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Dynamin 1

Dynamin I, Dynamin, dynamin-1
mediates GTP hydrolysis; plays a role in receptor mediated endocytosis; required for agonist-induced internalization of the epidermal growth factor receptor [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: V1a, CAN, Actin, HAD, Utrophin
Papers using Dynamin I antibodies
PI(4,5)P2-dependent microdomain assemblies capture microtubules to promote and control leading edge motility
Supplier
Caroni Pico et al., In The Journal of Cell Biology, 2002
... the following sources: FLAG, anti-vinculin (Sigma-Aldrich); Arp3, IQGAP1 (Santa Cruz Biotechnology, Inc.); cortactin (Upstate Biotechnology); Dynamin II (BD Biosciences); Tyr-tubulin, Ac-tubulin (Sigma-Aldrich); PKA ...
Nuclear export of actina novel mechanism regulating the subcellular localization of a major cytoskeletal protein
Supplier
Di Fiore Pier Paolo et al., In The Journal of Cell Biology, 1997
... Kirchhausen, Harvard Medical School, Boston, MA), polyclonals anti-CALM (C-18; Santa Cruz Biotechnology, Inc.), anti-dynamin II (C-18; Santa Cruz Biotechnology, Inc.), anti-epsin1 (R-20; Santa ...
Elevated intracellular calcium concentration increases secretory processing of the amyloid precursor protein by a tyrosine phosphorylation-dependent mechanism
Supplier
Slack Barbara E et al., In BMC Cell Biology, 1995
... CA), anti-dynamin monoclonal antibodies from BD Biosciences (San Diego, CA), goat polyclonal antibodies specific for dynamin I from Santa Cruz Biotechnology (Santa Cruz, CA), and ...
Papers on Dynamin I
Identification and function of conformational dynamics in the multidomain GTPase dynamin.
New
Schmid et al., Dallas, United States. In Embo J, Feb 2016
UNASSIGNED: Vesicle release upon endocytosis requires membrane fission, catalyzed by the large GTPase dynamin.
Dynamin is required for GnRH signaling to L-type calcium channels and activation of ERK.
New
Navratil et al., Seattle, United States. In Endocrinology, Jan 2016
It also has previously been established that a dominant negative form of the mechano-GTPase dynamin (K44A) attenuates GnRH activation of ERK.
Multiple Faces of Dynamin-related Protein 1 and Its Role in Alzheimer's Disease Pathogenesis.
Review
New
Hemachandra Reddy et al., Lubbock, United States. In Biochim Biophys Acta, Jan 2016
Recent studies suggest that amyloid beta (Aβ) and phosphorylated tau interact with the mitochondrial fission protein, dynamin-related protein 1 (Drp1), causing excessive fragmentation of mitochondria and leading to abnormal mitochondrial dynamics and synaptic degeneration in Alzheimer's disease (AD) neurons.
A high-throughput platform for real-time analysis of membrane fission reactions reveals dynamin function.
New
Impact
Pucadyil et al., India. In Nat Cell Biol, Dec 2015
Dynamin, the paradigmatic membrane fission catalyst, assembles as helical scaffolds that hydrolyse GTP to sever the tubular necks of clathrin-coated pits.
Pathophysiology of anorexia in the cancer cachexia syndrome.
Review
New
Morley et al., Saint Louis, United States. In J Cachexia Sarcopenia Muscle, Dec 2015
Dynamin is a guanosine triphosphatase that is responsible for internalization of melanocortin 4 receptors and prostaglandin receptors.
DNM3 Attenuates Hepatocellular Carcinoma Growth by Activating P53.
New
Geng et al., Tongling, China. In Med Sci Monit, Dec 2015
In our previous study, we found that the mRNA level of Dynamin3 (DNM3), a member of the Dynamin family, is significantly lower in hepatocellular carcinoma tissues than in non-tumor tissues.
Loss of Drp1 in the liver leads to an alteration in expression of the genes involved in the immune system.
