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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Dual oxidase 2

DUOX2, nicotinamide adenine dinucleotide phosphate oxidase, dual oxidase 2, THOX2
The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Ros, V1a, Duox1, CAN, HAD
Papers on DUOX2
DUOX2 Mutations Are Frequently Associated With Congenital Hypothyroidism in the Korean Population.
New
Kim et al., Seoul, South Korea. In Ann Lab Med, Mar 2016
All coding exons of TSHR, PAX8, TPO, DUOX2, DUOXA2, and SCL5A5 were sequenced.
Natural course of congenital hypothyroidism by dual oxidase 2 mutations from the neonatal period through puberty.
New
Takeuchi et al., Niigata, Japan. In Eur J Endocrinol, Feb 2016
OBJECTIVE: We previously reported that biallelic mutations in dual oxidase 2 (DUOX2) cause transient hypothyroidism.
Statins and oxidative stress in chronic heart failure.
New
Sousa et al., Porto, Portugal. In Rev Port Cardiol, Feb 2016
By regulating several molecular pathways that control nicotinamide adenine dinucleotide phosphate oxidase and endothelial nitric oxide synthase activity, statins help restore redox homeostasis.
Novel c.554+5C>T Mutation in the DUOXA2 gene Combinated with p.R885Q Mutation in the DUOX2 Gene Causes Congenital Hypothyroidism.
New
Shao et al., In J Clin Res Pediatr Endocrinol, Jan 2016
OBJECTIVE: The coexistence of mutations in the dual oxidase maturation factor 2 (DUOXA2) and dual oxidase 2 (DUOX2) genes is rarely identified in congenital hypothyroidism (CH).
Genetic disorders coupled to ROS deficiency.
Review
New
Knaus et al., Dublin, Ireland. In Redox Biol, Dec 2015
More recently, additional diseases have been linked to functionally altered variants in genes encoding for other NADPH oxidases, such as for DUOX2/DUOXA2 in congenital hypothyroidism, or for the Nox2 complex, NOX1 and DUOX2 as risk factors for inflammatory bowel disease.
The human Nox4: gene, structure, physiological function and pathological significance.
Review
New
Chen et al., Aomen, Macao. In J Drug Target, Dec 2015
Nox4, one of the seven members of Nox family (Nox1, Nox2, Nox3, Nox4, Nox5, Duox1 and Duox2), has been extensively investigated in recent years.
Genomics and phenomics of Hashimoto's thyroiditis in children and adolescents: a prospective study from Southern India.
New
Aparna Varma et al., Hyderābād, India. In Ann Transl Med, Nov 2015
In this context, we analysed the prevalence of TPO, NIS and DUOX2 gene mutations along with genotype-phenotype correlations in hypothyroid children with HT.
Blood flow modulation of vascular dynamics.
Review
New
Hsiai et al., Los Angeles, United States. In Curr Opin Lipidol, Oct 2015
Atheroprotective PSS promotes antioxidant, anti-inflammatory and antithrombotic responses, whereas atherogenic oscillatory shear stress induces nicotinamide adenine dinucleotide phosphate oxidase-JNK signalling to increase mitochondrial superoxide production, protein degradation of manganese superoxide dismutase and post-translational protein modifications of LDL particles in the disturbed flow-exposed regions of vasculature.
The blood-brain barrier endothelium: a target for pro-inflammatory cytokines.
Review
New
Cummins et al., Dublin, Ireland. In Biochem Soc Trans, Sep 2015
The mechanistic role of nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase)-induced oxidative stress in these events will also be addressed.
ANIMAL PHYSIOLOGY. Exceptionally low daily energy expenditure in the bamboo-eating giant panda.
New
Impact
Wei et al., Beijing, China. In Science, Aug 2015
A giant panda-unique mutation in the DUOX2 gene, critical for thyroid hormone synthesis, might explain these low thyroid hormone levels.
Role of Reactive Oxygen Species in the Abrogation of Oxaliplatin Activity by Cetuximab in Colorectal Cancer.
New
Hochhauser et al., London, United Kingdom. In J Natl Cancer Inst, Jun 2015
Chromatin immunoprecipitation (ChIP) measured signal transducer and activator of transcription 1 (STAT-1) binding to dual oxidase 2 (DUOX2) promoter.
Organ-Protective Effects of Red Wine Extract, Resveratrol, in Oxidative Stress-Mediated Reperfusion Injury.
Review
Yu et al., Taiwan. In Oxid Med Cell Longev, 2014
Such protective phenomenon is reported to be implicated in decreasing the formation and reaction of reactive oxygen species and pro-nflammatory cytokines, as well as the mediation of a variety of intracellular signaling pathways, including the nitric oxide synthase, nicotinamide adenine dinucleotide phosphate oxidase, deacetylase sirtuin 1, mitogen-activated protein kinase, peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, hemeoxygenase-1, and estrogen receptor-related pathways.
A Resource for the Transcriptional Signature of Bona Fide Trophoblast Stem Cells and Analysis of Their Embryonic Persistence.
Arnold et al., Freiburg, Germany. In Stem Cells Int, 2014
Analyses by qRT-PCR and in situ hybridisation validated novel TSC- and chorion-specific marker genes, such as Bok/Mtd, Cldn26, Duox2, Duoxa2, Nr0b1, and Sox21.
Dual oxidase 2 is essential for the toll-like receptor 5-mediated inflammatory response in airway mucosa.
GeneRIF
Yoon et al., Seoul, South Korea. In Antioxid Redox Signal, 2012
DUOX2 plays pivotal roles in TLR5-dependent inflammatory response of nasal airway epithelium.
NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.
GeneRIF
Yuan et al., Guangzhou, China. In Tumour Biol, 2011
Data show that comparing with adjacent non-neoplastic tissues, DUOX1, DUOX2, and NOX4 were expressed at higher frequencies in tumor specimens.
Reactive oxygen species regulate the levels of dual oxidase (Duox1-2) in human neuroblastoma cells.
GeneRIF
Avvedimento et al., Napoli, Italy. In Plos One, 2011
study reports DUOX 1 and 2 are expressed in neuroblastoma SK-N-BE cells as well as in an oligodendrocyte cell line (MO3-13); data unravel a novel mechanism of regulation of DUOX enzymes by reactive oxygen species and identify a circuitry linking NADPH oxidase activity to DUOX1 and 2 levels in neuroblastoma cells
Structural stability and heme binding potential of the truncated human dual oxidase 2 (DUOX2) peroxidase domain.
GeneRIF
Ortiz de Montellano et al., San Francisco, United States. In Arch Biochem Biophys, 2011
As was shown for DUOX1, the truncated DUOX2 domain purifies without a bound heme co-factor and displays no peroxidase activity. However, DUOX2(1-599) displays greater stability than DUOX1(1-593).
Identification and functional analysis of novel dual oxidase 2 (DUOX2) mutations in children with congenital or subclinical hypothyroidism.
GeneRIF
Tonacchera et al., Pisa, Italy. In J Clin Endocrinol Metab, 2011
Two new mutations (Y1150C and A728T) and the deletion S965FsX994 were responsible for the deficit in the organification process and the phenotypes and three polymorphisms (H678R, P982A, and R701Q) were identified.
The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology.
Review
Impact
Krause et al., Genève, Switzerland. In Physiol Rev, 2007
Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2.
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.
Impact
Ris-Stalpers et al., Amsterdam, Netherlands. In N Engl J Med, 2002
The DNA of the patients and their relatives was analyzed for mutations in the genes for thyroid oxidase 1 (THOX1 ) and 2 (THOX2 ).
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