Niigata, Japan. In Mol Cytogenet, 2014
In the candidate CNV regions, 26 regions had no overlaps with the common CNVs found in Asian populations and included the genes (i.e., ANTXRL, CHST9, DNM3, NDST3, SDK1, STRC, SKY) that are associated with schizophrenia and/or other psychiatric diseases.
Identification and validation of genes with expression patterns inverse to multiple metastasis suppressor genes in breast cancer cell lines.
Steeg et al., Bethesda, United States. In Clin Exp Metastasis, 2014
Five genes were selected for further analysis: PDE5A, UGT1A, IL11RA, DNM3 and OAS1.
Characterization of transcriptomes of cochlear inner and outer hair cells.
He et al., Ningbo, China. In J Neurosci, 2014
The top 10 differentially expressed genes include Slc17a8, Dnajc5b, Slc1a3, Atp2a3, Osbpl6, Slc7a14, Bcl2, Bin1, Prkd1, and Map4k4 in IHCs and Slc26a5, C1ql1, Strc, Dnm3, Plbd1, Lbh, Olfm1, Plce1, Tectb, and Ankrd22 in OHCs.
A dynamin 1-, dynamin 3- and clathrin-independent pathway of synaptic vesicle recycling mediated by bulk endocytosis.
De Camilli et al., New Haven, United States. In Elife, 2013
The exocytosis of synaptic vesicles (SVs) elicited by potent stimulation is rapidly compensated by bulk endocytosis of SV membranes leading to large endocytic vacuoles ('bulk' endosomes).
Classical dynamin DNM1 and DNM3 genes attain maximum expression in the normal human central nervous system.
Arola et al., Tarragona, Spain. In Bmc Res Notes, 2013
We found that the classical dynamin DNM1 and DNM3 genes reach their maximum expression levels (100% of maximal expression) in all normal human CNS tissues studied.
Genome-wide shRNA screening identifies host factors involved in early endocytic events for HIV-1-induced CD4 down-regulation.
Verhasselt et al., Gent, Belgium. In Retrovirology, 2013
By this stringent validation set-up, we could demonstrate that the knock-down of DNM3 (dynamin 3), SNX22 (sorting nexin 22), ATP6AP1 (ATPase, H+ Transporting, Lysosomal Accessory Protein 1), HRBL (HIV-Rev binding protein Like), IDH3G (Isocitrate dehydrogenase), HSP90B1 (Heat shock protein 90 kDa beta member 1) and EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15) significantly increases CD4 levels in HIV-infected SupT1 T cells compared to the non-targeting shRNA control.
Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.
De Camilli et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
These findings reveal a mechanism aimed at preventing synaptic transmission failure due to vesicle depletion when recycling vesicle traffic is backed up by a defect in dynamin-dependent endocytosis.
Distinct functional effects for dynamin 3 during megakaryocytopoiesis.
Reems et al., Seattle, United States. In Stem Cells Dev, 2011
DNM3 not only participates in megakaryocyte progenitor amplification, but is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system.
Overlapping role of dynamin isoforms in synaptic vesicle endocytosis.
De Camilli et al., New Haven, United States. In Neuron, 2011
Lack of dynamin 3 does not produce an overt phenotype in mice; however, it worsens the dynamin 1 KO phenotype, leading to perinatal lethality and a more severe defect in activity-dependent synaptic vesicle endocytosis.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Lindgren et al., Regensburg, Germany. In Nat Genet, 2010
We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1.8 × 10⁻⁴⁰) and the known signal at LYPLAL1.
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.
Lemmon et al., Philadelphia, United States. In Embo J, 2010
Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients.
Dynamin 3 participates in the growth and development of megakaryocytes.
Gilligan et al., Seattle, United States. In Exp Hematol, 2008
Dynamin 3 participates in the growth and development of megakaryocytes.
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