Novel developments in the use of antimetabolites.
Amsterdam, Netherlands. In Nucleosides Nucleotides Nucleic Acids, 2013
The cytidine-analog fluorocyclopentenylcytosine (RX-3117) is active in gemcitabine-resistant tumors and is activated by uridine-cytidine-kinase, can be incorporated into RNA and DNA and can downregulate DNA-methyltransferase-1. TAS-114 is a new generation dUTPase inhibitor.
DNA repair in Mycobacterium tuberculosis revisited.
Paris, France. In Fems Microbiol Rev, 2009
Novel characteristics of the M. tuberculosis DNA repair machinery have been found over the last decade, such as nonhomologous end joining, the presence of Mpg, ERCC3 and Hlr - proteins previously presumed to be produced exclusively in mammalian cells - and the recently discovered bifunctional dCTP deaminase:dUTPase.
Herpes simplex virus DNA replication.
Newark, United States. In Annu Rev Biochem, 1996
These enzymes include a deoxyuridine triphosphatase, a ribonucleotide reductase, a thymidine kinase, an alkaline endo-exonuclease, and a uracil-DNA glycosylase.
Crystal structure of a dUTPase.
Stockholm, Sweden. In Nature, 1992
The enzyme dUTPase catalyses the hydrolysis of dUTP and maintains a low intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
The incorporation of uracil into animal cell DNA in vitro.
In Cell, 1978
The high levels of dUTPase as well as the presence of RNA primers on most nascent DNA pieces (Tseng and Goulian, 1977) suggest that repair of uracil-containing DNA does not contribute to the generation of the small, nascent DNA pieces found during DNA synthesis in this in vitro system.