Molecular Pathogenesis of Peripheral T Cell Lymphoma.
Tsukuba, Japan. In Curr Hematol Malig Rep, Dec 2015
For example, genetic alterations have been discovered, including signal transducer and activator of transcription (STAT)3 and STAT5b mutations in several PTCLs, disease-specific ras homolog family member A (RHOA) mutations in angioimmunoblastic T cell lymphoma (AITL), and recurrent translocations at the dual specificity phosphatase 22 (DUSP22) locus in anaplastic lymphoma receptor tyrosine kinase (ALK)-negative anaplastic large cell lymphomas (ALCLs).
The biology and management of systemic anaplastic large cell lymphoma.
Vancouver, Canada. In Blood, Aug 2015
However, emerging data now highlight that ALK- ALCL is genetically and clinically heterogeneous with a subset having either a DUSP22 translocation and a survival rate similar to ALK+ ALCL or a less common P63 translocation, the latter associated with an aggressive course.
New biomarkers in T-cell lymphomas.
Liège, Belgium. In Best Pract Res Clin Haematol, 2012
Previously unrecognized gene rearrangements are being discovered (ITK-SYK translocation, IRF4/MUM1 and DUSP22 rearrangements), and may serve as diagnostic genetic markers.