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Dishevelled, dsh homolog 3

DVL3, Dishevelled-3
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PKI, Dvl2, V1a, Frizzled, ACID
Papers using DVL3 antibodies
Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
Hynes Nancy E et al., In Breast Cancer Research : BCR, 2004
... The following primary antibodies were used: c-Myc (9E10, to detect Myc-tagged protein), DVL2 and DVL3 (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, ...
Cdc42 and noncanonical Wnt signal transduction pathways cooperate to promote cell polarity
Hall Alan et al., In The Journal of Cell Biology, 2003
... used: mouse anti-Dvl1, rabbit anti-Dvl2 (used for Western blot), mouse anti-Dvl2 (used for immunoprecipitation), mouse anti-Dvl3, rabbit anti-aPKC, (Santa Cruz Biotechnology, Inc.), rabbit anti-axin (Zymed ...
Involvement of protein phosphatase 2A in the interleukin-3-stimulated Jak2-Stat5 signaling pathway
Malbon Craig C et al., In Journal of Molecular Signaling, 2000
... The following reagents were purchased from the indicated commercial supplier(s): anti-Dvl1, Dvl2 and Dvl3 antibodies from Santa Cruz Biotechnology (Santa Cruz, CA); anti-GSK3β ...
Papers on DVL3
The microRNA-29 family in cartilage homeostasis and osteoarthritis.
Clark et al., Farmington, United States. In J Mol Med (berl), Jan 2016
Amongst these, FZD3, FZD5, DVL3, FRAT2, and CK2A2 were validated as direct targets of the miR-29 family.
Dysregulation of Wnt-signaling and a candidate set of miRNAs underlie the effect of metformin on neural crest cell development.
Pal et al., Bengaluru, India. In Stem Cells, Dec 2015
We then revealed that metformin impedes Wnt axis, a major signaling pathway active during NC formation via DVL-3 inhibition and impairment in nuclear translocation of β-catenin.
Remarkable impairment of Wnt/β-catenin signaling in the brains of the mice infected with scrapie agents.
Dong et al., Hangzhou, China. In J Neurochem, Dec 2015
We also observed slightly decreased Wnt-3 and unchanged Dishevelled-3 (Dvl-3) in the brains of the infected mice.
Hematopoietic cyclooxygenase-2 deficiency increases adipose tissue inflammation and adiposity in obesity.
Saraswathi et al., Omaha, United States. In Obesity (silver Spring), Oct 2015
Wnt signaling markers which inhibit adipogenesis, including Wnt3A and DVL3, were reduced, and Wnt5a/b which promotes inflammation was increased in the VAT and/or adipocytes.
Identification of carcinogenic potential-associated molecular mechanisms in CD133(+) A549 cells based on microRNA profiles.
Yan et al., Wenzhou, China. In Tumour Biol, Sep 2015
Besides, for CSC property-related signaling pathways, six miRNAs (hsa-miR-1246, -15b-5p, -30b-5p, -3197, -4734, and -7110-5p) were dramatically enriched in Hedgehog, Notch, and Wnt signaling pathways via regulating 108 target genes (e.g., DVL1, DVL3, WNT3A, and WNT5A).
miR-204-5p promotes the adipogenic differentiation of human adipose-derived mesenchymal stem cells by modulating DVL3 expression and suppressing Wnt/β-catenin signaling.
Mo et al., Changsha, China. In Int J Mol Med, Jun 2015
We then used bioinformatics tools and luciferase reporter assay to establish that dishevelled segment polarity protein 3 (DVL3), a key regulator of the Wnt/β-catenin signaling pathway, is a direct target of miR-204-5p.
Dishevelled-3 activates p65 to upregulate p120-catenin transcription via a p38-dependent pathway in non-small cell lung cancer.
Wang et al., China. In Mol Carcinog, Jun 2015
Dishevelled-3 (Dvl-3) and p120-catenin (p120ctn) have abnormal expression in non-small cell lung cancer (NSCLC), which is associated with poor prognosis.
Gene expression in major depressive disorder.
Sullivan et al., Amsterdam, Netherlands. In Mol Psychiatry, Jun 2015
Comparisons of gene expression results to the Psychiatric Genomics Consortium (PGC) MDD genome-wide association study results revealed overlap with DVL3.
Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.
Schulte et al., Stockholm, Sweden. In J Biol Chem, Apr 2015
Surprisingly, different WNT-FZD pairs showed differential effects on phosphorylation of DVL2 and DVL3, revealing a previously unappreciated DVL isoform selectivity by different WNT-FZD pairs in 32D cells.
Dsh homolog DVL3 mediates resistance to IGFIR inhibition by regulating IGF-RAS signaling.
Macaulay et al., Oxford, United Kingdom. In Cancer Res, 2014
In this study, we used genetic screening and downstream validation to identify the WNT pathway element DVL3 as a mediator of resistance to IGFIR inhibition.
Functional analysis of dishevelled-3 phosphorylation identifies distinct mechanisms driven by casein kinase 1ϵ and frizzled5.
Bryja et al., Brno, Czech Republic. In J Biol Chem, 2014
Dishevelled-3 (Dvl3), a key component of the Wnt signaling pathways, acts downstream of Frizzled (Fzd) receptors and gets heavily phosphorylated in response to pathway activation by Wnt ligands.
Effect of Arctium lappa (burdock) extract on canine dermal fibroblasts.
Colitti et al., Udine, Italy. In Vet Immunol Immunopathol, 2014
The expression profile of canine dermal fibroblasts treated with burdock extract with or without H2O2 stimulation, showed an up-regulation of mitochondrial superoxide dismutase (SOD2), disheveled 3 (DVL3) and chondroitin sulfate N-acetylgalactosaminyltransferase 2 (CSGALNACT2).
Brain metastases from lung cancer show increased expression of DVL1, DVL3 and beta-catenin and down-regulation of E-cadherin.
Pećina-Šlaus et al., Zagreb, Croatia. In Int J Mol Sci, 2013
In the present study, 31 brain metastases that originated from primary lung carcinomas were analyzed regarding over expression of Dishevelled-1 (DVL1), Dishevelled-3 (DVL3), E-cadherin (CDH1) and beta-catenin (CTNNB1).
Expression of dishevelled gene in Hirschsprung's disease.
Gao et al., China. In Int J Clin Exp Pathol, 2012
In this study, we explore the cause of HSCR by studying the expression of DVL-1 and DVL-3 genes and their proteins in the aganglionic segment and the ganglionic segment of colon in HSCR patients.
Delicate analysis of post-translational modifications on Dishevelled 3.
Zeng et al., Shanghai, China. In J Proteome Res, 2012
Identification of novel post translational modifications of DVL3 by liquid chromatography coupled LTQ-Orbitrap analysis.
Rac1b recruits Dishevelled and β-catenin to Wnt target gene promoters independent of Wnt3A stimulation.
Bapat et al., Toronto, Canada. In Int J Oncol, 2011
In HEK293T cells with intact Wnt signaling, Rac1b is tethered to these same gene promoters independent of Wnt3A stimulation and is further observed to recruit Dishevelled and beta-catenin in the absence of Wnt3A stimulation.
The functions of maternal Dishevelled 2 and 3 in the early Xenopus embryo.
Heasman et al., Cincinnati, United States. In Dev Dyn, 2011
Data show that maternal Dvl2 and 3 are required for convergence extension movements downstream of the dorsally localized signaling pathway activated by Xnr3, but not downstream of the pathway activated by activin.
Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA.
Malbon et al., Stony Brook, United States. In J Cell Sci, 2010
Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability.
Helicobacter pylori-induced activation of beta-catenin involves low density lipoprotein receptor-related protein 6 and Dishevelled.
Naumann et al., Magdeburg, Germany. In Mol Cancer, 2009
The canonical Wnt-signaling proteins LRP6 and Dvl2 and Dvl3 are involved in the regulation of beta-catenin.
WNT/PCP signaling pathway and human cancer (review).
Katoh, Tokyo, Japan. In Oncol Rep, 2005
Human VANGL1, VANGL2 (Van Gogh homologs), CELSR1, CELSR2, CELSR3 (Starry night homologs), DVL1, DVL2, DVL3 (Dishevelled homologs), PRICKLE1, PRICKLE2 (Prickle homologs), and ANKRD6 (Diego homolog) are core PCP signaling molecules.
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