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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Split hand/foot malformation

DSS1, SEMI, SHFM1, Sem1, DSSI
The product of this gene has been localized within the split hand/split foot malformation locus SHFM1 at chromosome 7. It has been proposed to be a candidate gene for the autosomal dominant form of the heterogeneous limb developmental disorder split hand/split foot malformation type 1. In addition, it has been shown to directly interact with BRCA2. It also may play a role in the completion of the cell cycle. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, Dlx5, Dlx6, Rad51, HAD
Papers on DSS1
Physiological adaptations and ovarian cyclicity of Holstein and Montbéliarde cows under two low-input production systems.
New
Blanc et al., France. In Animal, Dec 2015
The objective was to study milk production, body reserve mobilization, metabolic and hormonal profiles, and ovarian cyclicity of Holstein-Friesian (HOLS) and Montbéliarde (MONT) cows under two low-input dairy production systems with seasonal spring calving: an extensive (EXT; 12 HOLS and 12 MONT) based on permanent diversified grasslands and zero concentrate, and a semi-extensive (SEMI; 12 HOLS and 10 MONT) based on established temporary grasslands and up to 4 kg/day of concentrate.
CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome.
New
Sharon et al., Israel. In Cell Rep, Nov 2015
Finally, on the basis of sequence and structural properties shared by both CSNAP and DSS1, a component of the related 19S lid proteasome complex, we propose that CSNAP, the ninth CSN subunit, is the missing paralogous subunit of DSS1.
Repurposing Hsp104 to Antagonize Seminal Amyloid and Counter HIV Infection.
New
Shorter et al., Philadelphia, United States. In Chem Biol, Sep 2015
Naturally occurring proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) form amyloid fibrils in seminal fluid, which capture HIV virions and promote infection.
Promotion of BRCA2-Dependent Homologous Recombination by DSS1 via RPA Targeting and DNA Mimicry.
New
Sung et al., New Haven, United States. In Mol Cell, Aug 2015
However, we find that RPA-RAD51 exchange requires the BRCA2 partner DSS1.
Upregulated, 7q21-22 amplicon candidate gene SHFM1 confers oncogenic advantage by suppressing p53 function in gastric cancer.
New
Ganesan et al., Madurai, India. In Cell Signal, Jun 2015
RNAi based functional screening of the genes reveal, SHFM1 as key gastric cancer driver gene.
Conformational stability of PCID2 upon DSS1 binding with molecular dynamics simulation.
New
Chen et al., Dezhou, China. In J Mol Model, May 2015
DSS1 is a small acidic intrinsically disordered protein (IDP) that can fold upon binding with PCID2 TREX-2.
A cytochrome P450, OsDSS1, is involved in growth and drought stress responses in rice (Oryza sativa L.).
New
Terauchi et al., Kitakami, Japan. In Plant Mol Biol, May 2015
Here, we report the characterization of dss1, a rice mutant showing dwarfism and reduced grain size.
Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils.
Shorter et al., Philadelphia, United States. In Biol Open, 2014
Semen harbors amyloid fibrils formed by proteolytic fragments of prostatic acid phosphatase (PAP248-286 and PAP85-120) and semenogelins (SEM1 and SEM2) that potently enhance HIV infectivity.
BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2.
Impact
Aguilera et al., Sevilla, Spain. In Nature, 2014
Here we show that the human TREX-2 complex, which is involved in mRNP biogenesis and export, prevents genome instability as determined by the accumulation of γ-H2AX (Ser-139 phosphorylated histone H2AX) and 53BP1 foci and single-cell electrophoresis in cells depleted of the TREX-2 subunits PCID2, GANP and DSS1.
Split-hand/foot malformation - molecular cause and implications in genetic counseling.
Review
Jamsheer et al., Poznań, Poland. In J Appl Genet, 2014
To date, seven chromosomal loci associated with isolated SHFM have been described, i.e., SHFM1 to 6 and SHFM/SHFLD.
Multiplex ligation-dependent probe amplification and array comparative genomic hybridization analyses for prenatal diagnosis of cytogenomic abnormalities.
Xie et al., Shenzhen, China. In Mol Cytogenet, 2013
for Jacobsen syndrome, a de novo 19.971 Mb deletion of 7q11.23-q21.3 for type 1 split-hand/foot malformation (SHFM1), and a de novo 28.909 Mb duplication of 3q21.1-q25.1 were detected.
Depletion of DSS1 protein disables homologous recombinational repair in human cells.
GeneRIF
Brenneman et al., United States. In Mutat Res, 2011
DSS1 has a role in homologous recombinational repair in human cells
Genome-wide profiling of p63 DNA-binding sites identifies an element that regulates gene expression during limb development in the 7q21 SHFM1 locus.
GeneRIF
Zhou et al., Nijmegen, Netherlands. In Plos Genet, 2010
p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development.
Association of the DSS1 c.143G>A polymorphism with skin squamous cell carcinoma.
GeneRIF
Teti et al., Messina, Italy. In J Invest Dermatol, 2010
The DSS1 c.143G>A variant is associated with reduced DSS1 expression at RNA and protein levels and altered traffic of the DSS1 protein from the cytoplasm to the nucleus. These alterations could impair DSS1 function and may be implicated in skin cancer.
PCI complexes: Beyond the proteasome, CSN, and eIF3 Troika.
Review
Glickman et al., Haifa, Israel. In Mol Cell, 2009
The breadth of functions associated with the extended PCI family is a factor of shared subunits, among them a common factor Sem1/DSS1 that facilitates complex assembly.
Sem1p and Ubp6p orchestrate telomeric silencing by modulating histone H2B ubiquitination and H3 acetylation.
GeneRIF
Wani et al., Columbus, United States. In Nucleic Acids Res, 2009
Results demonstrate that Sem1p and Ubp6p maintain telomeric heterochromatin structure through modulation of histone covalent modifications and association of silencing factors independently of the proteolytic function of the proteasome.
A genetic interaction map of RNA-processing factors reveals links between Sem1/Dss1-containing complexes and mRNA export and splicing.
GeneRIF
Krogan et al., San Francisco, United States. In Mol Cell, 2009
These data enabled the discovery of links between components of the mRNA export and splicing machineries and Sem1/Dss1, a component of the 19S proteasome.
BRCA2: breaks, mistakes and failed separations.
Review
Foulkes et al., Montréal, Canada. In Trends Mol Med, 2005
Other groups have also shown how BRCA2, RAD51 and DSS1 co-exist in a ménage à trois and how the disruption of any one of the three cohabitants can have disastrous consequences for the cell.
BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure.
Impact
GeneRIF
Pavletich et al., New York City, United States. In Science, 2002
3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif
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