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Dentin sialophosphoprotein

DSP, DPP, DSPP, desmoplakin I
This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1; in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Glucagon, Insulin, E4, CAN, HAD
Papers using DSP antibodies
Abnormal cardiac inflow patterns during postnatal development in a mouse model of Holt-Oram syndrome
Supplier
Drucker Daniel J. et al., In Diabetes, 2004
... receives partial operating grant support for DPP-4–related research from Merck Frosst ...
Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency
Supplier
Merzouki Abderrazzak et al., In International Journal of Nanomedicine, 2000
... siRNA sequences targeting the DPP-IV gene sequence were synthesized by Dharmacon (Thermo scientific, Dharmacon RNAi Technologies, USA) ...
Papers on DSP
Intestinal Bile Acid Composition Modulates Prohormone Convertase 1/3 (PC1/3) Expression and Consequent GLP-1 Production in male mice.
New
Itoh et al., Tokyo, Japan. In Endocrinology, Feb 2016
We also propose a combination of BABR and DPP-4 inhibitor in the context of GLP-1-based antidiabetic therapy.
Abelmoschus esculentus fractions potently inhibited the pathogenic targets associated with diabetic renal epithelial to mesenchymal transition.
New
Ker et al., Taiwan. In Food Funct, Feb 2016
Our recent studies have focused on diabetic renal epithelial to mesenchymal transition (EMT), which plays a critical role in fibrosis that accompanies increasing vimentin and suggested signals DPP-4/AT-1/TGF-β1.
A Protein Preload Enhances the Glucose-Lowering Efficacy of Vildagliptin in Type 2 Diabetes.
New
Rayner et al., Adelaide, Australia. In Diabetes Care, Feb 2016
This study was designed to evaluate whether a protein preload could improve the efficacy of the dipeptidyl peptidase-4 (DPP-4) inhibitor vildagliptin to increase incretin concentrations, slow gastric emptying, and lower postprandial glycemia in type 2 diabetes.
Diketopyrrolopyrrole Polymers for Organic Solar Cells.
New
Impact
Janssen et al., Beijing, China. In Acc Chem Res, Feb 2016
In this Account, we highlight progress on the development and our understanding of diketopyrrolopyrrole (DPP) based conjugated polymers for polymer solar cells.
Effects of endogenous GLP-1 and GIP on glucose tolerance after Roux-en-Y gastric bypass surgery.
New
Madsbad et al., Copenhagen, Denmark. In Am J Physiol Endocrinol Metab, Feb 2016
We used DPP-4 inhibition to enhance concentrations of intact GIP and GLP-1 and the GLP-1 receptor antagonist exendin 9-39 (Ex-9) for specific blockage of GLP-1 actions.
Drug development from the bench to the pharmacy: with special reference to dipeptidyl peptidase-4 inhibitor development.
Review
New
Carr, Ballerup, Denmark. In Diabet Med, Feb 2016
UNASSIGNED: The dipeptidyl peptidase-4 (DPP-4) inhibitor concept is an example of prospective drug design and development based upon a distinct endocrine hypothesis.
Strategies to Make Ramadan Fasting Safer in Type 2 Diabetics: A Systematic Review and Network Meta-analysis of Randomized Controlled Trials and Observational Studies.
Review
New
Wong et al., Malaysia. In Medicine (baltimore), Jan 2016
The most common strategy used was drug changes during the Ramadan period, which found that the use of DPP-4 (Dipeptidyl peptidase inhibitor -4) inhibitors were associated with a reduction in incidence of experiencing hypoglycemia during Ramadan in both RCTs (pooled relative risk: 0.56; 95% confidence interval: 0.44-0.72)
Polyphosphate-induced matrix metalloproteinase-3-mediated differentiation in rat dental pulp fibroblast-like cells.
New
Nakata et al., Japan. In Biosci Trends, Dec 2015
Poly(P) enhanced expression of mature odontoblast markers dentin sialophosphoprotein (DSPP) and dentin matrix protein (DMP)-1 in DPFCs.
