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Dishevelled, dsh homolog 2

Dvl2, Dishevelled-2
This gene encodes a member of the dishevelled (dsh) protein family. The vertebrate dsh proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. This gene encodes a 90-kD protein that undergoes posttranslational phosphorylation to form a 95-kD cytoplasmic protein, which may play a role in the signal transduction pathway mediated by multiple Wnt proteins. The mechanisms of dishevelled function in Wnt signaling are likely to be conserved among metazoans. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: PKI, DVL3, Wnt3a, V1a, Frizzled
Papers using Dvl2 antibodies
Mutation of Tyr307 and Leu309 in the protein phosphatase 2A catalytic subunit favors association with the alpha 4 subunit which promotes dephosphorylation of elongation factor-2
Malbon Craig C et al., In Journal of Molecular Signaling, 1998
... The following reagents were purchased from the indicated commercial supplier(s): anti-Dvl2 and SV40 anti-small t antigen antibodies were from Santa Cruz Biotechnology (Santa Cruz, CA); anti-GSK3β ...
Radiation survival parameters of antineoplastic drug-sensitive and -resistant human ovarian cancer cell lines and their modification by buthionine sulfoximine.
Abraham Edathara, In PLoS ONE, 1984
... Human DVL2 and β-catenin expression vectors were obtained from Origene (Rockville, MD) ...
Papers on Dvl2
A multicentric association study between 39 genes and nonsyndromic cleft lip and palate in a Brazilian population.
Gil-da-Silva-Lopes et al., Campinas, Brazil. In J Craniomaxillofac Surg, Jan 2016
RESULTS: Twenty-four SNPs in 16 genes were significantly associated with the etiology of NSCLP, including MSX1, SPRY1, MSX2, PRSS35, TFAP2A, SHH, VAX1, TBX10, WNT11, PAX9, BMP4, JAG2, AXIN2, DVL2, KIF7, and TCBE3.
Age-related neuroinflammation and changes in AKT-GSK-3β and WNT/ β-CATENIN signaling in rat hippocampus.
Scavone et al., São Paulo, Brazil. In Aging (albany Ny), Jan 2016
Aging also seems to induce a progressive decrease in canonical WNT/β-CATENIN signaling pathway once there is a decrease in DVL-2 levels and in the transcription ofAxin2 gene.
Upregulated PFTK1 promotes tumor cell proliferation, migration, and invasion in breast cancer.
Yang et al., Nantong, China. In Med Oncol, Jul 2015
Here, we first discovered and confirmed that cyclin B was a new interacting protein of PFTK1, and the complex might increase the amount of DVL2, which triggers Wnt/β-catenin signaling pathway.
Dichotomy of Genetic Abnormalities in PEComas With Therapeutic Implications.
Antonescu et al., New York City, United States. In Am J Surg Pathol, Jun 2015
Combined RNA sequencing and fluorescence in situ hybridization analysis identified 9 (23%) TFE3 gene-rearranged tumors, with 3 cases showing an SFPQ/PSF-TFE3 fusion and 1 case showing a novel DVL2-TFE3 gene fusion.
The Wnt Signaling Antagonist Dapper1 Accelerates Dishevelled2 Degradation via Promoting Its Ubiquitination and Aggregate-induced Autophagy.
Chen et al., Beijing, China. In J Biol Chem, Jun 2015
Here, we show that Dpr1 promotes the von Hippel-Lindau tumor suppressor (VHL)-mediated ubiquitination of Dvl2 and its autophagic degradation.
The Tumor-Suppressor WWOX and HDAC3 Inhibit the Transcriptional Activity of the β-Catenin Coactivator BCL9-2 in Breast Cancer Cells.
Lallemand et al., Paris, France. In Mol Cancer Res, May 2015
UNLABELLED: The WW domain containing oxidoreductase (WWOX) has recently been shown to inhibit of the Wnt/β-catenin pathway by preventing the nuclear import of disheveled 2 (DVL2) in human breast cancer cells.
Systematic mapping of WNT-FZD protein interactions reveals functional selectivity by distinct WNT-FZD pairs.
Schulte et al., Stockholm, Sweden. In J Biol Chem, Apr 2015
Surprisingly, different WNT-FZD pairs showed differential effects on phosphorylation of DVL2 and DVL3, revealing a previously unappreciated DVL isoform selectivity by different WNT-FZD pairs in 32D cells.
Expression patterns of dishevelled-2 in different colon tissue segments in Hirschsprung's disease.
