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Dystrobrevin, beta

DTNB
This gene encodes dystrobrevin beta, a component of the dystrophin-associated protein complex (DPC). The DPC consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and dystrobrevin alpha and beta. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin beta is thought to interact with syntrophin and the DP71 short form of dystrophin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, CAN, HAD, OUT, Thioredoxin
Papers using DTNB antibodies
Activation and inhibition of soluble guanylyl cyclase by S-nitrosocysteine: involvement of amino acid transport system L
Supplier
Arai Takao et al., In Oxidative Medicine and Cellular Longevity, 2008
... 5,5′-Dithiobis(2-nitrobenzoic acid) (DTNB) and mercury (II) chloride (HgCl2) were purchased from Wako Chemicals (Osaka, Japan) ...
Pharmacological studies of alcohol susceptability and brain monoamine function in stroke-prone spontaneously hypertensive rats (SHRSP) and stroke-resistant spontaneously hypertensive rats (SHRSR)
Supplier
Mitcheva Mitka et al., In Interdisciplinary Toxicology, 2002
... 2,2′-dinitro-5,5′dithiodibenzoic acid (DTNB), K2HPO4 and NaH2PO4×2H2O were obtained from MERCK (Germany).
Immunotoxin resistance in multidrug resistant cells
Supplier
Howell Stephen B. et al., In Cancer Chemotherapy and Pharmacology, 2002
... ester (BAADT) were purchased from Alexis Biochemicals (San Diego, CA) and 5-,5′-dithiobis (2-nitro benzoic acid) (DTNB, Ellman’s reagent) from Thermo Scientific.
Reaction of protein sulfhydryl groups with Ellman's reagent.
Supplier
Xue Bin, In PLoS ONE, 1971
... Ammonium acetate and 5,5′-dithiobis-(2-nitrobenzoic acid) (DTNB) were from Merck, and H ...
Papers on DTNB
A thiol fluorescent probe reveals the intricate modulation of cysteine's reactivity by Cu(II).
New
Hu et al., Beijing, China. In Talanta, Feb 2016
In contrast, Cu(II) could only partially inhibit the reaction between Cys and Ellman's reagent (DTNB).
Highly narrow nanogap-containing Au@Au core-shell SERS nanoparticles: size-dependent Raman enhancement and applications in cancer cell imaging.
New
He et al., Shanghai, China. In Nanoscale, Jan 2016
The well controlled distribution of Raman reporter molecules, such as 4,4'-dipyridyl (44DP) and 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB), are readily encoded in the nanogap and can generate strong, reproducible SERS signals.
Relationship between Caffeine and Levels of DNA Repair and Oxidative Stress in Women with and without a BRCA1 Mutation.
New
Kotsopoulos et al., Toronto, Canada. In J Nutrigenet Nutrigenomics, Jan 2016
The thiobarbituric acid-malondialdehyde and DTNB assays were used to estimate serum lipid peroxidation (µmol/l) and protein oxidation (µmol/l), respectively.
Magnetic-optical nanohybrids for targeted detection, separation, and photothermal ablation of drug-resistant pathogens.
New
Hamme Ii et al., Jackson, United States. In Analyst, Jan 2016
A Raman tag 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) generated a Raman signal upon 670 nm laser excitation enabling the detection and quantification of E. coli concentration with a limit of detection of 10(2) CFU mL(-1) and a linear logarithmic response range of 1.0 × 10(2) to 1.0 × 10(7) CFU mL(-1).
A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y).
New
Liu et al., Laurel, United States. In J Pharmacol Toxicol Methods, Nov 2015
A common absorbance-based AChE activity assay that uses 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) can have limited sensitivity and be prone to interference.
A novel detergent-stable solvent-tolerant serine thiol alkaline protease from Streptomyces koyangensis TN650.
New
Jaouadi et al., Sfax, Tunisia. In Int J Biol Macromol, Aug 2015
The results showed that this protease was completely inhibited by phenylmethanesulfonyl fluoride (PMSF), diiodopropyl fluorophosphates (DFP), and partially inhibited by 5,5-dithio-bis-(2-nitro benzoic acid) (DTNB), which strongly suggested its belonging to the serine thiol protease family.
Molecular cloning and characterization of Fasciola gigantica thioredoxin-glutathione reductase.
New
Chaithirayanon et al., Bangkok, Thailand. In Parasitol Res, Jun 2015
The rFgTGR exhibited specific activities in the 5,5'-dithiobis (2-nitro-benzoic acid) (DTNB) reductase assay for TR activity and in β-hydroxyethul disulfide (HED) for Grx activity.
Poststroke depression as a factor adversely affecting the level of oxidative damage to plasma proteins during a brain stroke.
