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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Ubiquilin 1

Dsk2, ubiquilin, ubiquilin 1, UBQLN1
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Papers on Dsk2
Ubiquilin-1 regulates amyloid precursor protein maturation and degradation by stimulating K63-linked polyubiquitination of lysine 688.
GeneRIF
Boehning et al., Galveston, United States. In Proc Natl Acad Sci U S A, 2012
These results reveal the mechanistic basis by which ubiquilin-1 regulates APP maturation.
Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion.
GeneRIF
Trojanowski et al., Philadelphia, United States. In Acta Neuropathol, 2012
Found a pathophysiological link between C9ORF72 expansions and ubiquilin-2 (UBQLN) proteins in amyotrophic lateral sclerosis and frontotemporal lobar degeneration that is associated with a highly characteristic pattern of UBQLN pathology.
UBQ-8i polymorphism is not an independent risk factor for mild cognitive impairment and Alzheimer's disease in APOE-4 carriers.
GeneRIF
Pancorbo et al., Vitoria-Gasteiz, Spain. In Curr Alzheimer Res, 2012
This study demonistrated that Allele C of polymorphism UBQ-8i of the UBQLN1 gene is not an independent risk factor for mild cognitive impairment or Alzheimer's disease
Mutations in UBQLN2 are rare in French amyotrophic lateral sclerosis.
GeneRIF
Salachas et al., Paris, France. In Neurobiol Aging, 2012
The results of this study suggested that UBQLN2 gene mutations are rare in French amyotrophic lateral sclerosis.
Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.
GeneRIF
Varmus et al., Bethesda, United States. In Proc Natl Acad Sci U S A, 2012
Ubqln stabilizes BCLb protein, while also promoting monoubiquitination on multiple lysine residues and relocation to the cytosol.
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