Gao et al., China. In Mol Med Report, Mar 2015
Hirschsprung's disease (HSCR) is a congenital disorder characterized by an absence of enteric ganglion cells in the terminal regions of the gut during development.
Dosage changes of a segment at 17p13.1 lead to intellectual disability and microcephaly as a result of complex genetic interaction of multiple genes.
Lupski et al., Houston, United States. In Am J Hum Genet, 2014
Dissection of this phenotype in zebrafish embryos revealed a complex genetic architecture: dosage perturbation of four genes (ASGR1, ACADVL, DVL2, and GABARAP) impeded neurodevelopment and decreased dosage of the same loci caused a reduced mitotic index in vitro.
Kirenol stimulates osteoblast differentiation through activation of the BMP and Wnt/β-catenin signaling pathways in MC3T3-E1 cells.
Hwang et al., Seoul, South Korea. In Fitoterapia, 2014
The effects of kirenol on osteoblast differentiation were accompanied by stimulating the expression of the BMP and Wnt/β-catenin signaling pathways, including BMP2, runt-related transcription factor 2 (Runx2), osterix (Osx), low density lipoprotein receptor related protein 5 (LRP5), disheveled 2 (DVL2), β-catenin, cyclin D1 (CCND1), and phosphorylated glycogen synthase kinase 3β (GSK3β).
DNA methylation status of a distinctively different subset of genes is associated with each histologic Lauren classification subtype in early gastric carcinogenesis.
Cho et al., Wŏnju, South Korea. In Oncol Rep, 2014
In PA using 12 selected genes from the IIMA results, the aberrant methylation statuses of DVL2 (p=0.0186) and ETS1 (p=0.0222) were significantly related to diffuse- and mixed-types rather than the intestinal-type, while C19orf35 (p=0.019) and CNRIP1 (p=0.0473) were related to the diffuse‑type rather than intestinal‑type, and GAL3ST2 (p=0.0158) and ITGA3 (p=0.0273) were related to the mixed-type rather than the other two types.
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis.
Cordes et al., Toronto, Canada. In Nature, 2013
Gumby interacts with disheveled 2 (DVL2), is expressed in canonical Wnt-responsive endothelial cells and encodes an ovarian tumour domain class of deubiquitinase that specifically cleaves linear ubiquitin linkages.
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.
Dixit et al., San Francisco, United States. In Science, 2013
RIPK4 interacted constitutively with the adaptor protein DVL2 and, after Wnt3a stimulation, with the co-receptor LRP6.
The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.
Chandrasekhar et al., Columbia, United States. In Dev Biol, 2012
loss of Dvl2 function in Vangl2(Lp/+) embryos did not exacerbate the Vangl2(Lp/+) neuronal migration phenotype
Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Lee et al., Bethesda, United States. In Embo J, 2012
Identification of a novel Wnt5a-CK1varepsilon-Dvl2-Plk1-mediated primary cilia disassembly pathway.
Wnt5a-Ror-Dishevelled signaling constitutes a core developmental pathway that controls tissue morphogenesis.
Greenberg et al., Boston, United States. In Proc Natl Acad Sci U S A, 2012
These findings suggest that Wnt5a-Ror-Dishevelled signaling constitutes a core noncanonical Wnt pathway that is conserved through evolution and is crucial during embryonic development.
Malin regulates Wnt signaling pathway through degradation of dishevelled2.
Jana et al., Gurgaon, India. In J Biol Chem, 2012
Our results indicate that malin regulates Wnt signaling pathway through the degradation of dishevelled2 and suggest possible deregulation of Wnt signaling in Lafora disease.
Dvl2-dependent activation of Daam1 and RhoA regulates Wnt5a-induced breast cancer cell migration.
Gu et al., Nanjing, China. In Plos One, 2011
Wnt5a promotes breast cancer cell migration via Dvl2/Daam1/RhoA.
WNT/PCP signaling pathway and human cancer (review).
Katoh, Tokyo, Japan. In Oncol Rep, 2005
Human VANGL1, VANGL2 (Van Gogh homologs), CELSR1, CELSR2, CELSR3 (Starry night homologs), DVL1, DVL2, DVL3 (Dishevelled homologs), PRICKLE1, PRICKLE2 (Prickle homologs), and ANKRD6 (Diego homolog) are core PCP signaling molecules.
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway.
Chen et al., San Diego, United States. In Nat Genet, 2005
Furthermore, parallel to the homologous pathway in Drosophila melanogaster, a mammalian PCP component Dishevelled2 shows PCP-dependent polarized subcellular localization across the organ of Corti.
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