Saluk et al., Łódź, Poland. In Oxid Med Cell Longev, 2014
Additionally, we checked differences in proteins thiol groups by spectrophotometric assay based on reaction between DTNB and thiols.
Single dose effect of diazinon on biochemical parameters in testis tissue of adult rats and the protective effect of vitamin E.
Mohammdzadeh et al., Mashhad, Iran. In Iran J Reprod Med, 2014
The amount of MDA was determined by the thiobarbituric acid assay and 5, 5-Dithio-bis (2nitrobenzoic acid) DTNB-recycling protocol was used for GSH assay.
Cholinesterase assay by an efficient fixed time endpoint method.
Estévez et al., Alacant, Spain. In Methodsx, 2013
In these methods, the chromogen reagent 5,5'dithiobis nitro benzoic acid (DTNB) is added with the substrate and colour is monitored.
Recent advances in the development of thioredoxin reductase inhibitors as anticancer agents.
Review
Zhao et al., Jinan, China. In Curr Drug Targets, 2012
Besides the reduction of some protein disulfide like Trx, TrxR still has a broad substrate specificity to reduce some small molecules like 5, 5 '-dithiobis-2- nitrobenzoic acid (DTNB).
The interaction with HMG20a/b proteins suggests a potential role for beta-dystrobrevin in neuronal differentiation.
GeneRIF
Macioce et al., Roma, Italy. In J Biol Chem, 2010
beta-dystrobrevin interacts with the HMG20 proteins iBRAF and BRAF35
Measurement of ligand binding to tubulin by sulfhydryl reactivity.
Review
Sackett et al., Bethesda, United States. In Methods Cell Biol, 2009
5',5'-Dithiobis(2-nitrobenzoate) (DTNB) reacts with free and accessible sulfhydryls and stoichiometrically produces a detectable product, which allows an exact measurement of reacted thiols.
The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder.
Review
Folsom et al., Minneapolis, United States. In Biochem Soc Trans, 2009
A number of genes associated with bipolar disorder, including Comt (catechol-O-methyltransferase), Vapa (vesicle-associated membrane protein-associated protein A), Dtnb (dystrobrevin beta) and Pkd1 (polycystic kidney disease 1), were significantly altered in our microarray dataset along with genes associated with synaptic transmission, apoptosis and transport among other functions.
Association of dystrobrevin and regulatory subunit of protein kinase A: a new role for dystrobrevin as a scaffold for signaling proteins.
GeneRIF
Macioce et al., Roma, Italy. In J Mol Biol, 2007
dystrobrevin is a scaffold protein that may play a role in different cellular processes involving PKA signaling
Biglycan regulates the expression and sarcolemmal localization of dystrobrevin, syntrophin, and nNOS.
GeneRIF
Fallon et al., Providence, United States. In Faseb J, 2006
biglycan is important for the maintenance of muscle cell integrity and plays a direct role in regulating the expression and sarcolemmal localization of the intracellular signaling proteins dystrobrevin-1 and -2, alpha- and beta1-syntrophin and nNOS
Reinvestigation of the dysbindin subunit of BLOC-1 (biogenesis of lysosome-related organelles complex-1) as a dystrobrevin-binding protein.
GeneRIF
Dell'Angelica et al., Los Angeles, United States. In Biochem J, 2006
results suggest that dysbindin assembled into BLOC-1 is not a physiological binding partner of the dystrobrevins, likely due to engagement of its dystrobrevin-binding region in interactions with other subunits
Cerebellar synaptic defects and abnormal motor behavior in mice lacking alpha- and beta-dystrobrevin.
GeneRIF
Sanes et al., Saint Louis, United States. In J Neurosci, 2006
AlphaDB, betaDB, & dystrophin are concentrated at a discrete subset of inhibitory synapses on the somata & dendrites of cerebellar Purkinje cells. Sensorimotor behaviors reflecting cerebellar function are perturbed in mice lacking any of these proteins.
Characterization of specific nucleosomal states by use of selective substitution reagents in model octamer and tetramer structures.
Review
Richard-Foy et al., Toulouse, France. In Methods, 1999
The single cysteine located at position 110 of histone H3 can be titrated with thiol reagents, such as iodoacetamide (IAM), N-ethylmaleimide (NEM), and dithiobisnitrobenzoic acid (DTNB), in both histone octamers and histone (H3-H4)(2) tetramers.
Transport ATPases in anion and proton transport.
Review
Schrijen et al., In Ann N Y Acad Sci, 1979
Similar studies of sulfhydryl modification with DTNB indicate that the enzyme contains an essential sulfhydryl group, which does not appear to be directly involved in ATP binding, but rather that ATP binding may induce a conformational change which makes the sulfhydryl group less accessible.
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