The role of lithium in modulation of brain genes: relevance for aetiology and treatment of bipolar disorder.
Minneapolis, United States. In Biochem Soc Trans, 2009
A number of genes associated with bipolar disorder, including Comt (catechol-O-methyltransferase), Vapa (vesicle-associated membrane protein-associated protein A), Dtnb (dystrobrevin beta) and Pkd1 (polycystic kidney disease 1), were significantly altered in our microarray dataset along with genes associated with synaptic transmission, apoptosis and transport among other functions.
Transport ATPases in anion and proton transport.
In Ann N Y Acad Sci, 1979
Similar studies of sulfhydryl modification with DTNB indicate that the enzyme contains an essential sulfhydryl group, which does not appear to be directly involved in ATP binding, but rather that ATP binding may induce a conformational change which makes the sulfhydryl group less accessible.