Lessons learned from cardiovascular outcome clinical trials with dipeptidyl peptidase 4 (DPP-4) inhibitors.
Review
New
Sesti et al., Catanzaro, Italy. In Endocrine, Dec 2015
Incretin-based therapies including dipeptidyl peptidase 4 (DPP-4) inhibitors, and injectable glucagon-like peptide 1 (GLP-1) receptor agonists are novel treatment options for patients with inadequate glucose control.
A Comparative Review of DPP-4 Inhibitors and Sulphonylureas.
Review
New
Lebovitz et al., Copenhagen, Denmark. In Diabetes Obes Metab, Dec 2015
Dipeptidyl peptidase-4 inhibitors (DPP-4i) are, by comparison, more recent, with the first compound being launched in 2006, but the class now globally encompasses at least eleven different compounds.
Decapentaplegic and growth control in the developing Drosophila wing.
New
Impact
Gibson et al., Kansas City, United States. In Nature, Dec 2015
As a central model for morphogen action during animal development, the bone morphogenetic protein 2/4 (BMP2/4)-like ligand Decapentaplegic (Dpp) is proposed to form a long-range signalling gradient that directs both growth and pattern formation during Drosophila wing disc development.
Dpp spreading is required for medial but not for lateral wing disc growth.
New
Impact
Caussinus et al., Basel, Switzerland. In Nature, Dec 2015
Drosophila Decapentaplegic (Dpp) has served as a paradigm to study morphogen-dependent growth control.
Nanotubes mediate niche-stem-cell signalling in the Drosophila testis.
New
Impact
Yamashita et al., Ann Arbor, United States. In Nature, Aug 2015
Perturbation of microtubule-based nanotubes compromises activation of Dpp signalling within germline stem cells, leading to germline stem cell loss.
Haemocytes control stem cell activity in the Drosophila intestine.
New
Impact
Jasper et al., Novato, United States. In Nat Cell Biol, Jun 2015
On tissue damage, haemocytes are recruited to the intestine and secrete the BMP homologue DPP, inducing ISC proliferation by activating the type I receptor Saxophone and the Smad homologue SMOX.
Alterations of Dopamine D2 Receptors and Related Receptor-Interacting Proteins in Schizophrenia: The Pivotal Position of Dopamine Supersensitivity Psychosis in Treatment-Resistant Schizophrenia.
Review
Iyo et al., Chiba, Japan. In Int J Mol Sci, 2014
Dopamine supersensitivity psychosis (DSP) is historically known as a by-product of antipsychotic treatment in the manner of tardive dyskinesia or transient rebound psychosis.
Proteolytic processing of dentin sialophosphoprotein (DSPP) is essential to dentinogenesis.
GeneRIF
Qin et al., Dallas, United States. In J Biol Chem, 2012
the proteolytic processing of DSPP is an activation step essential to its biological function in dentinogenesis.
Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?
GeneRIF
Llombart-Bosch et al., Valencia, Spain. In Virchows Arch, 2012
Desmoplakin and pGSK3beta constitute independent good prognostic factors for progression free survival in Ewing Sarcoma patients.
Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice.
GeneRIF
Lee et al., Birmingham, United States. In J Bone Miner Res, 2012
Trps1 is identified as a potent inhibitor of Dspp expression and the subsequent mineralization of dentin.
Expression patterns of nestin and dentin sialoprotein during dentinogenesis in mice.
GeneRIF
Ohshima et al., Niigata, Japan. In Biomed Res, 2012
Preodontoblasts began to express nestin and Dsp proteins and Dsp mRNA, which increased in their intensity according to the progress of odontoblast differentiation in both incisors and developing molars
Expressions of matrix metalloproteinase-9 (MMP-9), dentin sialophosphoprotein (DSPP), and osteopontin (OPN) at histologically negative surgical margins may predict recurrence of oral squamous cell carcinoma.
GeneRIF
Fisher et al., Augusta, United States. In Oncotarget, 2012
DSPP, OPN, or MMP-9 expressions at histologically-negative surgical margins predict Oral squamous cell carcinoma recurrence with MMP-9 being the preferred predictor.
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