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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Denticleless homolog

DTL, Cdt2, L2DTL
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Top mentioned proteins: Ubiquitin, V1a, HAD, IL-17RB, PCNA
Papers on DTL
Hydration status affects osteopontin expression in the rat kidney.
New
Han et al., Seoul, South Korea. In J Vet Sci, Jan 2016
Under control conditions, OPN protein and mRNA expression was detectable only in the descending thin limb (DTL).
Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung.
New
Brown et al., London, United Kingdom. In Dis Model Mech, Jan 2016
It has been proposed that FBXO11 regulates the cell's response to TGF-β through the ubiquitination of CDT2.
Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma.
New
Otsuji et al., Kyoto, Japan. In Oncotarget, Dec 2015
BACKGROUND: Denticleless E3 ubiquitin protein ligase homolog (DTL) has been identified in amplified region (1q32) of several cancers and has an oncogenic function.
Aberrant C-terminal domain of polymerase η targets the functional enzyme to the proteosomal degradation pathway.
New
Kannouche et al., Villejuif, France. In Dna Repair (amst), May 2015
We showed that Polη(721) is degraded by the proteasome in an ubiquitin-dependent manner and that this proteolysis is independent of the E3 ligases, CRL4(cdt2) and Pirh2, reported to promote Polη degradation.
The putative cellodextrin transporter-like protein CLP1 is involved in cellulase induction in Neurospora crassa.
New
Ma et al., Tianjin, China. In J Biol Chem, Feb 2015
The co-disruption of the cellodextrin transporters cdt2 and clp1 in strain Δ3βG formed strain CPL7.
CDK1-dependent inhibition of the E3 ubiquitin ligase CRL4CDT2 ensures robust transition from S Phase to Mitosis.
New
Cook et al., Chapel Hill, United States. In J Biol Chem, Feb 2015
Three proteins destroyed during replication via the CRL4(CDT2) ubiquitin E3 ligase, CDT1, p21, and SET8 (PR-SET7), are also essential or important during mitosis, making their reaccumulation after S phase a critical cell cycle event.
Toward more accurate ancestral protein genotype-phenotype reconstructions with the use of species tree-aware gene trees.
Gouy et al., Hamilton, New Zealand. In Mol Biol Evol, 2015
Here, we show with simulations that utilizing information on species history using a model that accounts for the duplication, horizontal transfer, and loss (DTL) of genes statistically increases ASR accuracy.
A fast method for calculating reliable event supports in tree reconciliations via Pareto optimality.
Scornavacca et al., Montpellier, France. In Bmc Bioinformatics, 2014
The DTL parsimonious approach searches for a most parsimonious reconciliation between a gene tree and a (dated) species tree, considering four possible macro-evolutionary events (speciation, duplication, transfer, and loss) with specific costs.
CUL4-DDB1-CDT2 E3 Ligase Regulates the Molecular Clock Activity by Promoting Ubiquitination-Dependent Degradation of the Mammalian CRY1.
Yin et al., Ann Arbor, United States. In Plos One, 2014
Here we show that CUL4-DDB1-CDT2 E3 ligase ubiquitinates CRY1 and promotes its degradation both in vitro and in vivo.
Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes.
Li et al., In Acta Neuropathol Commun, 2013
Importantly, we found that silencing BMI1 in CD133+ cells derived from 3 PDOX models did not affect most of the known genes previously associated with the activated BMI1, but modulated a novel set of core genes, including RPS6KA2, ALDH3A2, FMFB, DTL, API5, EIF4G2, KIF5c, LOC650152, C20ORF121, LOC203547, LOC653308, and LOC642489, to mediate the elimination of tumor formation.
MiR-30a-5p suppresses tumor growth in colon carcinoma by targeting DTL.
GeneRIF
Hahn et al., Bochum, Germany. In Carcinogenesis, 2012
data identified miR-30a-5p as a tumor-suppressing miRNA in colon cancer cells exerting its function via modulation of DTL expression, which is frequently overexpressed in colorectal cancer
1q gain and CDT2 overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma.
GeneRIF
de Álava et al., Salamanca, Spain. In Oncogene, 2012
CDT2, a 1q-located candidate gene encoding a protein involved in ubiquitin ligase activity and significantly overexpressed in 1qG Ewing sarcoma, was validated in vitro and in vivo proving its major contribution to this molecular and clinical phenotype
Control of Drosophila endocycles by E2F and CRL4(CDT2).
Impact
Edgar et al., Heidelberg, Germany. In Nature, 2012
Here, using genetic tests in parallel with computational modelling, we show that the endocycles of Drosophila are driven by a molecular oscillator in which the E2F1 transcription factor promotes CycE expression and S-phase initiation, S-phase then activates the CRL4(CDT2) ubiquitin ligase, and this in turn mediates the destruction of E2F1 (ref.
Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!
Review
GeneRIF
Thomä et al., Basel, Switzerland. In Febs Lett, 2011
Studies indicate the modular architecture of DDB1-CUL4 in complex with DDB2, CSA and CDT2 in DNA repair of UV-induced DNA lesions.
Ub-family modifications at the replication fork: Regulating PCNA-interacting components.
GeneRIF
Kirchmaier, West Lafayette, United States. In Febs Lett, 2011
Studies suggest that DNA damage-induced ubiquitination or sumoylation of PCNA prevents CRL4Cdt2-dependent degradation by inhibiting binding of Cdt1 to PCNA.
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1.
GeneRIF
Boland et al., Dallas, United States. In J Biol Chem, 2011
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1.
A new regulator of the cell cycle: the PR-Set7 histone methyltransferase.
Review
Rice et al., Los Angeles, United States. In Cell Cycle, 2011
Several recent reports reveal that PR-Set7 abundance is dynamically regulated during different cell cycle phases by distinct enzymes including cdk1/cyclinB, Cdc14, SCF(Skp2), CRL4(cdt2) and APC(cdh1).
PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?
Review
Gottifredi et al., Buenos Aires, Argentina. In Dna Repair (amst), 2010
Moreover, conclusive reports identified the E3-ligase CRL4(CDT2) (CUL4-DDB1-CDT2) as the enzymatic complex that promotes p21 proteolysis when treatments such as UV irradiation trigger replication fork stress.
CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.
Impact
Zhang et al., New Haven, United States. In Nat Cell Biol, 2006
Here, we show that CUL4-DDB1 complexes interact with multiple WD40-repeat proteins (WDRs) including TLE1-3, WDR5, L2DTL (also known as CDT2) and the Polycomb-group protein EED (also known as ESC).
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