New
Nomura et al., Fukuoka, Japan. In Genom Data, Dec 2015
Dynamin-related protein 1 (Drp1) is a member of the dynamin family of large GTPase, which cycles between the cytosol and the mitochondrial outer membrane, and mediates mitochondrial fission.
Crystal structure of the dynamin tetramer.
New
Impact
Eschenburg et al., Hannover, Germany. In Nature, Oct 2015
The mechanochemical protein dynamin is the prototype of the dynamin superfamily of large GTPases, which shape and remodel membranes in diverse cellular processes.
A hemi-fission intermediate links two mechanistically distinct stages of membrane fission.
New
Impact
Frolov et al., Dallas, United States. In Nature, Sep 2015
Here we analysed how the GTPase cycle of human dynamin 1, the prototypical membrane fission catalyst, is directly coupled to membrane remodelling.
[Expression of Dynamin in the cochlea of mice of different ages].
New
Yuan et al., Chongqing, China. In Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, Jul 2015
All subtypes expressed in the inner hair cell of mice, of which Dynamin-1 and 2 expressed in the whole inner hair cell in the group of young and adult.
Dynamin-related protein 1 as a therapeutic target in cardiac arrest.
Review
New
Sharp, Chicago, United States. In J Mol Med (berl), Mar 2015
New insights into mitochondrial dynamics and the role of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) in apoptosis have made targeting these mechanisms attractive for IR therapy.
Dynasore - not just a dynamin inhibitor.
Review
Sheldon et al., Swansea, United Kingdom. In Cell Commun Signal, 2014
Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells.
Membrane trafficking. Nucleoside diphosphate kinases fuel dynamin superfamily proteins with GTP for membrane remodeling.
Impact
Chavrier et al., Paris, France. In Science, 2014
Dynamin superfamily molecular motors use guanosine triphosphate (GTP) as a source of energy for membrane-remodeling events.
Regulating dynamin dynamics during endocytosis.
Review
Hinshaw et al., Bethesda, United States. In F1000prime Rep, 2013
Dynamin is a large GTPase that mediates plasma membrane fission during clathrin-mediated endocytosis.
Identification of CSPα clients reveals a role in dynamin 1 regulation.
GeneRIF
Chandra et al., New Haven, United States. In Neuron, 2012
Analysis of cysteine string protein alpha (CSPalpha)-dynamin 1 interactions reveals unexpectedly that CSPalpha regulates the polymerization of dynamin 1 in mouse hippocampal cell cultures.
Suppression of EGFR endocytosis by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane.
GeneRIF
Schlessinger et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
EGFR endocytosis suppression by dynamin depletion reveals that EGFR signaling occurs primarily at the plasma membrane
Reduced release probability prevents vesicle depletion and transmission failure at dynamin mutant synapses.
GeneRIF
De Camilli et al., New Haven, United States. In Proc Natl Acad Sci U S A, 2012
These findings reveal a mechanism aimed at preventing synaptic transmission failure due to vesicle depletion when recycling vesicle traffic is backed up by a defect in dynamin-dependent endocytosis.
Dynamin, a membrane-remodelling GTPase.
Review
Impact
De Camilli et al., New Haven, United States. In Nat Rev Mol Cell Biol, 2012
Dynamin, the founding member of a family of dynamin-like proteins (DLPs) implicated in membrane remodelling, has a critical role in endocytic membrane fission events.
A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.
Impact
GeneRIF
Dyda et al., Bethesda, United States. In Cell, 2011
Study presents the GMPPCP-bound structures of the truncated human dynamin 1 helical polymer at 12.2 A and a fusion protein, GG, linking human dynamin 1's catalytic G domain to its GTPase effector domain (GED) at 2.2 A.
Entry pathways of herpes simplex virus type 1 into human keratinocytes are dynamin- and cholesterol-dependent.
GeneRIF
Knebel-Mörsdorf et al., Köln, Germany. In Plos One, 2010
Herpes simplex virus type 1 can enter human keratinocytes by alternative entry pathways that require dynamin and host cholesterol.
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