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Dynactin 1

dynactin, p150Glued, DCTN1
This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA). [provided by RefSeq, Oct 2008] (from NCBI)
Top mentioned proteins: CD13, CAN, Actin, dynamitin, V1a
Papers on dynactin
TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.
New
Wang et al., Suzhou, China. In Embo J, Feb 2016
However, loss of TDP-43 also impaired the fusion of autophagosomes with lysosomes through dynactin 1 downregulation, leading to accumulation of immature autophagic vesicles and overwhelmed ALP function.
NuMA-microtubule interactions are critical for spindle orientation and the morphogenesis of diverse epidermal structures.
New
Lechler et al., Nashville, United States. In Elife, Feb 2016
A complex of NuMA and dynein/dynactin is required for robust spindle orientation in a number of cell types.
How dynein and dynactin transport cargos: a structural perspective.
Review
New
Urnavicius et al., Cambridge, United Kingdom. In Curr Opin Struct Biol, Feb 2016
Attention is now turning to how cytoplasmic dynein-1 and dynactin act together to carry cargos.
Acrylamide Retards the Slow Axonal Transport of Neurofilaments in Rat Cultured Dorsal Root Ganglia Neurons and the Corresponding Mechanisms.
New
Xie et al., Jinan, China. In Neurochem Res, Jan 2016
Then for the underlying mechanisms exploration, the protein level of neurofilament subunits, motor proteins kinesin and dynein, and dynamitin subunit of dynactin in DRG neurons were assessed by western blotting and the concentrations of ATP was detected using ATP Assay Kit.
Cell adhesion molecule control of planar spindle orientation.
Review
New
Ebnet et al., Münster, Germany. In Cell Mol Life Sci, Jan 2016
The orientation of the spindle apparatus is regulated by the immobilization of the astral microtubules at the lateral cortex and depends on the precise localization of the dynein-dynactin motor protein complex which captures microtubule plus ends and generates pulling forces towards the centrosomes.
Mutation analysis of genes within the dynactin complex in a cohort of hereditary peripheral neuropathies.
New
Kennerson et al., Kuala Lumpur, Malaysia. In Clin Genet, Jan 2016
The cytoplasmic dynein heavy chain (DYNC1H1) gene has been implicated in various neurodegenerative disorders, and dynactin 1 (DCTN1) genes have been implicated in a wide spectrum of disorders including motor neuron disease, Parkinson's disease, spinobulbar muscular atrophy and hereditary spastic paraplegia.
Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy.
New
Polenova et al., Newark, United States. In Proc Natl Acad Sci U S A, Dec 2015
Here, we report a structure of the cytoskeleton-associated protein glycine-rich (CAP-Gly) domain of dynactin motor on polymeric microtubules, solved by magic angle spinning NMR spectroscopy.
Cytoplasmic dynein and early endosome transport.
Review
New
Zhang et al., Bethesda, United States. In Cell Mol Life Sci, Sep 2015
Early endosomes represent a major cargo of dynein in filamentous fungi, and dynein regulators such as LIS1 and the dynactin complex are both required for early endosome movement.
Mitochondrial dynamics and inherited peripheral nerve diseases.
Review
New
Piscosquito et al., Milano, Italy. In Neurosci Lett, Jul 2015
Indeed, mitochondrial transport involves directly or indirectly components of the kinesin superfamily (KIF5A, KIF1A, KIF1B), responsible of anterograde transport, and of the dynein complex and related proteins (DYNC1H1, dynactin, dynamin-2), implicated in retrograde flow.
The structure of the dynactin complex and its interaction with dynein.
New
Impact
Carter et al., Cambridge, United Kingdom. In Science, Apr 2015
Dynactin is an essential cofactor for the microtubule motor cytoplasmic dynein-1.
Autoregulatory mechanism for dynactin control of processive and diffusive dynein transport.
Impact
Gross et al., Irvine, United States. In Nat Cell Biol, 2014
The latter function was thought to involve the N-terminal microtubule-binding region of the major dynactin polypeptide p150(Glued), although recent results disputed this.
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders.
Review
Hoogenraad et al., Rotterdam, Netherlands. In Front Neurosci, 2014
Mutations in dynein and its regulatory factors, including the dynactin subunit p150Glued, BICD2 and Lis-1, are associated with several human nervous system disorders, including cortical malformation and motor neuropathy.
Influenza A virus uses the aggresome processing machinery for host cell entry.
Impact
Yamauchi et al., Zürich, Switzerland. In Science, 2014
That other components of the aggresome processing machinery, including dynein, dynactin, and myosin II, were also required suggested that physical forces generated by microtubule- and actin-associated motors are essential for IAV entry.
Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein.
Impact
Surrey et al., London, United Kingdom. In Nat Cell Biol, 2014
Using a total internal reflection fluorescence microscopy-based reconstitution assay, we found that a hierarchical recruitment mode targets the large dynactin subunit p150Glued to growing microtubule ends via EB1 and CLIP-170 in the presence of competing SxIP-motif-containing peptides.
Activation of cytoplasmic dynein motility by dynactin-cargo adapter complexes.
Impact
Vale et al., San Francisco, United States. In Science, 2014
The dynactin protein complex is important for dynein activity in vivo, but its precise role has been unclear.
Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells.
GeneRIF
Alwine et al., Philadelphia, United States. In Genes Dev, 2012
mTORC1 activation requires dynein-dependent transport to a position in the cell where it can be activated
A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis.
GeneRIF
Watanabe et al., Tokyo, Japan. In J Cell Biol, 2012
It was shown KASH5 possesses hitherto unknown KASH-related sequences that directly interacted with SUN1 and mediated telomere localization. KASH5 interacted with the microtubule-associated dynein- dynactin complex.
Cooperative effect of p150Glued and microtubule stabilization to suppress excitotoxicity-induced axon degeneration.
GeneRIF
Morimoto et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2012
overexpression of p150Glued, a major component of the dynactin complex, and microtubule stabilization cooperatively suppress axon degeneration.
The p150(Glued) CAP-Gly domain regulates initiation of retrograde transport at synaptic termini.
GeneRIF
Kolodkin et al., Baltimore, United States. In Neuron, 2012
The p150(Glued) CAP-Gly domain regulates dynein-mediated retrograde transport at synaptic termini, and this function of dynactin is disrupted by a mutation that causes motor neuron disease.
Multiple modes of cytoplasmic dynein regulation.
Impact
GeneRIF
Ori-McKenney et al., New York City, United States. In Nat Cell Biol, 2012
Studies indicate that binding of dynactin, LIS1 and NudEL regulate cytoplasmic dynein motor activity.
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